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Taguchi Full Factorial Design of Experiments Optimisation of Cutting Parameters for energy Efficiency and Surface Roughness during the Dry Turning of en19 Material

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World Journal of engineering and Technology 2024年第2期12卷 438-454页

作者： Nicholas Tayisepi albert Nkulumo Mnkandla Godfrey Tigere Oscar Gwatidzo Winnie Mutenhabundo Emmanuel Ndala Lovelace Makakatanwa Wagoneka Department of Industrial and Manufacturing engineering National University of Science and Technology Bulawayo Zimbabwe Department of Industrial and Manufacturing engineering Harare Institute of Technology Harare Zimbabwe

During metal machining, the satisfactoriness of cost-quality-time matrix convergence effectively depends on the supreme selection of cutting parameters. This study investigated the energy use minimisation and quality surface generation through optimised cutting parameters application, as sustainability enhancement during dry turning of en19 material. Cutting parameter optimisation is a serious challenge confronting the machining industry as they strive to achieve low energy use and better component quality generation from their operations. The utility material, en19, is a medium-carbon low alloy steel which typically gets applied in the manufacturing of multiple profiled cylindrical machine tool, rail locomotives and motor vehicle component parts, inter alia. Taguchi Full Factorial experimental plan was used to organise the empirical experiments. ANOVA and the main effects plot signal-to-noise ratio optimisation analysis were utilised in the study to establish the influence of process parameters on the response parameters—surface roughness and energy use. The aim was to investigate and determine the correlation of the machining strategy parameters with the outcome of low energy use and quality surface texture of the components as the cutting parameters were varied, and optimised for minimum surface roughness and energy use. Results of the extensive experimental study, produced optimum cutting speed, rake angle variation and feed rate which respectively influence the response parameters positively for energy use minimisation and improved surface quality. Validation experiments confirmed model findings.

关键词： Machining energy Use ANOVA Sustainable Manufacturing Machining Strategy

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Toward an Intelligent System for Taurine Cattle Recognition

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Journal of Intelligent Learning Systems and Applications 2022年第1期14卷 1-13页

作者： Fulbert Bembamba Frédéric T. Ouédraogo Soudré albert Amadou Traoré Université Norbert Zongo Laboratoire Mathématiques Informatique et Applications (LAMIA) Koudougou Burkina Faso Université Norbert Zongo Koudougou Burkina Faso Institut de l’environnement et de Recherches Agricoles (INERA) Ouagadougou Burkina Faso

Unlike zebus, taurine cattle have the natural ability to resist trypanosomosis, a parasitic disease endemic to the humid areas of West Africa. However, repeated crossbreeding between zebus and taurine cattle is jeopardizing the genetic heritage of the Taurines and their ability to resist trypanosomosis. To strengthen protection and conservation efforts, it is essential to accurately distinguish purebred taurines from crossbreds. In this study, five Machine Learning models were built using morphological data collected from 1968 cattle. These models were trained to determine whether a given individual is purebred taurine or not. The classifiers yielded promising results. The random forest model and RBF Kernel SVM performed the best with up to 86% and 85% accuracy respectively. Moreover, the study of the correlation coefficients and the feature importance scores allowed us to define the most discriminating morphological traits.

关键词： Machine Learning Trypanosomosis Purebred Taurine Accuracy Model

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Molecular Diagnosis of Sexual Differentiation Disorders in Burkina Faso

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Journal of Biosciences and Medicines 2024年第3期12卷 1-15页

作者： Bazie Bapio Valérie Elvira Jean Télesphore Sawadogo Soumaïla Zohoncon Théodora Mahoukèdè Tall Ahmadou Bado Prosper Soubeiga Serge Théophile Ouattara Moussa Sorgho Abel Kiendrebeogo Touwendpoulimdé Isabelle Yonli albert Theophane Djigma Florencia Millogo/Traore Timongo Françoise Danielle Simpore Jacques Centre National de la Recherche Scientifique et Technologique (CNRST) Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Université Joseph KI-ZERBO Unité de Formation en Sciences de la Vie et de la Terre Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigonie (CERBA) Ouagadougou Burkina Faso Centre Hospitalier Universitaire Régional de Ouahigouya Ouagadougou Burkina Faso Centre Hospitalier Universitaire Yalgado Ouedraogo Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

Sex development anomalies represent a group of congenital pathologies in which chromosomal, gonadal and anatomical sex differentiation is atypical. The aim of our study was to use molecular biology techniques to elucidate sex in cases of anomalies of sexual differentiation in Burkina Faso. This cross-sectional study took place from March 2023 to June 2023. Oral and blood samples were collected respectively using sterile swabs and stored on Swab Kits and NUCLEIcardTM (https://***/product-ranges/nucleic-card/) were used to determine gonosome profiles. Extraction was carried out using the DNA Swap solution Kit and the DNA IQ System Kit, and a PowerPlex? 21 kit (Promega) for amplification. The Applied Biosystems 9700 thermal cycler was used for PCR followed by 36 cm capillary electrophoresis in the Applied Biosystems 3130 prism sequencer. Sequence files were analyzed using GeneMapper IDX v. 3.2 software. Seven (07) patients were registered during the study period. There were 4 cases of XX DSD or 46, XX DSD and 3 cases of XY DSD or 46, XY DSD. The median age of our patients was 16 years. Civilian sex was male in 4 cases and female in 3. The most frequent reason for consultation was micropenis in 3 cases, followed by primary amenorrhea and sex ambiguity. There were 03 cases of discrepancy between genetic sex and civil sex. The accessibility of molecular diagnosis is little known to clinicians. XX DSDs or 46, XX DSDs were the most frequent (4/7) in our study. The problem facing this situation is early diagnosis to help prevent complications in Burkina Faso.

关键词： Gonosome DSD Abnormal Sexual Development Burkina Faso

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Modeling shoreline sand waves on the coasts of Namibia and Angola

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International Journal of Sediment Research 2013年第3期28卷 338-348页

作者： Francesca RIBAS albert FALQUES Niels VAN Den BERG Miquel CABALLERIA Department of Applied Physics Universitat Politecnica de CatalunyaSpain

The southwestern（SW） coast of Africa（Namibia and Angola） features long sandy beaches and a wave climate dominated by energetic swells from the Southsouthwest（SSW）,therefore approaching the coast with a very high *** images reveal that along that coast there are many shoreline sand waves with wavelengths ranging from 2 to 8 km.A more detailed study,including a Fourier analysis of the shoreline position,yields the wavelengths（among this range） with the highest spectral density ***,it becomes apparent that at least some of the sand waves are dynamically active rather than being controlled by the geological setting.A morphodynamic model is used to test the hypothesis that these sand waves could emerge as free morphodynamic instabilities of the coastline due to the obliquity in wave *** is found that the period of the incident water waves,T;,is crucial to establish the tendency to stability or instability,instability increasing for decreasing period,whilst there is some discrepancy in the observed *** results for T;= 7-8 s clearly show the tendency for the coast to develop free sand waves at about 4 km wavelength within a few years,which migrate to the north at rates of 0.2-0.6 km yr;.For larger T;or steeper profiles,the coast is stable but sand waves originated by other mechanisms can propagate downdrift with little decay.

关键词： Shoreline evolution Shoreline sand waves High angle wave instability Longshore sediment transport

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Influence of the operating temperature on the ageing and interfaces of double layer polymer electrolyte solid state Li metal batteries

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Nano Research 2023年第6期16卷 8377-8384页

作者： Mikel Arrese-Igor María Martinez-Ibañez Ander Orue Ekaterina Pavlenko Erwan Dumont Michel Armand Frédéric Aguesse Pedro López Aranguren Centre for Cooperative Research on Alternative energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain Saft 111 Boulevard Alfred DaneyBordeaux Cedex 33074France

Solid-state lithium metal batteries(SSLMBs)are considered an auspicious technology to develop high energy density and safe energy storage *** double layer polymer electrolyte(DLPE)is a rational approach for engineering high-performance SSLMBs addressing electrolyte requirements with specifically designed polymers at the positive electrode and as *** this work,SSLMBs were assembled with poly(propylene carbonate)(PPC),offering stability toward oxidation at the positive electrode,and a gel polymer electrolyte with polyethyleneglycol dimethylether(PEGDME)as separator,offering high ionic conductivity at low temperature and sufficient interfacial stability with Li *** electrochemical properties and performance of cells with LiFePO_(4) and Li[Ni_(0.6)Mn_(0.2)Co_(0.2)]O_(2) positive electrodes are thoroughly investigated as function of the operating temperature by using a host of characterization ***-voltage cells with an areal capacity of 0.7 mAh·cm^(−2)cycled at 40℃ exhibit a higher capacity retention than the cells cycled at 70℃.To understand such differences,a three-electrode setup is applied to discriminate anodic processes from cathodic as function of the *** elucidate the ageing and interfacial evolution for DLPE cells with gel polymer electrolytes paving the way for building performance solid state batteries.

关键词： double layer polymer electrolyte solid-state lithium metal battery gel polymer electrolyte high voltage interfacial study

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Low-loss single-mode hybrid-lattice hollow-core photonic-crystal fibre

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Light(Science & Applications) 2021年第1期10卷 86-97页

作者： Foued Amrani Jonas HOsorio Frederic Delahaye Fabio Giovanardi Luca Vincetti Benoit Debord Frederic Gerome Fetah Benabid GPPMM Group XLIM InstituteCNRS UMR 7252University of LimogesLimoges 87060France GLOphotonics 123 Avenue Albert ThomasLimoges 87060France Department of engineering Menzo Ferrari University of Modena and Reggio EmiliaModena 41125Italy

Remarkable recent demonstrations of ultra-low-loss inhibited-coupling(1C)hollow-core photonic-crystal fibres(HCPCFs)established them as serious candidates for next-generation long-haul fibre optics systems.A hindrance to this prospect and also to short-haul applications such as micromachining,where stable and high-quality beam delivery is needed,is the difficulty in designing and fabricating an IC-guiding fibre that combines ultra-low loss,truly robust single-modeness,and polarisation-maintaining *** design solutions proposed to date require a trade-off between low loss and truly ***,we propose a novel IC-HCPCF for achieving low-loss and effective single-mode *** fibre is endowed with a hybrid cladding composed of a Kagome-tubular lattice(HKT).This new concept of a microstructured cladding allows us to significantly reduce the confinement loss and,at the same time,preserve truly robust single-mode *** results show an HKT-IC-HCPCF with a minimum loss of 1.6dB/km at 1050 nm and a higher-order mode extinction ratio as high as 47.0 dB for a 10 m long *** robustness of the fibre single-modeness is tested by moving the fibre and varying the coupling *** design proposed herein opens a new route for the development of HCPCFs that combine robust ultra-low-loss transmission and single-mode beam delivery and provides new insight into IC guidance.

关键词： fibre mode lattice

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Resection of T4 hepatocellular carcinomas with adjacent structures, is it justified？

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 52-57页

作者： Kenneth SH Chok Ka Kin Ng Tan To Cheung albert CY Chan See Ching Chan Chung Mau Lo Department of Surgery The University of Hong Kong

BACKGROUND： T4 hepatocellular carcinoma （HCC） with invasion to adjacent structure（s） may require resection of not only the tumor but also the invaded structure（s）. This study aims to assess whether such combined resection for T4 HCC is justifiable. METHODS： Adult patients with T4 HCC were divided into three groups. Group 1： tumors and invaded adjacent structures were resected together if histopathologically confirmed tumor invasion; group 2： same as group 1 but histopathologically confirmed tumor adhesion; group 3： tumor resection only. Group comparisons were made. RESULTS： Totally 144 patients were included in the study. There were 71, 14 and 59 patients in groups 1, 2 and 3, respec- tively. The groups were comparable in demographics, compli- cation and survival. Ten hospital deaths occurred （5, 0 and 5 in groups 1, 2 and 3, respectively; P=0.533）. The 5-year overall survival （hospital mortality excluded） was 17.8% in group 1, 14.3% in group 2, and 28.9% in group 3 （P=0.191）. The 5-year disease-free survival was 10.4% in group 1 and 14.5% in group 3 （no data for group 2 yet）（P=0.565）. On multivariate analysis, macrovascular invasion and poor differentiation were risk factors for survival whereas combined resection did not impact patients＇ survival. CONCLUSIONS： Combined resection achieved survival outcomes similar to tumor resection only. Patients with tumor invasion and those with tumor adhesion had comparable survival after combined resection. At centers with the required expertise, combined resection should be attempted to treat T4 HCCs with clinically suspected invasion of adjacent structures.

关键词： desmosplastic reaction en-bloc resection hepatocellular carcinoma invasion recurrence

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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis

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Translational Neurodegeneration 2023年第1期12卷 722-744页

作者： Cristina de Dios Xenia Abadin Vicente Roca-Agujetas Marina Jimenez-Martinez albert Morales Ramon Trullas Montserrat Mari Anna Colell Department of Cell Death and Proliferation Institut d’Investigacions Biomèdiques de BarcelonaConsejo Superior de Investigaciones Científicas(CSIC)Institut d’Investigacions Biomèdiques August Pi I Sunyer(IDIBAPS)BarcelonaSpain Centro de Investigación Biomédica en Red Sobre enferme-dades Neurodegenerativas(CIBERNED) MadridSpain Department of Biomedicine Faculty of MedicineUniversitat de BarcelonaBarcelonaSpain Present Address:Department of Biochemistry and Molecular Biology Faculty of PharmacyUniversidad de Sevilla.Instituto de Biomedicina de Sevilla(IBiS)-Hospital Universitario Virgen del Rocío/CSICSevilleSpain Present Address:Department of Clinical Immunology and Rheumatology Amsterdam UMCAmsterdamNetherlands

Background Persistent inflammatory response in the brain can lead to tissue damage and *** Alzheimer’s disease(AD),there is an aberrant activation of inflammasomes,molecular platforms that drive inflammation through caspase-1-mediated proteolytic cleavage of proinflammatory cytokines and gasdermin D(GSDMD),the executor of ***,the mechanisms underlying the sustained activation of inflammasomes in AD are largely *** have previously shown that high brain cholesterol levels promote amyloid-β(Aβ)accumulation and oxidative ***,we investigate whether these cholesterol-mediated changes may regulate the inflam-masome *** SIM-A9 microglia and SH-SY5Y neuroblastoma cells were cholesterol-enriched using a water-soluble cholesterol *** exposure to lipopolysaccharide(LPS)plus muramyl dipeptide or Aβ,activation of the inflammasome pathway was analyzed by immunofluorescence,ELISA and immunoblotting ***-labeled Aβwas employed to monitor changes in microglia *** medium was used to study how microglia-neuron interrelationship modulates the inflammasome-mediated *** In activated microglia,cholesterol enrichment promoted the release of encapsulated IL-1βaccompanied by a switch to a more neuroprotective phenotype,with increased phagocytic capacity and release of neurotrophic *** contrast,in SH-SY5Y cells,high cholesterol levels stimulated inflammasome assembly triggered by both bacterial toxins and Aβpeptides,resulting in GSDMD-mediated ***(GSH)ethyl ester treatment,which recovered the cholesterol-mediated depletion of mitochondrial GSH levels,significantly reduced the Aβ-induced oxidative stress in the neuronal cells,resulting in lower inflammasome activation and cell ***,using conditioned media,we showed that neuronal pyroptosis affects the function of the cholesterol-enriched microglia,lowering its phagocytic activity and,the

关键词： Neuroinflammation Mitochondrial oxidative stress Phagocytosis Alzheimer’s disease DAM signature NLRP3

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POTenTIAL PITFALLS IN USING DNA PROBES TO COUNSEL DUCHenNE AND BECKER MUSCULAR DYSTROPHY FAMILIES

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中华医学杂志(英文版) 1992年第6期105卷 469-475页

作者：史怡君 Kenneth H. Fischbeck albert Ritter Neurology Department Hospital of the University of Pennsylvania Philadelphia 19104 U.S.A.

Although the accuracy in prenatal diagnosis andcarrier detection with DNA probes in families withDuchenne and Becker's muscular dystrophies is veryhigh,various factors limit the accuracy of these probesin many *** report four potential pitfalls,ie,intragenic recombination,genetic heterogeneity,germline mosaicism,and an evolving genetic defect en-countered in a population of Duchenne and Beckerfamilies,and describe a strategy to incorporate thesefactors into genetic counseling.

关键词： GenE DIAGNOSIS INHERITANCE MUTATIONS LOCUS

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Historical fluxes of metal and metalloids in an aquatic ecosystem affected by land-use change and mining activities in northwestern Mexico

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International Journal of Sediment Research 2023年第5期38卷 724-738页

作者： Ochoa-Contreras Roberto Jara-Marini Martín enrique Ruiz-Fernández Ana Carolina Sanchez-Cabeza Joan albert Meza-Figueroa Diana Pérez-Bernal Libia Hascibe Posgrado en Ciencias Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo 2. Centro de Investigación en Alimentación y Desarrollo Unidad Hermosillo Unidad Acad emica Mazatlán Instituto de Ciencias del Mar y Limnología Universidad Nacional Autónoma de M exico Departamento de Geología División de Ciencias Exactas y Naturales Universidad de Sonora Rosales y Encinas

Freshwater reservoirs are essential owing because of their ecological, economic, and social *** are particularly vulnerable to contamination, as of metal and metalloids, derived from anthropogenic activities like mining. The temporal variations in trace element concentrations(arsenic(As),mercury(Hg), chromium(Cr), copper(Cu), nickel(Ni), lead(Pb), and zinc(Zn)), enrichment, fluxes, and possible sources were evaluated by studying two sediment cores from the La Angostura(ANG) Reservoir(northwest Mexico), using210Pb geochronology. The enrichment factors showed from null to minor enrichment for most elements, but moderate to severe enrichment of mercury(Hg). Most trace element concentrations had a detrital origin, and notable Hg concentration increases since the past decade were associated with severe drought periods, likely resulting from wildfires. The observed sediment concentrations of As and Hg can cause adverse effects on biota in the ecosystem since they are above the probable effect level(PEL). Development of strategies for metal attenuation in this reservoir is recommended and metals should be controlled until specific ecotoxicological studies are performed.

关键词： Aquatic ecosystems ~(210)Pb geochronology Mining activities Metals Metalloids enrichment factors

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