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Impact of the non-indigenous shrub species Spartium junceum (Fabaceae) on native vegetation in central Spain

Journal of Plant Ecology 2016年第2期9卷 132-143页

作者： Rosario G.Gavilán Daniel Sánchez-Mata Mylena Gaudencio alba gutiérrez-girón.beatriz vilches Departamento de Biología Vegetal II Facultad de FarmaciaUniversidad ComplutensePlaza de Ramón y Cajal s/nE-28040 MadridSpain

Aims The introduction of potentially invasive species through ornamental cultivation or for rehabilitation purposes is a serious environmental *** cause damage to biodiversity through loss,increased mortality or‘in situ’selection phenomena in natural *** junceum is a Mediterranean shrub that is not native in most areas of the Iberian Peninsula,although it is extensively grown for the rehabilitation of *** have investigated the effect on the native vegetation of an old ***(Fabaceae)plantation in a conservation area in the centre of the Iberian Peninsula:the Cuenca Alta del Manzanares nature reserve in *** We compared *** stands with the native nanophanerophytic Cistus ladanifer community at different ecosystem properties:soil properties,temporal soil seed bank contents,standing vegetation and net primary production of annual grasslands growing in these *** Findings The results highlighted ***’s ability to become established in the new environment(marginal areas of the nature reserve)and ensure its successful *** is more apparent in northern and eastern exposures where this formation contacts with the core of the best conserved native vegetation in the nature *** under Spartium showed a higher nitrogen content,indicating its capacity-in common with other legumes-to fix n,and conferring an advantage over Cistus,which is *** soil nutrients such as phosphorus,magnesium and calcium and water availability are also higher in Spartium soils than in *** is usually a constraint for n-fixers,but in our study,it is the most significant soil variable in both shrub formations and is important to the success of *** availability is a key factor for Mediterranean vegetation,and particularly in autumn when soils are *** Spartium formation is able to retain water as its growth produces a closer canopy than Cistus,thereby preventing water evaporatio

关键词： Cistus ladanifer community structure old fields invasive species Mediterranean plant communities non-native species soil seed bank shrublands rehabilitation practices

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Lipid droplets as metabolic determinants for stemness and chemoresistance in cancer

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World Journal of Stem Cells 2021年第9期13卷 1307-1317页

作者： alba Royo-Garcia Sarah Courtois beatriz Parejo-Alonso Pilar Espiau-Romera Patricia Sancho Hospital Universitario Miguel Servet IIS AragónZaragoza 50009Spain

Previously regarded as simple fat storage particles,new evidence suggests thatlipid droplets(LDs)are dynamic and functional organelles involved in keycellular processes such as membrane biosynthesis,lipid metabolism,cellsignalling and ***,an increased LD content is one of the mostapparent features resulting from lipid metabolism reprogramming necessary tosupport the basic functions of cancer *** have been associated to differentcellular processes involved in cancer progression and aggressiveness,such astumorigenicity,invasion and metastasis,as well as ***,all of these processes are controlled by a subpopulation of highly aggressivetumoral cells named cancer stem cells(CSCs),suggesting that LDs may befundamental elements for stemness in *** the key role of CSCs onchemoresistance and disease relapse,main factors of therapy failure,the design ofnovel therapeutic approaches targeting these cells may be the only chance forlong-term survival in cancer *** this sense,their biology and functionalproperties render LDs excellent candidates for target discovery and design ofcombined therapeutic *** this review,we summarise the currentknowledge identifying LDs and CSCs as main contributors to cancer aggressiveness,metastasis and chemoresistance.

关键词： Lipids Lipid droplets Lipid metabolism Stemness Cancer stem cells Chemoresistance

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The growth and production modeling of individual trees of Eucalyptus urophylla plantations

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Journal of Forestry Research 2020年第5期31卷 1663-1672页

作者： Joao Victor nobre Carrijo Ana beatriz de Freitas Ferreira Marcela Costa Ferreira Mario Cesar de Aguiar Eder Pereira Miguel Eraldo Aparecido Trondoli Matricardi alba Valeria Rezende Department of Forestry Faculty of TechnologyUniversity of Brası´liaBrası´lia 70910-900Brazil

Individual tree models(ITMs)are classified as growth and production models for projecting current and future forest *** are more complex than other growth and production models,show a higher level of detail and,consequently,produce a better modeling ***,the accuracy and efficiency of ITMs have not been properly assessed to *** this study,we estimated the growth in height,diameter,and individual tree volume of a Eucalyptus urophylla plantation by applying an *** used a continuing forest inventory dataset in which 1554 individual trees within 29 permanent plots were measured in the field over a 6-year period(24 to 72 months).Each individual tree volume was estimated for future tree *** achieve this,we adjusted the model to predict the height and diameter growth,and the probability of mortality as a function of the competition *** ITM accuracy was assessed based on the analysis of variance results and,subsequently,the multiple mean comparison test at the 5%significance *** tree volumes predicted by the ITM for the forest stand aged 72 months,beginning at ages 24,36,48,and 60 months,were compared to the field measured tree volume acquired from the 72-month forest inventory that was used as the reference *** and observed tree volumes were similar when the estimation was based on the 48-month forest *** results might help to reduce financial costs of forest inventory because the ITM produces accurate future predictions of forest stand *** estimated ITM for Eucalyptus plantations using measurement intervals up to 2 years is recommended because it significantly reduced the projected volume discrepancy compared to the field measurements.

关键词： Competition index Forest production Forest site Simulation models Tree mortality

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Lack of MICA Expression Predicts a Worse Prognosis in Patients with Bladder Cancer

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Open Journal of Pathology 2013年第1期3卷 41-50页

作者： Mauricio Orozco-Levi alba Ramírez-Sarmiento Michael Borchers Cristiane Murta-nascimento Francesc Macià beatriz Casado Maeba Polo Andrea Caballero-Benitez Fredy Diaz-Quijano Antoni Gelabert American Organization for the Promotion of Health Research (OLFIS) Bucaramanga Colombia Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CibeRes) Instituto de Salud Carlos III Ministerio de Ciencia y Tecnología Spain Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP) Spain Department of Environmental Health University of Cincinnati College of Medicine Cincinnati USA Epidemiology and Health Services Evaluation Department Hospital del Mar-Parc de Salut Mar Barcelona Spain Group of Research in Injury Immune Response and Lung Function (LIF) Hospital del Mar Research Institute (IMIM) Urology Department Group of Research in Solid Tumors Universidad Autónoma de Barcelona Barcelona Spain

Background: Bladder and lung cancer are among the ten most common cancers in both genders. The nKG2D receptor and one of its ligands, MICA, are associated with smoking and susceptibility to both chronic obstructive pulmonary disease and lung cancer. Objective: We hypothesized that nKG2D-MICA system was associated with other smoking-related epithelial cancers such as bladder cancer. Design, Setting, and Participants: 70 cases of primary non-muscle invasive bladder cancer were screened for the MICA expression and CD8+, CD4+ and nK cell infiltration. Most patients (n = 55, 78.6%) were current or former smokers. Measurements: Tissue microarray (TMA) technology was chosen to evaluate MICA and tumor infiltrating lymphocytes in samples with confirmed bladder cancer. Kaplan-Meier curves and univariate Cox analysis was used to assess relapse, all-cancer mortality and specific bladder cancer mortality. Results and Limitations: MICA was expressed in most cancer specimens examined (i.e., 70%). Relapse of bladder cancer was not associated with the status of MICA expression (log rank p = 0.1123). nevertheless, a significant association existed between high MICA expression and bladder cancer mortality (HR = 0.25;CI95% = 0.06 - 0.97). Tumor infiltrating CD4+ and CD8+ lymphocytes were found in the majority (64%) of samples. Cells expressing the nKG2D receptor were found in only 3% of the samples. There was no linear function between nKG2D+ cells and number or ratio of CD4+ and CD8+ TIL. Conclusions: MICA is expressed in a significant proportion of bladder carcinomas. MICA expression associates with significant survival advantages in the face of both all-cancer and bladder cancer. The nKG2D-MICA system could represent a common mechanism involved in the immunopathology and natural history of bladder neoplasms.

关键词： Bladder Cancer nKG2D Ligands MICA Survival Prognosis

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Effect of nanoparticles on Mechanical Properties of Cement-Sand Mortar Applications

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Advances in Chemical Engineering and Science 2017年第3期7卷 270-276页

作者： José Salvador Cavazos Gustavo González Oxana V. Kharissova beatriz Ortega Laura Pe&ntilde a Mario Osorio Mauricio Garza-Casta&ntilde ón Universidad de Monterrey Physics and Mathematics Department Engineering and Technologies Division San Pedro Garza-García N.L.México Universidad Autónoma de nuevo León Facultad de Ciencias Físico-Matemáticas Pedro de Alba S/N Ciudad Universitaria San Nicolás de los Garza N.L. Mexico

Cement-sand mortar is a construction material widely used;tile adhesive is one of the main applications where the compressive strength is the key performance metric. nanoparticles like MWCnTs and HnTs are currently being used to improve the mechanical performance of the cement mortar due to their properties. The cost of MWCnTs has limited their application in the construction industry. This study focuses on the effect of two different concentrations of MWCnTs and HnTs in cement mortar;HnTs are proposed in this study to compare performance and cost overall benefits. A common problem with MWCnTs is agglomeration;to achieve a proper dispersion an ultrasonic processor was utilized. Mechanical properties of a cement mortar modified with nanoparticles were investigated with compression and bending tests on specimens performed at the age of 7 days. Results showed that concentrations of 0.1% of MWCnTs increase in compression strength by 56% and concentrations of 0.1% of HnTs performance increased by 31%, both compared to plain cement mortar.

关键词： Mechanical Properties Compressive Strength Cement Cement Manufacture

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AB079. HER2 as a possible therapeutic target in squamous cell carcinoma of the conjunctiva

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Annals of Eye Science 2018年第1期 485-485页

作者： Paulina García de alba Graue Evangelina Esposito Pablo Zoroquiain Ana beatriz Toledo Dias Miguel Burnier MUHC-McGill Ocular Pathology Laboratory McGill UniversityMontrealQCCanada Department of Ophthalmology McGill UniversityMontrealQCCanada

Background:Invasive squamous carcinoma(SCC)is the most frequent malignant neoplasia of the conjunctiva,33%of which will metastasize.C-erbB-2/neu(HER2)is an oncogene associated with poor prognosis,metastatic potential and aggressive behavior in several tumors,including breast,stomach,among ***2 amplification is also associated with the response to anti-HER2 *** aim of this study is to evaluate HER2 expression in the progression of ocular surface squamous neoplasia(OSSn)and as a potential therapeutical ***:ninety-eight OSSn lesions including 17 papillomas(P),27 conjunctival intraepithelial neoplasia(CIn)I,19 CIn II,13 CIn III,and 11 SCC were *** conjunctivas from normal human eyes(nHE)were also included in the *** was performed to analyze HER2(clone 29D8)expression,which was graded as follows:complete membrane staining in more than 10%of malignant cells(3+);week to moderate complete staining in more than 10%of malignant cells(2+);none or fewer than 10%cells staining(0 to 1+,respectively).Positive HER2 was considered when a score 2+or 3+was *** carcinoma with HER2 amplification was used as a positive *** technique was performed in the positive cases to confirm *** analysis was performed using Fisher’s exact ***:HER2 positive expression was detected in 6%of P(100%score 2+),11%of CIn I(100%score 2+),32%of CIn II(100%score 2+),30%of CIn III(100%score 2+),29%of SCC(50%score 2+and 50%score 3+).Benign lesions showed lower HER2 expression than in situ(P=0.03)and invasive tumors(P=0.02).no correlation between HER2 and age or tumor thickness in SCC was found(P>0.05).Conclusions:HER2 is expressed in conjunctival ***,one third of SCC were graded as 2+or 3+.These results support the evaluation of anti-HER2 therapy in conjunctival ***-clinical trials should be performed to determine the importance of this marker in conjunctival SCC for predicting response

关键词： HER2 invasive squamous carcinoma conjunctiva

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