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In vitro cultures of circulating tumor cells:a potential tool to unravel drug sensitivity

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Cancer Drug Resistance 2022年第1期5卷 245-260页

作者： Gianluigi De Renzi Giulia De Marco Michela De Meo Eleonora del rosso Paola Gazzaniga Chiara Nicolazzo Cancer Liquid Biopsy Unit Department of Molecular MedicineSapienza University of RomeRome 00161Italy

Since taking part as leading actors in driving the metastatic process,circulating tumor cells(CTCs)have displayed a wide range of potential applications in the cancer-related research *** their well-proved prognostic value,the role of CTCs in both predictive and diagnostics terms might be extremely informative about cancer properties and therefore highly helpful in the clinical decision-making ***,CTCs are scarcely released in the blood circulation and their counts vary a lot among different types of cancer,therefore CTC detection and consequent characterization are still highly *** this context,in vitro CTC cultures could potentially offer a great opportunity to expand the number of tumor cells isolated at different stages of the disease and thus simplify the analysis of their biological and molecular features,allowing a deeper comprehension of the nature of neoplastic *** aim of this review is to highlight the main attempts to establish in vitro CTC cultures from patients harboring different tumor types in order to highlight how powerful this practice could be,especially in optimizing the therapeutic strategies available in clinical practice and potentially preventing or contrasting the development of treatment resistance.

关键词： Liquid biopsy circulating tumor cells liquid tumor biomarkers cell cultures circulating tumor cell cultures biomarker evaluation precision medicine drug sensitivity

Ammonia Diffusion Phenomena through Nalophan<sup>TM</sup>Bags Used for Olfactometric Analyses

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Journal of Environmental Protection 2014年第11期5卷 949-961页

作者： Selena Sironi Lidia Eusebio Laura Capelli Emanuela Boiardi Renato del rosso Jean-Michel Guillot Department of Chemistry Materials and Chemical Engineering “Giulio Natta” Politecnico di Milano Milano Italy Laboratory of Industrial Environment Engineering Ecole des Mines d’Alès Alès cedex France

The ammonia loss through NalophanTM bags has been studied. Ammonia was chosen as target compound in order to be representative of odorous molecules of small dimensions. The losses observed for storage conditions and times as allowed by the reference standard for dynamic olfactometry (EN 13725:2003) indicate that odour concentration values due to the presence of small molecules may be significantly underestimated if samples are not analysed immediately after sampling. The diffusion coefficient of ammonia through the NalophanTM film was evaluated using the Fick’s law, and it turned out to be equal to 2.38E-12 (m2/s). The results and their theoretical interpretation indicate that concentration losses due to ammonia diffusion through the NalophanTM film can be decreased by using large bags and filling them up to their maximum capacity.

关键词： Sampling Bag Diffusion Odour Sampling Ammonia Nalophan

Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 413-415页

作者： Miguel A Pinzon Juan C Pineda Fernando rosso Masaru Shinchi Fabio Bonilla-Abadia Department of Infectious Diseases Hospital San Vicente de PaulMedellinColombia Department of Internal Medicine Fundacion Clinica Valle del LiliICESI UniversityCaliColombia Department of Infectious Diseases Fundacion Clinica Valle del LiliCaliColombia Department of Neurology Fundacion Clinica Valle del LiliCuliColombia Department of Rheumatology Fundacion Clinica Valle del LiliICESI UniversityCaliColombia

Complicated malaria is usually due to Plasmodium ***,Plasmodium vivax is infrequently related with life-threatening *** cases have been reported of severe Plasmodium vivax infection,and most of them from Southeast Asia and *** report the first case of cerebral malaria due to Plasmodium vivax in Latin America,complicated with sagittal sinus thrombosis and confirmed by a molecular method.

关键词： Cerebral malaria Vivax malaria Plasmodium vivax Intracranial sinus thrombosis

透析后高血压:相关因素,患者的基本情况和心血管病死亡率

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中华高血压杂志 2016年第10期24卷 998-998页

作者： Losito A del Vecchio L del rosso G Locatelli F 陈云叶鹏

透析后血压增加是公认的，但经常是被人们忽视的并发症，相关的流行病学和诱发因素仍然不明确。该研究在一个大样本的意大利透析患者群中进行，评估透析后高血压Epostdiatysis hypertension，PDHYPER，定义为透析后较透析前收缩压上升〉... 详细信息

透析后血压增加是公认的，但经常是被人们忽视的并发症，相关的流行病学和诱发因素仍然不明确。该研究在一个大样本的意大利透析患者群中进行，评估透析后高血压Epostdiatysis hypertension，PDHYPER，定义为透析后较透析前收缩压上升〉10mmHg（1mm Hg=0．133kPa）]的患病率和相关因素，及其在心血管病死亡率中所起的作用。

关键词：相关因素心血管病透析患者透析后高血压死亡率 hypertension 诱发因素

Microcystis aeruginos strain[D-Leu^(1)]Mcyst-LR producer,from Buenos Aires province,Argentina

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Journal of Coastal Life Medicine 2014年第4期 287-296页

作者： Lorena rosso Daniela Sedan Maria Kolman Josep Caixach Cintia Flores Juan Manuel Oteiza Graciela Salerno Ricardo Echenique Leda Giannuzzi Darío Andrinolo Cátedra de Toxicología Facultad de Ciencias ExactasUniversidad Nacional de La Plata48 y 115(1900)La PlataArgentina CEBB-CIB Fundación para Investigaciones Biológicas Aplicadas(FIBA-Mar del Plata) Mar del PlataArgentina Laboratori d'Espectrometria de Masses/Contaminants Orgànics Institut de Diagnosi Ambiental i Estudis de l'Aigua(IDAEA)CSIC.J.Girona18-2608034-BarcelonaSpain División Ficología Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataPaseo del Bosque s/n°(1900)La PlataArgentina

Objective:To show the toxicological and phylogenetic characterization of a native Microcystis ceruginosa(***)strain(named CAAT 2005-3)isolated from a water body of Buenos Aires province,***:A *** strain was isolated from the drainage canal of the sewage treatment in the town of Pila,Buenos Aires province,Argentina and acclimated to laboratory *** amplification of cpcBA-IGS Phcocyanin(PC,intergenic spacer and flanking regions)was carried out in order to build a phylogenetic *** exactive/orbitrap mass spectrometer equipped with an electrospray ionization source(Thermo Fisher Scientific,Bremen,Germany)was used for the LC/ESI-HRMS microcystins *** number of cell/mL and[D-Leu^(1)]Mcyst-LR production obtained as a function of time was modelled using the Gompertz ***:The phylogenetic analysis showed that the sequence clustered with others *** sequences obtained from *** first Argentinian strain of ***(CAAT 2005-3)growing under culture conditions maintains the typical colonial architecture of *** with profuse *** CAAT 2005-3 expresses a toxin variant,that was identified by LC-HRMs/Orbitrapas as[D-Leu^(1)]microcystin-LR([M+H]+=1037.8 m/z).Conclusions:[D-Leu^(1)]microcystin-LR has been also detected in *** samples from Canada,Brazil and *** work provides the basis for technological development and production of analytical standards of toxins present in our region.

关键词： Cyanobacteria Microcystis aeruginosa [D-Leu^(1)]microcystin-LR[M+H]+ Harmful algal blooms