检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

卷尾猴的卵泡生长发育及排卵的超声监测

中国实验动物学报 2007年第1期15卷 25-29,I0004页

作者：唐东红 Maria Alejandra fuentes Priego Maria Elena Ortiz 叶尤松代解杰中国医学科学院中国协和医科大学医学生物学研究所昆明650118 智利医学生殖研究中心

目的建立卷尾猴正常月经周期卵泡生长发育变化规律及排卵的超声监测（ultrasound examination，US）技术。方法采用阴道细胞涂片及超声监测技术，对5只卷尾猴连续3个周期检查阴道细胞变化，对卵泡生长发育进行超声监测。结果阴道脱落细... 详细信息

目的建立卷尾猴正常月经周期卵泡生长发育变化规律及排卵的超声监测（ultrasound examination，US）技术。方法采用阴道细胞涂片及超声监测技术，对5只卷尾猴连续3个周期检查阴道细胞变化，对卵泡生长发育进行超声监测。结果阴道脱落细胞在生殖周期内呈周期性变化。月经周期为（21．13±2）d。阴道细胞学涂片显示卷尾猴的月经周期分为以下各期：月经期（menstrual phase，M）、滤泡期（follicular phase，F）、排卵前期（preovulation phase，Co），黄体期（luteal phase，L）。US技术在滤泡期及排卵前期可观测到直径约3～9min的优势卵泡（dominant follicle，DF）的生长过程。当DF较前一天至少小10％，轮廓不规则，回声较以前强，阴道细胞涂片显示淋巴细胞出现，提示排卵已发生，黄体开始形成。结论B型超声技术能实时监测卷尾猴的卵泡生长发育过程，预知优势卵泡排卵时间。

关键词：卷尾猴 B超卵泡生长发育排卵

Watch and wait approach in rectal cancer:Current controversies and future directions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第29期26卷 4218-4239页

作者： Fernando López-Campos Margarita Martín-Martín Roberto Fornell-Pérez Juan Carlos García-Pérez Javier Die-Trill Raquel fuentes-Mateos Sergio López-Durán JoséDomínguez-Rullán Reyes Ferreiro AlejandroRiquelme-Oliveira Asunción Hervás-Morón Felipe Couñago Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiology Hospital Universitario de BasurtoBilbao 48013VizcayaSpain Department of Surgery Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Medical Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Gastroenterology and Hepatology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Medical Oncology Hospital Infanta CristinaMadrid 28034Spain Department of Radiation Oncology Hospital Universitario QuirónsaludMadrid 28003Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Universidad Europea de Madrid(UEM) Madrid 28223Spain

According to the main international clinical guidelines,the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by ***,doubts have been raised about the appropriate definition of clinical complete response(cCR)after neoadjuvant therapy and the role of surgery in patients who achieve a *** resection is associated with significant morbidity and decreased quality of life(QoL),which is especially relevant given the favourable prognosis in this patient subset. Accordingly, therehas been a growing interest in alternative approaches with less morbidity,including the organ-preserving watch and wait strategy, in which surgery isomitted in patients who have achieved a cCR. These patients are managed with aspecific follow-up protocol to ensure adequate cancer control, including the earlyidentification of recurrent disease. However, there are several open questionsabout this strategy, including patient selection, the clinical and radiologicalcriteria to accurately determine cCR, the duration of neoadjuvant treatment, therole of dose intensification (chemotherapy and/or radiotherapy), optimal followupprotocols, and the future perspectives of this approach. In the present review,we summarize the available evidence on the watch and wait strategy in thisclinical scenario, including ongoing clinical trials, QoL in these patients, and thecontroversies surrounding this treatment approach.

关键词： Watch and wait Rectal cancer Clinical complete response Organ preservation Dose intensification

Immunotherapy in triple-negative breast cancer:A literature review and new advances

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2022年第3期13卷 219-236页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida Morante Rossana Ruiz Hugo fuentes Carlos A Castaneda Tatiana Vidaurre Silvia Neciosup Henry L Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15036Peru

Triple-negative breast cancer(TNBC)is a highly complex,heterogeneous disease and historically has limited treatment *** has a high probability of disease recurrence and rapid disease progression despite adequate systemic *** has emerged as an important alternative in the management of this malignancy,showing an impact on progression-free survival and overall survival in selected *** this review we focused on immunotherapy and its current relevance in the management of TNBC,including various scenarios(metastatic and early-neoadjuvant,adjuvant-),new advances in this subtype and the research of potential predictive biomarkers of response to treatment.

关键词： Triple-negative breast cancer Early disease Immunotherapy Biomarkers Metastatic disease

Platelet count/spleen diameter ratio to predict esophageal varices in Mexican patients with hepatic cirrhosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第8期20卷 2079-2084页

作者： Alejandro González-Ojeda Gabino Cervantes-Guevara Manuela Chávez-Sánchez Carlos Dávalos-Cobián Susana Ornelas-Cázares Michel Dassaejv Macías-Amezcua Mariana Chávez-Tostado Kenia Militzi Ramírez-Campos Anaís del Rocío Ramírez-Arce Clotilde fuentes-Orozco Research Unit in Clinical Epidemiology Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social SecurityGuadalajaraCP 44340JaliscoMéxico Gastroenterology Department Hospital Civil de Guadalajara "Fray Antonio Alcalde"GuadalajaraCP 44280JaliscoMéxico Gastroenterology Department Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social SecurityGuadalajaraCP 44340JaliscoMéxico

AIM: To validate whether the platelet count/spleen size ratio can be used to predict the presence of esophageal varices in Mexican patients with hepatic cirrhosis.

关键词： Platelet count/spleen diameter ratio Esophageal varices Hepatic cirrhosis Hepatitis C virus Mexican patients

Thoracic Unilateral Spinal Cord Syndrome Following Neuraxial Anaesthesia for Periprosthetic Knee Fracture: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Anesthesiology 2019年第11期9卷 197-202页

作者： Nahir Chalup Torija Á lvaro Ramiro Ruiz Rubén Rodriguez Salas Beatriz fuentes Benito Marina Nevado Villafruela Manuel Cortés Guerrero Anaesthesia Critical Care Department and Pain Medicine Hospital Universitario 12 de Octubre Madrid Spain Hospital Universitario Fundación Alcorcón Alcorcón Spain Centro de Salud de Torrelodones Áreanoroeste Torrelodones Spain

Neuraxial anaesthesia is widely used in surgical procedures;overall, epidural and intrathecal techniques. Nevertheless, several outcomes should be considered. The incidence of neurologic complications after neuraxial anaesthesia is not perfectly clear (0% - 0.08%), although there are several described cases of spinal cord ischemia. We present a case of thoracic unilateral spinal cord syndrome following lumbar spinal anaesthesia for periprosthetic knee fracture. Our patient suffered monoparesis in her left lower limb as well as decreasing of muscle strength and loss of tendon reflexes. The MNR showed left hyperintense intra-cord images from T7 to T12 attributed to spinal cord oedema and a lineal hypointensity related to minimal haematic component. What made this case surprising was the fact that spinal anaesthesia was performed between L3 and L4 and the patient did not suffer paraesthesia associated with local anaesthetic injection. She was treated with glucocorticoids, gabapentin and amitriptyline. She also was checked by physical rehabilitators, neurologists and Pain Unit physicians. We have found another case reported in the literature about thoracic cord injury after lumbar spinal puncture. In this paper, we report possible aetiologies according to a review and neurological evolution of the patient seven months later.

关键词： Neuraxial Anaesthesia Regional Anaesthesia Neurologic Complications Spinal Cord Injury

Synthesis of Pt and Pt-Fe nanoparticles supported on MWCNTs used as electrocatalysts in the methanol oxidation reaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2014年第4期23卷 483-490页

作者： J.R.Rodriguez R.M.Félix E.A.Reynoso Y.Gochi-Ponce Y.Verde Gómez S.fuentes Moyado G.Alonso-Núez Universidad Nacional Autónoma de Mxico Centro de Nanociencias y Nanotecnología Ensenada B.C. C.P.22860 Mexico Instituto Tecnológico de Tijuana Centro de Graduados e Investigación Tijuana B.C. C.P.22000 Mexico Instituto Tecnológico de Oaxaca Departamento de Ingeniería Química y Bioquímica Oaxaca Oax. C.P.68030 Mexico Instituto Tecnológico de Cancún Av.Kabah Km.3 Cancún Q.R. C.P.77500 Mexico

This work reports a feasible synthesis of highly-dispersed Pt and Pt-Fe nanoparticles supported on multiwall carbon nanotubes （MWCNTs） without Fe and multiwall carbon nanotubes with iron （MWCNTs-Fe） which applied as electrocatalysts for methanol electrooxidation. A Pt coordination complex salt was synthesized in an aqueous solution and it was used as precursor to prepare Pt/MWCNTs, Pt/MWCNTs-Fe, and Pt-Fe/MWCNTs using FeC12.4H20 as iron source which were named S 1, S2 and S3, respectively. The coordination complex of platinum （TOA）2PtC16 was obtained by the chemical reaction between （NH4）2PtC16 with tetraoctylammonium bromide （TOAB） and it was characterized by FT-IR and TGA. The materials were characterized by Raman spectroscopy, SEM, EDS, XRD, TEM and TGA. The electrocatalytic activity of Pt-based supported on MWCNTs in the methanol oxidation was investigated by cyclic voltammetry （CV） and chronoamperometry （CA）. Pt-Fe/MWCNTs electrocatalysts showed the highest electrocatalytic activity and stability among the tested electrocatalysts due to that the addition of ＂Fe＂ promotes the OH species adsorption on the electrocatalyst surface at low potentials, thus, enhancing the activity toward the methanol oxidation reaction （MOR）.

关键词： coordination complex salt MWCNTs nanoparticles catalysts electrooxidation

在线全文

学校读者我要写书评

暂无评论

资源枯竭全球最大产铜国遭遇大减产

商业周刊（中文版） 2023年第10期 29-31页

作者： James Attwood Valentina fuentes 孟洁冰(译) 不详

2010年,安德烈·索加雷特(AndréSougarret)作为总工程师,营救了33名被困在井下701米处长达两个多月的智利矿工,赢得全球赞誉。现在,作为智利国家铜业公司(Codelco)的首席执行官,他必须尝试完成另一项艰难的壮举:将这家全球头号铜生产... 详细信息

2010年,安德烈·索加雷特(AndréSougarret)作为总工程师,营救了33名被困在井下701米处长达两个多月的智利矿工,赢得全球赞誉。现在,作为智利国家铜业公司(Codelco)的首席执行官,他必须尝试完成另一项艰难的壮举:将这家全球头号铜生产商从目前的困境中解救出来。

关键词：铜业公司首席执行官安德烈资源枯竭智利生产商

Implications of Klotho in vascular health and disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2014年第12期6卷 1262-1269页

作者： Ernesto Martín-Núez Javier Donate-Correa Mercedes Muros-de-fuentes Carmen Mora-Fernández Juan F Navarro-González Research Unit University Hospital Nuestra Se?ora de Candelaria 38010 Santa Cruz de Tenerife Spain Clinical Analysis Service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain Nephrology Service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain

Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of NO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity.

关键词： Klotho Cardiovascular disease Vascular health Aging Endothelial dysfunction Vascular calcification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

门多萨中央公园

新建筑 2015年第6期 83-84页

作者： Daniel Becker Claudio Ferrari Oscar fuentes 宋玮 EMBT中国地区

城市的文化体验给予门多萨市一种独特的观感,这样的体验是由遍布于历史事件的网络所构成。这就是经由时间积累形成下来的场所意义不应被低估的原因。也许在许多方面这一观点已经过时,但是该公司仍然坚持用非量产的方式,关注除城市铁路... 详细信息

城市的文化体验给予门多萨市一种独特的观感,这样的体验是由遍布于历史事件的网络所构成。这就是经由时间积累形成下来的场所意义不应被低估的原因。也许在许多方面这一观点已经过时,但是该公司仍然坚持用非量产的方式,关注除城市铁路交通发展之外的其他不确定性因素。

关键词：中央公园不确定性因素城市铁路历史事件交通发展场所