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药物流行病学杂志 2014年第1期23卷 17-28页

作者： Christina D.Mack Nancy A.Dreyer Jaclyn Bosco alban fabre Quintiles Real World & Late Phase Research

中国的医疗体系正在经历着重大变革。2009年医疗改革措施的启动，标志着全面推进医改的良好开端：向全民提供可负担的医疗。到目前为止，取得的主要成就包括近乎覆盖全民的基本医疗保险、

关键词：真实世界观察性研究药物流行病学患者注册登记循证医学研究

Massive abdominal muscle atrophy during prolonged mechanical ventilation: Implications for tracheostomy removal

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Journal of Intensive Medicine 2024年第1期4卷 133-135页

作者： Pascal Beuret Florian Michelin Audrey Tientcheu Laurane Chalvet Benedicte Philippon-Jouve Jean-Charles Chakarian Xavier fabre Service de Réanimation et Soins continus Centre Hospitalier de RoanneRoanneFrance

Introduction Maintaining the functional integrity of respiratory muscles is crucial for critically ill patients to be weaned from mechanical ventilation and decannulated if *** of the diaphragm is frequent in patients under mechanical ventilation and has been associated with a longer duration of weaning.[1,2]Studies on expiratory muscles are *** recent studies demonstrated the feasibility and reproducibility of ultrasound in measuring the thickness of abdominal muscles,[3,4]with one study showing abdominal muscle atrophy in 22%of mechanically ventilated critically ill patients during the first week of mechanical ventilation.[4]

关键词： critically mechanical abdominal

On the Stability of Racing Sailing Boats with Foils

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 427-450页

作者： Philippe DESTUYNDER Caroline fabre Département d'ingénierie Mathématique Laboratoire M2N Conservatoire National des Arts et Métiers 292rue saint Martin75003 ParisFrance Laboratoire de Mathématiques d'Orsay Univ.Paris-SudCNRSUniversitéParis-Saclay 91405 OrsayFrance

The development of foils for racing boats has changed the strategy of sailing. Recently, the America＇s cup held in San Francisco, has been the theatre of a tragicomic history due to the foils. During the last round, the New-Zealand boat was winning by 8 to 1 against the defender USA. The winner is the first with 9 victories. USA team understood suddenly （may be） how to use the control of the pitching of the inain foils by adjusting the rake in order to stabilize the ship. And USA won by 9 victories against 8 to the challenger NZ. The goal in this paper is to point out few aspects which could be taken into account in order to improve this mysterious control law which is known as the key of the victory of the USA team. There are certainly many reasons and in particular the cleverness of the sailors and of all the engineering team behind this project. But it appears interesting to have a mathematical discussion, even if it is a partial one, on the mechanical behaviour of these extraordinary sailing boats. The nunlerical exanlples given here are not the true ones. They have just been invented in order to explain the theoretical developments concerning three points： The possibility of tacking on the foils for sailing upwind, the nature of foiling instabilities, if there are, when the boat is flying and the control laws.

关键词： Hydrodynamics of foils Mathematical analysis Stability

Silicon Photoelectrodes Prepared by Low-Cost Wet Methods for Solar Photoelectrocatalysis

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Accounts of Materials Research 2023年第2期4卷 133-142页

作者： Bruno fabre Gabriel Loget CNRS ISCR(Institut des Sciences Chimiques de Rennes)-UMR6226Univ RennesRennes F-35000France

The electrochemical conversion of sunlight by photoelectrochemical cells(PECs)is based on semiconductor electrodes that are interfaced with a liquid *** approach is highly promising,first,because it can be employed for the generation of a chemical fuel(e.g.,H2)to store solar energy that can be used on-demand to generate electricity when the sun is not ***,it can be seen as a concept reminiscent of photosynthesis,where CO_(2) is converted into a valuable feedstock by solar ***,photoelectrochemical cells are sometimes referred to as“artificial leaves”.Silicon,being the main semiconductor in the electronics and photovoltaic sector,is a prime candidate to be used as the light absorber and the substrate for building photoelectrochemical ***,Si alone has“poor-to-no photoelectrochemical performance”.This is caused by its weak electrocatalytic activity for cathodic reactions(namely,the hydrogen evolution reaction(HER),the CO_(2) reduction reaction(CDRR),and the N2 reduction reaction)and by its deactivation in the anodic regime,prohibiting its use for the oxygen evolution reaction(OER).This latter reaction is essential for supplying electrons to generate a solar *** to these problems,layers that both protect and are catalytically active are typically employed on Si photoelectrodes but require rather sophisticated manufacturing processes(e.g.,atomic layer or electron beam deposition),which hinders research and innovation in this ***,our group and others have demonstrated that these layers are not always required and that highly active and stable Si-based photoelectrodes can be manufactured using simple wet processes,such as drop casting,electroless deposition,or aqueous *** this Account,we first introduce the topic and the possible structures that can be easily obtained starting from commercial Si ***,we discuss strategies that have been employed to manufacture photocathodes based on p-ty

关键词： field starting absorber

Comparative Analysis of Different Evaluation Functions for Protein Structure Prediction Under the HP Model

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Journal of Computer Science & Technology 2013年第5期28卷 868-889页

作者： Mario Garza-fabre Eduardo Rodriguez-Tello Gregorio Toscano-Pulido Information Technology Laboratory CINVESTAV-Tamaulipas Km.5.5 Carretera Ciudad Victoria-Soto La Marina 87130 Ciudad Victoria Tamaulipas México

The HP model for protein structure prediction abstracts the fact that hydrophobicity is a dominant force in the protein folding process. This challenging combinatorial optimization problem has been widely addressed through metaheuristics. The evaluation function is a key component for the success of metaheuristics; the poor discrimination of the conventional evaluation function of the HP model has motivated the proposal of alternative formulations for this component. This comparative analysis inquires into the effectiveness of seven different evaluation functions for the HP model. The degree of discrimination provided by each of the studied functions, their capability to preserve a rank ordering among potential solutions which is consistent with the original objective of the HP model, as well as their effect on the performance of local search methods are analyzed. The obtained results indicate that studying alternative evaluation schemes for the HP model represents a highly valuable direction which merits more attention.

关键词： evaluation function protein structure prediction metaheuristics combinatorial optimization bioinformatics

Comment on:“Completion pancreatectomy or a pancreas-preserving procedure during relaparotomy for pancreatic fistula after pancreatoduodenectomy:a multicentre cohort study and meta-analysis”

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 94-96页

作者： Régis Souche Jean-Michel fabre Department of Oncologic and Minimally Invasive Digestive Surgery Hospital Saint EloiUniversity Hospital of MontpellierMontpellierFrance

We read with great interest the recently published article of Groen et *** the Dutch Pancreatic Cancer Group(1)appeared on British Journal of *** authors compared salvage completion pancreatectomy with a pancreas-preserving procedure in patients undergoing relaparotomy for severe pancreatic fistula after pancreatoduodenectomy(PD).This retrospective multi center cohort study included patients who underwent relaparotomy for pancreatic fistula after PD from 2005-2018 and provided a systematic review with a meta-analysis on postoperative *** the literature,large retrospective studies dedicated to this question are rare and no randomized study is available to date.

关键词： pancreas fistula

Effect of environmental enrichment on the body shape of the pumpkinseed

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Current Zoology 2020年第5期66卷 597-599页

作者： Noelle fabre Anna Vila-Gispert Cristina Galobart Dolors Vinyoles Linguistic Education and Experimental/Mathematics Sciences Didactics Department Faculty of EducationUniversity of BarcelonaSpain GRECO Institute of Aquatic EcologyUniversity of GironaSpain Evolutionary Biology Ecology and Environmental Sciences DepartmentFaculty of BiologyUniversity of BarcelonaSpain

How the morphology of captive-reared fish is affected by structural enrichment in their rearing tanks is not well *** studies have suggested that deficiencies in rearing environments could produce inappropriate body shape in salmonids(Vehanen and Huusko 2011).Garduho-Paz et al.(2010)have found significant differences in body and head shapes of 3-spine stickleback Gasterosteus aculeatus,depending on whether fish were reared in an environment with just gravel or in an environment enriched with large stones and artificial plants.

关键词： shape pump body

Multiplexing technology for in vitro diagnosis of pathogens： the key contribution of phosphorus dendrimers

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Science China Materials 2018年第11期61卷 1454-1461页

作者： Jean Pierre Majoral Jean Marie Francois Richard fabre Alice Senescau Serge Mignani Anne-Marie Caminade Laboratoire de Chimie de Coordination du CNRS 31077 Toulouse Cedex 4France LCC-CNRS Universit6 de Toulouse CNRSToulouseFrance Dendris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Universite Paris Descartes PRES Sorbonne Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on Pasteur's method and polymerase chain reaction(PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

关键词： phosphorus dendrimers diagnosis DNA arrays multiplexing technology

Integrative rodent models for assessing male reproductive toxicity of environmental endocrine active substances

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Asian Journal of Andrology 2014年第1期16卷 60-70页

作者： Jacques Auger Florence Eustache Virginie Rouiller-fabre Marie Chantal Canivenc-Lavier Gabriel Livera Service d'Histologie-Embryologie Biologie de la Reproduction/CECOS Site Port-Royal - Cochin/Broca/H6tel Dieu H6pitaux Universitaires Paris Centre Paris France Departement de Genetique et Developpement INSERM U 567 and Institut Cochin Universite Paris Descartes Paris and Service d'Histologie-Embryologie-Cytogen6tique 8iologie de la Reproduction/CECOS H6pital Jean Verdier Bondy France 1NRA/UMR 1324 CNRS/UMR6265 Centre des Sciences du GoOt et de I'Atimentation Dijon France. Laboratoire de Developpement des Gonades UMR 967 INSERM CEA DSV IRCM SCSR Universit Paris Diderot Sorbonne Paris Cite Universit Paris Sud Fontenay-aux Roses France and

In the present review, we first summarize the main benefits, limitations and pitfalls of conventional in vivo approaches to assessing male reproductive structures and functions in rodents in cases of endocrine active substance （EAS） exposure from the postulate that they may provide data that can be extrapolated to humans. Then, we briefly present some integrated approaches in rodents we have recently developed at the organism level. We particularly focus on the possible effects and modes of action （MOA） of these substances at low doses and in mixtures, real-life conditions and at the organ level, deciphering the precise effects and MOA on the fetal testis. It can be considered that the in vivo experimental EAS exposure of rodents remains the first choice for studies and is a necessary tool （together with the epidemiological approach） for understanding the reproductive effects and MOA of EASs, provided the pitfalls and limitations of the rodent models are known and considered. We also provide some evidence that classical rodent models may be refined for studying the multiple consequences of EAS exposure, not only on the reproductive axis but also on various hormonally regulated organs and tissues, among which several are implicated in the complex process of mammalian reproduction. Such models constitute an interesting way of approaching human exposure conditions. Finally, we show that organotypic culture models are powerful complementary tools, especially when focusing on the MOA. All these approaches have contributed in a combinatorial manner to a better understanding of the impact of EAS exposure on human reproduction.

关键词： endocrine active substance endocrine disruptor exposure gonad in culture low dose mixture mouse rat rodent strain

Rapid laser synthesis of surfactantless tantalum-based nanomaterials as bifunctional catalysts for direct peroxide–peroxide fuel cells

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SmartMat 2023年第6期4卷 84-97页

作者： Xiaoyong Mo Brigitte Bouchet fabre Nathalie Herlin-Boime Edmund C.M.Tse HKU-CAS Joint Laboratory on New Materials Department of ChemistryUniversity of Hong KongHong Kong SARChina NIMBE CEACNRSCEA SaclayUniversitéParis-SaclayGif-sur-YvetteFrance HKU Zhejiang Institute of Research and Innovation HangzhouChina

Efficient and durable electrocatalysts are instrumental in enabling next-generation fuel cell *** present,expensive precious metals are used as state-of-the-art *** this report,cost-effective nanosized tantalum-based alternatives are synthesized for the first time via a green and scalable laser pyrolysis method as bifunctional catalysts for direct peroxide–peroxide fuel *** rapid laser pyrolysis strategy allows for the production of nanoparticles at a laboratory scale of grams per hour,compatible with a detailed exploration of the functional properties of as-synthesized *** varying the precursor ratio between ammonia and tantalum ethanolate,five tantalum-based nanomaterials(TaNOC)are prepared with crystalline phases of Ta_(2)O_(5),Ta_(4)N_(5),Ta_(3)N_(5),and TaN in tunable *** studies in neutral and alkaline conditions demonstrate that Ta_(4)N_(5) is the active component for both H_(2)O_(2) oxidation and *** isotope effect studies show that protons are involved at or before the rate-determining ***-term stability studies indicate that Ta_(3)N_(5) grants surfactant-free TaNOC-enhanced longevity during electrocatalytic *** together,bifunctional TaNOC can act as active and robust electrocatalysts for H_(2)O_(2) reduction and *** pyrolysis is envisioned to produce refractory metal nanomaterials with boosted corrosion resistance for energy catalysis.

关键词： bifunctional catalysis laser pyrolysis peroxide fuel cells tantalum nanomaterials