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Addicts with chronic hepatitis C:Difficult to reach,manage or treat?

World Journal of Gastroenterology 2013年第44期19卷 8011-8019页

作者： Barbara Zanini Federica Benini Marie Graciella Pigozzi Patrizia Furba Ernesto Giacò Antonia Cinquegrana Mariagrazia Fasoli alberto lanzini Department of Clinical and Experimental Sciences Gastroenterology Unit University and Spedali Civili of Brescia I-25123 Brescia Italy Territorial Addiction Service (SerT) Local Health Authority (ASL) of Brescia I-25100 Brescia Italy

AIM:To assess the acceptance,safety and efficacy of care and treatment for chronic hepatitis C(CHC)in drug ***:We designed a multidisciplinary,phase IV prospective cohort *** illicit drug users(IDUs)visited a Territorial Addiction Service(SerT)in the District of Brescia,and hepatitis C antibody(HCVAb)testing positive were offered as part of a standardised hepatologic visit in our Gastroenterology *** with confirmed CHC and without medical contraindications were administered peginterferon alfa-2b 1.5μg/kg per week plus ribavirin(800-1400 mg/d)for *** IDUs were unselected because of ongoing addiction and read and signed an informed consent *** responses at weeks 4 and 12 of therapy,at the end of treatment and 24 wk after the end of treatment were the main measures of *** was estimated according to the 80/80/80 ***:From November 2007 to December 2009,162 HCVAb+IDUs were ***-seven patients(41%of the initial cohort)completed the diagnostic procedure,and CHC was diagnosed in 54(33%of the total).Forty-nine patients were offered therapy,and 39agreed(80%of acceptance rate).The prevalent HCV genotype was type 1,and the HCV RNA baseline level was over 5.6 log/mL in 61%of *** patients dropped out,two because of severe adverse events(SAEs)and three without medical ***-three and 14 patients achieved end of treatment responses(ETRs;59%)and sustained virologic responses(SVRs;36%),***-one patients were fully compliant with the study protocol(80%adherence).The prevalence of host and viral characteristics negatively affecting the treatment response was high:age over40 years(54%),male gender(85%),overweight body type(36%),previous unsuccessful antiviral therapy(21%),HCV genotype and viral load(60%and 62%,respectively),earlier contact with HBV(40%)and steatosis and fibrosis(44%and 17%,respectively).In a univariate analysis,alcohol intake was associated with a non-respon

关键词： Chronic hepatitis C Addiction Antiviral therapy Interferon Multidisciplinary

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面向城镇住宅建筑光伏一体化的GIS开放数据协同仿真平台

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Engineering 2023年第7期26卷 198-213,I0008页

作者： Marco Massano Enrico Macii Andrea lanzini Edoardo Patti Lorenzo Bottaccioli Interuniversity Department of Regional and Urban Studies and Planning Politecnico di TorinoTorino 10129Italy Department of Energy“Galileo Ferraris” Politecnico di TorinoTorino 10129Italy Department of Control and Computer Engineering Politecnico di TorinoTorino 10129Italy

The rising awareness of environmental issues and the increase of renewable energy sources(RESs)has led to a shift in energy production toward RES,such as photovoltaic(PV)systems,and toward a distributed generation(DG)model of energy production that requires systems in which energy is generated,stored,and consumed *** this work,we present a methodology that integrates geographic information system(GIS)-based PV potential assessment procedures with models for the estimation of both energy generation and consumption *** particular,we have created an innovative infrastructure that co-simulates PV integration on building rooftops together with an analysis of households’electricity *** model relies on high spatiotemporal resolution and considers both shadowing effects and real-sky conditions for solar radiation *** integrates methodologies to estimate energy demand with a high temporal resolution,accounting for realistic populations with realistic consumption *** a solution enables concrete recommendations to be drawn in order to promote an understanding of urban energy systems and the integration of RES in the context of future smart *** proposed methodology is tested and validated within the municipality of Turin,*** the whole municipality,we estimate both the electricity absorbed from the residential sector(simulating a realistic population)and the electrical energy that could be produced by installing PV systems on buildings’rooftops(considering two different scenarios,with the former using only the rooftops of residential buildings and the latter using all available rooftops).The capabilities of the platform are explored through an in-depth analysis of the obtained *** power and energy profiles are presented,emphasizing the flexibility of the resolution of the spatial and temporal *** energy indicators are presented for the self-consumption of produced energy and the avoidance of CO_(

关键词： Energy informatics Geographic information system Load estimation Open data Photovoltaic Residential Urban planning Co-simulation

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胆囊运动功能的评价

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国外医学（消化系疾病分册） 1990年第3期10卷 150-152页

作者： lanzini A 叶超平

传统概念认为胆囊运动功能似一“慢泵”,包括餐后的缓慢排空和消化间期的储存。作者提出一新设想,认为胆囊在餐后和消化间期均有快速变换的储存和排空,并对检测该设想的各种方法作了评价。

关键词：胆囊运动功能

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乳糜泻的流行病学、临床和组织病理学特点:意大利社区居民检出病例研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 60-61页

作者： lanzini A. Villanacci V. Apillan N. 王铮 Gastroenterology Unit Department of Medicine Spedali Civili and University of Brescia P. le Spedali Civili 1 IT- 25125 Brescia Italy Dr.

Objective. Celiac disease (CD) is underdiagnosed mainly because of lack of awareness of its heterogeneous clinical presentation. The Center for Surveillance and Control of Celiac Disease (CCD) was set up in June 2000 in the province of Brescia, Northern Italy (1,016,426) inhabitants to enhance case- finding, to standardize diagnostic criteria and to collect epidemiological data. Material and methods. The CCD has prompted an educational "celiac awareness program" in the primary- care setting focusing on selective serological screening of high- risk groups, and has reviewed by standardized criteria all diagnoses made in the province since 1984. Results. A total of 1437 CD patients have been identified by the CCD, 508 of them diagnosed after June 2000 during the 3 years of activity of the Center (M:F 2:1). Annual incidence was 0.11/1000 before and increased to 0.17/1000 during CCD activity, and this increase was greater for adult (from 0.07/1000 to 0.12/1000) than for pediatric CD (from 0.04/1000 to 0.05/1000). Mean age at diagnosis also increased from 20.2± 17.7 years to 27.2 ± 19.3 years (p < 0.0001) as did the proportion of asymptomatic patients (8% versus 15% ) before and during CCD activity. There was a linear trend towards increasing proportions of symptomatic patients with increasing severity of histopathologic lesions (p < 0.03). Conclusions. Our results indicate that educational programs promoting serological screening of CD in high- risk groups are effective for case- finding in large communities, particularly among the adult population, and suggest that primary- care doctors caring for adults should be particularly targeted by “ celiac awareness programs".

关键词：乳糜泻病例研究病理学特点血清学筛查初级保健高危人群布雷西亚病理学损害成人患者诊断标准

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弗布利病患者角膜和结膜活体共聚焦显微镜的特征

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 14-14页

作者： Mastropasqua L. Nubile M. lanzini M. 曹绪胜(译) Department of Medicine and Aging Science Ophthalmic Clinic University of Chieti-Pescara Chieti Italy 不详

PURPOSE:To describe the microscopic corneal and conjunctival findings in patients with Fabry disease(FD)related keratopathy by using in vivo confocal ***:Prospective observational case ***:Twelve eyes of six patients affected by Fabry disease,belonging to two different families,underwent in vivo confocal microscopic *** and conjunctival morphology were assessed by means of a scanning slit corneal confocal whitelight microscopy and confocal laser-scanning ***:Confocal microscopy examination evidenced two different types of corneal epithelial *** three hemizygous patients presented bright hyper-reflective intracellular inclusions located within the basal epithelial cells,while the three heterozygous patients showed fine diffusion of reflective substance at the level of superficial,basal epithelial cells and basal membrane,in all *** complex basal-Bowman’ s membrane appeared irregular,distorted,and nonhomogeneous in all *** increased reflectivity attributable to haze and epithelial ingrowth with bright intracellular inclusions was noticed in one hemizygous *** all patients,conjunctival epithelial involvement represented by bright roundish intracellular inclusions was evidenced,appearing more pronounced in tarsal than in bulbar ***:Although FD-related cornea verticillata attributable to glycosphingolipids accumulation is considered to be primarily a corneal disease,in vivo confocal microscopy demonstrated structural alterations throughout the entire ocular surface *** is still unclear whether the different type of corneal epithelial lesions observed for hemizygous and heterozygous patients is related to different physiopathological *** microscopy may assist ophthalmologists in the diagnosis of FD-related ocular surface and corneal manifestations.

关键词：活体共聚焦显微镜角膜病变球结膜共聚焦激光扫描显微镜共聚焦显微镜检查病患角膜上皮病变角膜营养不良

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