检索结果-南通市图书馆

Immunoassay development guidelines for neurodegenerative disorders:lessons from a failed pS129-α-synuclein electrochemiluminescence immunoassay

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2906-2908页

作者： Hash Brown Taha alanna Morris Leonard Davis School of gerontology University of Southern CaliforniaLos AngelesCAUSA Deparmtent of Neurobiology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA

An aging population is a double-edged *** one hand,advancements in biotechnology and healthcare allow more people to enjoy longer *** the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative *** aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).

关键词： aging degenerative necessarily

Stepping up after spinal cord injury:negotiating an obstacle during walking

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Impact of Zika virus non-structural protein mutations on hippocampal damage

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Effect of particle stress tensor in simulations of dense gas-particle flows in fluidized beds

在线全文

学校读者我要写书评

暂无评论

Particuology 2018年第3期16卷 31-43页

作者： Mohammad Reza Haghgoo Donald J. Bergstrom Raymond J. spiteri Department of Mechanical Engineering University of Saskatchewan Saskatoon SK SFN 5A9 Canada Department of Computer Science University of Saskatchewan Saskatoon. SK S7N 5C9 Canada

A two-fluid model based on the kinetic theory of granular flow for the rapid-flow regime and the Coulomb friction law for the quasi-static regime is applied to predict the hydrodynamics of dense gas-particle flow in a three-dimensional fluidized bed. Two different models for the particle stress tensor that use different constitutive equations in the elastic-inertial regime are examined to assess their ability to predict bed dynamics. To understand how particle stress models affect structural features of the flow, a quantitative analysis is performed on some important aspects of the mechanics of bubbling beds that have received relatively little attention in the literature. Accordingly, different flow regimes are identified in the context of fluidized beds through the dimensionless inertial number, and the main characteristics of each regime are discussed. In addition, how the particle stress tensor manifests itself in the bubble characteristics, natural frequency of the bed, and particle Reynolds stress are investigated, all of which help to better understand the complex dynamics of the fluidized bed. The numerical results are validated against pub- lished experimental data and demonstrate the significant role of the stress tensor in the elastic-inertial regime.

关键词： Two-fluid model Inertial number Fluidized bed Flow regime Particle Reynolds stress MFIX

Effects of variable retention harvesting on canopy transpiration in a red pine plantation forest

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2022年第1期11卷 374-385页

作者： alanna V.Bodo M.Altaf Arain School of Earth Environment and SocietyMcMaster University1280 Main Street WestHamiltonON L8S 4K1Canada McMaster Centre for Climate Change McMaster University1280 Main Street WestHamiltonON L8S 4K1Canada

Background:Variable Retention Harvesting(VRH)is a forest management practice applied to enhance forest growth,improve biodiversity,preserve ecosystem function and provide economic revenue from harvested *** are many different forms and compositions in which VRH is applied in forest *** this study,the impacts of four different VRH treatments on transpiration were evaluated in an 83-year-old red pine(Pinus Pinus resinosa)plantation forest in the great Lakes region in *** VRH treatments included 55%aggregated crown retention(55A),55%dispersed crown retention(55D),33%aggregated crown retention(33A),33%dispersed crown retention(33D)and unharvested control(CN)*** VRH treatments were implemented in 1-ha plots in the winter of 2014,while sap flow measurements were conducted from 2018 to ***:Study results showed that tree-level transpiration was highest among trees in the 55D treatment,followed by 33D,55A,33A and CN *** found that photosynthetically active radiation(PAR)and vapor pressure deficit(VPD)were major controls or drivers of transpiration in all VRH *** study suggests that dispersed or distributed retention of 55%basal area(55D)is the ideal forest management technique to enhance transpiration and forest ***:This study will help researchers,forest managers and decision-makers to improve their understanding of water cycling in forest ecosystem and adopt the best forest management regimes to enhance forest growth,health and resiliency to climate change.

关键词： Variable Retention Harvesting Forest management Transpiration Sap flow Red pine great Lakes region

Radial variations in xylem sap flux in a temperate red pine plantation forest

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2021年第1期10卷 328-336页

作者： alanna V.Bodo M.Altaf Arain School of Earth Environment and SocietyMcMaster UniversityHamiltonONCanada McMaster Centre for Climate Change HamiltonONCanada

Background:Scaling sap flux measurements to whole-tree water use or stand-level transpiration is often done using measurements conducted at a single point in the sapwood of the tree and has the potential to cause significant *** studies have shown that much of this uncertainty is related to(i)measurement of sapwood area and(ii)variations in sap flow at different depths within the tree ***:This study measured sap flux density at three depth intervals in the sapwood of 88-year-old red pine(Pinus resinosa)trees to more accurately estimate water-use at the tree-and stand-level in a plantation forest near Lake Erie in Southern Ontario,*** showed that most of the water transport(65%)occurred in the outermost sapwood,while only 26%and 9%of water was transported in the middle and innermost depths of sapwood,***:These results suggest that failing to consider radial variations in sap flux density within trees can lead to an overestimation of transpiration by as much as 81%,which may cause large uncertainties in water budgets at the ecosystem and catchment *** study will help to improve our understanding of water use dynamics and reduce uncertainties in sap flow measurements in the temperate pine forest ecosystems in the great Lakes region and help in protecting these forests in the face of climate change.

关键词： Sap flow Transpiration Water use Red pine Temperate forest great Lakes region

Four corner fusion using a multidirectional angular stable locking plate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2016年第8期7卷 501-506页

作者： Tahseen Chaudhry Michelle spiteri Dominic Power Mark Brewster Department of Hand Surgery Queen Elizabeth Hospital

AIM: To review the results of our experience with the Medartis Aptus plating system for four corner arthrodesis of the wrist, which uses a combination of compression screws and variable angle locking ***: We reviewed the results of 17 procedures in 16 patients that underwent scaphoid excision and four corner fusion using the Medartis Aptus system between May 2010 and June 2014. The primary outcome measure was radiographic and clinical union. RESULTS: The mean clinical follow up time was 20.6 mo. The mean union time was 6 mo. Two non-unions required revision procedures. The mean disabilities of the arm, shoulder and hand score taken after union was 36. The mean final grip strength was 27 kg. The mean final range of movement was 30° flexion and 31° of extension. All patients had a restored scapholunate angle on postoperative radiographs. There were no incidences of dorsal ***: Overall our experience with the Aptus plating system shows comparable results to other methods of fixation for four corner fusion, in the short to medium term.

关键词： Wrist surgery Arthrodesis Locking plate Scaphoidectomy Partial fusion