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时代英语（高二版） 2016年第5期 1-1页

作者：埃德加·艾伯特·格斯特

想要有个美丽花园，面积大小姑且不管。想要园中长满鲜花，就必须把汗水挥洒。

关键词：中学英语课外阅读阅读材料诗歌

肿瘤坏死因子在慢性结核及慢性结核复发中的作用

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肿瘤坏死因子在慢性结核及慢性结核复发中的作用

胃“复制”囊肿:成人中1例少见的内超声发现物

中华医学会结核病学分会2004年学术会议

作者：朱国峰 Charkravarty S Chan j 医学和微生物学及免疫学系 albert Einstoin Collage of Medicine

前言在结核杆菌引起疾病的过程中,慢性结核侵染及其复发扮演着十分重要的角色。目前全球人口中约有三分之一的人受到结核菌的侵染。这些潜伏在宿主体内的结核菌往往成为慢性结核侵染的复发中病菌的来源。事实上,这种潜伏状态也正是结核... 详细信息

前言在结核杆菌引起疾病的过程中,慢性结核侵染及其复发扮演着十分重要的角色。目前全球人口中约有三分之一的人受到结核菌的侵染。这些潜伏在宿主体内的结核菌往往成为慢性结核侵染的复发中病菌的来源。事实上,这种潜伏状态也正是结核病治疗中的一个主要的障碍。因此,深入研究了解在慢性结核侵染中宿主的免疫反应及其机理,是结核病预防,治疗和控制中的首要问题。

关键词：肿瘤坏死因子慢性结核

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 61-62页

作者： Hlouschek V. Domagk D. Naehrig j. 武敏 Department of Medicine B University of Muenster Albert-Schweitzer Str. 33 DE-48129 Münster Germany.Dr

Cystic lesions located in the gastric wall are a rare finding in endosonography of the gastrointestinal tract. Compared to all forms of benign and malignant tumours of the stomach, gastric duplication cysts are an uncommon anomaly-especially in adults. We report on a 59-year-old woman suffering from intermittent abdominal pain, weight loss and nausea. A gastric duplication cyst was identified by endoscopic ultrasound (EUS), but malignancy was excluded by EUS and fine-needle aspiration histology. Because of continuously increasing abdominal complaints, surgery was performed with partial resection of the gastric corpus and splenectomy. Gross anatomy and histology showed a gastric cyst measuring 150 mm in maximum diameter with no evidence of malignancy or inflammation. Following surgery, the patient's condition recovered fully.

关键词：超声内镜细针穿刺大体解剖学组织学检查囊性病变组织学分析

Microglial senescence in neurodegeneration:Insights,implications,and therapeutic opportunities

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Neuroprotection 2024年第3期2卷 182-195页

作者： Tobiloba Samuel Olajide Toheeb O.Oyerinde Omolabake I.Omotosho Oritoke M.Okeowo Olayemi j.Olajide Omamuyouwi M.Ijomone Laboratory for Experimental and Translational Neurobiology University of Medical SciencesOndoOndoNigeria Department of Physiology School of Basic Medical ScienceFederal University of TechnologyAkureOndoNigeria Center for Studies in Behavioral Neurobiology Department of PsychologyConcordia UniversityMontrealQuebecCanada Division of Neurobiology Department of AnatomyFaculty of Basic Medical SciencesUniversity of IlorinIlorinKwaraNigeria Department of Molecular Pharmacology Albert Einstein College of MedicineBronxNew YorkUSA

The existing literature on neurodegenerative diseases(NDDs)reveals a common pathological feature:the accumulation of misfolded ***,the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the understanding of the diverse clinical manifestations of individual ***,a hallmark symptom across various NDDs,serves as a multifaceted denominator,contributing to the clinical manifestations of these *** is a compelling hypothesis that therapeutic strategies capable of mitigating misfolded protein accumulation and disrupting ongoing pathogenic processes may slow or even halt disease *** research has linked disease-associated microglia to their transition into a senescent state—characterized by irreversible cell cycle arrest—in aging populations and *** senescent microglia are consistently observed in NDDs,few studies have utilized animal models to explore their role in disease *** evidence from experimental rat models suggests that disease-associated microglia exhibit characteristics of senescence,indicating that deeper exploration of microglial senescence could enhance our understanding of NDD pathogenesis and reveal novel therapeutic *** review underscores the importance of investigating microglial senescence and its potential contributions to the pathophysiology of NDDs,including Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral ***,it highlights the potential of targeting microglial senescence through iron chelation and senolytic therapies as innovative approaches for treating age-related NDDs.

关键词： aging ferritin microglia neurodegenerative diseases senescence-associated secretory phenotype senescent

ALPPS在合并轻中度肝纤维化肝细胞癌患者中的应用分析

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中华肝胆外科杂志 2019年第11期25卷 806-808页

作者：刘春红邓明武邱思远朱洪涛许邦仁洪晓明纪任吴国际陈智仁张丹图卢宠茂香港大学深圳医院肝胆胰外科深圳518053

目的探讨联合肝脏离断和门静脉结扎的二步肝切除术(ALPPS)在轻度、中度肝纤维化的肝细胞癌患者中的应用价值。方法回顾性分析2014年4月至2017年12月香港大学深圳医院肝胆胰外科14例行ALPPS的原发性肝癌患者资料,其中男性9例,女性5例,平... 详细信息

目的探讨联合肝脏离断和门静脉结扎的二步肝切除术(ALPPS)在轻度、中度肝纤维化的肝细胞癌患者中的应用价值。方法回顾性分析2014年4月至2017年12月香港大学深圳医院肝胆胰外科14例行ALPPS的原发性肝癌患者资料,其中男性9例,女性5例,平均年龄51(26~71)岁,Child-Pugh均为A级。分析患者肝纤维化程度、手术情况以及术后并发症等。结果14例肝癌患者均成功完成二步肝切除术,1例患者二步手术后因肝功能衰竭死亡。无纤维化4例患者,两手术间隔平均9.0 d,剩余肝体积增长率平均为58%。轻度纤维化5例,两手术间隔平均11.2 d,剩余肝体积增长率平均46%。中度纤维化5例,两手术间隔平均12.8 d,剩余肝体积增长率平均45.6%。14例患者术后发生并发症4例,2例肝功能衰竭,1例肠梗阻,1例肝腹水。结论ALPPS用于Child-Pugh A级合并轻度、中度肝纤维化肝细胞癌治疗安全可行。

关键词：肝硬化癌,肝细胞肝切除术联合肝脏离断和门静脉结扎的二步肝切除术

Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer

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Asian journal of Urology 2016年第4期3卷 229-239页

作者： Takeshi Hirata Seung Chol Park Michelle T.Muldong Christina N.Wu Tomonori Yamaguchi Amy Strasner Omer raheem Hiromi Kumon robert L.Sah Nicholas A.Cacalano Catriona H.M.jamieson Christopher j.Kane Koichi Masuda Anna A.Kulidjian Christina A.M.jamieson Department of Urology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayamaJapan Department of Urology Wonkwang University School of Medicine and HospitalIksanSouth Korea Moores Cancer Center University of CaliforniaSan DiegoLa JollaCAUSA Department of Urology University of CaliforniaSan DiegoLa JollaCAUSA Department of Surgery University of CaliforniaSan DiegoLa JollaCAUSA Department of Medicine University of CaliforniaSan DiegoLa JollaCAUSA Department of Orthopaedic Surgery School of MedicineUniversity of CaliforniaSan DiegoLa JollaCAUSA Department of Bioengineering University of CaliforniaSan DiegoLa JollaCAUSA Department of radiation Oncology University of California at Los AngelesLos AngelesCAUSA

Objective:Bone metastasis occurs in up to 90%of men with advanced prostate cancer and leads to fractures,severe pain and *** metastases induce a spectrum of types of bone lesions which can respond differently to therapy even within individual prostate cancer ***,the special environment of the bone makes the disease more complicated and incurable.A model in which bone lesions are reproducibly induced that mirrors the complexity seen in patients would be invaluable for pre-clinical testing of novel *** microstructural changes in the femurs of mice implanted with PCSD1,a new patient-derived xenograft from a surgical prostate cancer bone metastasis specimen,were ***:Quantitative micro-computed tomography(micro-CT)and histological analyses were performed to evaluate the effects of direct injection of PCSD1 cells or media alone(Control)into the right femurs of rag2/gc/male ***:Bone lesions formed only in femurs of mice injected with PCSD1 *** volume(BV)was significantly decreased at the proximal and distal ends of the femurs(preas BV(pr(pre significantly increased along the femur ***:PCSD1 cells reproducibly induced bone loss leading to osteolytic lesions at the ends of the femur,and,in contrast,induced aberrant bone formation leading to osteoblastic lesions along the femur ***,the interaction of PCSD1 cells with different bone region-specific microenvironments specified the type of bone *** approach can be used to determine if different bone regions support more therapy resistant tumor growth,thus,requiring novel treatments.

关键词： Bone metastatic prostate cancer Patient-derived xenograft microenvironment Microstructural CT Osteolytic lesions Osteoblastic lesions

mpMrI-TrUS融合导向活检与14针法活检在前列腺癌诊断价值的分析:前瞻性对照研究

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国际医学放射学杂志 2018年第2期 234-234页

作者： G.C.Mariotti P.M.Falsarella r.G.Garcia M.r.G.Queiroz G.C.Lemos r.H.Baroni 孙成凤 Department of Interventional radiology Hospital Israelita Albert Einstein

摘要目的比较实时多参数融合经直肠超声(mp MrITrUS)靶向活检和常规14针法前列腺活检的诊断价值。方法研究获得机构伦理委员会批准,100例男性前列腺疾病

关键词： mpMrI-TrUS MrI 诊断价值前列腺癌

伴或不伴脊髓空洞症ChiariⅠ型畸形的脑脊液Mr四维流体力学分析

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国际医学放射学杂志 2012年第6期 597-597页

作者： A.C.Bunck j.r.Kroeger A.juettner A.Brentrup B.Fiedler G.r.Crelier 徐国萍 Department of Clinical radiology University Hospital of MuensterAlbert-Schweitzer-Campus 1building A148149 MuensterGermany

目的使用四维Mr相位对比(PC)血流成像分析伴或不伴脊髓空洞症的ChiariⅠ型畸形(CM)病人的脑脊液(CSF)流体力学。方法 4D-PCCSF流动的数据中获得的20例CM病人(12例伴空洞)。4DCSF流动模式的特征被确定。定量评估颅颈交界区和颈椎椎管脑... 详细信息

目的使用四维Mr相位对比(PC)血流成像分析伴或不伴脊髓空洞症的ChiariⅠ型畸形(CM)病人的脑脊液(CSF)流体力学。方法 4D-PCCSF流动的数据中获得的20例CM病人(12例伴空洞)。4DCSF流动模式的特征被确定。定量评估颅颈交界区和颈椎椎管脑脊液流动参数,并将健康的志愿者与伴或不伴脊髓空洞症的病人之间进行比较。结果与健康志愿者相比,17例CM病人颅颈交界区CSF流动形式异常,多相流动(n=3)、前外侧喷射样流动(n=14)和涡流(n=5)在伴脊髓空洞症的病人中最普遍。病人颅颈交界区流速峰值的增加具有统计学意义[(-15.5±11.3)cm/s与其相对应健康志愿者为(-4.7±0.7)cm/s,PriI型畸形病人CSF的流动。伴脊髓空洞症的病人CSF流体力学的改变是最明显的。

关键词： Chiari畸形脊髓空洞症脑脊液四维流动成像 MrI

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头痛预防的预后与体重指数

世界核心医学期刊文摘(神经病学分册) 2006年第8期 9-10页

作者： Bigal M.E. Gironda M. Tepper S.j. 刘凯 Department of Neurology Albert Einstein College of Medicine 1165 Morris Park Avenue Bronx NY United States Dr.

A population- based longitudinal study suggests that obesity is a strong risk factor for the development of headaches on 15 or more days per month. Little is know about the influence of weight on the response to headache preventive treatment. Herein we prospectively assessed the influence of the baseline body mass index (BMI) on the response to headache preventive treatment. We included adults with episodic or chronic migraine (ICHD- 2), or transformed migraine (Silberstein and Lipton criteria) that sought care in a headache clinic. BMI was assessed in the first visit. Baseline information included headache frequency, number of days with severe headache (prospectively obtained over 1 month), and headache- related disability (HIT- 6). The same information was obtained after 3 months of preventive treatment. Subjects were categorized based on BMI in: normal weight (≤ 24.9), overweight (25- 29.9), or obese (≥ 30). We contrasted the headache end- points using anova with post- test and Kruskal- Wallis with post- test. We used logistic regression to model BMI and headache parameters adjusting for covariates. Our sample consisted of 176 subjects (79.5% women, mean of 44.4 years). At baseline 40.9% had normal weight, 29.5% were overweight and 27.3% were obese. No significant differences were observed in the number of headache days at baseline. After treatment, frequency declined in the entire population, but no significant differences were found by BMI group. regarding the number of days with severe pain per month, there were also no significant differences at baseline (normal = 6.1, overweight = 6.5, obese = 6.7), and improvement overall (P = 0.01). However, changes were greater in the obese (reduction in 2.7 days with treatment) and overweight (3.9) vs. normal (1.5, P res at baseline did not differ by BMI group (normal weight = 63.8, overweight = 64.1, obese = 63.6). However, compared with the normal weighted group, change in HIT scores (follow- u

关键词：头痛头疼疼痛体重指数正常体重头痛发作

0.3%精甲霜灵·噁霉灵SP药肥防治辣椒猝倒病及对生长的影响

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山东化工 2024年第11期53卷 33-35页

作者：孙文荣任士伟王庆菊刘村平朱晓洁乔治·艾伯特喻大昭金正大生态工程集团股份有限公司山东临沂276700 山东金秋园田生物科技有限公司山东临沂276700 农业农村部植物营养与新型肥料创制重点实验室山东临沂276700 广东清远金正大农业研究院有限公司广东清远511500 辽宁金正大生态工程有限公司辽宁铁岭112003

0.3%精甲霜灵·噁霉灵可溶粉剂药肥是集杀菌剂与肥料优势于一体的产品,采用滴灌施药的方式,研究其对辣椒苗期猝倒病的防治效果和植株生长影响。结果表明:在90和75 kg/hm^(2)滴灌施用量下,0.3%精甲霜灵·噁霉灵可溶粉剂药肥均对辣椒生长... 详细信息

0.3%精甲霜灵·噁霉灵可溶粉剂药肥是集杀菌剂与肥料优势于一体的产品,采用滴灌施药的方式,研究其对辣椒苗期猝倒病的防治效果和植株生长影响。结果表明:在90和75 kg/hm^(2)滴灌施用量下,0.3%精甲霜灵·噁霉灵可溶粉剂药肥均对辣椒生长具有明显促进作用,平均株高、平均茎粗、根鲜质量、根干质量和壮苗指数均显著高于空白对照,而且促生作用优于18.7%吡唑醚菌酯·烯酰吗啉WG 1.5 kg/hm^(2)+水溶肥75 kg/hm^(2)(CK3)。该药肥均对苗期猝倒病具有较好的防治效果,在处理两次后,2个施用量下的防治效果分别达到89.15%(75 kg/hm^(2))和89.68%(90 kg/hm^(2));死苗率分别为4.34%(75 kg/hm^(2))和4.23%(90 kg/hm^(2))。75和90 kg/hm^(2)的施用量相比较效果差异不显著,因此0.3%精甲霜灵·噁霉灵可溶粉剂药肥75 kg/hm^(2)的施用量符合生产上推广应用要求。

关键词：精甲霜灵·噁霉灵药肥辣椒猝倒病防治效果