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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez gabriel guízar-Sahagún Israel grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Impacts of pI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón pérez-Núñez María Fernanda gonzález Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(pI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the pI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/pI3K/AKT/connexin 43,and Notch/pI3K/AKT *** targeting the inactivation of the pI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the pI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.Juárez Adalbert. Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María portela-Lomba paloma Sobrado-Calvo Diana Simón Johnny Di pierdomenico Alejandro gallego-Ortega Mar pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEg3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEg3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEg3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEg3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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physical exercises for preventing injuries among adult male football players:A systematic review

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Journal of Sport and Health Science 2022年第1期11卷 115-122页

作者： Jorge pérez-gómez JoséCarmelo Adsuar pedro EAlcaraz Jorge Carlos-Vivas Health EconomyMotricity and Education(HEME)Research GroupFaculty of Sports SciencesUniversity of ExtremaduraCaceres 10003Spain UCAM Research Center for High performance Sport Catholic University of MurciaMurcia 30107Spain Faculty of Sport Sciences Catholic University of MurciaMurcia 30107Spain

Background:Football is the most practised sport in the world and is associated with the risk of injuries in the *** studies have been published that identify injury prevention programs,but there is no review of the full body of evidence on injury prevention programs for use by football *** aim of this article was to carry out a systematic review of published studies on injury prevention programs for adult male footballers,identify points of common understanding and establish recommendations that should be considered in the design of injury prevention ***:pubMed and EMBASE databases were used to identify relevant published articles using the following keywords:"soccer"AND"injury"AND"prevention".Results:A total of 2512 studies were identified initially,but only 11 studies met the inclusion criteria,and their outcomes are *** revealed that injury prevention programs in football have focused on strength training,proprioceptive training,multicomponent programs(balance,core stability,and functional strength and mobility),and warm-up ***:Based on results from the studies analyzed,football players can lower the incidence of match and training injuries by participating in dynamic warm-up programs that include preventive exercises before games or during training sessions,and by adding strength,balance,and mobility training to the training sessions.

关键词： Balance Core stability Injury prevention programs Soccer Warm-up

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Intravenous iron in inflammatory bowel disease

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World Journal of gastroenterology 2009年第37期15卷 4666-4674页

作者： Manuel Muoz Susana gómez-Ramírez José Antonio garcía-Erce Transfusion Medicine School of Medicine University of Málaga Málaga 29071 Spain Department of Internal Medicine University Hospital Virgen de la Victoria Málaga 29010 Spain Department of Hematology and Hemoterapy University Hospital Miguel Servet Zaragoza 50008 Spain

The prevalence of anemia across studies on patients with inflammatory bowel disease (IBD) is high (30%). Both iron defi ciency (ID) and anemia of chronic disease contribute most to the development of anemia in IBD. The prevalence of ID is even higher (45%). Anemia and ID negatively impact the patient's quality of life. Therefore, together with an adequate control of disease activity, iron replacement therapy should start as soon as anemia or ID is detected to attain a normal hemoglobin (Hb) and iron status. Many patients will respond to oral iron, but compliance may be poor, whereas intravenous (IV) compounds are safe, provide a faster Hb increase and iron store repletion, and presents a lower rate of treatment discontinuation. Absolute indications for IV iron treatment should include severe anemia, intolerance or inappropriate response to oral iron, severe intestinal disease activity, or use of an erythropoietic stimulating agent. Four different products are principally used in clinical practice, which differ in their pharmacokinetic properties and safety profi les: iron gluconate and iron sucrose (lower single doses), and iron dextran and ferric carboxymaltose (higher single doses). After the initial resolution of anemia and the repletion of iron stores, the patient's hematological and iron parameters should be carefully and periodically monitored, and maintenance iron treatment should be provided as required. New IV preparations that allow for giving 1000-1500 mg in a single session, thus facilitating patient management,provide an excellent tool to prevent or treat anemia and ID in this patient population, which in turn avoids allogeneic blood transfusion and improves their quality of life.

关键词： Inflammatory bowel disease Anemia Iron deficiency Functional iron deficiency Erythropoiesisstimulating agents Oral iron Intravenous iron

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A review of recent advances of kesterite thin films based on magnesium,iron and nickel for photovoltaic application:insights into synthesis,characterization and optoelectronic properties

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Clean Energy 2024年第2期8卷 217-238页

作者： Nelson Mauricio Espinel pérez Enrique Vera López Jairo albert. gómez Cuaspud Juan Bautista Carda Castelló grupo de Investigación en Integridad y Evaluación de Materiales(gIEM).Instituto para la Investigación e Innovación en Ciencia y Tecnología de Materiales(INCITEMA).Universidad pedagógica y Tecnológica de Colombia Av.Central del Norte 39-115.Tunja-BoyacáColombia Servicio Nacional de Aprendizaje(Sena).Centro Minero.Vereda MorcáSector Batá.Sogamoso-Boyacá Colombia Universidad Jaume I.grupo de Química Inorgánica y Orgánica.Castellón de la plana Campus del Riu Sec.Castellón de la PlanaEspaña

This review emphasizes the recent advancements and prospects of thin-film kesterite-based photovoltaic(pV)applications using magnesium,iron and *** quest for novel materials employed in solar cells has resulted in incorporating these elements into the composition of kesterite as substitutes or modifiers(dopants)for *** integration has induced notable repercussions on the structural,optoelectronics and morphological properties,which are *** first section of this paper offers a comprehensive review of the general characteristics of kesterite *** crucial materials exhibit a high absorption coefficient(104 cm-1)and an optical band gap of 1.0-1.8 ***,they are free of critical raw materials,non-toxic and *** second section depicts the substitution or modification of zinc by magnesium in ***,this paper provides a comprehensive review of the quaternary and pentanary systems Cu_(2)MgSn(S,Se)_(4) and Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),highlighting their advantages and *** the last section,a review of the quaternary or pentanary systems is conducted,namely Cu_(2)ZnxFe_(1-x)SnS_(4) and Cu_(2)ZnxNi_(1-x)SnS_(4),along with their effects on optoelectronic *** conclusion,various methods for obtaining modified or substituted kesterite materials using magnesium,iron and nickel have demonstrated sustainability,scalability for industrial production and potential candidacy as substitutes for conventional pV *** prospects for pentanary materials(Cu_(2)Zn_(1-x)Mg_(x)SnS_(4),Cu_(2)Zn_(1-x)FexSnS_(4) and Cu_(2)Zn_(1-x)NixSnS_(4))are to overcome the efficiency record of kesterite reported in 2014,which was 12.6%for Cu_(2)ZnSn(S,Se)_(4),and to enhance its optoelectronic properties through synthesis conditions that comply with the principles of green chemistry.

关键词： kesterite thin film magnesium iron nickel substitutes or modifiers novel materials sustainability

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne Moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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A Crystallization Study of Nanocrystalline pZT 53/47 granular Arrays Using a Sol-gel Based precursor

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Journal of Materials Science & Technology 2011年第6期27卷 489-496页

作者： A.Surez-gómez J.M.Saniger-Blesa F.Calderón-pinar CCADET-Universidad Nacional Autónoma de México Cd.UniversitariaCirc.Exterior s/nA.P.70-186Coyoacn 04510México D.F.México Laboratorio de Ingeniería Electroquímica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaCoyoacn 04510México D.F.México Facultad de Física/IMRE San Lzaro y LUniversidad de la Habana

In this work,we intend to perform a detailed study on the crystallization process of pZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based *** interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio ***,Fourier transform infrared spectroscopy（FT-IR）,Raman（Stokes and Anti-Stokes）,X-ray diffraction（XRD） and scanning electron microscopy（SEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TgA） *** results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈Dg〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

关键词： powders-chemical preparation pZT synthesis Sol-gel precursors Microstructure- final Vibrational spectroscopies X-ray diffraction

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Recent surface marine sediments of Cocos Island in Costa Rica

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International Journal of Sediment Research 2014年第1期29卷 59-72页

作者： Jeffrey A.SIBAJA-CORDERO Jesús S.TRONCOSO Eddy gómez-RAMírez Escuela de Biología&Centro de Investigación en Ciencias del Mary Limnología (CIMAR) Universidad de Costa Rica Dr.grad.by Departamento de Ecología y Biología Animal Facultad de Ciencias del MarUniversidad de Vigo Departamento de Ecología y Biología Animal Facultad de Ciencias del MarUniversidad de VigoCampus Lagoas Marcosende Centro de Investigación en Ciencias del Mary Limnología(CIMAR) Universidad de Costa RicaSan Pedro 115012 060 San JoséCosta Rica Dr.(Cand).Departamento de Biología Facultad de Ciencias del Mary AmbientalesUniversidad de Cádiz

Subtidal sediments of Isla del Coco(Cocos Island),Costa Rica were described in their grain size,sorting,organic matter,and carbonates from 27 dredge samples(3-75 m),collected in April *** organic matter range between 1.37-3.31%and carbonates presented a mean of 74±17%.The sorting was moderately or *** grain size ranged between *** pattern is that sediment change from inner to mouth of *** and gravel fractions increased offshore and organic matter have high values inner the *** of vegetal debris and mud was from the rivers of this island covered with rain and cloud forest.

关键词： Sand bottom Sorting Organic matter Carbonates Isla del Coco

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