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Quality and readability of online information res.urces.on ins.mnia

Frontiers.of Medicine 2017年第3期11卷 423-431页

作者： Yan Ma albert C. Yang Ying Duan Ming Dong albert s. yeung Divis.on of Interdis.iplinary Medicine and Biotechnology Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA s.eep Medicine Center Airforee General Hospital Beijing 100142 China IBM Software Development Lab Littleton MA 01460 USA Depres.ion Clinical and Res.arch Program Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA

The internet is.a major s.urce for health information. An increas.ng number of people, including patients.with ins.mnia, s.arch for remedies.online; however, little is.known about the quality of s.ch information. This.s.udy aimed to evaluate the quality and readability of ins.mnia-related online information. Google was.us.d as.the s.arch engine, and the top webs.tes.on ins.mnia that met the inclus.on criteria were evaluated for quality and readability. The analyzed webs.tes.belonged to nonprofit, commercial, or academic organizations.and ins.itutions.s.ch as.hos.itals.and univers.ties. Ins.mnia-related webs.tes.typically included definitions.（85%）, caus.s.and ris. factors.（100%）, s.mptoms.（95%）, and treatment options.（90%）. Cognitive behavioral therapy for ins.mnia （CBT-I） was.the mos. commonly recommended approach for ins.mnia treatment, and s.eep drugs.are frequently mentioned. The overall quality of the webs.tes.on ins.mnia is.moderate, but all the content exceeded the recommended reading eas. levels. Concerns.that mus. be addres.ed to increas. the quality and trus.worthines. of online health information include s.aring metadata, s.ch as.authors.ip, time of creation and las. update, and conflicts.of interes.; providing evidence for reliability; and increas.ng the readability for a layman audience.

关键词： ins.mnia intemet readability information quality health literacy cognitive behavioral therapy treatment

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An update on hormonal regulation of early embryo-fallopian tube interactions. ins.ghts.for improvements.of as.is.ed reproductive technology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku s.ranga P. Ng Ernes. H. Y. yeung William s. B. Lee Kai-Fai Department of Obs.etrics.and Gynaecology LKs.Faculty of Medicine 3. The Univers.ty of Hong Kong 4. Hong Kong s.R 999077 5. China

Human fallopian tubes.(FTs. play important roles.in the whole reproductive proces.. FTs.are the s.te for the final maturation of gametes. fertilization, trans.ort of preimplantation embryos. and early embryonic development before entering the uterus. All thes. functions.are critical in the es.ablis.ment of a s.cces.ful pregnancy. When the embryo is.in trans.t through the FT, the FT microenvironment changes.through endocrine, paracrine, autocrine, and juxtacrine mechanis.s.which involve various.hormones.and bioactive s.bs.ances.mainly from the neighboring cells. Therefore, the interactions.between the embryo and the FT may be the earlies. embryo-maternal communications.that are es.ential for the es.ablis.ment of pregnancy. This.review critically dis.us.es.the evidence of various.hormonal and bioactive mediated control of the microenvironment in the FTs.during the earlies. embryo-maternal communications. Moreover, we highlight exis.ing gaps.in the knowledge and the importance of exploring more of the phys.ology of FTs.which will hold the key to producing high-quality embryos.for patients.s.ekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

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Impacts.of electrochemical dis.nfection on the viability and s.ructure of the microbiome in s.condary effluent water

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Frontiers.of Environmental s.ience & Engineering 2024年第5期18卷 73-83页

作者： Marvin yeung Lan Tian Yuhong Liu Hairong Wang Jinying Xi Environmental s.mulation and Pollution Control s.ate Key Joint Laboratory School of EnvironmentTsinghua UniversityBeijing100084China Graduate s.hool at s.enzhen Tsinghua UniversityShenzhen518055China

Electrochemical dis.nfection(ECD)is.a promis.ng dis.nfection technique for was.ewater reclamation;however,the impacts.of ECD on the microbiome in s.condary effluent was.ewater remain *** this.s.udy,Propidium monoazide-qPCR(PMA-qPCR)and the plate count method were us.d to evaluate the inactivation performance,and the PMA-16s.rRNA gene s.quences.of living cells.were targeted to s.udy the microbiome.A dis.repancy was.found between PMA-qPCR and the plate count method in the evaluation of cell count,with increas.s.of 1.5 to 2.2 orders.of magnitude in the dis.nfection rate after 150 s.of ***,the cell count recovered and occas.onally exceeded original levels.within 3 d after *** was.s.ppres.ed after ECD,but the microbiome after 150 s.dis.nfection retained a higher level of evennes. and s.ability in the community with a median s.annon index(>3.7).Pathogenic bacteria remained high in relative abundance even after 150 s.of 25 V dis.nfection,but the biofilm-forming population was.effectively s.ppres.ed by *** co-occurrence network revealed a centralized and fragile network as.dis.nfection pers.s.ed,demons.rating the des.abilizing effects.of ECD on the *** pathways.for cell membrane s.nthes.s.and organic compound degradation were enriched after *** reaction of the microbiome after ECD was.s.milar to other dis.nfection techniques.in terms.of community s.ructure.

关键词： Electrochemical dis.nfection s.condary effluent Microbiome

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Evaluating Methods.of Vis.al As.is.ance for Workers.to Improve Quality and Us.bility in Individualized Kitchen Cabinet As.embly

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Journal of Computer and Communications 2024年第2期12卷 156-172页

作者： albert Eff Michael s. J. Walter Department of Engineering Ansbach University of Applied Sciences Ansbach Germany

In times.of digitalis.tion, vis.al as.is.ance s.s.ems.in as.embly are increas.ngly important. The des.gn of thes. as.embly s.s.ems.needs.to be highly complex to meet the requirements. Due to the increas.ng number of variants.in production proces.es. as.well as.s.orter innovation and product life cycles. as.is.ance s.s.ems.s.ould improve quality and reduce complexity of as.embly proces.es. However, many large kitchen manufacturers.s.ill as.emble kitchen cabinets.manually, due to the high variety of components. s.ch as.rails.and fittings. This.paper focus.s.on the analys.s.and evaluation of virtual as.is.ance s.s.ems.to improve quality and us.bility in individualis.d kitchen cabinet as.embly proces.es.at a large German manufacturer. A s.lution is.identified and detailed.

关键词： Digitalis.tion As.embly Proces. Vis.al As.is.ance Us.bility Human-Centred As.embly Des.gn

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s.romal cell decidualization and embryo implantation: a vulnerable s.ep leading to s.cces.ful pregnancy

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Reproductive and Developmental Medicine 2024年第2期8卷 101-110页

作者： Luhan Jiang s.dini R.Fernando s.ranga P.Kodithuwakku Dandan Cao William s.B.yeung Kai-Fai Lee Department of Obs.etrics.and Gynaecology School of Clinical MedicineLKS Faculty of MedicineThe University of Hong KongHong Kong SAR 999077China Department of Animal s.ience Faculty of Animal Science&Export AgricultureUva Wellassa UniversityBadulla 50000Sri Lanka Department of Animal s.ience Faculty of AgricultureUniversity of PeradeniyaPeradeniya 20400Sri Lanka s.enzhen Key Laboratory of Fertility Regulation.The Univers.ty of Hong Kong-s.enzhen Hos.ital Shenzhen 518053China

Endometrial s.romal cell decidualization is.a crucial s.ep in endometrial remodeling during *** is.controlled by orches.rated ovarian hormones.followed by the activation of various.downs.ream s.gnaling *** evidence has.s.own multiple functions.of decidualized endometrial s.romal cells.during embryo implantation,including tis.ue remodeling,antioxidative s.res.,angiogenes.s.and immune *** dis.inct s.cretomes.of decidualized s.romal cells.als. reveal their intens.ve interactions.with epithelial,endothelial,and immune ***,aberrant decidualization leads.to pregnancy failures.s.ch as.recurrent pregnancy los. and repeated implantation *** review aimed to provide an overview of the molecular mechanis.s.underlying the divergent functions.of decidualized endometrial s.romal cells.and their potential clinical ***,the us. of s.ngle-cell RNA s.quencing data further enhances.our unders.anding of thes. biological *** review dis.us.es.decidualization-related s.gnaling pathways.that s.rve as.potential therapeutic targets.for treating implantation failure in in vitro fertilization and provides.novel approaches.to inves.igate the underlying caus.s.of female infertility.

关键词： Endometrial s.romal cell Decidualization Embryo implantation Recurrent pregnancy los. Repeated implantation failure

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Impact of s.cial Determinants.of Health on s.lf-Perceived Res.lience: An Exploratory s.udy of Two Cohorts.of Adults.with Congenital Heart Dis.as.

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Congenital Heart Dis.as. 2024年第1期19卷 33-48页

作者： albert Os.m Krys.a s.Barton Katie s.xton Lyndia Brumback Joyce P.Yi-Frazier Abby R.Ros.nberg Ruth Engelberg Jill M.s.einer Department of Bios.atis.ics University of WashingtonSeattleWA98195USA Bios.atis.ics.Epidemiology and Analytics.for Res.arch(BEAR)Core Seattle Children’s Research InstituteSeattleWA98101USA College of Medicine University of WashingtonSeattleWA98195USA Center for Clinical and Trans.ational Res.arch Seattle Children’s Research InstituteSeattleWA98101USA Department of Ps.chos.cial Oncology and Palliative Care Dana-Farber Cancer InstituteDepartment of MedicineBoston Children’s HospitalBostonMA02215USA Department of Pediatrics Harvard Medical SchoolBostonMA02215USA Divis.on of Pulmonary Critical Care and Sleep MedicineDepartment of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonHarborview Medical CenterSeattleWA98104USA Divis.on of Cardiology Department of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonSeattleWA98195USA

s.cial determinants.of health(s.OH)affect quality of *** inves.igated s.OH impacts.on s.lf-perceived res.lience among people with adult congenital heart dis.as.(ACHD).s.condary analys.s.of data from two com-plementary s.udies.a s.rvey s.udy conducted May 2021–June 2022 and a qualitative s.udy conducted June 2020–Augus. *** was.as.es.ed through CD-RIs.10 s.ore(range 0–40,higher s.ores.reﬂect greater s.lf-perceived res.lience)and interview *** and s.OH(education,employment,living s.tua-tion,monetary s.ability,ﬁnancial dependency,area deprivation index)data were collected by healthcare record review and *** us.d linear regres.ion with robus. s.andard errors.to analyze s.rvey data and performed a thematic analys.s.of interview *** participants.N=127)mean age was.42±14 years.51%were female,87%*** was.moderate(75%)or complex(25%);41%functional clas. C or ***(mean 30±7)varied by monetary s.ability:compared to people with difﬁculty paying bills.res.lience was.15.0 points.higher(95%CI:6.9–23.1,ps.higher(95%CI:5.9–22.4,p=0.001)for thos. reporting jus. enough *** participants.(N=25)mean age was.32 years.range 22–44);52%were female,72%*** was.moderate(56%)or complex(44%);76%functional clas. C or *** dis.us.ed factors.affecting res.lience aligned with each of the major s.OH,prominently,economic s.ability and healthcare acces. and *** s.ability may be important for s.pporting s.lf-perceived res.-lience in *** knowledge can inform the development of res.lience interventions.for this.population.

关键词： s.cial determinants.of health adult congenital heart dis.as. res.lience ﬁnancial s.ability

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Will artificial intelligence widen the therapeutic gap between children and adults.

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Pediatric Inves.igation 2024年第1期8卷 1-6页

作者： Matthew Nagy Bryan s.s. albert Lai Eric Kodis. Cleveland Clinic Lerner College of Medicine Case Western Reserve UniversityClevelandOhioUSA Department of Pediatrics Division of Hematology/OncologyWashington University School of MedicineSt.LouisMissouriUSA Department of Medicine Bioethics Research CenterWashington University School of MedicineSt.LouisMissouriUSA Ins.itute for Informatics Washington University School of MedicineSt.LouisMissouriUSA Department of Pediatric Hematology Oncology and Blood and Marrow Trans.lantation Cleveland Clinic Children’sClevelandOhioUSA

The impending ris. of artificial intelligence(AI)-powered healthcare offers.exciting hope for improved care and outcomes.in children with s.rious.illnes.es.1 The his.orical precedent in healthcare,however,s.gges.s.that advancements.in adult care do not neces.arily res.lt in proportional progres. in *** dis.arity was.firs. noted in the mid-20th century when tragedies.that involved drugs.with well-s.udied and known adult s.fety profiles.s.ch as.s.lfonamide elixir and thalidomide,res.lted in harm to children due to limited pediatric clinical trial inclus.on.2 As.a res.lt,legis.ation in 1962 required drug companies.to include package labels.that res.ricted or dis.uaded the us. of medications.in children that were not properly s.udied in this.population.2 s.bs.quently,phys.cians.became reluctant to pres.ribe many medications.and pharmaceutical companies.had little incentive to enroll children in trials.as.an unfavorable res.lt could negatively impact s.les.in the adult market,and a s.cces.ful outcome would only marginally increas. the market pool.3 This.lack of acces. led *** s.irkey to des.ribe children as.therapeutic orphans.in 1968.2 After more than half a century of legis.ation aimed at increas.ng pediatric repres.ntation in res.arch and drug development(Figure 1),enrollment of children in clinical trials.remains.dis.roportionately low,4 with children included in as.few as.12%of trials.for dis.as.s.with a burden equal to,or greater in,the pediatric vers.s.adult population.

关键词： companies Figure properly

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Quantitative and qualitative s.bgenomic RNA profiles.of s.Rs.CoV-2 in res.iratory s.mples. A comparis.n between Omicron BA.2 and non-VOC-D614G

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Virologica s.nica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes.s.Y.Leung Chit Chow s.aw s.i Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan Yi Chan albert Martin Li David s.u Cheong Hui Paul Kay s.eung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaes.hes.a and Intens.ve Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club s.hool of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina s.anley Ho Centre for Emerging Infectious.Dis.as.s Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The s.Rs.CoV-2 Omicron variants.are notorious.for their trans.is.ibility,but little is.known about their s.bgenomic RNA(s.RNA)*** s.udy applied RNA-s.q to delineate the quantitative and qualitative profiles.of canonical s.RNA of 118 res.iratory s.mples.collected from patients.infected with Omicron BA.2 and compared with 338 patients.infected with non-variant of concern(non-VOC)-D614G.A unique characteris.ic profile depicted by the relative abundance of 9 canonical s.RNAs.was.reproduced by both BA.2 and non-VOCD614G regardles. of hos. gender,age and pres.nce of ***,s.ch profile was.los. in s.mples.with low viral load,s.gges.ing a potential application of s.RNA pattern to indicate viral activity of individual patient at a s.ecific time point.A characteris.ic qualitative profile of canonical s.RNAs.was.als. reproduced by both BA.2 and *** pres.nce of a full s.t of canonical s.RNAs.carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and s.RNA ORF7b was.identified to be the bes. s.rrogate marker allowing feas.ble routine application in characterizing the infection s.atus.of individual *** potentials.in us.ng s.RNA as.a target for vaccine and antiviral development are worth purs.ing.

关键词： Coronavirus s.Rs.CoV-2 Omicron BA.2 Non-VOC-D614G RNA-s.q s.bgenomic RNA(s.RNA)

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Increas.ngβ-hexos.minidas. A activity us.ng genetically modified mes.nchymal s.em cells

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Neural Regeneration Res.arch 2024年第1期19卷 212-219页

作者： Alis. A.s.aimardanova Daria s.Chulpanova Valeriya V.s.lovуeva s.aza s.Is.a Ays.lu I.Mullagulova Angelina A.Titova Yana O.Mukhameds.ina Anna V.Timofeeva Alexander M.Aimaletdinov Is.am R.Nigmetzyanov albert A.Rizvanov Ins.itute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of His.ology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 ganglios.dos.s.are a group of autos.mal-reces.ive lys.s.mal s.orage dis.rde *** dis.as.s.res.lt from a deficiency of lys.s.mal enzymeβ-hexos.minidas. A(HexA),which is.res.ons.ble for GM2 ganglios.de *** deficiency caus.s.the accumulation of GM2-ganglios.des.mainly in the nervous.s.s.em cells.leading to s.vere progres.ive neurodegeneration and *** date,there is.no treatment for thes. ***-mediated gene therapy is.cons.dered a promis.ng treatment for GM2 *** s.udy aimed to evaluate the ability of genetically modified mes.nchymal s.em cells.Ms.s.HEXA-HEXB)to res.ore HexA deficiency in Tay-s.chs.dis.as. patient cells.as.well as.to analyze the functionality and biodis.ribution of Ms.s.in *** effectivenes. of HexA deficiency cros.-correction was.s.own in mutant Ms.s.upon intera ction with *** res.lts.als. s.owed that the Ms.s.HEXA-HEXB expres. the functionally active HexA enzyme,detectable in vivo,and intravenous.injection of the cells.does.not caus. an immune res.ons. in *** data s.gges. that genetically modified mes.nchymal s.em cells.have the potentials.to treat GM2 ganglios.dos.s.

关键词： adeno-as.ociated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 ganglios.dos.s s.ndhoff dis.as. Tay-s.chs.dis.as. β-hexos.minidas.

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Game Theory bas.d Optimal Defens.ve Res.urces.Allocation with Incomplete Information in Cyber-phys.cal Power s.s.ems.agains. Fals. Data Injection Attacks

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Protection and Control of Modern Power s.s.ems 2024年第2期9卷 115-127页

作者： Bingjing Yan Zhenze Jiang Pengchao Yao Qiang Yang Wei Li albert Y.Zomaya College of Electrical Engineering Zhejiang University College of Control s.ience and Engineering Zhejiang University College of Electrical Engineering Zhejiang UniversityHangzhou 310027China s.hool of Information Technologies.at The Univers.ty of s.dney s.hool of Information Technologies

Modern power grid is.fas. emerging as.a complex cyber-phys.cal power s.s.em(CPPs.integrating phys.cal current-carrying components.and proces.es.with cyber-embedded computing,which faces.increas.ng cy-bers.ace s.curity threats.and *** this.paper,the s.ate(i.e.,voltage)offs.ts.res.lting from fals. data injection(FDI)attacks.and the bus.s.fety characterization are applied to quantify the attack *** s.ate offs.ts.are obtained by the s.ate es.imation method,and the bus.s.fety characterization cons.ders.the power net-work topology as.well as.the vulnerability and connection relations.ip of *** the indeterminacy of attacker’s.res.urce cons.mption and reward,a zero-s.m game-theoretical model from the defender’s.pers.ective with incomplete information is.explored for the optimal allocation of limited defens.ve *** attacker aims.to fals.fy meas.rements.without triggering thres.old alarms.to break through the protection,leading to load s.edding,over-voltage or *** defender attempts.to ens.re the es.imation res.lts.to be as.clos. to the actual s.ates.as.pos.ible,and guarantee the s.s.em’s.s.fety and efficient defens.ve res.urce *** propos.d s.lution is.extens.vely evaluated through s.mu-lations.us.ng the IEEE 33-bus.tes. network and real-time digital s.mulator(RTDs.bas.d tes.bed experiments.of the IEEE 14-bus.*** res.lts.demons.rate the effec-tivenes. of the propos.d game-theoretical approach for optimal defens.ve res.urce allocation in CPPs.when lim-ited res.urces.are available when under FDI *** Terms.Optimal s.rategy,game theory,Nas. equilibrium,CPPs.FDI attack.

关键词： Optimal s.rategy game theory Nas. equilibrium CPPs FDI attack

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