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外显生长指数

科学观察 2011年第1期6卷 7-11页

作者： Ronald rousseau 胡小君 KHBO(Association K.U.Leuven) Industrial Sciences and TechnologyZeedijk101B-8400OostendeBelgium University of Antwerp IBWVenusstraat35B-2000AntwerpenBelgium K.U.Leuven Dept.MathematicsCelestijnenlaan200BB-3000Leuven(Heverlee)Belguim 浙江大学公共管理学院浙江大学医学部医学信息中心

基于一篇文章所引用的参考文献和该文的被引频次两个维度,提出了衡量该文外显成长度的相对指标。该研究涉及的引用数据及每条参考文献的被引数据均来自网络版科学引文索引(Web of Science),检索日期为2010年4月最后一周。

关键词：引文分析外显生长指数参考文献被引频次

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h指数研究在2007-2008年的新进展

科学观察 2008年第3期3卷 19-25页

作者： Ronald rousseau 李志忠(翻译) KHBO (Association K.U. Leuven) Industrial Sciences and Technology Zeedijk 101 B-8400 Oostende Belgium.K.U. Leuven Steunpunt O&O Indicatoren Dekenstraat 2 B-3000 Leuven Belgium. 不详

该文对近期(2007-2008年)h指数及其衍生指数的发展进行了简单的回顾。

关键词： h指数 g指数 A指数 AR指数

Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator

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Light(Science & Applications) 2017年第1期6卷 410-416页

作者： Andreas Döpp Benoit Mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh Martin Hansson Julien Gautier Michaela Kozlova Jean Philippe Goddet Pascal rousseau Amar Tafzi Victor Malka Antoine Rousse Sebastien Corde Kim Ta Phuoc Laboratoire d’Optique Appliquée ENSTACNRS UMR7639Ecole PolytechniqueChemin de la Hunière91761 PalaiseauFrance Present address:Ludwig-Maximilians-Universität München Fakultät für PhysikAm Coulombwall 1Garching 85748Germany ELI Beamlines Project Institute of Physics of the ASCRNa Slovance 218221 Prague 8Czech Republic Department of Physics Lund UniversityPO Box 11822100 LundSweden Department of Physics and Complex Systems Weizmann Institute of Science76100 RehovotIsrael

Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative *** particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit *** betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial ***,despite its unique features,the usability of the betatron source has been constrained by its poor control and *** this article,we demonstrate the reliable production of X-ray beams with tunable *** ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and *** observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam *** polarization ratio reaches 80%,and the polarization axis can easily be *** anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications.

关键词： laser-plasma interaction laser-wakefield acceleration synchrotron light sources

政治秀场VS镜头真相英联社头牌政治摄影师用快门瓦解英国大选

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摄影之友 2015年第7期 78-85页

作者： Stefan rousseau 微雪英联社

2015年5月8日,卡梅伦所领导的保守党在英国大选中赢得了胜利。在过去的六周中,各种换汤不换药的新闻照片将原本枯燥的政治演绎得更让人昏昏欲睡。Stefan rousseau和他照片的出现,犹如一匹黑马让人眼前一亮。这位英联社(Press Associati... 详细信息

2015年5月8日,卡梅伦所领导的保守党在英国大选中赢得了胜利。在过去的六周中,各种换汤不换药的新闻照片将原本枯燥的政治演绎得更让人昏昏欲睡。Stefan rousseau和他照片的出现,犹如一匹黑马让人眼前一亮。这位英联社(Press Association)的首席政治摄影师,已身处整个国家政治风暴中心二十余年,他一直试图用相机这个"发声器",勇敢地告诉民众:"作秀只会让人麻木乏味,只有镜头下的真相才能让人抖擞精神!"

关键词：卡梅伦 VS 新闻照片 Stefan 风暴中心威斯敏斯特宫电视辩论自由民主党新闻摄影报道计

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核电大国俄罗斯:灾难或在酝酿

低碳世界 2012年第7期2卷 26-28页

作者： Richard rousseau 张瑜阿塞拜疆扎尔大学政治和国际关系学院

俄罗斯民用核能的现状令全球不寒而栗:放射性核废料处理厂处理能力过剩,许多反应堆已经过时且不能满足最基本的安全标准.长此以往,或许,新的灾难正在酝酿.2011年日本福岛发生的悲剧性核灾难,造成了严重的公共健康问题.

关键词：电大俄罗斯放射性核废料灾难健康问题处理厂安全标准反应堆悲剧性日本能力民用核能公共

Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model

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World Journal of Hepatology 2016年第21期8卷 902-914页

作者： Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol Institut Pasteur INSERM Institut Cochin INSERM U1016CNRS UMR8104Universite Paris Descartes(UMR S1016) Genoscience Pharma KU Leuven Rega Institute Laboratoire Alphabio APHP Groupe Hospitalier La Pitie Salpe-triereService de Chirurgie digestive et Hepato bilio pancreatique APHP Groupe Hospitalier CochinService de Chirurgie digestiveHepato-biliaire et Endocrinienne Universite Paris Descartes APHP Groupe Hospitalier CochinUnite d’Hepatologie Institut Pasteur Departement de Recherche TranslationnelleINSERM

AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.

关键词： Host antiviral therapy Hepatitis C virus Tissue culture Autophagy Quinoline derivative

Dual effect of pre-ischemic administration of TNF-alpha on myocardial infarct size

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World Journal of Cardiovascular Diseases 2013年第5期3卷 21-25页

作者： Thuy Tran Quang Raja Hatem Guy rousseau Audrey-Anne Gosselin Erick Schampaert Thierry Charron Centre de Recherche Hopital du Sacré-Caeur de Montréal Montréal Canada Centre de Recherche Hopital du Sacré-Caeur de Montréal Montréal Canada Département de Pharmacologie Université de Montréal Montréal Canada Centre de Recherche Hopital du Sacré-Caeur de Montréal Montréal Canada Département de Cardiologie Hopital du Sacré-Caeur de Montréal Montréal Canada Département de Cardiologie Hopital du Sacré-Caeur de Montréal Montréal Canada

Tumour necrosis factor-α is a cytokine released during myocardial infarction. According to the literature, the effect of TNFα on myocardial infarction is controversial, especially when administered before the ischemic period. The deleterious effects of TNFα seem to be related to the triggering of apoptosis. This study has been designed to determine if different doses of TNFα, administered before the ischemic period, have the same effect on infarct size and on activation of caspase-3 and-8, two enzymes involved in apoptosis. Four groups, using a porcine model of myocardial infarction, have been used: placebo and TNFα (0.1 μg/kg;1 μg/kg and 3 μg/kg). All administered 15 minutes before a 50 minutes occlusion of the left anterior descending artery. Myocardial infarct size has been determined at 3 hours of reperfusion. In a subgroup of animals, reperfusion period has been limited to 15 min to determine the activity of caspase-3 and-8 by spectrofluorometry. Results indicated that infarct size is significantly smaller in groups 0.1 μg/kg and 1 μg/ kg as compared to the placebo group. In contrast, the 3 μg/kg group presented an infarct size similar to the placebo group. Activity of caspase-3 and-8 is reduced in the ischemic region in groups 0.1 and 1 μg/ kg as compared to the placebo group whereas activity in the 3 μg/kg group was similar to the placebo. The results obtained indicated that a low dose of TNFα administered before the ischemic period reduces infarct size, whereas the cardioprotection is lost with the high dose.

关键词： TNF-Alpha Myocardial Infarct Size Protection Apoptosis Caspase-8

The safety and efficacy of palbociclib in older patients with advanced breast cancer in a real-world setting

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 15-27页

作者： Etienne Gouton Louis Tassy Joëlle Micallef Amir Meskine Renaud Sabatier Maud Cecile-Herry Cécile Braticevic Anthony Goncalves Frederic Viret Alexandre de Nonneville Coline Montegut Franck Rouby Frederique rousseau Department of Medical Oncology Institut Paoli-CalmettesMarseille 13009France Aix-Marseille Univ CNRS U7258INSERM U1068Institut Paoli-CalmettesCRCMMarseille 13009France Department of Clinical Pharmacology Régional Center of Pharmacovigilance Marseille-Provence-CorseAssistance Publique-Hôpitaux de MarseilleAix-Marseille Univ.Neurosciences InstituteMarseille 13005France

Aims:Palbociclib has been approved in combination with endocrine therapy(ET)for hormone receptor-positive(HR+)/human epidermal growth factor receptor 2-negative(HER2-)advanced breast cancer(ABC),regardless of *** though ABC is one of the most prevalent cancers in older patients,very few patients≥65 years old were included in pivotal ***,the current study evaluated the safety and efficacy of palbociclib in“real-world”routine treatment of unselected older patients with HR+/***:Data were collected on patients>70 years old who were treated with palbociclib plus ET for HR+/HER2-ABC in our *** analyzed safety data(CTCAE v4.0 criteria)and outcomes,such as progression-free survival(PFS)and overall survival(OS),as well as any associations between main geriatric characteristics and our ***,we assessed safety at a national level by analyzing all palbociclib-related adverse events(AEs)reported in the French Pharmacovigilance Database(FPVD)during the same ***:From February 2016 to July 2019,52 patients were identified with a median age of 80.9 years,of whom 88%presented an *** most common grade 3-4 AE was neutropenia(64%).Median PFS and OS were nine months and not reached,*** FPVD reports 227 cases of palbociclib-related AEs,with older and younger patients sharing similar ***:Palbociclib is well tolerated in older patients with efficacy comparable to that in younger ***,the addition of palbociclib to ET should be evaluated individually in this older and frailer subgroup.

关键词： Advanced breast cancer palbociclib older patients tolerance efficacy pharmacovigilance

R指数、AR指数:h指数功能扩展的补充指标

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科学观察 2007年第3期2卷 1-8页

作者：金碧辉 rousseau Ronald 中国科学院国家科学图书馆北京100080 University of Antwerp(UA) IBWB-2610 WilrijkBelgium KHBOIndustrial Sciences and TechnologyB-8400 OostendeBelgium

分析了h指数功能扩展后在科学家个人科研绩效评价中的三个缺陷,即缺乏灵敏度,缺乏区分度,缺乏波动性。针对这些缺陷,提出了R指数和AR指数。R指数用于解决h指数的灵敏度和区分度的问题;AR指数用于解决h指数只升不降的问题。利用17位普赖... 详细信息

分析了h指数功能扩展后在科学家个人科研绩效评价中的三个缺陷,即缺乏灵敏度,缺乏区分度,缺乏波动性。针对这些缺陷,提出了R指数和AR指数。R指数用于解决h指数的灵敏度和区分度的问题;AR指数用于解决h指数只升不降的问题。利用17位普赖斯奖得主的论文数量和被引频次数量进行了h指数、R指数和AR指数的测算。针对h指数与R指数或AR指数配伍使用后的双因素问题,设计了标准化(h,R)指数和等效(h,R)指数。实测数据证明R指数和AR指数是h指数功能扩展的补充指标。

关键词： h指数 R指数 AR指数科研绩效评价评价指标