检索结果-南通市图书馆

A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第12期20卷 1499-1512页

作者： Leticia Martín-Cruz Marcos Viñuela Ioanna Kalograiaki alba Angelina Paola Oquist-Phillips Irene Real-Arévalo Francisco Javier Cañada JoséIgnacio Tudela Luis Moltó Jesús Moreno-Sierra JoséLuis Subiza Oscar Palomares Department of Biochemistry and Molecular Biology School of ChemistryComplutense University of MadridMadridSpain Inmunotek Alcaláde HenaresMadridSpain Fundación Investigación Hospital Clínico San Carlos Martin Lagos s/n28040MadridSpain Centro de Investigaciones Biológicas Margarita Salas CSICRamiro de Maetzu 928040MadridSpain CIBER de Enfermedades Respiratorias(CIBERES)Avda Monforte de Lemos3-528029MadridSpain Servicio de Urología Hospital Clínico San CarlosUniversidad Complutense de MadridMartín Lagos s/n28040MadridSpain

Functional Tregs play a key role in tumor development and progression,representing a major barrier to anticancer *** mechanisms by which Tregs are generated in cancer and the influence of the tumor microenvironment on these processes remain incompletely ***,by using nMR,chemoenzymatic structural assays and a plethora of in vitro and in vivo functional analyses,we demonstrate that the tumoral carbohydrate A10(Ca10),a cell-surface carbohydrate derived from Ehrlich’s tumor(ET)cells,is a heparan sulfate-related proteoglycan that enhances glycolysis and promotes the development of tolerogenic features in human ***10-stimulated human DCs generate highly suppressive Tregs by mechanisms partially dependent on metabolic reprogramming,PD-L1,IL-10,and ***10 also reprograms the differentiation of human monocytes into DCs with tolerogenic *** solid ET-bearing mice,we found positive correlations between Ca10 serum levels,tumor size and splenic Treg *** of isolated Ca10 also increases the proportion of splenic Tregs in tumor-free ***,we provide evidence supporting the presence of a circulating human Ca10 counterpart(Ca10H)and show,for the first time,that serum levels of Ca10H are increased in patients suffering from different cancer types compared to healthy *** note,these levels are higher in prostate cancer patients with bone metastases than in prostate cancer patients without ***,we reveal novel molecular mechanisms by which heparan sulfate-related structures associated with tumor cells promote the generation of functional Tregs in *** discovery of this novel structural-functional relationship may open new avenues of research with important clinical implications in cancer treatment.

关键词： Tumoral carbohydrate A10 Heparan sulfate-related proteoglycan Cancer immunology Dendritic cell Regulatory T cell

The global climate monitor system:from climate data-handling to knowledge dissemination

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2019年第4期12卷 394-414页

作者： Juan Mariano Camarillo-naranjo José Ignacio Álvarez-Francoso natalia Limones-Rodríguez María Fernanda Pita-López Mónica Aguilar-alba Department of Physical Geography and Regional Analysis University of SevilleSevilleSpain Department of Human Geography University of SevilleSevilleSpain

This paper summarizes our work on building a data model and a geovisualization tool that provides access to global climate data:the Global Climate Monitor Web *** to this viewer,a complete set of climate-environmental indicators capable of displaying climate patterns on a global scale that is accessible to any potential user(scientists and laypeople)will be built and published using the same online *** data currently available correspond to the CRU TS3.21 version of the Climate Research Unit(University of East Anglia)database–a product that provides data at a spatial resolution of half of a degree in latitude and longitude,spanning January 1901 to December 2012,on a monthly *** January 2013,the datasets feeding the system have been the GHCn-CAMS temperature dataset and the Global Precipitation Climatology Centre(GPCC)First Guess precipitation ***,hydrologists,planners and non-experts users such as media workers,policymakers,non-profit organizations,teachers or students,can access useful climatological information through the Global Climate Monitor system.

关键词： Geovisualization climate indicators global climate databases open-source software

Environmental Protection of Biodiversity in Macedonia and albania under Legal Analysis View

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering(B) 2016年第3期5卷 153-160页

作者： Ismail Zejneli alba Dumi Law Department SEEU University Ilineska Tetovo 1200 Macedonia Management Department Economy Faculty "lsmail Qemali'" Vlore University Vlore 9400 Albania

Environmental problems in the Republic of Macedonia and albania are similar in other countries in the region. numerous problems and deficiencies identified through different projects. The studies and planning documents are evident for environmental media and areas. Such as lack of regional integrated systems for municipal solid waste management. The system for special waste types management, including hazardous waste, insufficient coverage of populated places and municipalities by wastewater collection and treatment systems （especially in agglomerations above 10,000 populations）. The need to establish integrated river basin management is in accordance with the new law on waters, air pollution with different intensity in different parts of the country. This paper presents the imperative reforms to protect the natural resources and biodiversity in the countries.

关键词： Analyze of pollution natural environment water resources protection plant and legal reforms.

Radiological diagnosis of hepatocellular carcinoma in non-cirrhotic patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoma Research 2017年第1期3卷 1-17页

作者： alba Castán Ylenia navarro Luis Sarría Raquel Larrosa Mario Serradilla Alejandro Serrablo Department of Radiology Miguel Servet University Hospital50009 ZaragozaSpain Division of Hepato-Pancreato-Biliary Department of SurgeryMiguel Server University Hospital50009 ZaragozaSpain

Hepatocellular carcinoma (HCC) arising in non-cirrhotic livers is relatively *** with HCC arising in cirrhotic livers they have some *** in healthy livers are large tumors at diagnosis,and are detected due to the onset of abdominal symptoms,outside of any scheduled monitoring *** non-cirrhotic patients,HCC has the same appearance as the classic image of cirrhotic HCC *** presence of capsule,extensive intratumoral necrosis and typical behavior in the dynamic study after administration of intravenous contrast are present in most of the non-cirrhotic *** the presence of a suspicious lesion of HCC,we must assess the existence of underlying chronic liver ***,computed tomography,and conventional magnetic resonance are imaging techniques that have a high specificity for the diagnosis of cirrhosis,but exhibit low sensitivity for diagnosis in the early stages of the *** recent years,new imaging methods are being developed to assess emerging liver *** particular,in patients without chronic liver disease it is imperative to consider the differential diagnosis with other tumors that may settle in healthy livers with similar radiological characteristics as ***,in the presence of a lesion with pathognomonic radiological characteristics of HCC in the absence of cirrhosis,biopsy is required.

关键词： Hepatocellular carcinoma non-cirrhotic liver ultrasound elastography computed tomography magnetic resonance

Multiscale modeling of ultrafast melting phenomena

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 324-333页

作者： Gaetano Calogero Domenica Raciti Pablo Acosta-alba Fuccio Cristiano Ioannis Deretzis Giuseppe Fisicaro Karim Huet Sébastien Kerdilès Alberto Sciuto Antonino La Magna CnR IMM CataniaItaly UniversitéGrenoble Alpes CEA-LETIGrenobleFrance LAAS CNRSUniversitéde ToulouseToulouseFrance Laser Systems&Solutions of Europe(LASSE) GennevilliersFrance Dipartimento di Fisica e Astronomia Universitàdi CataniaCataniaItaly

Ultraviolet nanosecond Laser Annealing(LA)is a powerful tool for both fundamental investigations of ultrafast,nonequilibrium phase-change phenomena and technological applications(e.g.,the processing of 3D sequentially integrated nano-electronic devices)where strongly confined heating and melting is *** the LA process along with the experimental design is challenging,especially when involving complex 3D-nanostructured systems with various shapes and *** this purpose,it is essential to model critical nanoscale physical LA-induced phenomena,such as shape changes or formation and evolution of point and extended *** date,LA simulators are based on continuum models,which cannot fully capture the microscopic kinetics of a solid–liquid *** this work a fully atomistic LA simulation methodology is presented,based on the parallel coupling of a continuum,finite elements,μm-scale electromagnetic-thermal solver with a super-lattice Kinetic Monte Carlo atomistic model for *** against phase-field models and experimental data validate the *** of a Si(001)surface is studied varying laser fluence and pulse shape,assuming both homogeneous and inhomogeneous nucleation,revealing how liquid Si nuclei generate,deform and coalesce during *** proposed methodology is applicable to any system where the atom kinetics is determined by a strongly space-and time-dependent field,such as temperature or strain.

关键词： kinetics shape melting

Advantages of early cholecystectomy in clinical practice of a terciary care center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 87-93页

作者： Marta Barceló Dulce María Cruz-Santamaría Cristina alba-López María José Devesa-Medina Manuel Díaz-Rubio Enrique Rey Health Research Institute San Carlos Clinical HospitalDepartment of MedicineSchool of MedicineComplutense University

BACKGROUnD:Despite a number of studies show the superiority of early over delayed cholecystectomy in the treatment of acute cholecystitis,there is still controversy over the time for *** study aimed to assess the use of early versus delayed cholecystectomy for the treatment of acute cholecystitis in terms of complications,conversion to open surgery and mean hospital ***:We collected patients with acute cholecystitis treated at a referral center for a year,and retrospectively analyzed the chosen therapeutic approach,the percentage of conversion of early cholecystectomy to open surgery,appearance of surgical complications,and mean hospital ***:The study included 117 patients,44 women and 73 men,who had a mean age of 67.36±15.74 *** cholecystectomy was chosen in 31(26.5%) and delayed cholecystectomy in 74 patients(63.2%).Of the 74 patients,28(37.8%) required emergency performance of delayed cholecystectomy,and 19(25.7%) had not undergone surgery by the end of the *** no differences were observed between early and delayed cholecystectomy in terms of surgical complications and conversion to open surgery,mean hospital stay was nevertheless significantly shorter in the early versus the delayed cholecystectomy group(8.32±4.98 vs 15.96±8.89 days).COnCLUSIOn:Under the routine working conditions of a hospital that is neither specially dedicated to the surgical treatment of acute cholecystitis nor provided with specific management guidelines,early cholecystectomy can reduce the hospital stay without increase of the conversion rate or complications.

关键词： acute cholecystitis cholecystectomy complications

Role of stem cells-based in facial nerve reanimation:A meta-analysis of histological and neurophysiological outcomes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2022年第6期14卷 420-428页

作者： Luca Ricciardi Resi Pucci Amedeo Piazza Giorgio Lofrese alba Scerrati nicola Montemurro Antonino Raco Massimo Miscusi Tamara Ius Marco Zeppieri Division of neurosurgery AOU Sant’AndreaDepartment of NESMOSSapienza UniversityRome 00189Italy Department of Oral and Maxillofacial Sciences Sapienza UniversityRome 00161Italy Division of neurosurgery Ospedale BufaliniCesena 47521Italy Department of neurosurgery Sant'Anna University HospitalS.Anna University HospitalFerrara 44121Italy Department of Morphology Surgery and Experimental MedicineUniversity of FerraraFerrara 44121Italy Department of neurosurgery Azienda Ospedaliera Universitaria PisanaPisa 56126Italy neurosurgery Unit Department of NeurosciencesSanta Maria della Misericordia University HospitalUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

BACKGROUnD Treatments involving stem cell(SC)usage represent novel and potentially interesting alternatives in facial nerve *** literature includes the use of SC in animal model studies to promote graft survival by enhancing nerve fiber growth,spreading,myelinization,in addition to limiting fibrotic degeneration after ***,the effectiveness of the clinical use of SC in facial nerve reanimation has not been clarified *** To investigate the histological,neurophysiological,and functional outcomes in facial reanimation using SC,compared to *** Our study is a systematic review of the literature,consistently conducted according to the preferred reporting items for systematic reviews and meta-analyses statement *** review question was:In facial nerve reanimation on rats,has the use of stem cells revealed as effective when compared to autograft,in terms of histological,neurophysiological,and functional outcomes?Random-effect meta-analysis was conducted on histological and neurophysiological data from the included comparative *** After screening 148 manuscript,five papers were included in our study.43 subjects were included in the SC group,while 40 in the autograft *** meta-analysis showed no significative differences between the two groups in terms of myelin thickness[CI:-0.10(-0.20,0.00);I^(2)=29%;P=0.06],nerve fibers diameter[CI:0.72(-0.93,3.36);I^(2)=72%;P=0.6],compound muscle action potential amplitude[CI:1.59(0.59,3.77);I^(2)=89%;P=0.15]and latency[CI:0.66(-1.01,2.32);I^(2)=67%;P=0.44].The mean axonal diameter was higher in the autograft group[CI:0.94(0.60,1.27);I^(2)=0%;P≤0.001].COnCLUSIOn The role of stem cells in facial reanimation is still relatively poorly studied,in animal models,and available results should not discourage their use in future studies on human subjects.

关键词： Facial nerve Palsy Reanimation Coaptation Stem cells nerve fibers Functional outcome

Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen M.Labandeira Arturo Fraga-Bau David Arias Ron Elena Alvarez-Rodriguez Pablo Vicente-alba Javier Lago-Garma Ana I.Rodriguez-Perez Department of Clinical neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and Molecular neurobiology of Parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain networking Research Center on neurodegenerative Diseases(Ciberned) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and Parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing Parkinson’s disease but can also determine the prognosis and progression of Parkinsonian ***,there are no available curative or disease modifying treatments for Parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against Parkinson’s disease,both in diabetic and nondiabetic Parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as Parkinson’s ***,we review the present evidence on the connection between Parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of Parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation Parkinson’s disease repurposing

Worldwide management of hepatocellular carcinoma during the COVID-19 pandemic

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第25期27卷 3780-3789页

作者： Riccardo Inchingolo Fabrizio Acquafredda Michele Tedeschi Letizia Laera Gianmarco Surico Alessia Surgo alba Fiorentino Stavros Spiliopoulos nicola de'Angelis Riccardo Memeo Department of Interventional Radiology Unit “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70124BariItaly Gianmarco Surico Department of Oncology“F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly Department of Radiation Oncology “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly Department of 2^(nd)Radiology National and Kapodistrian University of AthensAthens 12461Greece Unit of Minimally Invasive and Robotic Digestive Surgery “F.Miulli”General Regional HospitalAcquaviva delle Fonti 70021BariItaly

The coronavirus disease 2019(COVID-19)pandemic has impacted hospital organization,with the necessity to quickly react to face the *** management of the oncological patient has been modified by necessity due to different allocation of nurses and doctors,requiring new strategies to guarantee the correct assistance to the *** carcinoma,considered as one of the most aggressive types of liver cancer,has also required a different management during this period in order to optimize the management of patients at risk for and with this *** aim of this document is to review recommendations on hepatocellular carcinoma surveillance and management,including surgery,liver transplantation,interventional radiology,oncology,and *** and guidelines from the main scientific societies worldwide regarding the management of hepatocellular carcinoma during the COVID-19 pandemic were reviewed.

关键词： Hepatocellular carcinoma Interventional radiology Oncology Liver Management COVID-19