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Probabilistic estimate of rock mass static and dynamic demands for underground excavation stabilisation

Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 481-493页

作者： Ernesto Villaescusa alan thompson Christopher Windsor Western Australia School of Mines Curtin UniversityLocked Bag 30KalgoorlieWA 6433Australia alan thompson Geotechnology Pty Ltd. 40B Windich StreetEsperanceWA 6450Australia

Excavation damage under high in situ stress depends largely upon the potential block size associated with any violent *** size and shape of the dynamic instability are largely controlled by the location,orientation and extent of the pre-existing geological discontinuities.A new methodology is presented in which the rock mass demand can be expressed in terms of the mass in tonnes of unstable rock that is ejected per unit area of the excavation surface where failure occurs.A probabilistic approach has been implemented to estimate the potential rock mass instabilities and their associated static and dynamic *** new methodology considers that the strain energy released by the rock mass during violent stress-driven failure is largely converted into kinetic energy of ejection for *** estimated dynamic demand has been favourably compared with observations of rock mass damage in a number of underground excavations.

关键词： Geological structures Probabilistic design Underground excavations High stresses Dynamic and static demands Deep mining

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Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri

Purification and characterization of novel antimicrobial pep...

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中国食品科学技术学会第五届年会暨第四届东西方食品业高层论坛

作者： Stephen McClean alan thompson Chris Shaw b Anthony J．Bjourson Institute of Biomedical Sciences Centre for Molecular Biosciences University of UlsterCromore RoadColeraineNorthern Ireland BT52 1SAUK School of Pharmacy Queens University BelfastBT9 7BL Northern lrelandUK The Institute of Biolechnology Fuzhou University Fujian ProvincePeople’s Republic of China

Linear,amphipathic and cationic antimicrobial peptides have been previously reported from a wide range of amphibian species especially frogs of the genus *** antimicrobial peptides are attrac

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数字时代:超越广告点击率

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新营销 2012年第12期14卷 14-15页

作者： alan thompson Caryn Brouwe 蔡国良益普索品牌与广告研究(Ipsos ASI)数字产品开发部益普索品牌与广告研究(Ipsos ASI)数字战略部益普索大中华区

在广告行业，没有更好的时代，也从未有更坏的时代.在测量数字广告战役的影响和效率时，我们必须不仅仅只限于点击率，以及其他方便易得的行为指标只有这样，品牌才有可能正确理解其广告的成败．

关键词：智库广告行业行为指标点击率品牌

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Identification of new genetic risk factors for prostate cancer

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Asian Journal of Andrology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia Kote-Jarai Graham G. Giles Ali Amin Al Olama Sarah K. Jugurnauth Shani Mulholland Daniel A. Leongamomlert Stephen M. Edwards Jonathan Morrison Helen I. Field Melissa C. Southey Gianluca Severi Jenny L. Donovan Freddie C. Hamdy David R Dearnaley Kenneth R. Muir Charmaine Smith Melisa Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Brien Beatrice N. Gehr-Swain Rosemary A. Wilkinson Angela Cox Sarah Lewis Paul M. Brown Sameer G. Jhavar Malgorzata Tymrakiewicz Artitaya Lophatananon Sarah L. Bryant The UK Genetic Prostate Cancer Study Collaborators British Association of Urological Surgeons＇ Section of Oncology and The UK ProtecT Study Collaborators alan Horwich Robert A. Huddart Vincent S. Khoo Christopher C. Parker Christopher J. Woodhouse alan thompson Tim Christmas Chris Ogden Cyril Fisher Charles Jameson Colin S. Cooper Dallas R. English John L. Hopper David E. Neal Douglas E Easton Rosalind A. Eeles Section of Cancer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Social Medicine University of Bristol Bristol BS8 2PR UK Academic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundation Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingham Medical School Queens Medical Centre Nottingham NG7 2UH UK Institute for Cancer Studies University of Sheffield Sheffield SIO 2RX UK Surgical Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full list of authors is provided in the Supplementary Note online Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambridge Research Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence that a substantial part of genetic predisposition to prostate cancer （PCa） may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

关键词： prostate cancer genetics susceptibility loci SNPs relative risks

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Magnetic resonance imaging in assessment of stress urinary incontinence in women: Parameters differentiating urethral hypermobility and intrinsic sphincter deficiency

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World Journal of Radiology 2015年第11期7卷 394-404页

作者： Katarzyna Jadwiga Macura Richard Eugene thompson David alan Bluemke Rene Genadry The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University Johns Hopkins Biostatistics Center National Institutes of Health Clinical Center University of Iowa Hospitals and Clinics

AIM: To define the magnetic resonance imaging(MRI) parameters differentiating urethral hypermobility(UH) and intrinsic sphincter deficiency(ISD) in women with stress urinary incontinence(SUI).METHODS: The static and dynamic MR images of 21 patients with SUI were correlated to urodynamic(UD) findings and compared to those of 10 continent controls. For the assessment of the urethra and integrity of the urethral support structures, we applied the highresolution endocavitary MRI, such as intraurethral MRI, endovaginal or endorectal MRI. For the functional imaging of the urethral support, we performed dynamic MRI with the pelvic phased array coil. We assessed the following MRI parameters in both the patient and thevolunteer groups:(1) urethral angle;(2) bladder neck descent;(3) status of the periurethral ligaments,(4) vaginal shape;(5) urethral sphincter integrity, length and muscle thickness at mid urethra;(6) bladder neck funneling;(7) status of the puborectalis muscle;(8) pubo-vaginal distance. UDs parameters were assessed in the patient study group as follows:(1) urethral mobility angle on Q-tip test;(2) Valsalva leak point pressure(VLPP) measured at 250 cc bladder volume; and(3) maximum urethral closure pressure(MUCP). The UH type of SUI was defined with the Q-tip test angle over 30 degrees, and VLPP pressure over 60 cm H2 O. The ISD incontinence was defined with MUCP pressure below 20 cm H2 O, and VLPP pressure less or equal to 60 cm H2 O. We considered the associations between the MRI and clinical data and UDs using a variety of statistical tools to include linear regression, multivariate logistic regression and receiver operating characteristic(ROC) analysis. All statistical analyses were performed using STATA version 9.0(Stata Corp LP, College Station, TX).RESULTS: In the incontinent group, 52% have history of vaginal delivery trauma as compared to none in control group(P < 0.001). There was no difference between the continent volunteers and incontinent patients

关键词： Magnetic resonance imaging Stress urinary incontin

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改进型SOA电路实现安全工作区保护

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电子测试（新电子） 2004年第12期 31-36页

作者： alan Hastings Lemuel thompson Fred Trafton 德州仪器

功率管保护是通过将其操作限制在SOA的有限V-I平面(plane)区域内,保护电路通常采用返送(foldback)电流限制,但这种方法无法复制SOA功率界限的实际形状。本文将以TI的TPS2490系列功率限制(power-limiting)热插拔控制器为例介绍改进型SOA... 详细信息

功率管保护是通过将其操作限制在SOA的有限V-I平面(plane)区域内,保护电路通常采用返送(foldback)电流限制,但这种方法无法复制SOA功率界限的实际形状。本文将以TI的TPS2490系列功率限制(power-limiting)热插拔控制器为例介绍改进型SOA保护电路的原理与设计,它可通过模拟计算技术复制SOA的实际界限。

关键词： SOA 安全工作区电路实现保护电路功率管热插拔控制器电流限制区域内技术实际

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