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Fulminant myocarditis in adults: a narrative review

Journal of Geriatric Cardiology 2022年第2期19卷 137-151页

作者： Santiago Montero Darryl Abrams Enrico Ammirati Florent Huang Dirk WDonker Guillaume Hekimian Cosme García-García Antoni Bayes-Genis alain combes Matthieu Schmidt Acute Cardiovascular Care Unit Heart InstituteHospital Germans Trias i PujolDepartament de MedicinaUniversitat Autònoma de BarcelonaCIBERCVSpain Assistance Publique-Hôpitaux de Paris Pitié-Salpêtrière HospitalMedical Intensive Care UnitParisFrance Columbia University Vagelos College of Physicians&Surgeons/NewYork-Presbyterian Hospital New YorkUSA Center for Acute Respiratory Failure Columbia University Irving Medical CenterNew YorkUSA De Gasperis Cardio Center and Transplant Center Niguarda HospitalMilanoItaly Cardiology Hôpital FochSuresnesParisFrance Intensive Care Center University Medical Center UtrechtUtrechtthe Netherlands Cardiovascular and Respiratory Physiology TechMed CenterUniversity of TwenteEnschedethe Netherlands Sorbonne Université INSERM UMRS_1166-iCANInstitute of Cardiometabolism and NutritionParisFrance

Fulminant myocarditis(FM)is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation,often presenting as profound cardiogenic shock,life-threatening ventricular arrhythmias and/or electrical *** may be refractory to conventional therapies and require mechanical circulatory support(MCS).The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis,leading to an increased focus on immunosuppressive treatment *** data have highlighted not only the fact that FM has significantly worse outcomes than non-FM,but that prognosis and management strategies of FM are heavily dependent on histological subtype,placing greater emphasis on the role of endomyocardial biopsy in *** impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed,including whether MCS is *** patients with refractory cardiogenic shock secondary to FM end up requiring MCS,with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates,particularly when initiated prior to the development of multiorgan *** the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies,and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes.

关键词： myocarditis initiated storm

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Extracorporeal membrane oxygenation in COVID-19 associated acute respiratory distress syndrome:A narrative review

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Journal of Intensive Medicine 2023年第1期3卷 4-10页

作者： Benjamin Assouline alain combes Matthieu Schmidt Médecine Intensive Réanimation Institut de CardiologieAssistance Publique-Hôpitaux de ParisParis 75013France INSERM UMRS 1166ICAN Institute of Cardiometabolism and NutritionSorbonne UniversitéParis 75013France

Venovenous extracorporeal membrane oxygenation(VV-ECMO)is an established rescue therapy in the management of refractory acute respiratory distress syndrome(ARDS).Although ECMO played an important role in previous respiratory viral epidemics,concerns about the benefits and usefulness of this technique were raised during the coronavirus disease 2019(COVID-19)***,the mortality rate initially reported in small case series from China was concerning and exceeded 90%.A few months later,the critical care community published the findings from several observational cohorts on the use of extracorporeal membrane oxygenation(ECMO)in COVID-19-related *** to the preliminary results,data from the first surge supported the use of ECMO in experienced centers because the mortality rate was comparable to those from the ECMO to Rescue Lung Injury in Severe ARDS(EOLIA)trial or other large prospective ***,the mortality rate of the population with severe disease evolved during the pandemic,in conjunction with changes in the management of the disease and the occurrence of new *** results from subsequent studies confirmed that the outcomes mainly depend on strict patient selection and center *** comparison with non-COVID-related ARDS,the duration of ECMO for COVID-related ARDS was longer and increased over *** and decision-makers must integrate this finding in the ECMO decision-making process to plan their ICU capacity and resource *** narrative review summarizes the current evidence and specific considerations for ECMO use in COVID-19-associated ARDS.

关键词： Extracorporeal membrane oxygenation (ECMO) Acute respiratory distress syndrome(ARDS) COVID-19 Mortality

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体外膜肺氧合监测和护理

体外膜肺氧合监测和护理

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作者： (法)希里纳·摩萨台(Chirine Mossadegh)， alain combes

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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： alain Frigon Charly G.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

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Some Remarks on Korn Inequalities

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Chinese Annals of Mathematics,Series B 2018年第2期39卷 335-344页

作者： alain damlamian Dedicated to Philippe G. Ciarlet on the occasion of his 80th birthda

A recent joint paper with Doina Cioranescu and Julia Orlik was concerned with the homogenization of a linearized elasticity problem with inclusions and cracks(see[Cioranescu, D., Damlamian, A. and Orlik, J., Homogenization via unfolding in periodic elasticity with contact on closed and open cracks, Asymptotic Analysis, 82, 2013, 201–232]). It required uniform estimates with respect to the homogenization parameter. A Korn inequality was used which involves unilateral terms on the boundaries where a nopenetration condition is imposed. In this paper, the author presents a general method to obtain many diverse Korn inequalities including the unilateral inequalities used in [Cioranescu, D., Damlamian, A. and Orlik, J., Homogenization via unfolding in periodic elasticity with contact on closed and open cracks, Asymptotic Analysis, 82, 2013, 201–232]. A preliminary version was presented in [Damlamian, A., Some unilateral Korn inequalities with application to a contact problem with inclusions, C. R. Acad. Sci. Paris, Ser. I,350, 2012, 861–865].

关键词： Korn domains Korn-Wirtinger domains Unilateral Korn inequality

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Pfaffians and Representations of the Symmetric Group

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Acta Mathematica Sinica,English Series 2009年第12期25卷 1929-1950页

作者： alain LASCOUX CNRS IGM Universite Paris-Est

Pfaffians of matrices with entries z[i, j]/（xi ＋ xj）, or determinants of matrices with entries z[i, j]/（xi - xj）, where the antisymmetrical indeterminates z[i, j] satisfy the Pliicker relations, can be identified with a trace in an irreducible representation of a product of two symmetric groups. Using Young＇s orthogonal bases, one can write explicit expressions of such Pfaffians and determinants, and recover in particular the evaluation of Pfaffians which appeared in the recent literature.

关键词： Pfaffians symmetric group representations

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A non-ideal solution theory for the mechanics and electrochemistry of charged membranes

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npj Computational Materials 2022年第1期8卷 1365-1378页

作者： alain Boldini Maurizio Porfiri Center for Urban Science and Progress Department of Mechanical and Aerospace EngineeringNew York University Tandon School of Engineering370 Jay StreetBrooklyn11201NYUSA Center for Urban Science and Progress Department of Mechanical and Aerospace EngineeringDepartment of Biomedical EngineeringNew York University Tandon School of Engineering370 Jay StreetBrooklyn11201NYUSA

Understanding how ions and solvent molecules migrate within charged membranes is fundamental for advancing the analysis of biological membranes and the design of energy storage and production *** efforts highlighted a significant interplay between mechanics and electrochemistry in charged membranes,calling for the development of high-fidelity models to describe their ***,we propose a continuum theory of the chemoelectromechanics of charged membranes,accounting for potentially large deformations and non-idealities of the solution permeating the *** demonstrate the potential applications of our theory within the study of ionic polymer *** theory predicts sizeable effects of non-idealities and mechanical deformations,enabling insight into the role of mechanics on solute and solvent transport within charged membranes.

关键词： interaction. theory electrochemistry

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The Guianese population of the fire ant Solenopsis saevissima is unicolonial

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Insect Science 2016年第5期23卷 739-745页

作者： alain Lenoir Severine Devers Axel Touchard alain Dejean lRBI Institut de Recherche sur la Biologie de I'lnsecte UMR CNRS 7261 Universite Francois Rabelais 37200 Tours CNRS Ecologie des Forets de Guyane (UMR CNRS 8172) Campus agronomique BP 316 97379 Kourou cedex Universite de Toulouse UPS INP Ecolab 118 route de Narbonne 31062 Toulouse and CNRS Ecolab (UMR-CNRS 5245) 31062 Toulouse France

In this study, conducted in French Guiana, a part of the native range of the fire ant Solenopsis saevissima, we compared the cuticular hydrocarbon profiles of media workers with previous results based on intraspecific aggressiveness tests. We noted a strong congruence between the two studies permitting us to delimit 2 supercolonies extending over large distances （up to 54 kin）, a phenomenon known as unicoloniality. Solenopsis geminata workers, taken as an out-group for cluster analyses, have a very different cuticular hydrocarbon profile. Because S. saevissima has been reported outside its native range, our conclusion is that this species has the potential to become invasive because unicoloniality （i.e., the main attribute for ants to become invasive） was shown at least for the Guianese population.

关键词： biological invasions cuticular hydrocarbons fire ants unicoloniality

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Impact of Drops on Non-wetting Biomimetic Surfaces

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Journal of Bionic Engineering 2009年第4期6卷 330-334页

作者： alain Merlen Philippe Brunet Institut d'Electronique de Microelectronique et Nanotechnologie IEMN Universite des sciences et technologies de Lille1UMR CNRS 8520Avenue Poincare BP 6006959652 Villeneuve d'Ascq cedexFrance

We have carried out an experimental study of liquid drop impact on superhydrophobic substrates covered by a carpet of chemically coated *** micro-structure of the surface is similar to some biological ones(Lotus leaf for example).In this situation the contact angle can then be considered as equal to 180 degrees,with no *** to its initial inertia,the drop experiences a flattening phase after it hits the surface,taking the shape of a *** it reaches its maximal lateral extension,the drop begins to retract and bounces *** have extracted the lateral extension of the drop,and we propose a model that explains the *** find a limit initial velocity beyond which the drop protrudes into the nano-wire *** discuss the relevance of practical issues in terms of self-cleaning surfaces or spray-cooling.

关键词： superhydrophobic surfaces drop impact

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Atomic-scale structural signature of dynamic heterogeneities in metallic liquids

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npj Computational Materials 2017年第1期3卷 179-188页

作者： alain Pasturel Noel Jakse University Grenoble Alpes CNRSGrenoble INPSIMaPF-38000 GrenobleFrance

With sufficiently high cooling rates,liquids will cross their equilibrium melting temperatures and can be maintained in a metastable undercooled state before *** of undercooled liquids reveal several intriguing dynamic phenomena and because explicit connections between liquid structure and liquids dynamics are difficult to identify,it remains a major challenge to capture the underlying structural link to these *** initio molecular dynamics(AIMD)simulations are yet especially powerful in providing atomic-scale details otherwise not accessible in *** the AIMD-based study of Cr additions in Al-based liquids,we evidence for the first time a close relationship between the decoupling of component diffusion and the emergence of dynamic heterogeneities in the undercooling *** addition,we demonstrate that the origin of both phenomena is related to a structural heterogeneity caused by a strong interplay between chemical short-range order(CSRO)and local fivefold topology(ISRO)at the short-range scale in the liquid phase that develops into an icosahedral-based medium-range order(IMRO)upon ***,our findings reveal that this structural signature is also captured in the temperature dependence of partial pair-distribution functions which opens up the route to more elaborated experimental studies.

关键词： structural dynamic signature

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