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Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease:A systematic review

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1408-1428页

作者： Gopalsamy Rajiv Gandhi Thiruchenduran Mohana Kumaraswamy Athesh Varghese Edwin Hillary alan bruno silva vasconcelos Mariana Nobre Farias de Franca Monalisa Martins Montalvão Stanislaus Antony Ceasar Gnanasekaran Jothi Gurunagarajan Sridharan Ricardo Queiroz Gurgel Baojun Xu Division of Phytochemistry and Drug Design Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Department of Biochemistry Meenakshi Ammal Dental College and Hospital(MAHER)Maduravoyal600095ChennaiTamil NaduIndia Department of Biochemistry Srimad Andavan Arts and Science College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirapalli620005Tamil NaduIndia Division of Plant Molecular Biology and Biotechnology Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Laboratory of Biology and Immunology of Cancer and Leishmania Department of MorphologyFederal University of SergipeSao CristovaoSergipeBrazil Postgraduate Program in Health Sciences(PPGCS) Federal University of Sergipe(UFS)Campus Prof.Joao Cardoso NascimentoAracajuCEP 49060.108SergipeBrazil Programme of Food Science and Technology Department of Life SciencesBNU-HKBU United International CollegeZhuhaiGuangdong519087China

This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules in managing inflammatory bowel disease(IBD).Specifically,the objective is to examine the impact of these substances on interleukins and other key inflammatory signaling *** articles published up to December 2022 were identified through a search of the PubMed,Scopus,Web of Science,and Embase *** search used keywords including“inflammatory bowel disease”,“medicinal plants”,“natural molecules”,“anti-inflammatory”,and“ulcerative colitis”,and identified 1,878 potentially relevant articles,of which 89 were included in this review after completion of the selection *** study provides preclinical data on natural products(NPs)that can potentially treat IBD,including ulcerative *** main actions of these NPs relate to their effects on nuclear factor kappa B(NF-κβ),the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway,the regulation of T helper 17/regulatory T cells balance,and oxidative *** ability of these NPs to inhibit intestinal inflammation appears to be dependent on lowering levels of the pro-inflammatory cytokines tumor necrosis factor-alpha(TNF-α),interleukin(IL)-1β,and IL-17,via the Jun N-terminal kinase(JNK)1,NF-κβ-p65,and STAT3 *** addition,NPs were shown to reduce oxidative stress and the severity of ulcerative colitis,as well as increase the activity of antioxidant *** actions suggest that NPs represent a promising treatment for IBD,and potentially have greater efficacy and safety than current treatments.

关键词： Crohn's disease Inflammation Interleukins Oxidative stress Phytochemicals Ulcerative colitis

Spatial-temporal distribution of fatal yellowing in different oil palm genetic materials in eastern amazon

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Information Processing in Agriculture 2022年第3期9卷 365-377页

作者： bruno Borella Anhe Artur Vinicius Ferreira dos Santos Thiago alan Ferreira da silva Lana Leticia Barbosa de Carvalho Paulo Roberto silva Farias Universidade Federal Rural da Amazonia Geoestatistics Department66.077-830 BelemBrazil Universidade Federal Rural da Amazonia Entomology Department66.077-830 BelemBrazil

Oil palm (Elaeis guineensis Jacq.) is one of the agricultural crops with the greatest potentialfor vegetable oil production in Brazil. However, a disease of unknown etiology popularlyknown as Fatal Yellowin (FY) has caused damage to Brazilian farmers particularly in theeastern region of the Amazon. So, the objective of this study was to evaluate the spatialdependence of FY on three oil palm genotypes, grown for many years in an organic produc-tion system in the Amazon region. The study area had 4104 ha, divided into 139 plots. Ineach plot, the monthly incidence of disease was monitored forming a database. The num-ber of diseased plants per year, number of accumulated diseased plants, number of dis-eased plants per hectare, growth rate of diseased plants and incidence of accumulateddisease were evaluated. The results indicated spatial distribution of the variables adjustedto the gaussian, spherical and exponential models, with predominance of the first *** increases the purpose that FY is caused by biotic factors. The highest range achievedin the study was 2929 m indicating the susceptibility of the tested genotypes. Some plotsclose to the river had the highest incidence of the disease on the study, probably associatedwith higher soil moisture.

关键词： Elaeis guineensis Geostatiscal analysis Kriging Palm oil Spatial dependence

Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal bruno Lima Rodrigues Marina Moreira de Castro alan Sidnei Corrêa Martins Dante Orsetti silva Araújo Luis Eduardo Miani Gomes Michel Gardere Camargo Maria de Lourdes Setsuko Ayrizono Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(P<0.0001),and in 44%,there was an increase of≥2 g/dL in a single *** addition,86%of the patients showed an increase in serum iron(P<0.0001)and ferritin(P=0.0008)and 50%in transferrin saturation(P=0.01).The serum iron levels at baseline showed a negative association with the ileal and colonic CD and use of biologics and a positive association with patients who developed CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

Experience of more than 3000 cycles of Brazilian women using the contraceptive vaginal ring (nuvaring<sup>®</sup>)

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Open Journal of Obstetrics and Gynecology 2014年第1期4卷 10-15页

作者： Denise Leite Maia Monteiro Ricardo vasconcelos bruno Zuleide A. F. Cabral Célia Regina da silva Danielle Bittencourt Sodré Barmpas Nádia Cristina Pinheiro Rodrigues Gynecology and Obstetrics Department Universidade do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Gynecology and Obstetrics Department Universidade Federal de Mato Grosso (UFMT) Cuiabá Brazil Obstetrics Department Maternidade Escola Universidade Federal do Rio de Janeiro (ME-UFRJ) Rio de Janeiro Brazil Ongoing MSc at UERJ Rio de Janeiro Brazil Public Health Researcher of Instituto Oswaldo Cruz (FIOCRUZ)/Universidade do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Reproduction Department Institutode Ginecologia Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil

Objective: To evaluate the profile of the Brazilianvaginal ring user, reasons for choosing it, satisfaction, menstrual pattern, tolerability, efficacy, side effects and reasons for discontinuation. Methods: We reviewed the files of 148 users who attended the Hospital de Jacarepaguáand private clinics, between 2005 and 2011, in a total of 3107 cycles. Kaplan-Meier survival curves and regression models were used in statistical analysis. Results: The profile was: single, nulligravida, 30 years (mean) and with university education. The previous contraception used was mostly the oral hormonal contraception (75.7%). Women chose the ring for: practicality (32.4%), forgetting the pill (32.4%) and irregular vaginal bleeding (13.5%). The satisfaction degree was 80.5% (119). There were good cycle control and no pregnancies. Thirty-eight patients discontinued the use (25.7%). The main reasons were wish for pregnancy (6%), spotting (3.4%) and increased vaginal discharge (2.7%). At the end of the first year, use of the greatest reduction of continuity probability was observed (19.3%). Women with side effects were 68% less likely to be satisfied with the method than those without (p-value Conclusion: Nuvaring®is an excellent contraceptiveoption due to its sefficacy, cycle control, tolerability, practicality and safety.

关键词： Vaginal Ring Hormonal Contraception Efficacy Tolerability

Family Organization in the Care of Pediatric Heart Transplant Patients:The Genogram as an Investigative Tool

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Health 2015年第11期7卷 1409-1418页

作者： silvania Braga Ribeiro Angela Maria Alves e Souza Ana Ruth Macedo Monteiro Kiarelle Lourenco Penaforte Sarah Maria de Sousa Feitoza Virna Ribeiro Feitosa Cestari Flávia Paula Magalhaes Monteiro Maria Gyslane vasconcelos Sobral Samila Torquato Araújo Máguida Gomes da silva Mona Lisa Menezes bruno Islene Victor Barbosa Isabelle Barbosa Pontes Department of Nursing Universidade de FortalezaFortalezaBrazil

This study aimed to describe structure, functionality and development of pediatric heart transplant families, from the understanding of the experienced chronic condition. A descriptive, exploratory study using a qualitative approach was developed in a hospital situated in a city of Northeast Brazil, in 2012. The study was conducted with three families, using the Calgary Family Assessment Model (CFAM). In addition to the genogram, an analysis of the children’s/adolescents’ family members was conducted at the time of interview. Two families were binuclear families and one was mononuclear. From the evaluation, it was possible to determine the care and support network of children and adolescents with heart transplants, as well as some difficulties faced by the investigated families. Nurses are important in this family context since the visualization of the family genogram can generate a change in the nursing care to each family.

关键词： Chronic Disease Heart Transplant Child Family Nursing Assessment