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最小城市? 最大城市?

世界建筑 2010年第8期 120-125页

作者：阿拉斯泰尔.唐纳德张烨剑桥大学建筑学院

经济危机之后,西方社会的城市探讨更多地被对于未来发展的种种悲观和深刻焦虑所主导,进而导致了对可持续发展、环境保护主义等概念的教条化。这一趋势根植于整个西方文化对于人类社会自我能力的失信,并进而可能冲蚀城市文明的进程。本... 详细信息

经济危机之后,西方社会的城市探讨更多地被对于未来发展的种种悲观和深刻焦虑所主导,进而导致了对可持续发展、环境保护主义等概念的教条化。这一趋势根植于整个西方文化对于人类社会自我能力的失信,并进而可能冲蚀城市文明的进程。本文试图对此局限的观念进行反思并鼓励人本为中心的城市进程。

关键词：城市焦虑脆弱性风险人性文明探索

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永恒的生命线?

商业周刊（中文版） 2024年第2期 98-109页

作者： alastair Philip Wiper(文/图) 竹西(译) 不详

在阿尔科生命延长基金会(AlcorLife Extension Foundation)位于亚利桑那州斯科茨代尔的总部,你可以看到一些独特的景象。这家非营利组织在那里以冷冻方式保存了200多具人的遗体和头部,以及一些主人们心爱的宠物遗体。阿尔科基金会由弗... 详细信息

在阿尔科生命延长基金会(AlcorLife Extension Foundation)位于亚利桑那州斯科茨代尔的总部,你可以看到一些独特的景象。这家非营利组织在那里以冷冻方式保存了200多具人的遗体和头部,以及一些主人们心爱的宠物遗体。阿尔科基金会由弗雷德·张伯伦(Fred)和琳达·张伯伦(Linda Chamberlain)于1972年创立,致力于人体冷冻研究和教育,目前有大约1500名成员在计划某种形式的低温保存。当会员还活着的时候。

关键词：张伯伦亚利桑那州低温保存阿尔非营利组织人体冷冻

Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： Bryce David Beutler alastair E Moody Jerry Mathew Thomas Benjamin Phillip Sugar Mark B Ulanja Daniel Antwi-Amoabeng Lucas Anthony Tsikitas Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-D-aspartate receptor-associated encephalitis(NMDARE)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMDARE has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-D-aspartate receptor-associated encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

Arbitrary Lagrangian–Eulerian simulations of highly electrically charged micro-droplet Coulomb explosion deformation pathways

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第3期7卷 136-149页

作者： alastair Radcliffe CIMAP unit´e mixte CEA-CNRS-ENSICAEN-UCBN 6252 BP 5133F-14070 CaenCedex 05France University of Warwick Coventry CV47ALUK.

Numerical simulation results of the Coulomb explosion pathways of cooled water and heated glycol droplets electrically charged to the critical Rayleigh limit are presented,calculated using an axi-symmetric finite element scheme previously used for the same problem[Radcliffe A.J.,Non-conforming finite elements for axisymmetric charged droplet deformation dynamics and Coulomb explosions,*** 71:249–268,(2013),doi:10.1002/fld.3667.]which has been adapted to use arbitrary Lagrangian–Eulerian(ALE)methods and a novel tip reconstruction technique in order to greatly improve its accuracy in matching available experimental data.

关键词： Electrohydrodynamics finite elements droplet deformations.

Omics Approaches to Identify PotentialBiomarkers of Inflammatory Diseases in the FocalAdhesion Complex

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Genomics, Proteomics & Bioinformatics 2017年第2期15卷 101-109页

作者： Johanne Brooks alastair Watson Tamas Korcsmaros Gut Health and Food Safety Institute Strategic Programme Institute of Food Research Norwich Research Park Norwich NR4 7UA United Kingdom Norwich Medical School University of East Anglia Norwich Research Park Norwich NR4 7T J United Kingdom Gastroenterology Department Norfolk and Norwich University Hospital Norwich NR4 7UY United Kingdom Earlham Institute Norwich Research Park Norwich NR4 7UZ United Kingdom

Inflammatory diseases such as inflammatory bowel disease(IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and assess disease activity, and to determine optimal therapeutic strategies. Simple ‘bedside’ biomarkers could be used in all phases of patient management to avoid unnecessary investigation and guide further management. The focal adhesion complex(FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, and multiple sclerosis. Utilizing omics technologies has proven to be an efficient approach to identify biomarkers from within the FAC in the field of cancer medicine. Predictive biomarkers are paving the way for the success of precision medicine for cancer patients, but inflammatory diseases have lagged behind in this respect. This review explores the current status of biomarker prediction for inflammatory diseases from within the FAC using omics technologies and highlights the benefits of future potential biomarker identification approaches.

关键词： Focal adhesion complex Biomarkers Inflammation Omics Systems biology

In search of a roadmap towards improving care of patients with cirrhosis and ascites, could a platform trial design transform clinical research?

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 889-892页

作者： alastair O’Brien University College London(UCL)Institute for Liver and Digestive Health Division of MedicineRoyal Free CampusLondonUK

The authors of“Diagnosis,Evaluation,and Management of Ascites,Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome:2021 Practice Guidance by the American Association for the Study of Liver Diseases”are to be congratulated on their exhaustive assessment of the data published on patients with cirrhosis and ascites and their guidelines represent a pragmatic,evidence-based,common-sense approach(1).

关键词： patients ascites cirrhosis

Mastering Financial Mathematics In Microsoft Excel: A Practical Guide For Business Calculations (2nd Edition) (Financial Times Series) 2nd

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Interaction of Waves, Surface Currents, and Turbulence: the Application of Surface-Following Coordinate Systems

丛书名： (Marketeditions)

2010年

作者： alastair Day

ISBN: (数字)9780273730330

ISBN: (纸本)9780273730330

Designed for finance directors, finance managers, analysts and decision-makers, Mastering Financial Mathematics in Microsoft Excel, is a practical guide to applying Excel for solving mathematical problems. Financial mathematics can be applied more quickly and easily in Excel than any other package, there is therefore demand for a book in this field. Will improve financial managers’ abilities with Excel and provide them with solutions to their financial problems. Highly practical: includes a library of templates, exercises and solutions as an illustration of the methods. Part of the highly respected and recognised Mastering series. The second edition will be updated throughout. Specific amendments: Excel 2007 and Windows Vista, Addition of a glossary of key terms, Functions list in English and Euro languages, Continuity check on all formats, layouts and charts, More worked examples, Addition of exercises at the end of each chapter to help build models

关键词： practical guide busine excel microsoft financial mathematics mastering

来源：畅想之星图书光盘版（南... 评论

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Journal of Ocean University of China 2007年第4期6卷 319-331页

作者： Jenkins alastair D Bjerknes Centre for Climate Research Geophysical Institute Allegaten 70 N-5007 Bergen Norway

Surface waves comprise an important aspect of the interaction between the atmosphere and the ocean, so a dynamically consistent framework for modelling atmosphere-ocean interaction must take account of surface waves, either implicitly or explicitly. In order to calculate the effect of wind forcing on waves and currents, and vice versa, it is necessary to employ a consistent formula- tion of the energy and momentum balance within the airflow, wave field, and water column. It is very advantageous to apply sur- face-following coordinate systems, whereby the steep gradients in mean flow properties near the air-water interface in the cross-interface direction may be resolved over distances which are much smaller than the height of the waves themselves. We may account for the waves explicitly by employing a numerical spectral wave model, and applying a suitable theory of wave–mean flow interaction. If the mean flow is small compared with the wave phase speed, perturbation expansions of the hydrodynamic equations in a Lagrangian or generalized Lagrangian mean framework are useful: for stronger flows, such as for wind blowing over waves, the presence of critical levels where the mean flow velocity is equal to the wave phase speed necessitates the application of more general types of surface-following coordinate system. The interaction of the flow of air and water and associated differences in temperature and the concentration of various substances (such as gas species) gives rise to a complex boundary-layer structure at a wide range of vertical scales, from the sub-millimetre scales of gaseous diffusion, to several tens of metres for the turbulent Ekman layer. The bal- ance of momentum, heat, and mass is also affected significantly by breaking waves, which act to increase the effective area of the surface for mass transfer, and increase turbulent diffusive fluxes via the conversion of wave energy to turbulent kinetic energy.

关键词： wind-wave-current interaction coordinate systems upper-ocean turbulence air-sea exchange of momentum, heat, andmass

Mastering Risk Modelling: A Practical Guide to Modelling Uncertainty with Microsoft Excel (2nd Edition) (Financial Times Series) 2

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