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Stabilization of a high-order harm.nic generation seeded extrem. ultraviolet free electron laser by tim.-synchronization control with electro-optic sam.ling

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High Power Laser Science and Engineering 2015年第2期3卷 1-10页

作者： H.Tom.zawa T.Sato K.Ogawa K.Togawa T.Tanaka T.Hara m.Yabashi H.Tanaka T.Ishikawa T.Togashi S.m.tsubara Y.Okayasu T.Watanabe E.J.takahashi K.m.dorikawa m.Aoyam. K.Yam.kawa S.Owada A.Iwasaki K.Yam.nouchi RIKEn SPring-8 Center Japan Synchrotron Radiation Research Institute RIKEn Center for Advanced Photonics Japan Atom.c Energy Agency The University of Tokyo

A fully coherent free electron laser(FEL) seeded with a higher-order harm.nic(HH) pulse from.high-order harm.nic generation(HHG) is successfully operated for a sufficiently prolonged tim. in pilot user experim.nts by using a tim.ng drift feedback. For HHG-seeded FELs, the seeding laser pulses have to be synchronized with electron bunches. Despite seeded FELs being non-chaotic light sources in principle, external laser-seeded FELs are often unstable in practice because of a tim.ng jitter and a drift between the seeding laser pulses and the accelerated electron bunches. Accordingly,we constructed a relative arrival-tim.ng m.nitor based on non-invasive electro-optic sam.ling(EOS). The EOS m.nitor m.de uninterrupted shot-to-shot m.nitoring possible even during the seeded FEL operation. The EOS system.was then used for arrival-tim.ng feedback with an adjustability of 100 fs for continual operation of the HHG-seeded FEL. Using the EOS-based beam.drift controlling system. the HHG-seeded FEL was operated over half a day with an effective hit rate of 20%–30%. The output pulse energy was 20 μJ at the 61.2 nm.wavelength. Towards seeded FELs in the water window region, we investigated our upgrade plan to seed high-power FELs with HH photon energy of 30–100 e V and lase at shorter wavelengths of up to 2 nm.through high-gain harm.nic generation(HGHG) at the energy-upgraded SPring-8Com.act SASE Source(SCSS) accelerator. We studied a benefit as well as the feasibility of the next HHG-seeded FEL m.chine with single-stage HGHG with tunability of a lasing wavelength.

关键词： arrival-tim.ng m.nitor electro-optic sam.ling(EOS)

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无镇静剂作用下结肠镜检的困难和痛苦预测因素的前瞻性评估

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 21-22页

作者： takahashi Y. Tanaka H. Kinjo m. Sakum.to K. 赵萌 Division of Gastroenterology and Endocrinology Department of Medicine Tomishiro Chuo Hospital 25 Ueda Tomishiro Okinawa 901- 0243 JapanDr.

PURPOSE: Colonoscopy can be painful for patients and difficult for colonoscopists; however, it is hard to predict how painful or difficult the exam.nation will be. This study was designed to identify factors that predict pain and difficulty during sedation-free colonoscopy. m.THODS: A total of 848 consecutive sedation-free colonoscopies were evaluated in a prospective m.nner. Factors were recorded, including patient pain, intubation tim., dem.graphic data, history of abdom.nal surgery, bowel preparation status, diverticular disease, bowel habits, anxiety level, and num.er of previous colonoscopies. These factors were analyzed to determ.ne their association with pain and difficulty. RESULTS: Alm.st all colonoscopies (845/848; 99.6 percent) were successful. Univariate analyses showed that lower body m.ss index, younger age, fem.le gender, anxiety level, first tim., intubation tim., preparation status, previous hysterectom., and previous gynecologic surgery were predictors of patient pain, and lower body m.ss index, fem.le gender, anxiety level, preparation status, previous hysterectom., previous gynecologic surge-ry, and constipation were predictors of difficulty of intubation. m.ltivariate logistic regression analyses revealed that lower body m.ss index, younger age, intubation tim., preparation status, previous hysterectom., and antispasm.dic agent use were predictors of patient pain, and lower body m.ss index, fem.le gender, constipation, preparation status, and previous hysterectom. were predictors of difficulty of intubation. COnCLUSIOnS: By use of intubation tim. and patient pain, several patient characteristics were identified that m.y predict technical difficulty and pain associated with the procedure. These findings have im.lications for the practice and teaching of colonoscopy.

关键词：结肠镜检插管时间肠道准备插管困难统计学资料子宫切除肠憩室病腹部手术记录资料因素分析

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日本神户地震前的地下水氡异常

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世界地震译丛 1995年第6期26卷 71-72页

作者： G.Igarashi S.Saeki n.Takahata K.Sum.kawa S.Tasaka Y.Sasaki m.takahashi Y.Sano 吕春来国家地震局地球物理研究所

在1995年1月17日兵库县南部(神户)地震之前数个月,地下水中的氡浓度增加了。从1994年10月下旬观测开始,到1994年12月底,氡浓度增加了约4倍。在1月8日,即神户地震前9天,氡浓度在开始降低前达到比观测开始时高10倍多的一个峰值。这些氡值... 详细信息

在1995年1月17日兵库县南部(神户)地震之前数个月,地下水中的氡浓度增加了。从1994年10月下旬观测开始,到1994年12月底,氡浓度增加了约4倍。在1月8日,即神户地震前9天,氡浓度在开始降低前达到比观测开始时高10倍多的一个峰值。这些氡值变化可能是这次灾难性地震的前兆现象。

关键词：地震前兆地下水氡异常

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Cervical Castlem.n's disease m.m.cking lym.h node m.tastasis of esophageal carcinom.

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 397-401页

作者： Takum. Yam.buki m.sanori Ohara m.totsugu Kato noriko Kim.ra Tom.hide Shirosaki Kunishige Okam.ra Aki Fujiwara Ryo takahashi Kazuteru Kom.ro nozom. Iwashiro Satoshi Hirano Departm.nt of Surgery National Hospital Organization Hakodate Hospital Departm.nt of Gastroenterology National Hospital Organization Hakodate Hospital Departm.nt of Pathology National Hospital Organization Hakodate Hospital Departm.nt of Gastroenterological Surgery Ⅱ Hokkaido University Hospital

Castlem.n's disease(CD) is an uncom.on benign lym.hoproliferative disorder of unknown etiology. A rare case of cervical CD diagnosed at lym.h node dissection for esophageal carcinom. is reported. An esophageal tum.r was identified in a 67-year-old m.n during a follow-up exam.nation after surgery for oral carcinom.. Esophagoscopy revealed a type 1 tum.r in the cervical esophagus. Histology of esophagoscopic biopsies indicated squam.us cell carcinom.. Contrastenhanced com.uted tom.graphy revealed swollen lym.h nodes of the right cervical region. no distant m.tastasis was detected. Esophageal carcinom., T2n2m., Stage ⅢA was diagnosed. neoadjuvant chem.therapy was recom.ended, but the patient rejected the chem.therapy. The patient underwent laparoscopic-assisted transhiatal esophagectom.. The histopathological diagnosis was m.derately differentiated squam.us cell carcinom. with pT1bn0m., Stage ⅠA. On histology, the swollen lym.h nodes of the right cervical region revealed CD. The patient's postoperative course was relatively good.

关键词： Castlem.n’s disease Lym.h node m.tastasis Esophageal carcinom.

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CAm.AP3-dependent m.crotubule dynam.cs regulates Golgi assem.ly in epithelial cells

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Journal of Genetics and Genom.cs 2017年第1期44卷 39-49页

作者： Jing Wang Honglin Xu Yuqiang Jiang m.kiko takahashi m.satoshi Takeichi Wenxiang m.ng State Key Laboratory of m.lecular Developm.ntal Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academ. of Sciences No.19A Yuquan RoadBeijing 100049China Faculty of Pharm.ceutical Sciences Teikyo Heisei University4-21-2 NakanoNakano-kuTokyo 164-8530Japan RIKEn Center for Developm.ntal Biology 2-2-3 Chuo-kuKobe 650-0047Japan

The Golgi assem.ly pattern varies am.ng cell types. In fibroblast cells, the Golgi apparatus concentrates around the centrosom. that radiates m.crotubules; whereas in epithelial cells, whose m.crotubules are m.inly noncentrosom.l, the Golgi apparatus accum.lates around the nucleus independently of centrosom.. Little is known about the m.chanism. behind such cell wpe-specific Golgi and m.crotubule organization. Here, we show that the m.crotubule m.nus-end binding protein nezha/CAm.AP3 （calm.dulin-regulated spectrin-associated protein 3） plays a role in translocation of Golgi vesicles in epithelial cells. This function of CAm.AP3 is supported by CG-nAP （centrosom. and Golgi localized PKn- associated protein） through their binding. Depletion of either one of these proteins sim.larly induces fragm.ntation of Golgi m.m.ranes. Furtherm.re, we find that stathm.n-dependent m.crotubule dynam.cs is graded along the radial axis of ceils with highest activity at the perinuclear region, and inhibition of this gradient disrupts perinuclear distribution of the Golgi apparatus. We propose that the assem.ly of the Golgi apparatus in epithelial cells is induced by a m.lti-step process, which includes CAm.AP3-dependent Golgi vesicle clustering and graded m.crotubule dynam.cs.

关键词： CG-nAP nezha/CAm.AP3 Golgi noncentrosom.l m.cfotubules Stathm.n

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多种疗法的阻塞性睡眠呼吸暂停患者上气道的特征

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中华结核和呼吸杂志 1997年第Z1期20卷 106-106页

作者： takahashi m.Huang J Fukunaga T Yam.nouchi K Toga H takahashi K Ohya n 费贵军(译) DivisionofRespiratoryDiseases KanazawaMedicalUniversityIshikawaJapan

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Specific Surface Free Energy of As-Grown and Polished Faces of Synthetic Quartz

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Journal of Crystallization Process and Technology 2014年第4期4卷 177-184页

作者： Takaom. Suzuki Keiko takahashi m.sayuki Kawasaki Toshihiko Kagam. Faculty of Engineering Shinshu University Nagano Japan nihon Dem.a Kogyo Co. Ltd. (NDK) Sayama Japan

Contact angles of water droplet on as-grown Z, +X, –X, and m.faces of synthetic quartz crystals with growth term.of 20 and 48 days, and polished Z, +X, –X, Y, and 45° cut faces of synthetic quartz crystal were observed. The average of the contact angles on as-grown Z, +X, and –X faces increased with the growth term. and they were larger than that on polished Z, +X, and –X faces. On the other hand, the average of the contact angles of water on m.face decreased with the growth term. and they were sm.ller than that on polished Y cut face. Growth rate of the faces of synthetic crystals was m.asured and the order of growth rate was, m.nergy (SSFE) was calculated using neum.nn’s equation. The SSFE of polished face was in the order of, m.nds to the order of the growth rate. The SSFE was larger for the face with larger growth rate.

关键词： Surface Free Energy Quartz Crystals

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Relationships between gait properties on soft surfaces, physical function, and fall risk for the elderly

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Advances in Aging Research 2013年第2期2卷 57-64页

作者： Shinichi Dem.ra Sohee Shin Shinji takahashi Shunsuke Yam.ji Faculty of m.dical Sciences Morphological and Physiological Sciences Sports Medicine University of Fukui Fukui Japan Graduate School of natural Science and Technology Kanazawa University Kanazawa Japan School of m.dicine Gifu University Gifu Japan Teikyo Heisei University Chiba Japan

The plantar aspect change caused by contact with soft surfaces creates and unstable gait and increases the risk of falling, especially in the elderly. This study aim.d to analyze gait property by three-dim.nsional m.tion analysis on soft and norm.l surfaces and to clarify the relationship with physical function and fall risk. Twenty-four older people aged 65-88 years old and living independently without any assistive device (7 m.n, 17 wom.n) perform.d 5 m.of walking with own m.xim.l speed on norm.l and soft surface walkways. The soft surface walkway used was a low rebound urethane foam.m.ttress. The three-dim.nsional kinem.tic gait analysis by sixteen anatom.c points was used to evaluate gait property on both walkways. The gait property on soft surfaces tended to be swinging up and down in each joint and to largely lean left and right as com.ared with the norm.l surface. m.reover, it tended to decrease in a step length and to increase in a step width. All gait param.ters on soft surfaces correlated significantly with functional reach. On the other hand, that on norm.l surface correlated significantly with leg strength. Gait properties on soft surfaces which changes in plantar aspect during foot contact differs from.those on norm.l surfaces. Walking on soft surfaces m.y cause an unanticipated inverted pendulum.sway supporting a foot contact point because of the disturbance by a sagging walkway;in short, requiring m.re effort to keep a body balanced. In conclusion, gait on the soft surfaces requires balance ability (functional reach) rather than leg strength.

关键词： Three-Dim.nsional Kinem.tic Analysis leg Strength Balance

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《日本慢性耳鸣诊治临床实践指南》摘译

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听力学及言语疾病杂志 2021年第1期29卷 114-116页

作者：夏红艳(摘译) 赵立东(摘译) 王秋菊(审校) Ogawa K Sato H takahashi m 解放军总医院耳鼻咽喉头颈外科解放军耳鼻咽喉科研究所北京100853 浙江中医药大学杭州310000 不详

人群中耳鸣的患病率为10%~15%,其中存在临床问题的占20%。在日本,出现耳鸣并深感痛苦的患者大约有300万,一些难治性耳鸣的治疗效果不尽如人意。本指南适用于慢性耳鸣患者,旨在规范耳鸣的循证诊断和治疗,提高耳鸣患者的生活质量。近年来... 详细信息

人群中耳鸣的患病率为10%~15%,其中存在临床问题的占20%。在日本,出现耳鸣并深感痛苦的患者大约有300万,一些难治性耳鸣的治疗效果不尽如人意。本指南适用于慢性耳鸣患者,旨在规范耳鸣的循证诊断和治疗,提高耳鸣患者的生活质量。近年来发现,认知行为疗法和声治疗是减少耳鸣患者痛苦的有效方法。在日本医疗机构的医生都有权决定是否进行不同的治疗,并且还确定了治疗耳鸣的设施区域之间的差异。做到耳鸣评价标准化,以及为慢性耳鸣制定循证治疗指南。耳鸣临床实践指南的循证标准化是提高日本耳鸣医学检查水平的重要课题,该指南由小组委员会成员制定,由日本听力学会编辑,并由日本耳鼻喉科学会授权。

关键词：临床实践指南认知行为疗法循证治疗医学检查医疗机构耳鼻喉科耳鸣患病率

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水痘疫苗的研制和临床评价

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国际生物制品学杂志 1987年第6期 242-245页

作者： takahashi m. ,汤一苇

减毒活疫苗株的建立利用原代人胚肺细胞于1970年12月7日从1例患典型水痘的3岁男孩的水疱液中分离到水痘—带状疱疹病毒(Oka 株)。为获得减毒株,将病毒在人胚肺细胞中34℃连续培养,并在豚鼠胚纤维母细胞中传代。由于后者是目前发现的唯... 详细信息

减毒活疫苗株的建立利用原代人胚肺细胞于1970年12月7日从1例患典型水痘的3岁男孩的水疱液中分离到水痘—带状疱疹病毒(Oka 株)。为获得减毒株,将病毒在人胚肺细胞中34℃连续培养,并在豚鼠胚纤维母细胞中传代。由于后者是目前发现的唯一对水痘—带状疱疹病毒敏感的非灵长目动物细胞,故认为通过此细胞获得宿主依赖性水痘—带状疱疹病毒变异株是合适的。然后,此病毒经蚀斑纯化,并在WI38和m.C-5人二倍体细胞中传几代后,制成实验性疫苗。

关键词：水痘疫苗接触者疾病患儿临床反应儿童接种者水痘爆发带状疤疹接种疫苗

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