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Food Science and Human Wellness 2016年第3期5卷 124-140页

作者： Alice Yuen-Ting Wong albert wai-kit chan albert wai-kit chan Intellectual Property Limited Hong Kong Special Administrative Region United States-China Intellectual Property Institute New YorkUSA Law Offices of albert wai-kit chan PLLCNew YorkUSA

Food is a basic and personal necessity to *** of food is a prime factor to consider apart from nutrition,quality and *** modified(GM)foods first came on the market in *** safety,transparency and traceability ofGMfoods are still under hot ***,the market of GM foods is huge and *** affairs and intellectual property(IP)are two critical factors affecting the development and commercial success of a food *** article will take a look at the GM food technology and regulatory framework for GM foods in China and the United *** article will also discuss the unique patent issues and non-patent IP tools for safeguarding the technology in these two countries.

关键词： property modified attractive

A novel reductive ring-opening reaction of isoxazolidine to form functionalized 1,3-aminoalcohol

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Chinese Chemical Letters 2007年第6期18卷 629-632页

作者： Wing Hong chan albert W.M. Lee wai Yeung Wong Department of Chemistry Hong Kong Baptist University Kowloog Tong Hong Kong

Reductive cleavage of the NO bond of isoxazolidine ring with catalytic hydrogenation over Raney nickel was described. Bicyclic isoxazolidines could be effectively converted into the corresponding 1,3-amino-alcohol possessing a sultone or sultam moiety with high conversion and yield when the hydrogenation was catalyzed by freshly prepared Raney nickel under a pressure of 40 psi in the presence of triethylamine.

关键词： Isoxazolidine Hydrogenation Raney nickel 1,3-Amino-alcohol

Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： Kim-Hung Lam Sarah Sze-Wah Ho Pik-Ling Lam Johnny Cheuk-On Tang Zhao-Xiang Bian albert Sun-Chi chan Hua Li wai-Yeung Wong Chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

A novel mitofusin 2 gene mutation causing Charcot-Marie-Tooth type 2A disease in a Chinese family

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Chinese Medical Journal 2010年第11期123卷 1466-1469页

作者： CHING Chor Kwan LAU Kwok Kwong YU Kwok wai chan Yan Wo albert MAK Miu Chloe Chemical Pathology Laboratory. Department of Pathology Princess Margaret hospital Hong Kong China Department of Medicine and Geriatrics Princess Margaret hospital Hong Kong China

Charcot-Marie-Tooth disease （CMT）, also known as hereditary motor and sensory neuropathies,comprises a genetically heterogeneous group of inherited peripheral neuropathies. Clinically it is characterized by progressive distal weakness, muscle atrophy, distal sensory loss and loss of deep tendon reflexes. Following electrophysiological criteria, CMT is divided into two main forms：

关键词： Charcot-Marie-Tooth type 2A mitofusin 2 gene Hong Kong

A NOVEL PHASE CONTROL TECHNIQUE FOR INJECTION LOCKED OSCILLATORS

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Journal of Electronics(China) 1995年第4期12卷 374-377页

作者： Kwok-wai Wong albert K. Y. Lai 曾学刚 Department of Electronic Engineering the Chinese University of Hong Kong Shatin Hong Kong University of Electronic Science and Technology of China Chengdu 610054 A novel technique to obtain injection locked oscillators phase tuning beyond 180°is demonstrated. The idea is to cascade injection locked oscillators together for phase change accumulation. A two stage injection locked oscillators can theoretically provide a maximum of 360?phase change within the locking range. This is particularly useful for phased array antenna applications.

A novel technique to obtain injection locked oscillators phase tuning beyond 180° is demonstrated. The idea is to cascade injection locked oscillators together for phase change accumulation. A two stage injection locked oscillators can theoretically provide a maximum of 360?phase change within the locking range. This is particularly useful for phased array antenna applications.

关键词： Phase control Locking Oscillators Antenna array

Phenylketonuria in Hong Kong Chinese： a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China

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Chinese Medical Journal 2011年第16期124卷 2556-2558页

作者： Chloe Miu Mak Chun-hung Ko Ching-wan Lam wai-ling Lau wai-kwan Siu Sammy Pak-lam Chen Chun-yiu Law Chi-kong Lai Chak-man Yu albert Yan-wo chan Kowloon West Cluster Laboratory Genetic Service ChemicalPathology Laboratory Department of Pathology Princess MargaretHospital Hong Kong China Department of Paediatrics and Adolescent Medicine CaritasMedical Centre Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine TheUniversity of Hong Kong Hong Kong China

Hyperphenylalaninemia is one of the commonest inborn errors of metabolism affecting approximately 1 in 15 000 live births. Among Chinese, BH4 deficiency leading to hyperphenylalaninemia is much commoner than in Caucasians. Exact diagnosis is important for the treatment and genetic counseling. In 2000, newborn screening for phenylketonuria is mandatory by law in China throughout the whole country. However, it is not yet included in the newborn screening program of the Hong Kong Special Administrative Region, China. Published data on hyperphenylalaninemia among Hong Kong Chinese are largely lacking. We report a 1-year-old Hong Kong Chinese girl with severe 6-pyruvoyl-tetrahydropterin synthase （PTPS） deficiency. The patient presented with infantile hypotonia and was misdiagnosed as cerebral palsy. She had very mild hyperphenylalaninemia （95 IJmol/L）, significantly high phenylalnine-to-tyrosine ratio （3.1）, and ele~,ated prolactin of 1109 m lU/L. Genetic analysis confirmed a homozygous known disease-causing mutation PTS NM_000317.1： c.259C〉T; NP_000308.1： p.P87S in the proband. In our local experience, while the estimated prevalence of hyperphenylalaninemia due to PTPS deficiency was reported to be 1 in 29 542 live births, not a single case of phenylalanine hydroxylase deficiency has been reported. Furthermore, there is a general lack of awareness of inherited metabolic diseases in the community as well as among the medical professionals. Very often, a low index of clinical suspicion will lead to delay in diagnosis, multiple unnecessary and costly investigations, prolonged morbidity and anxiety to the family affected. We strongly recommend that expanded newborn screening for hyperphenylalaninemia should be implemented for every baby born in the Hong Kong Special Administrative Region, China.

关键词： Hong Kong Chinese hyperphenylalaninemia newborn screening phenylketonuria 6-pyruvoyl-tetrahydropterin synthase deficiency

Ferroptosis and glaucoma: implications in retinal ganglion cell damage and optic nerve survival

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Neural Regeneration Research 2023年第3期18卷 545-546页

作者： Ming Yang Kwok-Fai So wai-Ching Lam Amy Cheuk Yin Lo Department of Ophthalmology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Glaucoma and visual pathway degeneration:Glaucoma is the leading cause of irreversible blindness worldwide,which leads to a progressive loss of *** can be classified into two types:primary open-angle glaucoma and primary closed-angle *** open-angle glaucoma can be caused by the blockage of the trabecular meshwork,and this results in elevation of the intraocular pressure(IOP),leading to retinal ganglion cell(RGC)***,many glaucoma patients have normal IOP;this is known as normal-tension ***,excitotoxic damage and oxidative stress can also lead to RGC damage in normal-tension glaucoma(Almasieh et al.,2012).Glaucomatous genes such as TIGR,OPTN,and CYP1B1 have been suggested to contribute to the pathogenesis of ***,some glaucomatous patients may remain asymptomatic in the early,moderate,and late *** type of glaucoma is primary closed-angle *** this clinical condition,a relative pupillary block is contributed by the iris obstructing aqueous *** patients may suffer from corneal swelling,headache,nausea,and blurred vision during the acute phase.

关键词： glaucoma damage degeneration

Analysis of inborn errors of metabolism： disease spectrum for expanded newborn screening in Hong Kong

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Chinese Medical Journal 2011年第7期124卷 983-989页

作者： Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam albert Yan-Wo chan Chemical Pathology Laboratory Department of Pathology Princess Margaret Hospital Hong Kong SAR China Division of Clinical Biochemistry Queen Mary Hospital Hong Kong SAR China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China Chemical Pathology Laboratory Department of Pathology Queen Elizabeth Hospital Hong Kong SAR China

Background Data of classical inborn errors of metabolism （IEM） of amino acids, organic acids and fatty acid oxidation are largely lacking in Hong Kong, where mass spectrometry-based expanded newborn screening for IEM has not been initiated. The current study aimed to evaluate the approximate incidence, spectrum and other characteristics of classical IEM in Hong Kong, which would be important in developing an expanded newborn screening program for the local area.

关键词： biochemical genetics chemical pathology expanded newborn screening Hong Kong," inborn errorsof metabolism tandem mass spectrometry

Molecular basis of von Hippel-Lindau syndrome in Chinese patients

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Chinese Medical Journal 2011年第2期124卷 237-241页

作者： SIU wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan chan Kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung chan albert Yan-wo Department of Pathology Princess Margaret Hospital Hong Kong China Department of Medicine & Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong China Clinical Genetic Service Department of Health Hong Kong China Department of Medicine and Geriatrics Princess Margaret Hospital Hong Kong China Department of Paediatrics and Adolescent Medicine Princess Margaret Hospital Hong Kong China Department of Obstetrics & Gynaecology Tsan Yuk Hospital Hong Kong China Department of Obstetrics & Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Background Von Hippel-Lindau （VHL） syndrome is an autosomal dominant familial cancer syndrome predisposing the affected individuals to multiple tumours in various *** genetic basis of VHL in Southern Chinese is largely *** this study,we characterized the mutation spectrum of VHL in nine unrelated Southern Chinese *** Nine probands with clinical features of VHL,two symptomatic and eight asymptomatic family members were included in this *** diagnosis was performed twice for one *** probands had only isolated bilateral *** VHL gene was screened for mutations by polymerase chain reaction,direct sequencing and multiplex ligation-dependent probe amplification （MLPA）.Results The nine probands and the two symptomatic family members carried heterozygous germline *** different VHL mutations were identified in the nine *** splicing mutation,NM_000551.2：c.463＋1G〉T,was *** other seven VHL mutations,c.233A〉G [***78Ser],c.239G〉T [***80lle],c.319C〉G [***107Gly],c.481C〉T [***161X],c.482G〉A [***161GIn],c.499C〉T [***167Trp] and an exon 2 deletion,had been previously *** asymptomatic family members were positive for the mutation and the other five tested *** prenatal diagnosis,the fetuses were positive for the *** Genetic analysis could accurately confirm VHL syndrome in patients with isolated tumours such as sporadic phaeochromocytoma or epididymal papillary *** detection in asymptomatic family members allows regular tumour surveillance and early intervention to improve their ***-based diagnosis can have an important impact on clinical management for VHL families.

关键词： von Hippel-Lindau syndrome VHL gene Chinese VHL mutations

Effects of resistance training on cardiovascular health in non-obese active adolescents

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World Journal of Clinical Pediatrics 2016年第3期5卷 293-300页

作者： Clare Chung-Wah Yu Alison Mary McManus Hung-Kwan So Ping Chook Chun-Ting Au albert Martin Li Jack Tat-Chi Kam Raymond Chi-Hung So Christopher wai-Kei Lam Iris Hiu-Shuen chan Rita Yn-Tz Sung Department of Health and Physical Education the Education University of Hong Kong Institute of Human Performance the University of Hong Kong Centre for Heart Lung and Vascular HealthSchool of Health and Exercise SciencesUniversity of British Columbia Department of Paediatrics the Chinese University of Hong Kong Hong Kong Sports Institute Faculty of Health Sciences and University Hospital Macao University of Science and Technology Department of Chemical Pathology Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active ***:This is a pragmatic randomised controlled *** study was carried out in a Hong Kong Government secondary ***-eight lean and active boys and girls were randomised to either the resistance training group or the control *** in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 *** outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic ***:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(Pchange was more likely an outcome of normal growth and development as opposed to a training ***:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children.

关键词： Strength training Children Cardiometabolic risk factors Endothelial function School-based training program High sensitive C-reactive protein 24-h ambulatory blood pressure Aerobic fitness