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Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 488-493页

作者： Calvin HY Chan fergal Donnellan Michael f Byrne alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher alan A Weiss Eric M Yoshida Division of Gastroenterology General Hospital University of British Columbia Department of Surgery Vancouver General Hospital University of British Columbia

BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two *** study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus ***:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver *** frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and *** response of anastomotic stricture to endoscopic therapy was also ***:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary ***-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic *** comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver *** strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups.

关键词： endoscopic retrograde cholangiopancreatography liver transplantation biliary tract surgical procedures biliary tree liver failure

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Treatment for Mild Chronic Hypertension during Pregnancy

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四川生理科学杂志 2022年第2期44卷 328-328页

作者： alan T Tita from the Department of Obstetrics and Gynecology (A.T.T. W.W.A.) the Center for Women's Reproductive Health (A.T.T. J.M.S. N.A. S.O. G.R.C. W.W.A.) the Department of Biostatistics (J.M.S. G.R.C.) the Division of Neonatology Department of Pediatrics (N.A.) and the Division of Cardiovascular Disease Department of Medicine (S.O.) University of Alabama Birmingham the Department of Obstetrics and Gynecology University of North Carolina at Chapel Hill (K.B.) and the Department of Obstetrics and Gynecology Duke University Durham (B.L.H.) - both in North Carolina the Department of Obstetrics and Gynecology University of Pennsylvania (L.D.) and the Department of Obstetrics and Gynecology Drexel University College of Medicine (L.P.) Philadelphia St. Luke's University Health Network Fountain Hill (J.B.) and the Department of Obstetrics and Gynecology Magee Women's Hospital University of Pittsburgh Pittsburgh (H.N.S.) - all in Pennsylvania the Department of Obstetrics and Gynecology University of Texas (B.S.) and the Department of Obstetrics and Gynecology Baylor College of Medicine and Texas Children's Hospital Houston (K.A.) the Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center Dallas (B.C.) the Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston (G.R.S.) and the Department of Women's Health University of Texas Austin (L.H.) the Department of Obstetrics and Gynecology Columbia University (K.L.) Weill Cornell University (P.A.) and the Department of Obstetrics and Gynecology New York Presbyterian Queens Hospital (D.S.) New York and the Department of Obstetrics and Gynecology Winthrop University Hospital Mineola (W.K.) - all in New York the Department of Obstetrics and Gynecology University of Oklahoma Health Sciences Oklahoma City (R.K.E.) MetroHealth System Cleveland (K.G.) the Department of Obstetrics and Gynecology Indiana University Indianapolis (D.M.H.) the Department of Obstetrics and Gynecology

Background:The benefits and safety of the treatment of mild chronic hypertension(blood pressure,<160/100 mm Hg)during pregnancy are *** are needed on whether a strategy of targeting a blood pressure of less than 140/9... 详细信息

Background:The benefits and safety of the treatment of mild chronic hypertension(blood pressure,f targeting a blood pressure of less than 140/90 mm Hg reduces the incidence of adverse pregnancy outcomes without compromising fetal growth.

关键词： pregnancy fetal hypertension

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Heterogeneity of neutrophils in cancer:one size does not fit all

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Cancer Biology & Medicine 2022年第12期19卷 1629-1648页

作者： Song Chen Qingyu Zhang Lisha Lu Chunhui Xu Jiajia Li Jiali Zha fengxia Ma Hongbo R.Luo alan Y.Hsu State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Department of Pathology Harvard Medical SchoolBostonMA 02115USA Department of Laboratory Medicine The Stem Cell ProgramBoston Children's HospitalBostonMA 02115USA Dana-farber/Harvard CancerCenter BostonMA02115USA

Neutrophils play an essential role in the defense against bacterial infections and orchestrate both the innate and adaptive immune *** their abundant numbers,diverse function and short life span,these cells are at the forefront of immune responses,and have gained attention in recent years because of their presence in tumor *** involvement pertains to tumor cells'ability to construct a suitable tumor microenvironment(TME)that accelerates their own growth and malignancy,by facilitating their interaction with surrounding cells through the circulatory and lymphatic systems,thereby influencing tumor development and *** have indicated both pro-and anti-tumor properties of infiltrating *** TME can exploit neutrophil function,recruitment,and even production,thus resulting in pro-tumor properties of neutrophils,including promotion of genetic instability,tumor cell proliferation,angiogenesis and suppression of anti-tumor or inflammatory *** contrast,neutrophils can mediate anti-tumor resistance by direct cytotoxicity to the tumor cells or by facilitating anti-tumor functions via crosstalk with T ***,we summarize current knowledge regarding the effects of neutrophil heterogeneity under homeostatic and tumor conditions,including neutrophil phenotype and function,in cancer biology.

关键词： Neutrophils in cancer tumor microenvironment TAN neutrophil heterogeneity neutrophils

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Pentoxifylline treatment and penile calcifications in men Nith Peyronie＇s disease

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Asian Journal of Andrology 2011年第2期13卷 322-325页

作者： James f Smith alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence flechner Benjamin N Breyer Michael L Eisenberg Tom f Lue Department of Urology University of California San Francisco CA USA Department of Obstetrics Gynecology and Reproductive Sciences University of California San Francisco CA 94143-0738 USA

This retrospective cohort study from a single clinical practice enrolled patients with evidence of calcified Peyronie＇s disease （PD） plaques detected on penile ultrasound at the time of initial presentation. The primary objective was to describe the effect of pentoxifylline （PTX） treatment on subtunical calcifications in men with PD. A PD-specific questionnaire was administered and sonographic evaluations were performed at baseline and follow-up visits. Descriptive statistics and X2 analysis were used to characterize the effect of PTX on calcified tunical plaques. In all, 71 men （mean age： 51.9 years） with PD and sonographic evidence of calcification were identified. Of them, 62 of these men were treated with PTX for a mean duration of I year, and nine with vitamin E or no treatment. Improvement or stabilization in calcium burden at follow-up was noted in 57 （91.9%） of men treated with PTX versus four （44,4%） of those not treated with PTX （P〈0.001）. PTX users were much less likely to have a subjective worsening of their clinical condition （25.0% versus 78.3%, P=0.002）. Treatment with PTX appeared to stabilize or reduce calcium content in PD plaques. A randomized controlled trial is warranted to further explore this effect.

关键词： penile calcifications pentoxifylline Peyronie's disease treatment

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QTL mapping and identification of SNP-haplotypes affecting yield components of Theobroma cacao L.

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Horticulture Research 2020年第1期7卷 2444-2461页

作者： Luciel dos Santos fernandes fábio M.Correa Keith TIngram Alex-alan furtado de Almeida Stefan Royaert Mars Center for Cocoa Science CP 55ItajuípeBA CEP 45.630-000Brazil Departamento de Ciências Biológicas Universidade Estadual de Santa CruzRodovia Ilhéus-ItabunaKm 16Bairro SalobrinhoIlhéusBA CEP 45.662-900Brazil Mars Incorporated13601 Old Cutler RoadMiamiFL 33158USA

Cacao is a crop of global relevance that faces constant demands for improved bean ***,little is known about the genomic regions controlling the crop yield and genes involved in cacao bean ***,to identify the quantitative trait loci(QTL)associated with cacao yield and bean filling,we performed a QTL mapping in a segregating mapping population comprising 459 trees of a cross between‘TSH 1188’and‘CCN 51’.All variables showed considerable phenotypic variation and had moderate to high heritability *** identified 24 QTLs using a genetic linkage map that contains 3526 single nucleotide polymorphism(SNP)*** analysis at the significant QTL region on chromosome IV pointed to the alleles from the maternal parent,‘TSH 1188’,as the ones that affect the cacao yield components the *** recombination events identified within these QTL regions allowed us to identify candidate genes that may take part in the different steps of pod growth and bean *** candidate genes seem to play a significant role in the source-to-sink transport of sugars and amino acids,and lipid metabolism,such as fatty acid *** SNP markers mapped in our study are now being used to select potential highyielding cacao varieties through marker-assisted selection in our existing cacao-breeding experiments.

关键词： breeding mapping linkage

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一种基于基本语义单元合成Petri网的足球视频查询描述模型

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计算机研究与发展 2006年第1期43卷 159-168页

作者：老松杨黄广连 alan f.Smeaton Gareth J.f.Jones Hyowon Lee 国防科学技术大学信息系统与管理学院长沙410073 都柏林城市大学数字视频处理研究中心

足球是最具世界性的体育运动之一,球迷遍布五大洲,因此在体育视频节目中足球备受广大观众青睐·在分析了足球视频特点的基础上,提出了一种基于基本语义单元合成Petri网的足球视频查询描述模型·该模型首先定义了一种类似文本字词集合的... 详细信息

足球是最具世界性的体育运动之一,球迷遍布五大洲,因此在体育视频节目中足球备受广大观众青睐·在分析了足球视频特点的基础上,提出了一种基于基本语义单元合成Petri网的足球视频查询描述模型·该模型首先定义了一种类似文本字词集合的足球视频基本语义单元集合,在此基础上采用基本语义单元合成Petri网模型建立了一种足球查询语义的描述模型,并分别构建了进球、进攻、角球、犯规、换人等足球语义·初步的实验结果验证了该模型的有效性,并能推广至球类视频和其他体育视频·

关键词：基本语义单元合成Petri网足球视频查询模型

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Chronic pancreatitis:a sequela of acute fatty liver of pregnancy

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Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 101-104页

作者： Wichian Apiratpracha Eric M.Yoshida Scudamore H.Charles alan A.Weiss Michael f.Byrne Division of Gastroenterology Department of Medicine University of British ColumbiaVancouverBCCanada Division of Surgery Department of MedicineUniversity of British ColumbiaVancouverBCCanada

BACKGROUND: Chronic pancreatitis following acute fatty liver of pregnancy is rarely ***: We treated a 34-year-old woman who developed acute fatty liver of pregnancy (AfLP) after delivery by caesarean section at 32 weeks of gestation. AfLP was complicated by acute pancreatitis and multiple organ failure. The management of the disease was primarily supportive. She recovered from acute fulminant liver failure and multi-organ failure, apart from the development of symptomatic chronic pancreatitis thereafter. RESULTS: Investigations failed to identify any other causes of chronic pancreatitis. The patient responded very well to pancreatic enzyme supplement for the treatment of ***: To our knowledge, this is the first report of chronic pancreatitis as a consequence of multi-organ dysfunction caused by AfLP.

关键词： pancreatitis, chronic fatty liver acute pregnancy multiorgan dysfunction syndrome

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Development and Validation of an Instrument to Measure STEM Undergraduate Students’ Comprehensive Educational Process

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frontiers of Education in China 2019年第4期14卷 575-611页

作者： ZHUANG Tengteng CHEUNG alan C.K. LAU Wilfred W.f. TANG Yipeng Department of Educational Administration&Policy Faculty of EducationThe Chinese University of Hong KongHong KongChina Department of Curriculum and Instruction Faculty of EducationThe Chinese University of Hong KongHong KongChina College of Education Capital Normal UniversityBeijing 100089China

This study reports the development and validation of an instrument,“Undergraduate STEM Educational Process Questionnaire”(USEPQ)to assess the learning experiences of STEM(science,technology,engineering and mathematics)-major undergraduates from the perspective of a conceptualized comprehensive STEM educational process framework that consists of key essentials such as course learning and instruction,educational environment,assessment methods,and unique STEM *** factor Analysis and Confirmatory factor Analysis performed on independent samples indicate that the finalized 9-factor,41-item USEPQ possesses a stable factor structure and sound psychometric *** factors of the validated scale are Classroom Instruction of Courses,Support from faculty Members,Alternative Assessment Methods,Cooperative Learning,Resources and Service,Academic Competition,Cross-discipline features of Program Courses,Connectedness of Program Courses,and Examination Difficulty.

关键词： higher education educational process STEM program,measurement instrument development and validation

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Circular smooth muscle contributes to esophageal shortening during peristalsis

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World Journal of Gastroenterology 2012年第32期18卷 4317-4322页

作者： Anil K Vegesna Keng-Yu Chuang Ramashesai Besetty Steven J Phillips alan S Braverman Mary f Barbe Michael R Ruggieri Larry S Miller Department of Medicine Section of GastroenterologyHofstra Northshore Long Island Jewish HospitalHofstra University School of MedicineManhassetNY 11030United States Department of Medicine Section of GastroenterologyTemple University School of MedicinePhiladelphiaPA 19140United States Department of Anatomy and Cell Biology Temple University School of MedicinePhiladelphiaPA 19140United States Department of Urology Temple University School of MedicinePhiladelphiaPA 19140United States Department of Anatomy and Cell Biology and Department of Urology Temple University School of MedicinePhiladelphiaPA 19140United States

AIM:To study the angle between the circular smooth muscle(CSM) and longitudinal smooth muscle(LSM) fibers in the distal ***:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 *** outer longitudinal layer of the muscularis propria was exposed after stripping the outer *** inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis *** of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle *** were measured every one cm for 10 cm proximal to the squamocolumnar junction(SCJ) by two independent *** human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography(micro CT) and Image J ***:All data are presented as mean ± *** CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P = *** CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P = 0.013,P = 0.008,P = 0.004,P = 0.009 *** CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P = 0.05,P = 0.02,P = 0.03 *** CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P =

关键词：平滑肌食管蠕动计算机断层扫描圆形 CSM LSM 角度测量

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粉末材料压制过程的DEM分析

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重庆大学学报（自然科学版） 2007年第7期30卷 1-4页

作者：温彤 COCKS alan C f 重庆大学机械工程学院重庆400030 Department of Engineering Science University of Oxford

应用离散单元法(DEM)研究了粉末材料在开口容器中受到刚性凸模压制时的流动特点,获得了压制过程中颗粒的运动轨迹、运动速度以及粉末密度分布等重要信息;总结了几种典型的粉末流动模式,并在相关实验中得到了印证,说明了应用DEM分析具有... 详细信息

应用离散单元法(DEM)研究了粉末材料在开口容器中受到刚性凸模压制时的流动特点,获得了压制过程中颗粒的运动轨迹、运动速度以及粉末密度分布等重要信息;总结了几种典型的粉末流动模式,并在相关实验中得到了印证,说明了应用DEM分析具有强剪切行为的粉末流动是可行的,结论可供粉末冶金工艺和模具设计人员参考。

关键词：粉末冶金离散单元法压制成形

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