检索结果-南通市图书馆

Characterization of Bleeding and Laboratory Phenotype in Hemophilia A Carriers: A Cross-Sectional Study in Benin

Open Journal of Blood Diseases 2023年第4期13卷 148-159页

作者： Tatiana Baglo Agbodandé alban zohoun Abdel Aziz Ouabi Edwige Araba Bienvenu Houssou Romaric Massi Charlotte Orou Guiwa Ludovic Anani Dorothée Kindé Gazard Awa Oumar Touré Fall Hematology Laboratory National Teaching Hospital Hubert KoutoukouMaga of Cotonou Cotonou Benin Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Hematology Laboratory of The Aristide le Dantec Hospital Dakar Senegal Pharmacy and Odontostomatology Faculty of Medicine Cheikh Anta Diop University of Dakar Dakar Senegal

Background: In Africa, hemophilia is underdiagnosed and carriers have long been considered free from bleeding symptoms. However, recent research has begun to reveal hemostatic abnormalities and bleeding manifestations in carriers of hemophilia A, particularly due to excessive inactivation of normal X chromosomes. Objective: To describe the bleeding symptoms and hemostatic abnormalities in carriers of hemophilia A (HA) in Benin. Methods: This study was conducted as a prospective cross-sectional investigation between April 2021 to March 2022. The study population consisted of identified through pedigrees of persons with hemophilia A being treated in various hospitals in Benin. Data were collected through interviews conducted by trained physician and each carrier underwent a biological workup. Results: A total of 71 hemophilia A carriers were included and 38 of whom were obligatory carriers. Thirty-one carriers (43.7%) reported abnormal bleeding symptoms. Menorrhagia has (71%) being the most important manifestation, followed by bleeding during or after childbirth (45.2%). Among the 71 carriers, 45 were of reproductive age. Of whom 22 (48.8%) had a Higham score exceeding 100. Activated partial thromboplastin time was prolonged in 7 carriers (9.9%). The mean activity factor VIII:C (FVIII:C) levels were 68.8 ± 34.9 IU/dL. The average FVIII:C level in obligatory carriers was 56.9% and among potential carriers, the average FVIII:C level was higher at 80.4%. However twelve female carriers (16.9%) had FVIII:C levels < 40%. The FVIII:C/FvWAg ratio was below 0.7 in 73.2% of female drivers. Obligatory carriers (p = 0.00003) and FVIII;C/FvWAg ratio = 0.003) were statistically associated with abnormal bleeding symptoms, while blood group O (p = 0.0002) and FVIII/FvWAg ratio = 0.0016) were associated with a higher risk of menorrhagia. Conclusion: In Benin, carriers of haemophilia A present bleeding symptoms and haemostatic abnormalities. Further studies on a larger number of carrie

关键词： Carrriers of Hemophilia A Bleeding Symptoms APTT Factor VIII FVIII:C/FvW:Ag ratio

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Introduction of monkeypox virus in Benin,2022

引用

军事医学研究:英文版 2023年第4期10卷 572-574页

作者： Anges Yadouleton Martin Faye Carine Tchibozo Mariam Oke Oumar Faye Thierry Lawale Eric Denon RenéKeke Ange Dossou alban zohoun Francis Dossou Moussa Moise Diagne Sourakou Salifou Khadija Leila Diatta Mignane Ndiaye Safietou Sankhe Amadou Diallo Sonia Bedie Clément Glele-Kakai Al Fattah Onifade Raoul Saizonou Gildas Hounkanrin Olga Quenum Yvette Badou Benjamin Hounkpatin Amadou Alpha Sall Ousmane Faye Laboratoire des Fièvres Hémorragiques Virales(LFHV) Ministry of Health of Benin01-882CotonouBenin Ecole Normale Supérieure de Natitingou UniversitéNationale des SciencesTechnologiesIngénierie et Mathématiques(UNSTIM)2282GohoAbomeyCotonouBenin Virology Department Institut Pasteur de Dakar36 Avenue Pasteur220DakarSenegal Ministry of Health of Benin 01-882CotonouBenin National Public Health Laboratory Ministry of Health of Benin01-882CotonouBenin Epidemiology Clinical Research and Data Science DepartmentInstitut Pasteur de Dakar220DakarSenegal WHO Country Office in Benin Avenue CENSAD-Les Cocotiers01BP 918CotonouBenin

Dear Editor,Monkeypox is an infectious disease that is endemic in a dozen of African *** imported cases have been also reported outside of Africa in the past[1].Since early May 2022,monkeypox infections including human-to-human transmission,were reported in a multi-country outbreak in non-endemic countries and declared Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)in July 2022[2].As of 20 September 2022,a total of at least 62,798 human cases of monkeypox with 20 deaths have been confirmed in 115 countries in five WHO regions[3].

关键词： Monkeypox virus Introduction Human-to-human transmission Benin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevalence of Association of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease at the National Teaching Hospital of Cotonou in Benin

引用

Open Journal of Blood Diseases 2023年第3期13卷 93-101页

作者： alban zohoun Tatiana Baglo-Agbodande Thierry Adje Bienvenu Houssou Romaric Massi Gnon Gourou Orou Guiwa Justin Dèhoumon Josiane Mehou Ludovic Anani Anne Vovor Dorothée Kinde-Gazard Laboratoire d’Hématologie Clinique Universitaire des Maladies du Sang CNHU-HKM Cotonou Benin Faculté des Sciences de la Santé de Cotonou Université d’Abomey Calavi Cotonou Benin Faculté des Sciences de la Santé Université de Lomé Lomé Togo

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell disease are common genetic defects of red blood cells that lead to hemolytic anemia. The prevalence of G6PD deficiency in sickle cell patients is unknown in Benin. Objective: This study aimed to determine the prevalence of G6PD deficiency in sickle cell patients at the CNHU-HKM of Cotonou. Methods: This prospective study was conducted from April to November 2022 at the blood-related diseases teaching clinic and included sickle cell patients in the stationary phase. G6PD determination was performed using the enzymatic method on a Mindray BS 200 machine following the Herz method. Hematological parameters were determined using the XT 4000i analyzer and supplemented by a blood smear stained with May Grunwald Giemsa. Data were analyzed using Epi Info 3.5.4 software. Results: One hundred and sixty-four sickle cell patients (80 SS homozygotes and 84 SC heterozygotes) in the intercritical phase, with a mean age of 26.30 ± 10.76 years, were included. The prevalence of G6PD deficiency was 9.1% (15 cases found in 7 SS patients and 8 SC patients). In G6PD-deficient patients, the mean concentration of the enzyme was lower in Hb SC heterozygotes than in Hb SS homozygotes: 3.56 IU/g Hb versus 4.98 IU/g Hb. The mean reticulocyte count was 231.43 G/L in the deficient group, compared to 216.32 G/L in the non-deficient group. Conclusion: The preliminary results of our study reveal a high prevalence of G6PD deficiency in sickle cell patients. The impact of this association on hematologic and biological parameters should be evaluated for better management of sickle cell disease.

关键词： Sickle Cell Disease G6PD Deficiency Prevalence Hemogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：