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中枢神经系统郎罕细胞组织细胞增生症一例

中华放射学杂志 2002年第2期36卷 187-188页

作者：包颜明 albert lam 昆明医学院第一附属医院医学影像科 650031 Medical Imaging Department Royal Alexandra Hospital For Children

郎罕细胞组织细胞增生症（LCH）是1种罕见的反应性疾病，在儿童更为少见。笔者报道1例累及垂体轴的儿童郎罕细胞组织细胞增生症。

关键词：中枢神经系统郎罕细胞组织细胞增生症磁共振成像

Inferior vena cava reconstruction in extended right hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 533-534页

作者： Karin KY Ho Sui Ling Sin Kin Pan Au Henry HY Lee Daniel TL Chan albert Chan Department of Surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Surgery Yan Chai Hospital7 Yan Chai StreetHong KongChina State Key Laboratory of Liver Research(Li Ka Shing Faculty of Medicine The University of Hong Kong)102 Pok Fu Lam RoadHong KongChina

To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.

关键词： invasion vena Liver

Parental behaviors and sleep/wake patterns of infants and toddlers in Hong Kong, China

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World Journal of Pediatrics 2017年第5期13卷 496-502页

作者： Xin-Ting Yu Avi Sadeh Hugh Simon lam Jodi A.Mindell albert Martin Li Department of Pediatrics The Chinese University of Hong KongHong KongChina and Department of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA The School of Psychological Sciences Tel Aviv UniversityIsracl Department of Pediatrics The Chinese University of Hong KongHong KongChina Saint Joseph's University and The Children's Hospital of Philadelphia Philadelphia PAUSA

Background:To describe the sleep patterns of children below 36 months in Hong Kong,and evaluate the associations between parental behaviors and childhood sleep/wake ***:Parents of 1049 infants and toddlers completed an internet-based expanded version of the Brief Infant Sleep ***:Total sleep duration (P<0.001),frequency (P<0.001) and duration (P<0.001) of nocturnal awakenings decreased with age,whereas the longest sleep duration (P<0.001) and nocturnal sleep duration (P<0.001) increased with *** who room-or bed-shared with parents had later bedtimes (P<0.001),but similar sleep duration compared with those who had a separate sleep *** asleep independently was associated with longer nocturnal sleep duration (P<0.001) and less sleep awakenings (P<0.001).Full-time employment of parents was associated with shorter total sleep duration of children (P<0.001).Although breastfeeding was associated with more nocturnal awakenings (P<0.001),no association was detected between breastfeeding and shorter sleep duration in ***:As infants and toddlers develop,their sleep *** asleep independently was associated with longer nocturnal sleep duration and fewer sleep awakenings,whereas sleep location was *** is an important finding,especially for families with limited living space where parent/ child room-or bed-sharing cannot be avoided.

关键词： infant parental behaviors sleep sleep/wake patterns toddler

Novel N-heteroaromatic dyes for textile substrates

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Chinese Chemical Letters 2014年第8期25卷 1165-1168页

作者： Kim-Hung lam Sarah Sze-Wah Ho Pik-Ling lam Johnny Cheuk-On Tang Zhao-Xiang Bian albert Sun-Chi Chan Hua Li Wai-Yeung Wong Chung-Hin Chui Department of Applied Biology and Chemical Technology Institute of Textile and Clothing The Hong Kong Polytechnic University Clinical Division School of Chinese Medicine Hong Kong Baptist University Institute of Molecular Functional Materials Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist University College of Life and Environmental Sciences Minzu University of China HKBU Institute of Research and Continuing Education Shenzhen Virtual University Park

This study reports the synthesis and characterization of quinoline derivatives. The synthesized quinoline compounds were applied to the dyeing treatment of acrylic fabrics. The color fastness to washing and light of quinoline compound-dyed fabrics was examined. Human skin HaCaT cell line was also used for the skin cytotoxicity evaluation of the quinoline compound-dyed acrylic fabrics.

关键词： Acrylic fabrics Fluorescent Quinoline dyes Skin cytotoxicity

Packing and film thickness theories for the mix design of high-performance concrete

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第10期17卷 759-781页

作者： Pui-lam NG albert Kwok-Hung KWAN Leo Gu LI Department of Civil Engineering The University of Hong Kong Pokfulam Hong Kong China Faculty of Civil Engmeering Vilnius Gediminas Technical University Vilnius Lithuania Schoo of Cicil and Transportation Engmeering Guangdong University of Technology Guangzhou 510006 China

A high-performance concrete （HPC） is required to have superior performance in various aspects such as workability,strength, durability, dimensional stability, segregation stability, and passing ability. The mix design of HPC is rather complicatedbecause the number of ingredients in HPC is usually more than those in conventional concrete and some of the required propertiesare conflicting with each other in the sense that improvement in one property would at the same time cause impairment of anotherproperty. However, there is still lack of understanding regarding how the various mix parameters should be optimised forachieving best overall performance. Most practitioners are still conducting mix design primarily through trial concrete mixing,which is laborious, ineffective, and often unable to timely respond to fluctuations in the properties of raw materials. To addressthese issues, the authors have been developing the packing and film thickness theories of concrete materials, in order to revamp themix design philosophy of HPC in terms of the water film thickness （WFT）, paste film thickness （PFT）, and mortar film thickness（MFT） in the concrete. Based on the findings from an extensive experimental programme, suitable ranges ofWFT, PFT, and MFThave been recommended.

关键词： Concrete mix design, Concrete science, Film thickness, High-performance concrete, Packing density, Sustainability

Influences of fiber length and water film thickness on fresh properties of basalt fiber-reinforced mortar

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第5期22卷 344-356页

作者： Leo Gu LI Yi OUYANG Pui-lam NG Kai-long ZENG albert Kwok Hung KWAN Department of Civil Engineering Guangdong University of TechnologyGuangzhou 510006China Department of Civil Engineering The University of Hong KongHong Kong 999077China Mott MacDonald(Hong Kong)Ltd. Hong Kong 999077China China Jinmao Holdings Group Ltd. Guangzhou 510030China

In plain mortar,the water film thickness(WFT)has been found to play a key role in the fresh ***,in fiber-reinforced mortar,the role of WFT has not been investigated *** this research,basalt fibers of different lengths were added to the mortar,and the dynamic and static flowability,cohesiveness,adhesiveness,and packing density were tested to study the effects of fiber length on the packing density and WFT,and the combined effects of fiber length and WFT on the fresh *** results showed that in fiber-reinforced mortar,the WFT also plays a key role,whereas the fiber length exerts its influences through the indirect effects on the packing density and WFT and the direct effect on fiber-mortar ***,an increase in fiber length decreases the packing density and WFT,decreases the dynamic and static flowability needed for placing,increases the cohesiveness needed for avoiding segregation,and,quite unexpectedly,decreases the adhesiveness needed for rendering and spraying *** analysis yielded good correlation of the fresh properties to fiber length and WFT,and best-fit formulas for the mix design for basalt fiber-reinforced mortar were obtained.

关键词： Basalt fiber Fiber-reinforced mortar Fresh properties Water film thickness(WFT)

Prader-Willi Syndrome:16-Year Experience in Hong Kong

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Journal of Genetics and Genomics 2012年第4期39卷 191-194页

作者： Ivan F.M. Lo Ho Ming Luk luksite@*** Tony M.F. Tong Kent K.S. Lai Daniel H.C. Chan albert C.F. lam David K.H. Chan Edgar W.L. Hau Connie O.Y. Fung Stephen T.S. lam Clin Genet Serv Dept Hlth Kowloon Hong Kong Peoples R China

Prader-Willi syndrome （PWS） is an important, well-recognized syndromic form of neurodevelopmental disorder. The incidence is about 1 in 15,000-25,000 live births, and it affects both males and females （Vogels et al... 详细信息

关键词： PWS Prader-Willi Syndrome

Ferroptosis and glaucoma: implications in retinal ganglion cell damage and optic nerve survival

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Neural Regeneration Research 2023年第3期18卷 545-546页

作者： Ming Yang Kwok-Fai So Wai-Ching lam Amy Cheuk Yin Lo Department of Ophthalmology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Glaucoma and visual pathway degeneration:Glaucoma is the leading cause of irreversible blindness worldwide,which leads to a progressive loss of *** can be classified into two types:primary open-angle glaucoma and primary closed-angle *** open-angle glaucoma can be caused by the blockage of the trabecular meshwork,and this results in elevation of the intraocular pressure(IOP),leading to retinal ganglion cell(RGC)***,many glaucoma patients have normal IOP;this is known as normal-tension ***,excitotoxic damage and oxidative stress can also lead to RGC damage in normal-tension glaucoma(Almasieh et al.,2012).Glaucomatous genes such as TIGR,OPTN,and CYP1B1 have been suggested to contribute to the pathogenesis of ***,some glaucomatous patients may remain asymptomatic in the early,moderate,and late *** type of glaucoma is primary closed-angle *** this clinical condition,a relative pupillary block is contributed by the iris obstructing aqueous *** patients may suffer from corneal swelling,headache,nausea,and blurred vision during the acute phase.

关键词： glaucoma damage degeneration

Phenylketonuria in Hong Kong Chinese： a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China

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Chinese Medical Journal 2011年第16期124卷 2556-2558页

作者： Chloe Miu Mak Chun-hung Ko Ching-wan lam Wai-ling Lau Wai-kwan Siu Sammy Pak-lam Chen Chun-yiu Law Chi-kong Lai Chak-man Yu albert Yan-wo Chan Kowloon West Cluster Laboratory Genetic Service ChemicalPathology Laboratory Department of Pathology Princess MargaretHospital Hong Kong China Department of Paediatrics and Adolescent Medicine CaritasMedical Centre Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine TheUniversity of Hong Kong Hong Kong China

Hyperphenylalaninemia is one of the commonest inborn errors of metabolism affecting approximately 1 in 15 000 live births. Among Chinese, BH4 deficiency leading to hyperphenylalaninemia is much commoner than in Caucasians. Exact diagnosis is important for the treatment and genetic counseling. In 2000, newborn screening for phenylketonuria is mandatory by law in China throughout the whole country. However, it is not yet included in the newborn screening program of the Hong Kong Special Administrative Region, China. Published data on hyperphenylalaninemia among Hong Kong Chinese are largely lacking. We report a 1-year-old Hong Kong Chinese girl with severe 6-pyruvoyl-tetrahydropterin synthase （PTPS） deficiency. The patient presented with infantile hypotonia and was misdiagnosed as cerebral palsy. She had very mild hyperphenylalaninemia （95 IJmol/L）, significantly high phenylalnine-to-tyrosine ratio （3.1）, and ele~,ated prolactin of 1109 m lU/L. Genetic analysis confirmed a homozygous known disease-causing mutation PTS NM_000317.1： c.259C〉T; NP_000308.1： p.P87S in the proband. In our local experience, while the estimated prevalence of hyperphenylalaninemia due to PTPS deficiency was reported to be 1 in 29 542 live births, not a single case of phenylalanine hydroxylase deficiency has been reported. Furthermore, there is a general lack of awareness of inherited metabolic diseases in the community as well as among the medical professionals. Very often, a low index of clinical suspicion will lead to delay in diagnosis, multiple unnecessary and costly investigations, prolonged morbidity and anxiety to the family affected. We strongly recommend that expanded newborn screening for hyperphenylalaninemia should be implemented for every baby born in the Hong Kong Special Administrative Region, China.

关键词： Hong Kong Chinese hyperphenylalaninemia newborn screening phenylketonuria 6-pyruvoyl-tetrahydropterin synthase deficiency