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Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling

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Cellular & Molecular Immunology 2023年第1期20卷 26-37页

作者： Kelly A.Dingess Max Hoek Danique M.Hvan Rijswijk Sem Tamara Maurits Aden Boer Tim Veth Mirjam J.A.Damen Arjan Barendregt Michelle Romijn Hannah G.Juncker Britt Jvan Keulen Gestur Vidarsson Johannes Bvan Goudoever albert Bondt albert J.R.Heck Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical SciencesUniversity of UtrechtPadualaan 8Utrecht 3584 CHThe Netherlands Netherlands Proteomics Center Padualaan 8Utrecht 3584 CHThe Netherlands Amsterdam UMC Vrije UniversiteitUniversity of AmsterdamEmma Children’s HospitalAmsterdam Reproduction&Development Research InstituteDepartment of PediatricsAmsterdamthe Netherlands Department of Experimental Immunohematology Sanquin Research and Landsteiner LaboratoryAmsterdam UMCUniversity of AmsterdamAmsterdamNetherlands

The most abundant immunoglobulin present in the human body is IgA. It has the highest concentrations at the mucosal lining and in biofluids such as milk and is the second most abundant class of antibodies in serum. We assessed the structural diversity and clonal repertoire of IgA1-containing molecular assemblies longitudinally in human serum and milk from three donors using a mass spectrometry-based approach. IgA-containing molecules purified from serum or milk were assessed by the release and subsequent analysis of their Fab fragments. Our data revealed that serum IgA1 consists of two distinct structural populations, namely monomeric IgA1 (∼80%) and dimeric joining (J-) chain coupled IgA1 (∼20%). Also, we confirmed that IgA1 in milk is present solely as secretory (S)IgA, consisting of two (∼50%), three (∼33%) or four (∼17%) IgA1 molecules assembled with a J-chain and secretory component (SC). Interestingly, the serum and milk IgA1-Fab repertoires were distinct between monomeric, and J-chain coupled dimeric IgA1. The serum dimeric J-chain coupled IgA1 repertoire contained several abundant clones also observed in the milk IgA1 repertoire. The latter repertoire had little to no overlap with the serum monomeric IgA1 repertoire. This suggests that human IgA1s have (at least) two distinct origins;one of these produces dimeric J-chain coupled IgA1 molecules, shared in human serum and milk, and another produces monomeric IgA1 ending up exclusively in serum.

关键词： Antigen binding fragment Immunoglobulin A1 Clonal repertoires human milk Serum

Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment

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World Journal of Gastroenterology 2009年第19期15卷 2314-2328页

作者： albert J Czaja Yusuf Bayraktar Division of Gastroenterology and Hepatology Mayo Clinic College of MedicineRochesterMinnesotaUnited States and the Department of GastroenterologyHacettepe University School of MedicineAnkara 06100Turkey

Non-classical manifestations of autoimmune hepatitis can delay diagnosis and *** aims were to describe the clinical phenotypes that can confound the diagnosis,detail scoring systems that can ensure their recognition,and outline advances in treatment that can improve their *** source and review articles in English were selected through Medline from 1970-2008 and assimilated into personal libraries spanning 32 *** severe or asymptomatic presentations and atypical histological findings,including centrilobular zone 3 necrosis and concurrent bile duct changes,are compatible with the *** abnormalities may be present in children and adults with the disease,and autoimmune hepatitis must be considered in patients without autoantibodies or with antimitochondrial antibodies and no other cholestatic *** patients frequently become symptomatic;mild disease can progress;and there are no conf ident indices that justify withholding *** diagnostic scoring systems with complementary virtues have been developed to evaluate patients with confusing *** liver tests and tissue constitute the optimal end point of treatment,and the f irst relapse is an indication for long-term azathioprine ***,tacrolimus and mycophenolate mofetil are promising salvage therapies,and budesonide with azathioprine may be a superior frontline *** conclude that the non-classical phenotypes of autoimmune hepatitis can be recognized promptly,diagnosed accurately,and treated effectively.

关键词：自身免疫性肝炎经典型延迟诊断抢救治疗正常肝组织诊治评分系统胆管畸形

Biophoton Emission as a Potential Measure of Organizational Order

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Science China Chemistry 1994年第9期37卷 1099-1112页

作者：顾樵 Popp Fritz-albert Also in Department of Physics Northwest University Xi'an 710069 PRC International Institute of Biophysics Technology Centre 67661 Kaiserslautern Germany

Beginning with the quantum theory of biophoton emission,a c-number equation character-izing the excited-state dynamics of a complex system of collective biomolecules in interaction with both the"pumping"field and the biophoton field is presented,and then the order-growth process of the system interms of both determinism and statistics is investigated.A general expression describing the order-growthdynamics of biological systems,which reduces in a limiting case to the well-known growth curve,is obt*** a Fokker-Planck equation for probability density function of an order parameter q of the systemhas been *** solution predicts that the system under consideration can evolute from an arbitraryinitial state to a pure state characterized by the steady-state order parameter q1.Furthermore,the evolutionof the maximum entropy of the system is discussed,which shows that the system investigated is to keep anabsolute maximum of entropy,and at the same time,to minimize its entropy value by reducing the uncertain-ty of the order ***,some agreements of the theoretical results with the corresponding experi-mental observations of order-growth process demonstrated by the biophoton emission are shown,which indi-cates that biophoton emission may serve as a potential measure of the organizational order.

关键词： biophoton emission complex system nonlinear dynamics organizational order maximum entropy

The Finite-dimensional Decomposition Property in Non-Archimedean Banach Spaces

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Acta Mathematica Sinica,English Series 2014年第11期30卷 1833-1845页

作者： albert KUBZDELA Cristina PEREZ-GARCIA Institute of Civil Engineering Poznań University of TechnologyUl.Piotrowo 561-138 PoznańPoland Department of Mathematics Facultad de CienciasUniversidad de CantabriaAvda.de los Castros s/n39071SantanderSpain

A non-Archimedean Banach space has the orthogonal finite-dimensional decomposition property（OFDDP） if it is the orthogonal direct sum of a sequence of finite-dimensional *** property has an influence in the non-Archimedean Grothendieck＇s approximation theory,where an open problem is the following： Let E be a non-Archimedean Banach space of countable type with the OFDDP and let D be a closed subspace of *** D have the OFDDP？ In this paper we give a negative answer to this question; we construct a Banach space of countable type with the OFDDP having a one-codimensional subspace without the *** we prove that,however,for certain classes of Banach spaces of countable type,the OFDDP is preserved by taking finite-codimensional subspaces.

关键词： Non-Archimedean Banach spaces finite-dimensional decomposition property orthogonal base

The heritage of world civilizations=世界文明遗产 albert M. Craig ... [et al.]. 7th ed.

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Using genetic algorithms to calibrate a dimethylsulfide production model in the Arctic Ocean

2006年

作者： albert M. Craig ... [et al.].

来源：畅想之星图书光盘版（南... 评论

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Chinese Journal of Oceanology and Limnology 2010年第3期28卷 573-582页

作者：瞿波 GABRIC J.albert Nantong University Griffith University

The global climate is intimately connected to changes in the polar oceans. The variability of sea ice coverage affects deep-water formations and large-scale thermohaline circulation patterns. The polar radiative budget is sensitive to sea-ice loss and consequent surface albedo changes. Aerosols and polar cloud microphysics are crucial players in the radioactive energy balance of the Arctic Ocean. The main biogenic source of sulfate aerosols to the atmosphere above remote seas is dimethylsulfide (DMS). Recent research suggests the flux of DMS to the Arctic atmosphere may change markedly under global warming. This paper describes climate data and DMS production (based on the five years from 1998 to 2002) in the region of the Barents Sea (30–35°E and 70–80°N). A DMS model is introduced together with an updated calibration method. A genetic algorithm is used to calibrate the chlorophyll-a (CHL) measurements (based on satellite SeaWiFS data) and DMS content (determined from cruise data collected in the Arctic). Significant interannual variation of the CHL amount leads to significant interannual variability in the observed and modeled production of DMS in the study region. Strong DMS production in 1998 could have been caused by a large amount of ice algae being released in the southern region. Forcings from a general circulation model (CSIRO Mk3) were applied to the calibrated DMS model to predict the zonal mean sea-to-air flux of DMS for contemporary and enhanced greenhouse conditions at 70–80°N. It was found that significantly decreasing ice coverage, increasing sea surface temperature and decreasing mixed-layer depth could lead to annual DMS flux increases of more than 100% by the time of equivalent CO2 tripling (the year 2080). This significant perturbation in the aerosol climate could have a large impact on the regional Arctic heat budget and consequences for global warming.

关键词：生产模式二甲基硫遗传算法北冰洋校准

It takes two to tango: Unraveling a new post-translational modification involved in SnRK2.6 activation

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Molecular Plant 2021年第11期14卷 1779-1781页

作者： Miguel Daniel-Mozo Armando albert Instituto de Quimica Ffsica Rocasolano Consejo Superior de Investigaciones Cientificas(IQFR-CSIC)Calle Serrano 11928006 MadridSpain

Protein kinases are a conserved superfamily of proteins that play an essential role in signal transduction by attaching a phosphoryl group to serine,threonine,or tyrosine residues of a protein,hence converting them to *** process,which can be reversed by protein phosphatases,regulates vital cellular processes in plants,including metabolism,proliferation,and *** is also key to trigger response mechanisms to drought,increased salinity,and other abiotic stresses(Zhu,2016).

关键词： hence reversed translational

Comment on “Low-frequency sea level variation and its correlation with climate events in the Pacific”

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Chinese Science Bulletin 2013年第14期58卷 1708-1713页

作者： PARKER albert University of Ballarat

The tide gauge results exhibit strong multi-decadal oscillations with detected periodicities up to a quasi-60 years. This translates in the requirement of at least 60-70 years of continuously recorded data without any quality issue and the use of a procedure appropriate for time series with periodic components to infer the acceleration trend. This is not what is done in many recent papers where the oscillating behaviour is neglected and short or incomplete records arbitrarily extended or reconstructed are used to infer wrong accelerating trends. All the tide gauges of enough length and quality show the sea levels are oscillating with important multi-decadal periodicities but absolutely not positively accelerating. The satellite radar altimeter reconstruction of the global mean sea level only available since 1993 shows despite the many uncertainties of a still imperfect procedure a not positively accelerating behaviour. The presence of acceleration in the reconstructed or extended data sets and the lack of acceleration in all the individual tide gauge measurements of enough quality and length certainly deserve further discussion. This is a comment to a previously published original paper made on the basis of other previously published results and not a new original paper.

关键词：太平洋地区海平面变化气候事件低频率年代际振荡周期性振荡评论潮汐测量

Bowel intussusception caused by a percutaneously placed endoscopic gastrojejunostomy catheter: A case report

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 621-625页

作者： Maarten WJ Winters Sjoerd Kramer albert HA Mazairac Ewoud H Jutte Paul G van Putten Department of Gastroenterology and Hepatology Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands Department of Radiology Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands Department of Surgery Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands

BACKGROUND In adults,bowel intussusception is a rare diagnosis and is mostly due to an organic bowel *** rare cases,this is a complication of a percutaneously placed endoscopic gastro(jejunostomy)*** SUMMARY We describe a case of a 73-year-old patient with a history of myocardial infarction,chronic idiopathic constipation and Parkinson’s *** the admission of his Parkinson’s medication,a percutaneous endoscopic gastrostomy with jejunal extension(PEG-J)was *** patient presented three times at the emergency department of the hospital with intermittent abdominal pain with nausea and *** were no distinctive abnormalities from the physical and laboratory *** abdominal computed tomography scan showed a small bowel *** push endoscopy,a jejunal bezoar at the tip of the PEG-J catheter was found to be the cause of small bowel *** intussusception was resolved after removing the bezoar during push *** Endoscopic treatment of bowel intussusception caused by PEG-J catheter bezoar.

关键词： Bowel intussusception Percutaneous endoscopic gastrojejunostomy Bezoar Percutaneous endoscopic gastrostomy Case report