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Journal of Pharmacy and Pharmacology 2017年第8期5卷 565-571页

作者： Daniel Amaral Alves Marliere Caio Bellini Lovisi alan robert moreira schmitt Bruno Salles Sotto-Maior Henrique Duque de Miranda Chaves Netto MSc in Clinical Dentistry- Juiz de Fora Dental School Federal University of Juiz de Fora Juiz de Fora 36036-300 Brazil MSc in Dentistry - Dental School University of the State of Rio de Janeiro Rio de Janeiro 20551-030 Brazil Lecturer in Dentistry- Juiz de Fora Dental School Federal University of Juiz de Fora Juiz de Fora 36036-300 Brazil

Orthognathic surgery involves correction of functional and often esthetic disharmonies. The purpose of this case report is topresent the case of a 22 years-old female with class III dentofacial deformity that required orthognathic surgery to treat hermalocclusion and buccal fat pad excision for optimizing soft-tissue facial contour. Treatment planning involved a counterclockwiserotation of the maxilomandibular complex with genioplasty based on digital 3D surgical planning using the Dolphin Imaging 11.7 3DPremium software. Prototyping splints allowed surgical procedures （bilateral sagital mandibular osteotomy associated to a Le fort Iosteotomy） that corrected position of the gnathic bones. In the same surgical procedure, the buccal fat pad was partially removed for asharp cheek contour giving a slimmer appearance to her face. After 5 months, the patient was reassessed and reported no complaintsregarding esthetics or function. This case illustrates that a combination oforthognathic surgery and an esthetic procedure can result in astable and harmonious facial as well as occlusal outcomes.

关键词： Orthognathic surgery, occlusal plane, malocclusion, buccal fat pad, aesthetic procedure.

Clinical applications of the jugal lipectomy technique:case reports

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Plastic and Aesthetic Research 2018年第3期5卷 27-35页

作者： Bárbara do Amaral Antunes alan robert moreira schmitt Michel Abrao Neto Filipe Jaeguer Maria da Graea Naclério-Homem Matheus Furtado de Carvalho Dental School Federal University of Juiz de ForaGovernador Valadares 35010-177Brazil Department of Oral and Maxillofacial Surgery University of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil Department of Oral and Maxillofacial Surgery President Tancredo de Almeida Neves UniversitySao Joao Del Rei 36301-182Brazil Department of Oral and Maxillofacial Surgery Pontifical Catholic University of Minas GeraisBelo Horizonte 30535-901Brazil Department of Oral and Maxillofacial Surgery Federal University of Sao PauloSao Paulo 05508-000Brazil Department of Oral and Maxillofacial Surgery Federal University of Juiz de ForaGovernador Valadares 35010-177Brazil

The adipose body of cheek is the tissue located in the buccal space. In the past, the partial removal of this tissue, called jugal lipectomy, was indicated to fill defects resulting from buccosinusal communications and/or maxillary resections. Recently, such technique became popular in facial aesthetics as it gives patients the feel of a more delicate face, in which the zygomatic bone appears to be more prominent due to the reduction in the volume of the cheeks. However, many professionals are unaware of how to establish the correct diagnosis of facial volume alterations, as well as in performing and treating the complications that may arise from jugal lipectomy. The aim of this paper is to present three clinical cases with different applications of jugal lipectomy, discussing some relevant aspects of surgical planning that involve the request for imaging exams and a previous study of this tissue's anatomical features.

关键词： Face lipectomy adipose tissue aesthetics

Interferometric measurement of injection nozzles using ultra-small fiber-optical probes

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Chinese Optics Letters 2011年第7期9卷 37-40页

作者： Tilo Pfeifer robert schmitt Niels Knig Guilherme Francisco Mallmann Fraunhofer Institute for Production Technology Steinbachstr. 17 52074 Aachen Germany Laboratory for Machine Tools and Production Engineering of RWTH Aachen University

The measurement of boreholes with diameters smaller than 500 μm is a demanding task that cannot be performed using state-of-the-art production metrology. In this letter, a miniaturized fiber probe with a diameter of 80μm is presented. A probe is used for low-coherence interferometry to conduct highly precise measurements of form deviations of small boreholes. Measurements conducted in nozzles are also presented. The results prove the potential of the fiber-optical sensor for quality inspection of high-precision parts, such as injection nozzles, for common-rail diesel engines.

关键词： Charge coupled devices Fizeau interferometry Low coherence interferometry Metrology Michelson interferometers Optical fibers

Novel fiber-optical interferometer with miniaturized probe for in-hole measurements

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Optoelectronics Letters 2008年第2期4卷 140-142页

作者： robert schmitt Tilo Pfeifer Frank Depiereux Niels Knig Fraunhofer Institute for Production Technology (IPT) Steinbachstrasse 17 52074 Aachen Germany

Today, micro-system technology and the development of new MEMS (Micro-Electro-Mechanical Systems) are emerging rapidly. In order for this development to become a success in the long run, measurement systems have to ensure product quality. Most often, MEMS have to be tested by means of functionality or destructive tests. One reason for this is that there are no suitable systems or sensing probes available which can be used for the measurement of quasi inaccessible features like small holes or cavities. We present a measurement system that could be used for these kinds of measurements. The system combines a fiber optical, miniaturized sensing probe with low-coherence interferometry, so that absolute distance measurements with nanometer accuracy are possible.

关键词：纤维光干扰术光检测技术测量方法

Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non‑essential blood AA profile in pigs

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1336-1346页

作者： Maximiliano Muller Elout Van Liefferinge alan Tilbrook robert van Barneveld Eugeni Roura Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueensland 4072Australia Laboratory of Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyGhent University339000 GhentFlandersBelgium Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation and the School of Veterinary ScienceThe University of QueenslandBrisbaneQueensland 4072Australia SunPork Group BrisbaneQueensland 4009Australia

Background Commercial diets are frequently formulated to meet or exceed nutrient levels including those of lim-iting essential amino acids(AA)covering potential individual variations within the ***,the provision of dietary excess of AA,such as Lys,may lead to reduced appetite and growth in *** mechanisms modulat-ing these responses have not been extensively *** study evaluated the effect of Lys dietary excesses on performance and satiety biomarkers in post weaning *** Twenty-four pigs aged 21 d and weighing 6.81±0.12kg(mean±SEM)were individually housed and offered 1 of 4 dietary treatments for 3weeks:a diet containing a standardized ileal digestible Lys reaching 100%(T0),120%(T1),150%(T2)or 200%(T3)of the NRC(2012)*** the end of the experiment,blood samples from the cephalic vein of the T0 and T3 groups were obtained for AA *** addition,primary intestinal cultures from T0 pigs were used,following their humane killing,to evaluate the effect of Lys on gut hormone secretion and AA sensors gene expression under ex vivo *** Feed intake was linearly reduced(P<0.001)and the weight gain to feed ratio reduced(P<0.10)with increased dietary levels of Lys during the third-and first-week post weaning,*** con-centration(P<0.05)and the metabotropic glutamate receptor 1 and the solute carrier family 7 member 2(P<0.10)gene expression was enhanced in proximal jejunum tissues incubated with Lys at 20mmol/L when compared to the control(Lys 0mmol/L).Plasma Lys and Glu(P<0.05)concentration increased in the T3 compared to T0 *** contrast,plasma levels of His,Val,Thr,Leu(P<0.05)and Gln(P<0.10)were lower in T3 than T0 *** The present results confirm that excess dietary Lys inhibits hunger in ***,the results provide evidence of pre-and post-absorptive mechanisms modulating these *** dietary excesses should be nar-rowed,when possible,to avoid negative effects of

关键词： Amino acid Blood Cholecystokinin Feed intake Lysine Pig Satiety

Esophageal lichen planus:Current knowledge,challenges and future perspectives

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World Journal of Gastroenterology 2022年第41期28卷 5893-5909页

作者： Annegrit Decker Franziska Schauer Adhara Lazaro Carmen Monasterio Arthur robert Schmidt Annette schmitt-Graeff Wolfgang Kreisel Department of Medicine II GastroenterologyHepatologyEndocrinology and Infectious DiseasesMedical Center-University of FreiburgFaculty of MedicineFreiburg 79106Germany Department of Dermatology Medical Center-University of FreiburgFaculty of MedicineFreiburg 79104Germany Department of Medicine Institute of Exercise and Occupational MedicineMedical Center–University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute for Dermatohistology Pathologyand Molecular Pathology Prof.Dr.LaafFreiburgGermany and:University of FreiburgFreiburg 79106Germany

Lichen planus(LP)is a frequent,chronic inflammatory disease involving the skin,mucous membranes and/or skin *** involvement in lichen planus(ELP)is a clinically important albeit underdiagnosed inflammatory *** narrative review aims to give an overview of the current knowledge on ELP,its prevalence,pathogenesis,clinical manifestation,diagnostic criteria,and therapeutic options in order to provide support in clinical *** on ELP were collected using PubMed/*** clinical and therapeutical characteristics from published patient cohorts including our own cohort were extracted and *** mainly affects middle-aged *** principal symptom is ***,asymptomatic cases despite progressed macroscopic esophageal lesions may *** pathogenesis is unknown,however an immune-mediated mechanism is ***,ELP is characterized by mucosal denudation and tearing,trachealization,and *** esophageal stenosis may occur in chronic *** findings include mucosal detachment,T-lymphocytic infiltrations,epithelial apoptosis(Civatte bodies),dyskeratosis,and *** immuno-fluorescence shows fibrinogen deposits along the basement membrane *** date,there is no established ***,treatment with topical steroids induces symptomatic and histologic improvement in two thirds of ELP patients in *** severe cases may require therapy with *** symptomatic esophageal stenosis,endoscopic dilation may be *** may be regarded as a precancerous condition as transition to squamous cell carcinoma has been documented in *** is an underdiagnosed yet clinically important differential diagnosis for patients with unclear dysphagia or *** diagnosis and therapy might prevent potential sequelae such as esophageal stenosis or development of invasive squamous cell *** studies are needed to gain

关键词： Lichen planus Esophagitis T-lymphocytes Budesonide Dysphagia Precancerosis

Conservation of natural enemy fauna in citrus canopies by horticultural mineral oil： Comparison with effects of carbaryl and methidathion treatments for control of armored scales

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Insect Science 2010年第5期17卷 414-426页

作者： Weiguang Liang alan Meats G. Andrew C. Beattie robert Spooner-Hartt Laura Jiang Centre for Plant and Food Sciences University of Western Sydney School of Biological Sciences University of Sydney Sydney New South Wales Austrafia

The disruptive effects of an nC24 horticultural mineral oil （HMO） and two other insecticides （carbaryl and methidathion） on two armored scale insects and natural enemy fauna were evaluated in two citrus orchards. In the first orchard, all three spray treatments and non-sprayed controls were distributed separately among individual trees in one block, whereas in the second orchard the control, HMO and methidathion treatments were applied at the level of whole blocks. The results in both orchards were similar. All three of the spray treatments had a lethal effect on the red scale insects and the effects of HMO and methidathion tested at the second site lasted for at least 19 weeks and for purple scale, at least 50 weeks. HMO did not have a significant effect on the abundance and species diversity of parasitoids and （for the most part） did not affect coccinellids and predatory mites. Both carbaryl and methidathion caused significant ongoing disruption to the above groups. No treatment resulted in the resurgence of the scale insects or the outbreak ofphytophagous mites, even where whole blocks were sprayed.

关键词： conservation HMO replacement resurgence water saving

Appraisal of the current guidelines for management of cholangiocarcinoma-using the Appraisal of Guidelines Research and Evaluation Ⅱ (AGREE Ⅱ) Instrument

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 126-135,中插1页

作者： Paschalis Gavriilidis alan Askari Keith J.roberts robert P.Sutcliffe Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustBirminghamUK Department of Upper Gastro-Intestinal Surgery West Hertfordshire Hospitals NHS TrustWatfordUK

Cholangiocarcinoma(CC)is the second most common primary liver ***-quality guidelines are essential for effective patient stratification and individualised *** study aimed to appraise the methodological quality of existing guidelines for the resection of CC using the Appraisal of Guidelines for Research&Evaluation(AGREE II)instrument.A systematic search of the literature in Cochrane,PubMed,Google Scholar,and Embase was *** of the clinical practice guidelines(CPGs)and consensuses was performed using the AGREE II instrument by four clinicians experienced in surgical practice and the AGREE II appraisal *** searches identified 13 guidelines of highly variable quality according to the AGREE II *** guidelines scored well in certain domains such as scope&purpose(median score across all guidelines;65%),clarity of presentation(76%),and editorial independence(56%).However,they scored poorly for applicability(13%),rigour of development(30%),and stakeholder involvement(39%).None of the 13 guidelines was recommended universally for use without ***,the methodological quality of guidelines on the surgical management of CC is *** updates should address and modify shortcomings detected by the AGREE II instrument,thereby facilitating better patient stratification and individualised treatment strategies.

关键词： Cholangiocarcinoma(CC) clinical practice guidelines(CPGs) Appraisal of Guidelines for Research and Evaluation instrument(AGREE II instrument)

How Could Evidence-Based Reform Advance Education?

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ECNU Review of Education 2021年第1期4卷 7-24页

作者： robert E.Slavin alan C.K.Cheung Tengteng Zhuang Johns Hopkins University The Chinese University of Hong Kong Beijing Normal University

Purpose:This article presents a definition and rationale for evidence-based reform in education,and a discussion of the current state of evidence-based research,focusing on China,the U.S.,and the ***/Approach/Methods:The article contrasts the state of educational research in the U.S.,the UK,and China,world leaders in evidence-based ***:The article suggests ways in which Chinese,U.S.,UK,and other scholars might improve the worldwide quality of evidence-based reform in *** indicator of this partnership is an agreement among the Chinese University of Hong Kong,Nanjing Normal University,and Johns Hopkins University to work together on Chinese and English versions of the website Best Evidence in Brief and a collaboration between Johns Hopkins and the ECNU Review of Education at East China Normal ***/Value:This article is the first to compare developments in evidence-based reform in education in China with parallel developments in the *** UK Building understanding of current evidence-based policies should help all countries learn how evidence can play a greater role in education policy and benefit many students.

关键词： Evidence-based reform in education experiments international comparisons meta-analysis research designs

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in autumn in Beijing, China

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 433-440页

作者： Cao LIU Yiping XU Mei MA Bingbin HUANG Jingdong WU Qingyi MENG Zijian WANG robert alan GEARHEART State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Beijing Water Science and Technology Institute Beijing 100048 China Environmental Engineering Department Humboldt State University Arcata CA95521 USA

Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-O- deethylase （EROD） assay using H4IIE cells for aryl hydrocarbon receptor （Ah-R） agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities （0.9 ng E2. g-1 to 6.8 ng E2. gl, dw）, but relative higher androgen receptor antagonistic activ- ities （nd to 45%）, progestin receptor antagonistic activities （nd to 80%） and Ah-R agonistic activities （1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin （TCDD）·g-1, dw） were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol （E2） equivalent quantity （EEQ） level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodi- benzo-p-dioxin toxic equivalent quantity （TEQ） level of sewagesludge composted was much lower than that of sewage sludge.

关键词： sewage sludge in vitro bioassay endocrine disruption dioxin-like effect