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Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden M Gallegos Tanner Reed Paige Deville Blake Platt Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen alan Marr Anil Paramesh Alison A Smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with P0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine Hormone replacement therapy Steroids Organ donor Retrospective

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Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic Michelle Van Kuiken Mark Khemmani Ahmer V.Farooq Larissa Bresler Thomas M.T.Turk alan J.Wolfe Kristin G.Baldea Loyola University Medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(MetS).The association between MetS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 MetS patients(78.9%).Both cohorts were similar with respect to demographics and non-MetS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in MetS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of MetS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in MetS stones than control *** findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis Metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

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后ART时代艾滋病治疗面临的挑战与展望

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中国皮肤性病学杂志 2024年第6期38卷 656-662页

作者：孙雪晴王亚楠张海燕徐立然 alan Wang 李青雅河南中医药大学中医学院河南郑州450000 河南中医药大学第一附属医院河南郑州450000 Faculty of Medicine and Health Sciences of Auckland University New Zealand 6000

后抗逆转录病毒疗法(antiretroviral therapy,ART)时代,艾滋病逐渐转为慢性传染性疾病,HIV/AIDS的治疗难点主要集中在艾滋病的HIV潜伏、慢性炎症反应与免疫重建不良及长期服用药物对患者生活质量的影响,而治疗的优化方向则更偏向于患者... 详细信息

后抗逆转录病毒疗法(antiretroviral therapy,ART)时代,艾滋病逐渐转为慢性传染性疾病,HIV/AIDS的治疗难点主要集中在艾滋病的HIV潜伏、慢性炎症反应与免疫重建不良及长期服用药物对患者生活质量的影响,而治疗的优化方向则更偏向于患者生命质量的改善及HIV靶向基因疗法的研发工作。本文现总结近年来艾滋病的治疗中面临的挑战与相关进展,为未来艾滋病的治疗提供方向。

关键词：艾滋病潜伏库慢性炎症后抗逆转录病毒疗法时代

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Periodic Addition of Glucose Suppressed Cyanobacterial Abundance in Additive Lake Water Samples during the Entire Bloom Season

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Journal of Water Resource and Protection 2024年第2期16卷 140-155页

作者： David Linz Ian Struewing Nathan Sienkiewicz alan David Steinman Charlyn Gwen Partridge Kyle McIntosh Joel Allen Jingrang Lu Stephen Vesper United States Environmental Protection Agency Cincinnati Ohio USA Annis Water Resources Institute Grand Valley State University Muskegon USA Oak Ridge Institute for Science and Education Oak Ridge Tennessee USA

Previously, we showed that prophylactic addition of glucose to Harsha Lake water samples could inhibit cyanobacteria growth, at least for a short period of time. The current study tested cyanobacterial control with glucose for the entire Harsha Lake bloom season. Water samples (1000 ml) were collected weekly from Harsha Lake during the algal-bloom season starting June 9 and lasting until August 24, 2022. To each of two 7-liter polypropylene containers, 500 ml of Harsha Lake water was added, and the containers were placed in a controlled environment chamber. To one container labeled “Treated,” 0.15 g of glucose was added, and nothing was added to the container labeled “Control.” After that, three 25 ml samples from each container were collected and used for 16S rRNA gene sequencing each week. Then 1000 ml of Harsha Lake water was newly collected each week, with 500 ml added to each container, along with the addition of 0.15 g glucose to the “Treated” container. Sequencing data were used to examine differences in the composition of bacterial communities between Treated and Control containers. Treatment with glucose altered the microbial communities by 1) reducing taxonomic diversity, 2) largely eliminating cyanobacterial taxa, and 3) increasing the relative abundance of subsets of non-cyanobacterial taxa (such as Proteobacteria and Actinobacteriota). These effects were observed across time despite weekly inputs derived directly from Lake water. The addition of glucose to a container receiving weekly additions of Lake water suppressed the cyanobacterial populations during the entire summer bloom season. The glucose appears to stimulate the diversity of certain bacterial taxa at the expense of the cyanobacteria.

关键词： Glucose Cyanobacteria 16S Amplicon Sequencing Microbial Community

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Why Sustainable Porous Carbon Should be Further Explored as Radar-Absorbing Material? A Comparative Study with Different Nanostructured Carbons

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Journal of Renewable Materials 2024年第10期12卷 1639-1659页

作者： alan F.N.Boss Manuella G.C.Munhoz Gisele Amaral-Labat Rodrigo G.A.Lima Leonardo I.Medeiros Nila C.F.L.Medeiros Beatriz C.S.Fonseca Flavia L.Braghiroli Guilherme F.B.Lenz e Silva Department of Metallurgical and Materials Engineering University of de São PauloAvenida Mello MoraesCidade UniversitáriaSão PauloSP 05508-030Brazil Coordination of Applied Research and Technological Development National Institute for Space ResearchAvenida dos AstronautasJardim da GranjaSão Josédos CamposSP 12227-010Brazil Department of Exact and Technological Sciences Santa Cruz State UniversityRodovia Jorge Amadokm16IlhéusBA 45662900Brazil Institut de recherche sur les forêts Universitédu Québec en Abitibi-TémiscamingueRouyn-Noranda445 Bd de l’UniversitéRouyn-NorandaQC J9X 5E4Canada

Radar Absorbing Materials(RAM)are a class of composites that can attenuate incident electromagnetic waves to avoid radar *** carbon allotropes that have the potential to be used as RAM are either carbon nano-tubes(CNTs),graphene,carbon black(CB)and ultimately,sustainable porous carbon(SPC).Here,black wattle bark waste(following tannin extraction)was used as a sustainable source to produce SPC made from biomass *** was characterized and used as aﬁller for a silicone rubber matrix to produce aﬂexible *** elec-tromagnetic performance of this composite was compared with composites made with commercial CB and CNT through reﬂection loss(RL),where-10 dB is equivalent to 90%of *** composites were evaluated in single-layer,double-layer,and as radar absorbing structures(RAS)with the aim of improving their effective absorption bandwidth(EAB)performances and a reduction in *** CNT composite presented a RL of-26.85 dB at 10.89 GHz and an EAB of 2.6 GHz with a 1.9 mm thickness,while the double-layer structures using CNT and SPC provided a RL of-19.74 dB at 10.75 GHz and an EAB of 2.51 ***,the double-layer structures are~42%cheaper than the composite using only CNT since less material is ***,the largest EAB was achieved with a RAS using SPC,reaching~2.8 GHz and a RL of-49.09 dB at 10.4 ***,SPC made of black wattle bark waste can be a competitive,alternative material for use as RAM and RAS since it is cheaper,sustainable,and suitable for daily life uses such as absorbers for anechoic chambers,sensors,and elec-tromagnetic interference shields for electronics,wallets,vehicles,and others.

关键词： Microwave absorption material tannin waste dielectric constant carbon composite reﬂectivity

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内蒙古草原优势物种光合速率对极端干旱的响应

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Journal of Plant Ecology 2024年第3期17卷 5-15页

作者： Yalong Shi Yuanbo Cao Honghui Wu Chong Xu Qiang Yu Xiaoan Zuo Xingguo Han Melinda D.Smith alan K.Knapp Chengjie Wang Guodong Han State Key Laboratory of Effcient Utilization of Arid and Semi-arid Arable Land in Northern China Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Arable Land Quality Monitoring and Evaluation Ministry of Agriculture and Rural AffairsInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China China Rida Investment and Development Group Corp Ltd Beijing 100040China School of Grassland Science Beijing Forestry UniversityBeijing 100083China Urat Desert-grassland Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China Department of Biology and Graduate Degree Program in Ecology Colorado State UniversityFort CollinsCO 80523USA College of Grassland Resource and EnvironmentalInner Mongolia Agricultural UniversityHohhot 010011China

评估极端干旱对优势植物物种光合速率(Pn)的影响对于我们理解极端干旱影响生态系统功能的机制至关重要。极端干旱可能由降雨量减少或降雨频率减少造成。这两种不同模式的极端干旱可能造成不同的影响。此外,不同草原类型可能对这两种极... 详细信息

评估极端干旱对优势植物物种光合速率(Pn)的影响对于我们理解极端干旱影响生态系统功能的机制至关重要。极端干旱可能由降雨量减少或降雨频率减少造成。这两种不同模式的极端干旱可能造成不同的影响。此外,不同草原类型可能对这两种极端干旱模式表现出不同的敏感性。然而,目前尚不清楚这两种极端干旱模式对草原优势植物物种Pn的影响有何差异,以及在不同草原类型这两种不同模式的极端干旱的效应是否改变。为此,我们于2014年在内蒙古草原两个不同类型的草原(荒漠草原vs.典型草原)站点各进行了一项多年的极端干旱(CHR:将生长季期间每次降雨事件的降雨量减少66%***:完全排除生长季内一段较短时间的降水)模拟实验。于2017年的7月和8月,我们在这两个草原站点各测量了两种优势物种的Pn。结果发现,CHR和INT均显著降低了优势物种的Pn。无论草原类型如何,INT对Pn造成的负面影响都更大。在荒漠草原,极端干旱对Pn的负面影响普遍大于典型草原,尤其是对于CHR处理下的羊草(Leymus chinensis)。这些结果表明,与降雨量减少相比,降雨频率减少所引起的极端干旱对Pn的负面影响更大。草地类型可能会改变极端干旱模式效应的程度,但不会改变其方向。这些发现强调了应对未来极端干旱的草原生态系统管理应考虑极端干旱模式和草地类型的影响。

关键词：极端气候荒漠草原典型草原极端干旱模式季节性干旱

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出色的问题解决者——伊莱亚斯·梅亚

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中国花卉园艺 2024年第8期 27-29页

作者：王新悦(译) Patrick alan Coleman 不详

1987年,在墨西哥萨卡特卡斯州(Zacatecas)南部地区的一个小城镇,15岁的伊莱亚斯·梅亚(Elias Mejia)面临选择一一是继续上学,还是像他的哥哥们一样早早开始出去闯荡。他从小参与某种形式的农场工作,和家人一起种植玉米和豆类,这是当地... 详细信息

1987年,在墨西哥萨卡特卡斯州(Zacatecas)南部地区的一个小城镇,15岁的伊莱亚斯·梅亚(Elias Mejia)面临选择一一是继续上学,还是像他的哥哥们一样早早开始出去闯荡。他从小参与某种形式的农场工作,和家人一起种植玉米和豆类,这是当地的传统。不过,他想要挑战自己,最终选择外出打拼。

关键词：萨卡特卡斯梅亚伊莱亚斯小城镇问题解决者墨西哥

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日记的教育价值——朱永新与剑桥大学社会人类学系艾伦•麦克法兰教授的对话

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华东师范大学学报（教育科学版） 2024年第2期42卷 119-126页

作者：朱永新 [英]艾伦•麦克法兰苏州大学新教育研究院江苏苏州215123 剑桥大学社会人类学系英格兰剑桥郡CB21TN3

作为人们日常生活的重要组成部分,日记不仅是教育生活的记录方式,它也在历史研究和文化塑造中扮演至关重要的角色,但是,有关日记在个人成长、家庭传承、历史研究等方面的教育价值还没有得到充分挖掘。本文通过朱永新与剑桥大学社会人类... 详细信息

作为人们日常生活的重要组成部分,日记不仅是教育生活的记录方式,它也在历史研究和文化塑造中扮演至关重要的角色,但是,有关日记在个人成长、家庭传承、历史研究等方面的教育价值还没有得到充分挖掘。本文通过朱永新与剑桥大学社会人类学系教授艾伦·麦克法兰进行的对话,重申了日记在作为教育生活的记录方式、作为历史人类学的研究方法、作为促进师生成长的行动路径等方面所具有的重要教育价值,并解释了撰写日记的主要原因以及介绍了周记、月记、书信等日记的其他补充形式,最后结合新教育实验共读共写共同生活的理念提出了共同体写作的日记写作形式。

关键词：日记教育价值社会人类学共同体写作

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2024,“守正出奇”方成大事!

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中国会展 2024年第3期 12-13页

作者：兰宇鑫不详

1月17日,国家统计局发布了2023年经济发展成绩单。数据显示2023年我国GDP增速为5.2%,经济总量超过126万亿元,基本满足预期。这其中,值得会展人关注的制造业、服务业与消费领域发展同比均有增长。稳定的市场环境一方面反映出国家政策的... 详细信息

1月17日,国家统计局发布了2023年经济发展成绩单。数据显示2023年我国GDP增速为5.2%,经济总量超过126万亿元,基本满足预期。这其中,值得会展人关注的制造业、服务业与消费领域发展同比均有增长。稳定的市场环境一方面反映出国家政策的科学性、精准性与有力性,另一方面也对经济增长动力提出了新的要求。去年底,中央经济工作会议提出的方针引起经济社会的广泛关注。政策层面提出的“破”与“立”不仅显示出国家在应对当前经济产业发展变革的积极态度,也体现出应对国际经贸环境复杂多变的决心与勇气。在政策大环境的积极倡导下,服贸业发展迈向新阶段。而作为服贸领域重要载体的会展业,也迎来新的发展机遇期。因此,2024年中国会展业面对新的环境该如何发展,已成为焦点。

关键词：经济增长动力国际经贸国家统计局中国会展业数据显示经济产业发展服务业精准性

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会展推动高水平对外开放

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中国会展 2024年第20期 10-11页

作者：兰宇鑫不详

2024年11月5日至10日,万众瞩目的第七届中国国际进口博览会(简称:进博会)在上海举办。而作为第七届进博会上海市会议活动配套论坛的第七届中国会展业国际经贸论坛也同期举办。本届论坛的主题设定为“会展推动高水平对外开放”,旨在凸显... 详细信息

2024年11月5日至10日,万众瞩目的第七届中国国际进口博览会(简称:进博会)在上海举办。而作为第七届进博会上海市会议活动配套论坛的第七届中国会展业国际经贸论坛也同期举办。本届论坛的主题设定为“会展推动高水平对外开放”,旨在凸显会展业在促进开放方面起到的重要作用。当前,我国步入中国式现代化经济建设的起步阶段,因此把深化国际经贸交往与合作、推动经济全球化发展作为重要任务。

关键词：经贸论坛国际经贸中国会展业对外开放会展经济全球化发展博览会高水平

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