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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell ling Agnes S.Y.Leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan albert martin li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

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Parental behaviors and sleep/wake patterns of infants and toddlers in Hong Kong, China

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World Journal of Pediatrics 2017年第5期13卷 496-502页

作者： Xin-Ting Yu Avi Sadeh Hugh Simon Lam Jodi A.Mindell albert martin li Department of Pediatrics The Chinese University of Hong KongHong KongChina and Department of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA The School of Psychological Sciences Tel Aviv UniversityIsracl Department of Pediatrics The Chinese University of Hong KongHong KongChina Saint Joseph's University and The Children's Hospital of Philadelphia Philadelphia PAUSA

Background:To describe the sleep patterns of children below 36 months in Hong Kong,and evaluate the associations between parental behaviors and childhood sleep/wake ***:Parents of 1049 infants and toddlers completed an internet-based expanded version of the Brief Infant Sleep ***:Total sleep duration (Plies with limited living space where parent/ child room-or bed-sharing cannot be avoided.

关键词： infant parental behaviors sleep sleep/wake patterns toddler

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Introducing the Hong Kong Medical Journal and its important role in the timely dissemination of COVID-19 related knowledge

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Chinese Medical Journal 2024年第3期137卷 253-254页

作者： Rashid N Lui Kenneth KW li martin CS Wong Hong Kong Medical Journal Hong Kong SARChina The JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina

Hong Kong Medical Journal(HKMJ)is the flagship general medical journal in the Hong Kong Special Administrative Region,China,with an international *** are committed to publishing and promoting high-quality *** by our Editor-in-Chief,Professor martin CS Wong,our Editorial Board is pleased to collaborate with *** Wang,the Editor-in-Chief of the Chinese Medical Journal(CMJ),as well as the editors of CMJ to enhance the visibility of our respective journals and foster a collaborate environment that brings forth ideas and knowledge to our readers.

关键词： journal knowledge visibility

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From concept to commercialization:A review of tubular solid oxide fuel cell technology

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Journal of Energy Chemistry 2024年第10期97卷 79-109页

作者： Ruyan Chen Yuan Gao Jiutao Gao Huiyu Zhang martin Motola Muhammad Bilal Hanif Cheng-Xin li State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi'an Jiaotong University Department of Inorganic Chemistry Faculty of Natural Sciences Comenius University Bratislava

The reduced sealing difficulty of tubular solid oxide fuel cells(SOFCs) makes the stacking of tubular cell groups relatively easy,and the thermal stress constraints during stack operation are smaller,which helps the stack to operate stably for a long *** special design of tubular SOFC structures can completely solve the problem of high-temperature sealing,especially in the design of multiple single-cell series integrated into one tube,where each cell tube is equivalent to a small electric stack,with unique characteristics of high voltage and low current output,which can significantly reduce the ohmic polarization loss of tubular *** paper provides an overview of typical tubular SOFC structural designs both domestically and *** on the geometric structure of tubular SOFCs,they can be divided into bamboo tubes,bamboo flat tubes,single-section tubes,and single-section flat tube ***,this article provides an overview of commonly used materials and preparation methods for tubular SOFCs,including commonly used materials and preparation methods for support and functional layers,as well as a comparison of commonly used preparation methods for microtubule SOFCs,It introduced the three most important parts of building a fuel cell stack:manifold,current collector,and ceramic adhesive,and also provided a detailed introduction to the power generation systems of different tubular SOFCs,Finally,the development prospects of tubular SOFCs were discussed.

关键词： Geometric structure Preparation methods Stack Support material Tubular solid oxide fuel cell

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Game Theory based Optimal Defensive Resources Allocation with Incomplete Information in Cyber-physical Power Systems against False Data Injection Attacks

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Protection and Control of Modern Power Systems 2024年第2期9卷 115-127页

作者： Bingjing Yan Zhenze Jiang Pengchao Yao Qiang Yang Wei li albert Y.Zomaya College of Electrical Engineering Zhejiang University College of Control Science and Engineering Zhejiang University College of Electrical Engineering Zhejiang UniversityHangzhou 310027China School of Information Technologies at The University of Sydney School of Information Technologies

Modern power grid is fast emerging as a complex cyber-physical power system(CPPS)integrating physical current-carrying components and processes with cyber-embedded computing,which faces increasing cy-berspace security threats and *** this paper,the state(i.e.,voltage)offsets resulting from false data injection(FDI)attacks and the bus safety characterization are applied to quantify the attack *** state offsets are obtained by the state estimation method,and the bus safety characterization considers the power net-work topology as well as the vulnerability and connection relationship of *** the indeterminacy of attacker’s resource consumption and reward,a zero-sum game-theoretical model from the defender’s perspective with incomplete information is explored for the optimal allocation of limited defensive *** attacker aims to falsify measurements without triggering threshold alarms to break through the protection,leading to load shedding,over-voltage or *** defender attempts to ensure the estimation results to be as close to the actual states as possible,and guarantee the system’s safety and efficient defensive resource *** proposed solution is extensively evaluated through simu-lations using the IEEE 33-bus test network and real-time digital simulator(RTDS)based testbed experiments of the IEEE 14-bus *** results demonstrate the effec-tiveness of the proposed game-theoretical approach for optimal defensive resource allocation in CPPS when lim-ited resources are available when under FDI *** Terms—Optimal strategy,game theory,Nash equilibrium,CPPS,FDI attack.

关键词： Optimal strategy game theory Nash equilibrium CPPS FDI attack

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The FRB-searching Pipeline of the Tianlai Cylinder Pathfinder Array

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Research in Astronomy and Astrophysics 2024年第8期24卷 113-132页

作者： Zijie Yu Furen Deng Shijie Sun Chenhui Niu Jixia li Fengquan Wu Wei-Yang Wang Yougang Wang Shifan Zuo lin Shu Jie Hao Xiaohui liu Reza Ansari Ue-li Pen albert Stebbins Peter Timbie Xuelei Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of ScienceBeijing 100101China Institute of Astrophysics Central China Normal UniversityWuhan 430079China Institute of Automation Chinese Academy of SciencesBeijing 100190China Guangdong Institute of Artificial Intelligence and Advanced Computing Guangzhou 510535China UniversitéParis-Saclay CNRS/IN2P3IJCLab91405 OrsayFrance Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617TaiwanChina Canadian Institute for Theoretical Astrophysics University of Toronto60 Saint George StreetTorontoON M5S 3H8Canada Department of Physics University of Wisconsin-MadisonMadisonWI 53706USA Fermi National Accelerator Laboratory P.O.Box 500Batavia IL 60510-5011USA Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Center of High Energy Physics Peking UniversityBeijing 100871China

This paper presents the design,calibration,and survey strategy of the Fast Radio Burst(FRB)digital backend and its real-time data processing pipeline employed in the Tianlai Cylinder Pathfinder *** array,consisting of three parallel cylindrical reflectors and equipped with 96 dual-polarization feeds,is a radio interferometer array designed for conducting drift scans of the northern celestial *** FRB digital backend enables the formation of 96 digital beams,effectively covering an area of approximately 40 square degrees with the 3 dB *** pipeline demonstrates the capability to conduct an automatic search of FRBs,detecting at quasi-realtime and classifying FRB candidates *** current FRB searching pipeline has an overall recall rate of88%.During the commissioning phase,we successfully detected signals emitted by four well-known pulsars:PSR B0329+54,B2021+51,B0823+26,and B2020+*** report the first discovery of an FRB by our array,designated as FRB *** also investigate the optimal arrangement for the digitally formed beams to achieve maximum detection rate by numerical simulation.

关键词： instrumentation interferometers-methods data analysis-(stars )pulsars general-telescopes

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A Comparison of Hydrothermal Aging, SO₂ and Propene Poisoning Effects on NH₃-SCR over Cu-ZSM-5 and Cu-SAPO-34 Catalysts

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Journal of Materials Science and Chemical Engineering 2024年第5期12卷 10-28页

作者： Kouadio Brou albert Koffi Konan martin Zran Van Eric-Simon Horo Kone Unité de Formation et de Recherche des Sciences et de Technologies (UFR ST) Universit&#233 Alassane Ouattara Bouak&#233 C&#244te d&#8217Ivoire Unité de Formation et de Recherche Environnement (UFR E) Universit&#233 Jean Lorougnon Gu&#233d&#233 Daloa C&#244te d&#8217Ivoire Unité de Formation et de Recherche des Sciences des Structures de la Mati&#232re et de Technologie (UFR SSMT) Abidjan C&#244te d&#8217Ivoire

This study was aimed to investigate the effects of hydrothermal aging, propene and SO2 poisoning on the ammonia-selective catalytic reduction (NH3-SCR) performance of both Cu-SAPO-34 and Cu-ZSM-5. The catalytic activities of fresh, aged and poisoned samples were tested in ammonia-selective catalytic reduction (NH3-SCR) of NOx conditions. The XRD, TG and N2-desorption results showed that the structures of the Cu-SAPO-34 and Cu-ZSM-5 remained intact after 750˚C hydrothermally aged, SO2 and propene poisoned. After hydrothermal aging at 750˚C for 12 h, the NO reduction performance of Cu-ZSM-5 was significantly reduced at lower temperatures, while that of Cu-SAPO-34 was less affected. Moreover, Cu-SAPO-34 catalyst showed high NO conversion with SO2 or propene compared to Cu-ZSM-5. However, Cu-ZSM-5 showed a larger drop in catalytic activity with SO2 or propene compared to Cu-SAPO-34 catalyst. The H2-TPR results showed that Cu2 ions could be reduced to Cu and Cu0 for Cu-ZSM-5, while no significant transformation of copper species was observed for Cu-SAPO-34. Meanwhile, the UV-vis DRS results showed that CuO species were formed in Cu-ZSM-5, while little changes were observed for the Cu-SAPO-34. Cu-SAPO-34 showed high sulfur and hydrocarbon poison resistance compared to Cu-ZSM-5. In summary, Cu-SAPO-34 with small-pore zeolite showed higher hydrothermal stability and better hydrocarbon and sulfur poison resistant than Cu-ZSM-5 with medium-pore.

关键词： Hydrothermal Aging Propene and SO2Poisoning Ammonia-Selective Catalytic Reduction(NH3-SCR) Cu-SAPO-34 Cu-ZSM-5

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Enhancing 3D Reconstruction Accuracy of FIB Tomography Data Using Multi‑voltage Images and Multimodal Machine Learning

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Nanomanufacturing and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmanov Yong li Lukas Riedel Shan Shi Christian J.Cyron Roland C.Aydin martin Ritter Institute for Continuum and Material Mechanics Hamburg University of TechnologyHamburgGermany Electron Microscopy Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physics and Technology Hamburg University of TechnologyHamburgGermany Institute of Materials Mechanics Helmholtz-Zentrum HereonGeesthachtGermany Research Group of Integrated Metallic Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful technique that integrates a focused ion beam(FIB)and a scanning electron microscope(SEM)to capture high-resolution imaging data of *** approach involves collecting in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby producing image ***,theseimage stacks in FIB-SEM tomography are subject to the shine-through effect,which makes structures visible from theposterior regions of the current *** artifact introduces an ambiguity between image intensity and structures in thecurrent plane,making conventional segmentation methods such as thresholding or the k-means algorithm *** study,we propose a multimodal machine learning approach that combines intensity information obtained at differentelectron beam accelerating voltages to improve the three-dimensional(3D)reconstruction of *** treatingthe increased shine-through effect at higher accelerating voltages as a form of additional information,the proposed methodsignificantly improves segmentation accuracy and leads to more precise 3D reconstructions for real FIB tomography data.

关键词： Multimodal machine learning Multi-voltage images FIB-SEM Overdeterministic systems 3D reconstruction FIB tomography

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Gravitational waves and primordial black hole productions from gluodynamics by holography

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 31-42页

作者： Song He li li Zhibin li Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Max Planck Institute for Gravitational Physics(albert Einstein Institute) Golm 14476Germany CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China

Understanding the nature of quantum chromodynamics(QCD)matter is important but challenging due to the presence of nonperturbative dynamics under extreme *** construct a holographic model describing the gluon sector of QCD at finite temperatures in the non-perturbative *** equation of state as a function of temperature is in good accordance with the lattice QCD ***,the Polyakov loop and the gluon condensation,which are proper order parameters to capture the deconfinement phase transition,also agree quantitatively well with the lattice QCD *** obtain a strong first-order confinement/deconfinement phase transition at Tc=276.5 Me V that is consistent with the lattice QCD *** on our model for a pure gluon hidden sector,we compute the stochastic gravitational waves and primordial black hole(PBH)productions from this confinement/deconfinement phase transition in the early *** resulting stochastic gravitational-wave backgrounds are found to be within detectability in the International Pulsar Timing Array and Square Kilometre Array in the near future when the associated productions of PBHs saturate the current observational bounds on the PBH abundances from the liGO-Virgo-Collaboration O3 data.

关键词： AdS/QCD confinement/deconfinement phase transition gravitational wave primordial black hole

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Remote sensing and its applications using GNSS reflected signals:advances and prospects

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Satellite Navigation 2024年第1期5卷 10-51页

作者： Shuanggen Jin Adriano Camps Yan Jia Feng Wang Manuel martin-Neira Feixiong Huang Qingyun Yan Shuangcheng Zhang Zhongyu li Komi Edokossi Dongkai Yang Zhiyu Xiao Zhongmin Ma Weihua Bai Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China School of Surveying and Land Information Engineering Henan Polytechnic UniversityJiaozuo454003China Department of Signal Theory and Communications Technical University of CataloniaBarcelona08034Spain Department of Surveying and Geoinformatics Nanjing University of Posts and TelecommunicationsNanjing210023China School of Electronics and Information Engineering Beihang UniversityBeijing100191China European Space Research and Technology Centre(ESTEC) European Space Agency2200-AGNoordwijkThe Netherlands National Space Science Center Chinese Academy of SciencesBeijing100190China School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing210044China College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China University of Electronic Science and Technology of China Chengdu611731China

The Global Navigation Satellite Systems(GNSS),including the US’s GPS,China’s BDS,the European Union’s Galileo,and Russia’s GLONASS,offer real-time,all-weather,any-time,anywhere and high precision observations by transmitting L band signals continuously,which have been widely used for positioning,navigation and *** the development of GNSS technology,it has been found that GNSS-reflected signals can be used to detect Earth’s surface characteristics together with other signals of *** this paper,the current status and latest advances are presented on Global Navigation Satellite System-Reflectometry(GNSS-R)in theory,methods,techniques and *** developments and progresses in GNSS-R instruments,theoretical modeling,and signal processing,ground and space-/air-borne experiments,parameters retrieval(*** speed,sea surface height,soil moisture,ice thickness),sea surface altimetry and applications in the atmosphere,oceans,land,vegetation,and cryosphere are given and reviewed in ***,the challenges in the GNSS-R development of each field are also ***,the future applications and prospects of GNSS-R are discussed,including multi-GNSS reflectometry,new GNSS-R receivers,GNSS-R missions,and emerging applications,such as mesoscale ocean eddies,ocean phytoplankton blooms,microplastics detection,target recognition,river flow,desert studies,natural hazards and landslides monitoring.

关键词： GNSS Reflectometry Remote sensing Environmental change

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