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Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo Sánchez tala alakhras Barbara Schreier Michael Gekle Stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

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A Multi-Stage Secure IoT Authentication Protocol

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Computer Systems Science & Engineering 2023年第4期45卷 459-481页

作者： Khalid Alhusayni Raniyah Wazirali Mousa alakhras Marwah Almasri Samah Alhazmi College of Computing and Informatics Saudi Electronic UniversityRiyadh11673Saudi Arabia King Abdullah II School for Information Technology The University of JordanAmman11942Jordan

The Internet of Things(IoT)is a network of heterogeneous and smart devices that can make decisions without human *** can connect millions of devices across the *** ability to collect information,perform analysis,and even come to meaningful conclusions without human capital intervention *** circumstances require stringent security measures and,in particular,the extent of *** applied in the IoT paradigm point out high-interest levels since enormous damage will occur if a malicious,wrongly authenticated device finds its way into the IoT *** research provides a clear and updated view of the trends in the IoT authentication *** the issues covered include a series of authentication protocols that have remained research gaps in various *** study applies a comparative evaluation of authentication protocols,including their strengths and ***,it forms the foundation in the IoT authentication field of *** that direction,a multi authentication architecture that involves secured means is proposed for protocol *** analysis can affect the security of the ***-Abadi-Needham(BAN)logic provides proof of the attainment of mutual ***3 simulator tool is used to compare the performance of the proposed protocol to verify the formal security offered by the BAN logic.

关键词： Internet of Things(IoT) security authentication BAN logic sensor networks

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非遗视域下潮绣核心文化要素的系统性创新设计研究

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江苏丝绸 2024年第3期53卷 42-46,22页

作者：杨秋华安刚袁塔拉深圳职业技术大学艺术设计学院广东深圳518055

潮绣作为中国传统民间刺绣艺术的瑰宝,其蕴含的文化要素与技艺具有浓厚的地域特征和特有的审美特质。本研究在广泛梳理潮绣传统核心文化要素的基础上,系统地构建了创新设计框架,探究了如何将传统潮绣元素与现代设计进行有效结合的具体... 详细信息

潮绣作为中国传统民间刺绣艺术的瑰宝,其蕴含的文化要素与技艺具有浓厚的地域特征和特有的审美特质。本研究在广泛梳理潮绣传统核心文化要素的基础上,系统地构建了创新设计框架,探究了如何将传统潮绣元素与现代设计进行有效结合的具体方向和策略,为推动非遗文化的现代转化提供了理论支撑,验证了在非遗保护与创意设计领域可行的实践路径。

关键词：非遗——潮绣核心文化要素创新设计

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内蒙古林草过渡区欧亚绣线菊和土庄绣线菊叶绿体基因组比较研究

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北京林业大学学报 2024年第3期46卷 103-114页

作者：宋晴宿逸然王铁梅胥健梁留喜董昊野邰塔拉北京林业大学草业与草原学院北京100083 内蒙古科尔沁草原生态系统国家定位观测研究站内蒙古兴安盟137400 北京林业大学草地资源与生态研究中心北京100083 内蒙古兴安盟林业和草原工作站内蒙古兴安盟137400 内蒙古科尔沁右翼前旗草原工作站内蒙古兴安盟137400 内蒙古科尔沁右翼前旗绿水种畜场繁育中心内蒙古兴安盟137400

【目的】我国是绣线菊属植物的现代分布和分化中心,欧亚绣线菊和土庄绣线菊是同域分布在内蒙古林草过渡区的两种绣线菊属植物,分析两个物种的叶绿体基因组差异可为鉴定同属植物亲缘关系提供依据。【方法】本研究采用二代测序技术,利用Il... 详细信息

【目的】我国是绣线菊属植物的现代分布和分化中心,欧亚绣线菊和土庄绣线菊是同域分布在内蒙古林草过渡区的两种绣线菊属植物,分析两个物种的叶绿体基因组差异可为鉴定同属植物亲缘关系提供依据。【方法】本研究采用二代测序技术,利用Illumina Novaseq 6000平台,通过组装、注释后得到两个物种完整的叶绿体全基因组序列,并利用生物信息学方法分析其序列结构并构建系统发育树。【结果】结果显示:欧亚绣线菊叶绿体序列全长为155916 bp,总GC含量为36.72%,土庄绣线菊叶绿体序列全长为155942 bp,总GC含量为36.76%。二者均注释得到130个基因,其中111个基因是独有的,包含78个蛋白质编码基因、29个tRNA基因和4个rRNA基因。欧亚绣线菊和土庄绣线菊分别检测到238和241个简单重复序列,以A或U结尾的密码子偏好性大于以G或C结尾的密码子偏好性,基因组变异区域主要分布于非编码区域。二者编码亮氨酸的密码子含量最多,半胱氨酸密码子含量最低。系统发育树结果显示:欧亚绣线菊和土庄绣线菊构成姐妹类群,存在较近的亲缘关系,绣线菊属与鲜卑花属亲缘关系较近,呈姐妹类群关系。【结论】研究结果可为绣线菊属植物的系统发育、分类鉴定和资源开发利用等相关研究提供基础资料。

关键词：欧亚绣线菊土庄绣线菊叶绿体基因组系统发育

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Exact transverse solitary and periodic wave solutions in a coupled nonlinear inductor-capacitor network

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Chinese Physics B 2018年第9期27卷 434-443页

作者： Serge Bruno Yamgoué Guy Roger Deffo Eric tala-Tebue Francois Beceau Pelap Department of Physics Higher Teacher Training College Bambili the University of Bamenda Unité de Recherche de Mécanique et de Modélisation des Systèmes Physiques (UR-2MSP) Faculté des Sciences Université de Dschang Department of Telecommunication and Network Engineering Fotso Victor University Institute of Technology The University of Dschang P.O. Box 134 Bandjoun Cameroon

Through two methods, we investigate the solitary and periodic wave solutions of the differential equation describing a nonlinear coupled two-dimensional discrete electrical lattice. The fixed points of our model equation are examined and the bifurcations of phase portraits of this equation for various values of the front wave velocity are presented. Using the sineGordon expansion method and classic integration, we obtain exact transverse solutions including breathers, bright solitons,and periodic solutions.

关键词： nonlinear electrical lattices two-dimensional network sine-Gordon expansion exact transverse solitary wave solutions

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Association between heavy metals and antibiotic-resistant human pathogens in environmental reservoirs: A review

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Frontiers of Environmental Science & Engineering 2019年第3期13卷 41-57页

作者： Christine C. Nguyen Cody N. Hugie Molly L. Kile tala Navab-Daneshmand Department of Environmental Sciences Oregon State University Corvallis OR 97331 USA School of Chemical Biological and Environmental Engineering Oregon State University Corvallis OR 97331 USA School of Biological and Population Health Sciences Oregon State University Corvallis OR 97331 USA

Antibiotic resistance in human pathogens can proliferate under selective pressures. Heavy metals in environmental reservoirs may contribute to selecting antibiotic-resistant strains. To determine the associations between heavy metals and antibiotic resistance, a literature review was conducted to systematically collect and categorize evidence for co-occurrence of resistance to heavy metals and antibiotics within human pathogenic bacteria in water, wastewater, and soil. In total, 42 publications adhered to inclusion criteria. Across the reservoirs, zinc and cadmium were the most commonly observed heavy metals associated with resistance to antibiotics. Pseudomonas aeruginosa and Escherichia coli were the most commonly studied bacteria with reported co-occurrence of resistance to several heavy metals and antibiotic classes. As co-selecting agents, prevalence of heavy metals in the environment can proliferate resistance to heavy metals and antibiotics through co-resistance and crossresistance mechanisms. In comparing different reservoirs, soils and sediments harbor higher heavy metal and antibiotic resistances compared to water environments. Additionally, abiotic factors such as pH can affect the solubility and hence, the availability of heavy metals to bacterial pathogens. Overall, our review demonstrates heavy metals act as co-selecting agents in the proliferation of antibiotic resistance in human pathogens in multiple environmental reservoirs. More studies that include statistical data are needed to further describe the exposure-response relationships between heavy metals and antibiotic resistance in different environmental media. Moreover, integration of culturebased and molecular-based methods in future studies are recommended to better inform our understanding of bacterial co- and cross-resistance mechanisms to heavy metals and antibiotics.

关键词： Zinc Cadmium Copper Lead E. coli P. aeruginosa

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兴安盟草原灌丛植被潜在适生区分布模拟分析

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草地学报 2024年第2期32卷 579-587页

作者：宋晴付鸿莉王铁梅宿逸然梁留喜通拉嘎胥健董昊野邰塔拉北京林业大学草业与草原学院北京100083 内蒙古科尔沁草原生态系统国家定位观测研究站内蒙古兴安盟137400 北京林业大学草地资源与生态研究中心北京100083 内蒙古兴安盟林业和草原工作站内蒙古兴安盟137400 内蒙古科尔沁右翼前旗草原工作站内蒙古兴安盟137400 内蒙古科尔沁右翼前旗绿水种畜场繁育中心内蒙古兴安盟137400

兴安盟位于大兴安岭向松嫩平原过渡带,是一道重要的草原生态保护屏障,兴安盟草原对于气候变化和人为干扰十分敏感,灌丛作为其原生植被受到外界干扰有可能会进一步扩张。为了探究影响兴安盟草原灌丛植被的环境因子,本研究基于61个兴安盟... 详细信息

兴安盟位于大兴安岭向松嫩平原过渡带,是一道重要的草原生态保护屏障,兴安盟草原对于气候变化和人为干扰十分敏感,灌丛作为其原生植被受到外界干扰有可能会进一步扩张。为了探究影响兴安盟草原灌丛植被的环境因子,本研究基于61个兴安盟草原灌丛分布点和22个环境因子,利用MaxEnt模型对兴安盟草原灌丛植被潜在适生区预测。结果表明,等温性、坡度、最干月降水量、年平均气温是影响兴安盟草原灌丛分布的主导环境因子。兴安盟灌丛植被潜在适生区主要分布于西部、西南部的科尔沁右翼前旗、中旗等地区;未来气候情境下,兴安盟草原灌丛总体分布将向高纬度地区延伸,灌木线向上爬升。当温室气体排放量持续增加时可能会引起兴安盟地区水分匮缺,导致草原灌丛高适生区面积大幅降低,部分高适生区向中、低适生区转化。

关键词： MaxEnt模型灌丛植被潜在适生区

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Diffusion analysis and modeling of kinetic behavior for treatment of brine water using electrodialysis process

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Water Science and Engineering 2021年第1期14卷 36-45页

作者： Fadi alakhras Emna Selmane Bel Hadj Hmida Ioannis Anastopoulos Zina Trabelsi Walid Mabrouk Noureddine Ouerfelli Jean François Fauvarque Department of Chemistry College of ScienceImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Laboratoire de Chimie Analytique et Electrochimie Departement de ChimieUniversite de Tunis El ManarTunis 2092Tunisia Department of Electronic Engineering School of EngineeringHellenic Mediterranean UniversityChania 73100Greece Laboratoire de Biophysique et Technologies Medicales Universite de Tunis El ManarTunis 1006Tunisia Laboratory of Water Membranes and Environmental BiotechnologySoliman 8020Tunisia Laboratoire d’Electrochimie Industrielle Conservatoire National des Arts et Metiers(CNAM)de ParisParis 75003France

In this study,the removal of monovalent and divalent cations,Nat,Kt,Mg2t,and Ca2t,in a diluted solution from Chott-El Jerid Lake,Tunisia,was investigated with the electrodialysis *** process was tested using two cation-exchange membranes:sulfonated polyether sulfone cross-linked with 10%hexamethylenediamine(HEXCl)and sulfonated polyether sulfone grafted with octylamine(S-PESOS).The commercially available membrane Nafion®was used for *** results showed that Nafion®and S-PESOS membranes had similar removal behaviors,and the investigated cations were ranked in the following descending order in terms of their demineralization rates:Nat>Ca2t>Mg2t>*** cations were more effectively removed by HEXCl than by monovalent *** plots based on the WebereMorris model showed a strong *** reveals that intra-particle diffusion was not the removal rate-determining step,and the removal process was controlled by two or more concurrent *** Boyd plots did not pass through their origin,and the sole controlling step was determined by film-diffusion resistance,especially after a long period of ***,a semi-empirical model was established to simulate the temporal variation of the treatment process,and the physical significance and values of model parameters were compared for the three *** findings of this study indicate that HEXCl and S-PESOS membranes can be efficiently utilized for water softening,especially when effluents are highly loaded with calcium and magnesium ions.

关键词： Ionic exchange membrane Electrodialysis Brine water Boyd diffusion model Intraparticle diffusion

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中医学专业预防医学课程思政的设计和评价

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中国中医药现代远程教育 2024年第12期22卷 11-14页

作者：宓伟李宁石塔拉韩春蕾滨州医学院公共卫生与管理学院山东烟台264003

在中医学专业教学设计中,预防医学课程围绕“立德树人”构建课程思政融入体系,通过增强教师团队课程思政意识和能力,实施结合线上课前引导、线下翻转课堂、线下实验教学和线上教学评价的混合式教学,并对2020级中医学专业学生进行预防医... 详细信息

在中医学专业教学设计中,预防医学课程围绕“立德树人”构建课程思政融入体系,通过增强教师团队课程思政意识和能力,实施结合线上课前引导、线下翻转课堂、线下实验教学和线上教学评价的混合式教学,并对2020级中医学专业学生进行预防医学课程思政教学效果评价,进一步完善了预防医学课程思政在中医学专业的教学设计,形成了预防医学课程思政与思政课程同向同行的课程新体系。

关键词：课程思政中医预防医学教学设计教学改革

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Modulational Instability in a Pair of Non-identical Coupled Nonlinear Electrical Transmission Lines

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Communications in Theoretical Physics 2013年第7期60卷 93-100页

作者： Eric tala-Tebue Aurelien Kenfack-Jiotsa Marius Herv Tatchou-Ntemfack Timolon Crpin Kofan Laboratory of Mechanics Department of Physics Faculty of Sciences University of YaoundI Nonlinear Physics and Complex Systems Group Department of Physics The Higher Teachers' Training College University of Yaounde I

In this work, we investigate the dynamics of modulated waves non-identical coupled nonlinear transmission lines. Traditional methods for avoiding mode mixing in identical coupled nonlinear electrical lines consist of adding the same number of linear inductors in each branch. Adding linear inductors in a single line leads to asymmetric coupled nonlinear electrical transmission lines which propagate the signal and the mode mixing. On one hand, the difference between the two lines induced the fission for only one mode of propagation. This fission is influenced by the amplitude of the signal and the amount of the input energy as well; it also narrows the width of the input pulse soliton, leading to a possible increasing of the bit rate. On the other hand, the dissymmetry of the two lines converts the network into a good amplifier for the ω_ mode which corresponds to the regime admitting low frequencies.

关键词： nonlinear lines mixing suppression fission

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