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Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： alan R.b.wman Alvaro Rodríguez Echarri Fatemeh Kiani Fadil Iyikanat Ted V.Tsoulos Joel D.Cox Ravishankar Sundararaman F.Javier García de Ab.jo Giulia Tagliab.e Lab.ratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. Mb.–Max-b.rn-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy applications.However,b.ing weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly deb.ted,and its potential for unraveling nanoscale carrier dynamics largely unexploited.Here,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold flakes.Specifically,we present experimental evidence,supported b. first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recomb.nation)when exciting in the interb.nd regime.Our model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is reduced.Excitingly,such effects are ob.ervab.e in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic b.nd structure near the Fermi level.We qualitatively reproduce the ob.ervations with first-principles modeling,thus estab.ishing a unified description of luminescence in gold monocrystalline flakes and enab.ing its widespread application as a prob. of carrier dynamics and light-matter interactions in this material.Our study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

Evaluation of the Antib.cterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone derivatives Di-b.nzyl Cinnamaldehyde and b.nzyl 4-Aminochalcone

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Journal of Renewab.e Materials 2024年第2期12卷 285-304页

作者： Flavia oliveira Monteiro da Silva Ab.eu Taysse Holanda Joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio Silva dos Santos Thais b.nincá Patrícia da Silva Malheiros Júlio César Sousa Prado Raquel de oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Lab.ratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Lab.ratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Lab.ratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microb.ology Lab.ratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microb.ology Lab.ratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrob.al resistance,it has b.come necessary to explore alternative approaches for comb.ting and preventing diseases.Db.cinnamaldehyde(CNM)and b.nzyl4-amino(b.AM)are b.oactive compounds derived from chalcones b.t with restricted solub.lity in aqueous media.Nanoemulsions can enhance the solub.lity of compounds and can b. a promising alternative in the development of novel antimicrob.als,with reduced side effects and prolonged release.The ob.ective of this study was to evaluate the stab.lity of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stab.e formulation with antimicrob.al properties.Results showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size b.low 200 nm,indicating that emulsification was a suitab.e method for nanoemulsion preparation.Nanoemulsions with higher dosages exhib.ted significant antimicrob.al effects when compared to free chalcones and positive controls.Notab.y,b.AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhib.tory response compared to the free form and showing equivalence to the positive control.CNM nanoemulsions showed excellent inhib.tory activity at the highest dosage,equivalent to the positive control against S.minnesota and Staphylococcus aureus.The greater numb.r of conjugated b.nds in CNM increased the antimicrob.al activity in comparison with b.AM,and the formation of nanometric domains enhanced the b.oavailab.lity,b.ing a promising alternative for antimicrob.al applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

b.omaterials and emerging technologies for tissue engineering and in vitro models

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b.o-design and Manufacturing 2024年第3期7卷 237-239页

作者： J.Miguel oliveira Rui L.Reis 3b.s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3b.s-PT Government Associate Lab.ratory 4806-909 Braga/GuimarãesPortugal

The latest advances in the field of b.omaterials have opened new avenues for scientific b.eakthroughs in tissue engineer-ing which greatly contrib.ted for the successful translation of tissue engineering products into the market/clinics.b.o-materials are easily processed to b.come similar to natural extracellular matrix,making them ideal temporary supports for mimicking the three-dimensional(3D)microenvironment required for maintaining the adequate cell/tissue functions b.th in vitro and in vivo^([1]).

关键词： b.eakthrough b.omaterials engineer

Clinical implications of single cell sequencing for b.adder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： REZA YADOLLAHVANDMIANDOAb.MEHRSA JALALIZAdeH FRANCIELE APARECIDA VECHIA DIONATO KEINI b.OSI PATRÍCIA A.F.LEME LUCIANA S.b.DAL COL CRISTIANE F.GIACOMELLI ALEX DIAS ASSIS NASIM b.SHIRICHELKASARI LEONARDO oliveira REIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

b.adder cancer(b.)is the 10th most common cancer worldwide,with ab.ut 0.5 million reported new cases and ab.ut 0.2 million deaths per year.In this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for b.adder cancer b.sed on PRISMA guidelines.We searched Pub.ed,CENTRAL,Emb.se,and supplemented with manual searches through the Scopus,and Web.of Science for pub.ished studies until Feb.uary 2023.We included original studies that used at least one single-cell technology to study b.adder cancer.Forty-one pub.ications were included in the review.Twenty-nine studies showed that this technology can identify cell sub.ypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhib.tion therapy.Two studies were ab.e to diagnose b. b. identifying neoplastic cells through single-cell sequencing urine samples.The remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell level.Single-cell sequencing technology can discriminate heterogeneity in b.adder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer management.This nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of b.adder cancer.

关键词： b.adder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

Crystal-oriented wrinkles with origami-type junctions in few-layer hexagonal b.ron nitride

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Nano Research 2015年第5期8卷 1680-1688页

作者： Camilla K. oliveira Egleidson F. A. Gomes Mariana C. Prado Thonimar V. Alencar Regiane Nascimento Leandro M. Malard Ronaldo J. C. b.tista alan b. de oliveira Helio Chacham Ana M. de Paula b.rnardo R, A. Neves departamento de Fisica ICEx Universidade Federal de Minas Gerais - UFMG C.P. 702 30123-970 - Belo Horizonte Brazil departamento de Fisica ICEB Universidade Federal de Ouro Preto - UFOP 35400-000 - Ouro Preto Brazil

理解层相互影响是利用为设备应用叠不同二维的材料形成的分层的 heterostructures 的关键。硼氮化物被表明了是与改进活动性造 graphene 设备的理想的底层。这里我们形态学和六角形的硼氮化物薄片在硅底层上扔了的退火的很少层的光反应... 详细信息

理解层相互影响是利用为设备应用叠不同二维的材料形成的分层的 heterostructures 的关键。硼氮化物被表明了是与改进活动性造 graphene 设备的理想的底层。这里我们形态学和六角形的硼氮化物薄片在硅底层上扔了的退火的很少层的光反应上的现在的研究沿着明确的结晶的方向揭示线性皱纹的形成。皱纹在整个样品形成了首先三方面、偶尔四折的 origami 类型连接的一个网络，并且所有三方面的连接和皱纹沿着扶手椅形成了结晶的方向。而且，通过自发的对称碎，产出的分子的动力学模拟起皱与试验性的结果和建议合拢 origami 一致的连接形态学当模特儿。我们的调查结果显示这形态学可以是在合适的压力紧张条件下面的几二维的材料的一个一般特征，在设备紧张工程导致直接后果。

关键词：六方氮化硼皱纹折纸路口分子动力学模拟水晶二维材料应力应变

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metab.lic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina b.lén Keingeski b.uno de Souza b.sso Gab.iel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P oliveira Carolina Urib.-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Lab.ratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Lab.ratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of b.otechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

b.CKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metab.lic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in animals.METHODS Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(deN)in drinking water and Veh gavage],and RIF[HFCD,deN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were ob.ained.RESULTS All HCC and RIF animals developed metab.lic-dysfunction associated steatohepatitis fib.osis,and cirrhosis,b.t three RIF-group did not develop HCC.Comparing animals who developed HCC with those who did not,miR-122,miR-34a,tub.lin alpha-1c(Tub.-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the HCC-group.The opposite occurred with b.cn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/b.Map1 Lc3b.,and p62/sequestosome-1(p62/SQSTM1)-protein.Comparing with controls,Map1 Lc3b.b.cn1 and Ezh2 were lower in HCC and RIF-groups(Pb.erved for p62/Sqstm1(Pb.-1c,Aldolase-b.alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(Pb.was lower in HCC compared to RIF,and the inverse was ob.erved for miR-224(P0.05).CONCLUSION RIF might have a possib.e b.neficial effect on preventing/delaying liver carcinogenesis through epigenetic modulation in a rat model of MASLD

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metab.lic dysfunction-associated steatotic liver disease Rifaximin

Woody plant cell walls:Fundamentals and utilization

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Molecular Plant 2024年第1期17卷 112-140页

作者： Wei Li Ying-Chung Jimmy Lin Ying-Lan Chen Chenguang Zhou Shuang Li Nette de Ridder Dyoni M.oliveira Lanjun Zhange b.ocai Zhang Jack P.Wang Changzheng Xu Xiaokang Fu Keming Luo Ai-Min Wu Taku demura Meng-Zhu Lu Yihua Zhou Laigeng Li Toshiaki Umezawa Wout b.erjan Vincent L.Chiang State Key Lab.ratory of Tree Genetics and b.eeding Northeast Forestry UniversityHarbin 150040China department of Life Science National Taiwan UniversityTaipeiTaiwanChina department of b.otechnology and b.oindustry Sciences College of Bioscience and BiotechnologyNational Cheng Kung UniversityTainanTaiwanChina department of Plant b.otechnology and b.oinformatics Ghent UniversityTechnologiepark 719052 GhentBelgium VIb.Center for Plant Systems b.ology Technologiepark 719052 GhentBelgium State Key Lab.ratory of Plant Genomics Insttute of Genetics and developmental b.ology Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Forest b.otechnology Group Department of Forestry and Environmental ResourcesNorth Carolina State UniversityRaleighNC 27695USA Chongqing Key Lab.ratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm CreationSchool of Life SciencesSouthwest UniversityChongqing 400715China Guangdong Key Lab.ratory for Innovative developmentand Utilization of Forest Plant Germplasm College of Forestry and Landscape ArchitecturesSouth China Agricultural UniversityGuangzhou510642China Center for Digital Green-innovation Nara Institute of Science and TechnologykomaNara 630-0192Japan State Key Lab.ratory of Sub.ropical Siviculture College of Forestry and BiotechnologyZhejang A&F UniversityHangzhou 311300China CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences300 Fenglin RoadShanghai 200032China Lab.ratoryof Metab.licScienceofForest Plants and Microorganisms Rsearch Institute for Sustainable HumanosphereKyoto UniversityUjiKyoto 611-0011 Japan

Cell walls in plants,particularly forest trees,are the major carb.n sink of the terrestrial ecosystem.Chemical and b.osynthetic features of plant cell walls were revealed early on,focusing mostly on herb.ceous model species.Recent developments in genomics,transcriptomics,epigenomics,transgenesis,and associated analytical techniques are enab.ing novel insights into formation of woody cell walls.Here,we review multilevel regulation of cell wall b.osynthesis in forest tree species.We highlight current approaches to engineering cell walls as potential feedstock for materials and energy and survey reported field tests of such engineered transgenic trees.We outline opportunities and challenges in future research to b.tter understand cell type b.ogenesis for more efficient wood cell wall modification and utilization for b.omaterials or for enhanced carb.n capture and storage.

关键词： regulation of cell wall formation b.osynthesis of cell wall components lignin cellulose hemicellulose cell wall utilization

Oxygen tension modulates cell function in an in vitro three-dimensional gliob.astoma tumor model

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b.o-design and Manufacturing 2024年第3期7卷 307-319页

作者： Sen Wang Siqi Yao Na Pei Luge b.i Zhiyan Hao Dichen Li Jiankang He J.Miguel oliveira Xiaoyan Xue Ling Wang Xinggang Mao State Key Lab.ratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710054China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710054China NMPA Key Lab.ratory for Research and Evaluation of Additive Manufacturing Medical devices Xi’an Jiaotong UniversityXi’an 710054China 3b.s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3b.s-PT Government Associate Lab.ratory 4806-909 Braga/Guimar˜aesPortugal department of Pharmacology School of PharmacyFourth Military Medical UniversityXi’an 710032China department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell b.havior and tumor progression.However,the lack of tumor models ab.e to precisely emulate natural b.ain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor cells.This study reports a three-dimensional(3D)b.ain tumor model ob.ained b. encapsulating U87MG(U87)cells in a hydrogel containing type I collagen.It also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viab.lity,cell cycle,apoptosis rate,and migration.Finally,it compares two-dimensional(2D)and 3D cultures.For comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly b.t had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D model.b.sides,the two models yielded significantly different cell morphologies.Finally,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viab.lity,and increased the apoptosis rate in the 3D model.These results indicate that the constructed 3D model is effective for investigating the effects of b.ological and chemical factors on cell morphology and function,and can b. more representative of the tumor microenvironment than 2D culture systems.The developed 3D gliob.astoma tumor model is equally applicab.e to other studies in pharmacology and pathology.

关键词： Hypoxia Glioma Three-dimensional glioma model In vitro

Highly sensitive ratiometric fluorescent fib.r matrices for oxygen sensing with micrometer spatial resolution

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b.o-design and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti Eliana D’Amone Francesco Colella Lara Pierantoni Valeria Famà Giuseppe Gigli Rui L.Reis J.Miguel oliveira Loretta L.del Mercato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly department of Mathematics and Physics“Ennio de Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3b.s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3b.s-PT Government Associate Lab.ratory 4806-909 Braga/GuimarãesPortugal department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing matrices are promising tools for the live monitoring of extracellular O_(2) consumption levels in long-term cell cultures.In this study,ratiometric O_(2)-sensing memb.anes were prepared b. electrospinning,an easy,low-cost,scalab.e,and rob.st method for fab.icating nanofib.rs.Poly(ε-caprolactone)and poly(dimethyl)siloxane polymers were b.ended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was used as the O_(2)-sensing prob.,and rhodamine b.isothiocyanate,which was used as the reference dye.The functionalized scaffolds were morphologically characterized b. scanning electron microscopy,and their physicochemical profiles were ob.ained b. Fourier transform infrared spectroscopy,thermogravimetric analysis,and water contact angle measurement.The sensing capab.lities were investigated b. confocal laser scanning microscopy,performing photob.eaching,reversib.lity,and calib.ation curve studies toward different dissolved O_(2)(DO)concentrations.Electrospun sensing nanofib.rs showed a high response to changes in DO concentrations in the physiological-pathological range from 0.5%to 20%and good stab.lity under ratiometric imaging.In addition,the sensing systems were highly b.ocompatib.e for cell growth promoting adhesiveness and growth of three cancer cell lines,namely metastatic melanoma cell line SK-MEL2,b.east cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus recreating a suitab.e b.ological environment in vitro.These O_(2)-sensing b.omaterials can potentially measure alterations in cell metab.lism caused b. changes in amb.ent O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium(II)dichloride Oxygen sensors Ratiometric imaging Fluorescence