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Nutritional modulation of the inflammatory response in inflammatory bowel disease-From the molecular to the integrative to the clinical

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World Journal of Gastroenterology 2007年第1期13卷 1-7页

作者： Gary E Wild Laurie Drozdowski Carmela Tartaglia M Tom Clandinin alan br thomson Department of Medicine Division of Gastroen- terology McGill University Montreal Quebec Department of Anatomy and Cell Biology McGill University Montreal Quebec Canada Division of Gastro- enterology University of Alberta Edmonton Alberta Canada Department of Physiology McGill Univer- sity Montreal Quebec Canada Department of Agriculture Foods and Nutri- tion University of Alberta Edmonton Alberta Canada

Nutrient deficiencies are common in patients with inflammatory bowel disease （IBD）. Both total parenteral and enteral nutrition provide important supportive therapy for IBD patients, but in adults these are not useful for primary therapy. Dietary intervention with omega-3 polyunsaturated fatty acids contained in fish oil may be useful for the care of IBD patients, and recent studies have slyessed the role of PPAR on NFKB activity on the potential beneficial effect of dietary lipids on intestinal function.

关键词： Crohn's disease Ulcerative colitis Enteral nutrition Parenteral nutrition Glutamine Fiber Long chain fatty acids

Recent advances in small bowel diseases:Part Ⅰ

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World Journal of Gastroenterology 2012年第26期18卷 3336-3352页

作者： alan br thomson Angeli Chopra Michael Tom Clandinin Hugh Freeman Department of Medicine University of Western OntarioLondonON N6A 5A5Canada Division of General Internal Medicine University of AlbertaEdmontonAB T6G 2X8Canada Department of Agricultural Foodand Nutritional ScienceUniversity of AlbertaEdmontonAB T6G 2R1Canada Division of Gastroenterology University of British ColumbiaVancouverBC V6T 2B5Canada

As is the case in all parts of gastroenterology and hepatology,there have been many advances in our knowledge and understanding of small intestinal *** 1000 publications were reviewed for 2008 and 2009,and the important advances in basic science as well as clinical applications were *** Part Ⅰ of this Editorial Review,seven topics are considered:intestinal development;proliferation and repair;intestinal permeability;microbiotica,infectious diarrhea and probiotics;diarrhea;salt and water absorption;necrotizing enterocolitis;and immunology/*** topics were chosen because of their importance to the practicing physician.

关键词： Diarrhea Infectious diarrhea Intestinal development Intestinal proliferation and repair Intestinalpermeability Microbiotica Necrotizing enterocolitis Probiotics

Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe alan br thomson M Tom Clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of Laboratory Medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of Medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold

关键词： Ganglioside Phospholipid Fatty acid Lipid Inflamma

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英国入学资格考试的利与弊

世界教育信息 2004年第12期17卷 47-48页

作者： alan thomson 文慧北京利丰源文化中心

“我们正处于危机关头。”伯明翰大学法律学院招生办负责人提姆·凯(Tim Kaye)在总结了众多负责大学招生工作的同行的观点后如是说。

关键词：入学资格招生工作学法学院考试大学同行利与弊负责人危机

Handbook of Stem Cells

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基于WebofScience分类的跨学科测度研究

丛书名： v. 1

2004年

作者： Robert Lanza John Gearhart brigid Hogan Douglas Melton Roger Pedersen James thomson Michael West

ISBN: (数字)9780080533735

ISBN: (纸本)9780124366435

New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, John Gearhart, brigid Hogan, Douglas Melton, Malcolm Moore, Roger Pedersen, E. Donnall Thomas, James thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin Pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, alan Trounson, and Leonard Zon. This comprehensive set should be a much-needed addition to the library of students and researchers alike.

关键词： Stem cells.

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科研管理 2016年第3期37卷 124-132页

作者：黄颖高天舒王志楠汪雪锋 alan L. Porter 朱东华北京理工大学知识管理与数据分析实验室北京100081 北京理工大学管理与经济学院北京100081 佐治亚理工理工学院公共政策学院美国亚特兰大30332

在全球知识经济发展的大背景下,跨学科研究的深度和广度已经成为影响创新进程的一个重要因素,对于国家的社会经济发展和学术成长具有重要的影响。本文在梳理当前国内外跨学科测度研究的基础上,基于汤森路透(thomson Reuters)科学引文索... 详细信息

在全球知识经济发展的大背景下,跨学科研究的深度和广度已经成为影响创新进程的一个重要因素,对于国家的社会经济发展和学术成长具有重要的影响。本文在梳理当前国内外跨学科测度研究的基础上,基于汤森路透(thomson Reuters)科学引文索引(SCI)以及社会科学引文索引(SSCI)中的Web of Science分类,从学科专业化指数、学科集成指数和学科扩散指数三个方面来衡量研究的跨学科性,并通过科学地图可视化的方法来展示跨学科研究的学科分布特征。最后,本文选取2005年至2014年诺贝尔物理学奖获得者所著文献作为实证案例,通过构建的测度指标来研究这些顶级学者论文的跨学科特征。研究结果表明物理学的创新性成果具有明显的学科特征,诺贝尔物理学奖获得者们的研究成果总体上专注于物理学科领域,学科的集成程度和扩散程度还处于较低水平。

关键词：跨学科科学计量 Web of Science分类诺贝尔学奖

2010年世界胃肠病学组织关于炎症性肠病诊断和治疗的实践指南

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胃肠病学 2010年第9期15卷 548-558页

作者： Charles N.Bernstein Michael Fried J.H.Krabshuis Henry Cohen R.Eliakim Suleiman Fedail Richard Gearry K.L.Goh Saheed Hamid Aamir Ghafor Khan A.W.LeMair Malfertheiner Qin Ouyang J.F.Rey Ajit Sood Flavio Steinwurz Ole O.Thomsen alan thomson Gillian Watermeyer 杨钊斌杨川华钱本余

炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和... 详细信息

炎症性肠病(IBD)是一组特发性、慢性、炎症性肠道疾病状态,包括两种主要类型:克罗恩病(CD)和溃疡性结肠炎(UC),两者的临床和病理特征既有重叠又有区别。IBD过去常见于发达国家,近几十年,发展中国家的患病率逐步上升。本指南就IBD诊断和治疗方面提出的独特议题在当前的文献和指南中几乎从未被提及。由于各地区的IBD临床特点差异较大,因此根据患者的主诉诊断IBD或评估疾病活动度需随地区的变化而变化。同样,治疗亦应根据疾病的分类和当地医疗资源进行调整。世界胃肠病学组织根据世界各国医疗资源的差异,采用级联方法制订了IBD的诊疗指南。

关键词：炎症性肠病克罗恩病溃疡性结肠炎实践指南级联