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脊髓灰质炎自然免疫和病毒疫苗诱导免疫的特性

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江西医药 1963年第5期 30-32页

作者： albert b.sabin 郝鸿纶

脊髓灰质炎的自然感染和获得免疫 1.脊髓灰质炎病毒在致病中有三种特性: ①在消化道表面上皮的繁殖能力;②在消化道和神经以外的组织繁殖能力;③在神经元内的繁殖能力,包括中枢神经系在内,它能决定病毒传播的范围,是否神经元受累而发生... 详细信息

脊髓灰质炎的自然感染和获得免疫 1.脊髓灰质炎病毒在致病中有三种特性: ①在消化道表面上皮的繁殖能力;②在消化道和神经以外的组织繁殖能力;③在神经元内的繁殖能力,包括中枢神经系在内,它能决定病毒传播的范围,是否神经元受累而发生瘫痪.这种性质不仅在不同的毒株在分量上有不同的差别,而且细胞对脊髓灰质炎病毒繁殖的敏感性也各有不同,都成为决定传染后果的因素.

关键词：病毒疫苗脊髓脑病毒血症获得免疫自然传染毒株高效价抗体

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今日的疫苗与未来疫苗的评价

国外医学情报 1981年第2期 19-20页

作者： albert b.sabin 美国南卡罗来纳医科大学生物医学专家教授

许多病毒性疾病都用疫苗进行预防,还有不少新的疫苗正在研究之中。现在,我主要谈谈疫苗使用的现状及将来的评价。脊髓灰质炎小儿麻痹症除了由三型脊髓灰质炎病毒引起外,还可由柯萨奇A7、A9、b2,b3、b4、b5型病毒,埃可1、2、4、6、7、9... 详细信息

许多病毒性疾病都用疫苗进行预防,还有不少新的疫苗正在研究之中。现在,我主要谈谈疫苗使用的现状及将来的评价。脊髓灰质炎小儿麻痹症除了由三型脊髓灰质炎病毒引起外,还可由柯萨奇A7、A9、b2,b3、b4、b5型病毒,埃可1、2、4、6、7、9、11、18、30型病毒和70、71型肠道病毒引起。此外,还有许多病毒可以引起麻痹性质不同、但临床症状相似的麻痹症。目前,人们对上述肠道病毒能引起那些疾病尚未真正了解。但是1975年在保加利亚曾发生71型肠道病

关键词：脊髓灰质炎病毒美国肠道病毒小儿小儿麻痹病毒美利坚合众国北美洲疫苗菌苗麻痹性脊髓灰质炎

Seroprevalence of HbV and HCV among People Living with HIV in burkina Faso and Diagnostic Performance of HIV/HCV/HbsAg Combined Rapid Test in Comparison with Architect Assays

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Open Journal of Medical Microbiology 2024年第1期14卷 1-10页

作者： Serge Theophile Soubeiga albert Theophane Yonli Alain Megabtche Nantchouang Jacques Simpore Department of biomedical and Public Health Research Institute for Health Sciences (IRSS) Ouagadougou Burkina Faso Pietro Annigoni biomolecular Research Centre (CERbA) Ouagadougou Burkina Faso Laboratory of Molecular biology and Genetics (LAbIOGENE) University Joseph Ki-Zerbo Ouagadougou Burkina Faso bIOMEX Laboratory Heidelberg Germany

background: The diagnosis of human immunodeficiency virus (HIV), hepatitis b virus (HbV), and hepatitis C virus (HCV) remains a constraint for some populations in sub-Saharan Africa. This study aimed to determine the prevalence of HbV and HCV in people living with HIV and to evaluate the performance of a combined rapid test for the simultaneous detection of HIV, HbV, and HCV. Methods: This is a cross-sectional study that took place from February 2017 to November 2018 and included 139 HIV-infected individuals followed up at different medical centers in Ouagadougou, burkina Faso. HbV and HCV serology tests were performed on-site using finger prick whole blood with HIV/HCV/HbsAg combined rapid test and then serum with two reference tests “Architect HbsAg Qualitative” and “Architect HIV Ag/Ab Combo”. Results: The mean age of the participants was 57 ± 8 years. Of the 139 participants, 10% (14/139) were HIV-1 positive, 71.9% (100/139) were HIV-2 positive, and 18.0% (25/139) were HIV-1/HIV-2 coinfected. The sensitivity and specificity of the HIV/HCV/HbsAg combined rapid test were 33.33% vs 99.11% and 20% vs 99.25% compared to Architect HbsAg Qualitative and Architect HIV Ag/Ab Combo, respectively. The Kappa and Youden Index values were 0.4262 and 0.3244 and 0.2707 and 0.1925, respectively, compared to each of the two reference tests. Conclusion: The results show that the HIV/HCV/HbsAg combined rapid test has poor diagnostic efficiency and should not be recommended for the diagnosis of these viruses.

关键词： HIV HbV HCV Prevalence Diagnosis burkina Faso

Calcium-Magnesium Ca/Mg Ratios and Their Agronomic Implications for the Optimization of Phosphate Fertilization in Rainfed Rice Farming on Acidic Ferralsol in the Forest Zone of Ivory Coast

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Open Journal of Soil Science 2024年第1期14卷 81-96页

作者： Fernand G. Yao brahima Kone Franck M. L. bahan Kouadio Amani Jean L. Essehi Mamadou b. Ouattara Konan E. b. Dibi brou Kouame François Lompo albert Yao-Kouame Central Laboratory Soils Water and Plants (LCSEP) National Center for Agronomic Research (CNRA) Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Cocody-Abidjan Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast Department of Rice Program Man Research Station National Center for Agronomic Research (CNRA) Man Ivory Coast Department of Geography Unit of Training and Research (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast Food Crops Research Station (SRCV) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Institute of the Environment and Agricultural Research (INERA) Ouagadougou Burkina Faso

This study is a contribution to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is based on taking into account the cationic balances of the soil in order to optimize the phosphorus (P) nutrition of rice on these acidic soils, where this nutrient constitutes a limiting factor for agricultural production. Three (3) pot trials were conducted in Adiopodoumé in the forested south of Côte d’Ivoire. The interactive effects of calcium carbonate (0, 25, 50 and 75 kg Ca ha−1) and magnesium sulfate (0, 25, 50 and 75 kg Mg ha−1) were evaluated on the response of NERICA 5 rice at doses 0, 25, 50 and 75 kg P ha−1 of natural phosphate from Togo, applied only once at the start of the experiment. Additional fertilizers of nitrogen (N) (100 kg N ha−1) and potassium (K) (50 kg KCl ha−1) were added to each of the tests in a split-plot device. The test results revealed a paddy production potential of approximately 3 to 5 t⋅ha−1 for NERICA 5 on an acidic soil, under the effect of the interaction of P, Ca and Mg. The quadratic response of rice yield to the doses of these fertilizers would be more dependent on their balance, itself influenced by Ca nutrition. For the sustainability and maintenance of rice production in agro-ecology studied, it was recommended doses of 38 kg Ca ha−1, 34 kg Mg ha−1 in a Ca/Mg ratio (1/1) with intakes of 41 kg P ha−1, overall in a ratio 1/1/1 (P/Ca/Mg) more favorable to the availability of free iron considered a guiding element of mineral nutrition. Thus, these promising results should be confirmed in a real environment for better management of the fertilization of rice cultivated on acidic plateau soils in Côte d’Ivoire.

关键词： Soil Acidity Ca/Mg Ratios Phosphate Fertilization Rice Growing Ivory Coast

The FRb-searching Pipeline of the Tianlai Cylinder Pathfinder Array

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Research in Astronomy and Astrophysics 2024年第8期24卷 113-132页

作者： Zijie Yu Furen Deng Shijie Sun Chenhui Niu Jixia Li Fengquan Wu Wei-Yang Wang Yougang Wang Shifan Zuo Lin Shu Jie Hao Xiaohui Liu Reza Ansari Ue-Li Pen albert Stebbins Peter Timbie Xuelei Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of ScienceBeijing 100101China Institute of Astrophysics Central China Normal UniversityWuhan 430079China Institute of Automation Chinese Academy of SciencesBeijing 100190China Guangdong Institute of Artificial Intelligence and Advanced Computing Guangzhou 510535China UniversitéParis-Saclay CNRS/IN2P3IJCLab91405 OrsayFrance Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617TaiwanChina Canadian Institute for Theoretical Astrophysics University of Toronto60 Saint George StreetTorontoON M5S 3H8Canada Department of Physics University of Wisconsin-MadisonMadisonWI 53706USA Fermi National Accelerator Laboratory P.O.Box 500Batavia IL 60510-5011USA Department of Physics College of SciencesNortheastern UniversityShenyang 110819China Center of High Energy Physics Peking UniversityBeijing 100871China

This paper presents the design,calibration,and survey strategy of the Fast Radio burst(FRb)digital backend and its real-time data processing pipeline employed in the Tianlai Cylinder Pathfinder *** array,consisting of three parallel cylindrical reflectors and equipped with 96 dual-polarization feeds,is a radio interferometer array designed for conducting drift scans of the northern celestial *** FRb digital backend enables the formation of 96 digital beams,effectively covering an area of approximately 40 square degrees with the 3 db *** pipeline demonstrates the capability to conduct an automatic search of FRbs,detecting at quasi-realtime and classifying FRb candidates *** current FRb searching pipeline has an overall recall rate of88%.During the commissioning phase,we successfully detected signals emitted by four well-known pulsars:PSR b0329+54,b2021+51,b0823+26,and b2020+*** report the first discovery of an FRb by our array,designated as FRb *** also investigate the optimal arrangement for the digitally formed beams to achieve maximum detection rate by numerical simulation.

关键词： instrumentation interferometers-methods data analysis-(stars )pulsars general-telescopes

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The interaction of versican with its binding partners

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Cell Research 2005年第7期15卷 483-494页

作者： David P. LA PIERRE,albert J. YEE,burton b. YANG Sunnybrook & Women’s College Health Sciences Centre 2075 bayview Avenue Toronto M4N 3M5 Canada Department of Laboratory Medicine and Pathobiology University of Toronto Canada Sunnybrook & Women’s College Health Sciences Centre 2075 bayview Avenue Toronto M4N 3M5 Canada Sunnybrook & Women’s College Health Sciences Centre 2075 bayview Avenue Toronto M4N 3M5 Canada Department of Laboratory Medicine and Pathobiology University of Toronto Canada

Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within theextracellular matrix (ECM). Versican, like other members of its family, has unique N- and C-terminal globular regions,each with multiple motifs. A large glycosaminoglycan-binding region lies between them. This review will begin byoutlining these structures, in the context of ECM proteoglycans. The diverse binding partners afforded to versican byvirtue of its modular design will then be examined. These include ECM components, such as hyaluronan, type Icollagen, tenascin-R, fibulin-1, and -2, fibrillin-1, fibronectin, P- and L-selectins, and chemokines. Versican also binds tothe cell surface proteins CD44, integrin β1, epidermal growth factor receptor, and P-selectin glycoprotein *** multiple interactors play important roles in cell behaviour, and the roles of versican in modulating such processesare discussed.

关键词： extracellular matrix proteoglycan G3 domain glycosaminoglycan interaction.

Academic productivity correlates with industry earnings in foot and ankle fellowship programs in the United States:A retrospective analysis

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World Journal of Orthopedics 2024年第2期15卷 129-138页

作者： albert T Anastasio Anthony N baumann Kempland C Walley Kyle J Hitchman Conor O’Neill Jonathan Kaplan Samuel b Adams Department of Orthopedic Surgery Duke University HospitalDurhamNC 27710United States College of Medicine Northeast Ohio Medical UniversityRootstownOH 44272United States Department of Orthopedic Surgery University of MichiganAnn ArborMI 48109United States School of Osteopathic Medicine Campbell UniversityLillingtonNC 27546United States

bACKGROUND The study investigates the connection between academic productivity and industry earnings in foot and ankle orthopedic surgery *** metrics like the H-index and Open Payments Database(OPD)data,it addresses a gap in understanding the relationship between scholarly achievements and financial outcomes,providing a basis for further exploration in this specialized medical *** To elucidate the trends between academic productivity and industry earnings across foot and ankle orthopedic surgery fellowship programs in the United *** This study is a retrospective analysis of the relationship between academic productivity and industry earnings of foot and ankle orthopedic surgery fellowships at an individual faculty and fellowship *** productivity was defined via H-index and recorded from the Scopus *** earnings were recorded from the *** Forty-eight foot and ankle orthopedic surgery fellowships(100%of fellowships)in the United States with a combined total of 165 physicians(95.9%of physicians)were *** individual physician(n=165)total life-time earnings reported on the OPD website was United States Dollar(USD)451430.30±1851084.89(range:USD 25.16-21269249.85;median:USD 27839.80).Mean physician(n=165)H-index as reported on Scopus is 14.24±12.39(range:0-63;median:11).There was a significant but weak correlation between individual physician H-index and individual physician total life-time earnings(Pbetween combined fellowship H-index and total life-time earnings per fellowship(P=0.004,Spearman’s rho=0.409).CONCLUSION There is a significant and positive correlation between academic productivity and industry earnings at foot and ankle orthopedic surgery fellowships in the United *** observation is true on an individual physician level as well as on a fellowship level.

关键词： Sunshine act Foot and ankle Orthopedic surgery Orthopedic fellowship Industry earnings

Prevalence of diverticulosis in recurrent Clostridium difficile infection

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World Journal of Gastroenterology 2010年第3期16卷 345-347页

作者： Michael J Lipp Odelya E Pagovich David Rabin albert D Min brett b bernstein Division of Digestive Diseases Beth Israel Medical Center Division of Medicine Beth Israel Medical Center

AIM:To re-evaluate the theory that colonic diverticulosis is associated with relapse of Clostridium difficile associated disease (CDAD) in light of data suggesting increasing rates of CDAD infection and ***: Charts were reviewed for patients with recurrent CDAD who had also had a prior colonoscopy or flexible sigmoidoscopy. An age and gender matched control group was used to compare the prevalence of ***: Twenty-two patients met the study criteria, and the prevalence of diverticulosis in patients with CDAD relapse was 23% compared to 32% in age and sex matched controls (P=0.44). A significant proportion of patients with CDAD relapse had comorbidities associated with immune ***: Diverticulosis does not appear to be associated with CDAD relapse.

关键词： Clostridium diff icile Diverticulosis Relapse Immune suppression Clostridium difficile associated disease

Development of fatal acute liver failure in HIV-HbV coinfected patients

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World Journal of Gastroenterology 2010年第32期16卷 4107-4111页

作者： albert M Anderson Marina b Mosunjac Melody P Palmore Melissa K Osborn Andrew J Muir Emory University School of Medicine Grady Health System Infectious Diseases Program341 Ponce de Leon AvenueAtlantaGA 30308United States Duke University School of Medicine DUMC 3913DurhamNorth CarolinaCA 27710United States

Coinfection with hepatitis b virus(HbV) is not uncommon in human immunodeficiency virus(HIV)-infected individuals and patients with HIV-HbV coinfection are at high risk for progression of liver *** guidelines regarding the treatment of HIV infection recommend that patients who are coinfected with HIV and HbV receive highly active antiretroviral therapy(HAART) with activity against hepatitis *** HIVHbV coinfected patients often experience liver enzyme elevations after starting antiretroviral therapy,acute liver failure(ALF) is rare and typically occurs with older antiretroviral agents with known potential for *** describe two cases of fatal ALF in the setting of HIV-HbV coinfection after initiation of *** cases occurred despite treatment with antiretrovirals that have activity against HbV and highlight the challenges in distinguishing drug hepatotoxicity and HbV immune reconstitution inflammatory ***-HbV coinfected patients should be monitored closely when initiating HAART,even when treatment includes agents that have activity against HbV.

关键词： Hepatitis b virus Human immunodeficiency virus Liver failure