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普那布林联合多西他赛治疗晚期非小细胞肺癌(NScLc)患者的Ⅱ期随机临床研究

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普那布林联合多西他赛治疗晚期非小细胞肺癌(NSCLC)患者的Ⅱ期随...

Seroprevalence of Viral Hepatitis B and c and HIV co-Infection among Voluntary Blood Donors in the Northern Region of Burkina Faso

遵循诊疗规范、鼓励临床试验——第八届中国肿瘤内科大会、第三届中国肿瘤医师大会、中国抗癌协会肿瘤临床化疗专业委员会2014年学术年会

作者： Rebecca S Heist Osvaldo Aren alain c mita Jonathan A Polikoff Lyudmila Bazhenova G Kenneth Lloyd William Mikrut Steven D Reich Matthew A Spear Massachusetts General Hospital MA 02114 Instituto Nacional del cancer Oncology Chile University of Texas Health Science center at San Antonio TX currently cedars-Sinai Medical center CA 90048 Kaiser Hospital San Diego CA 92108 UcSD Moores cancer center CA 92093-0698 Nereus Pharmaceuticals Inc.CA 92191 currently Sunovion Pharmaceutica lsInc.MA 01752 G Kenneth Lloyd:currently GKOL Inc.cA.92064 大连万春药业有限公司

目的:普那布林靶向作用于肿瘤新生和原生血管,并通过RAS-JNK通道诱导肿瘤凋亡。本研究对普那布林和多西他赛联合用药(DN)与多西他赛单独用药(D)进行比较。方法:之前经历标准化疗的晚期NScLc患者,被随机分至DN组和D组,21天治疗周期中,第...

目的:普那布林靶向作用于肿瘤新生和原生血管,并通过RAS-JNK通道诱导肿瘤凋亡。本研究对普那布林和多西他赛联合用药(DN)与多西他赛单独用药(D)进行比较。方法:之前经历标准化疗的晚期NScLc患者,被随机分至DN组和D组,21天治疗周期中,第1天多西他赛(75 mg/m,静注),DN组:第1和8天还给普那布林(静注,剂量:30或20 mg/m,简称30或20剂量组)。经历1次或2次既往化疗的ⅢB/Ⅳ期NScLc患者入组,既往给D或血管阻断剂不入组。主要终点是总生存期(OS)。结果:172名患者被随机分为2个剂量组,其中163名进行治疗:30剂量组(DN:50;D:55)和20剂量组(DN:40;D:18)。30剂量组:DN组OS(月,90%cI)为8.7(6.6,12.6),D组7.5(6.3,10.5);客观缓解率:DN:14.0%对D:14.5%);DOR(月,90%cI):DN:12.7(4.0,13.9)对D:1.5(1.1,3.1),P=0.049。20剂量DN组的这些参数没30剂量组好。事后亚组分析:DN组经历1次既往化疗并有大肺肿瘤(>3 cm)患者,生存期可能更长。该亚组OS(月,95%cI)为DN组11.5(7.1,15.1)对D组7.8(4.1,17.4)。最常见不良反应为恶心,乏力,腹泻,便秘和厌食。30剂量组中DN组多西他赛初始剂量降低10%,而D组降低18.2%,所以DN组耐受性可能比D组更好。DN组中性粒细胞减少症发病率显著低于D组(30剂量组:8.0%对36.4%,P<0.001;20剂量组:7.5%对22.2%)。结论:经历1次既往化疗并有大肺肿瘤患者中,DN组OS比D组长,这发现与普那布林的靶向血管作用机制一致。计划在大肺肿瘤患者中进行Ⅲ期临床。

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Open Journal of Gastroenterology 2025年第1期15卷 13-20页

作者： Ouattara Zanga Damien Kafando Amadou Koura Mâli Zoungrana Stève Léonce Dah Elias Samné Souleymane Bougouma alain Department of Gastroenterology Ouahigouya Regional Teaching Hospital Ouahigouya Burkina Faso Ouahigouya Blood Sampling and Distribution Depot (BSDD) Ouahigouya Burkina Faso Department of Gastroenterology Souro Sanou Teaching Hospital Bobo-Dioulasso Burkina Faso Department of Public Health Ouahigouya Regional Teaching Hospital Ouahigouya Burkina Faso Department of Gastroenterology Fada Regional Hospital Fada Burkina Faso Department of Gastroenterology Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso

The aim of this study was to assess the seroprevalence of viral hepatitis B and c and co-infection with HIV among volunteer blood donors at the blood sampling and distribution depot (BSDD) in Ouahigouya. Patients and methods: Our study population consisted of all volunteer blood donors who had donated during a 2-year period from 1 January 2019 to 31 December 2020. Samples were taken from patients with no contraindications and serological tests were performed using ELISA tests. HBsAg, HcV-Ac and HIV serology were tested. All samples reactive for HIV, HBV and HcV were retested for confirmation using a second enzyme-linked immunosorbent assay. A result was considered positive if both the first and second tests were positive. Results: In two years, the Ouahigouya BSDD recorded 9726 donations, including 7983 new donors and 1743 former donors. The average age of donors was 25.59 years, with a sex ratio of 3.4. The seroprevalence of HBV, HcV and HIV was 7.31%, 3.10% and 2.12% respectively. HBV-HcV co-infection was found in 0.32% of cases, HIV-HBV, HIV-HcV, and HIV-HBV-HcV co-infection were found in 0.25%, 0.09% and 0.04% respectively. conclusion: The seroprevalence of viral hepatitis B and c remains high among volunteer blood donors in Ouahigouya, although a decline in seroprevalence appears to be on the horizon.

关键词： Viral Hepatitis B and c HIV co-Infection Volunteer Blood Donors

Exercise-Induced Bronchospasm, Prevalence and Associated Factors in University Students in STAPS

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Journal of Biosciences and Medicines 2025年第1期13卷 92-101页

作者： Paul Roger Mabounda Kounga alain Boussana Florent Nsompi Hue Olivier Department of Physiology Higher Institute of Physical and Sports Education (ISEPS) Marien Ngouabi University Brazzaville Republic of the Congo Laboratory of Education Health Expertise and Motor Performance (ESEPM) Brazzaville Republic of the Congo Molecular Biology Laboratory Shanghai Sports University Shanghai China Unit of Sciences and Technics of Physical Education and Sport University of Montpellier Montpellier France Laboratoy AcTES Antilles Guyane University Cedex France Laboratory Respiratory Hormonal and Gerontological Sports Explorations Unit National Institute of Youth Physical Education and Sport (INJEPS) University of Abomey-Calavi (UAC) Abomey-Calavi Benin

Background: There are links between physical exercise, fine particles and the prevalence of exercise-induced bronchospasm (EIB). Objective: The aim of this study was to assess the prevalence of exercise-induced bronchospasm in students of sciences and techniques of physical activities and sports (STAPS) exercising in a hot, humid and relatively polluted environment. Methods: Twenty-two first-year undergraduate students, including 11 in PE and 11 in SPORT, aged 21.64 ± 1.80 years, participated in a football match. Resting spirometry was performed before and 5 minutes after the match. During the match, particulate matter (PM2.5 and PM10) was measured every 10 minutes around the football pitch. Ambient temperature and relative humidity were recorded. The diagnosis of EIB was based on a decrease in FEV1 of at least 10% after the match. If there was a decrease, the participant was considered susceptible to EIB. Results: Five subjects were positive for exercise-induced bronchospasm, a percentage of 22%. Ambient temperature and relative humidity were 34.22˚c ± 1.38˚c and 52.2% ± 4.97%, respectively. concentrations of PM2.5 and PM10 were between 53.3 - 115.5 µg/m3 and 75.5 - 168.2 µg/m3, respectively, exceeding WHO limits. conclusion: These results show a high incidence of exercise-induced bronchospasm in students without a history of asthma but exercising in a hot, humid and environment polluted by fine particles.

关键词： Bronchoconstriction Air Pollution Sports Health Respiratory Asthma Athlete

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New BrunswickFrederictonNB E3B 5A3Canada

As environmental concerns from fossil fuel consumption intensify,large-scale energy storage becomes imperative for the integration of renewable sources like wind,hydro,and solar with the electrical *** flow batteries,particularly those employing organic molecules,are positioned as a key technology for this *** review explores the growing field of symmetric organic redox flow batteries(ORFBs)within this *** traditional asymmetric designs based on unique active materials for each electrode,symmetric ORFBs involve a single bipolar species for both *** review highlights the benefits of a symmetric design,and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous *** providing a comprehensive overview of their cell cycling and performance characteristics,the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems,as are opportunities for future *** should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueousel ectrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque Satish S c Rao School of Medicine and Biomedical Sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early cancer Management Research Group RISE@cI-IPO(Health Research Network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback Neuropathy Sacral neuromodulation

Recent progress on elemental tellurium and its devices

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Journal of Semiconductors 2025年第1期46卷 91-106页

作者： Jiachi Liao Zhengxun Lai You Meng Johnny c.Ho Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong 999077China changsha Semiconductor Technology and Application Innovation Research Institute College of Semiconductors(College of IntegratedC ircuits)Hunan UniversityChangsha 410082China Institute for Materials chemistry and Engineering Kyushu UniversityFukuoka 8168580Japan State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong 999077China

The rapid advancement of information technology has heightened interest in complementary devices and *** p-type semiconductors often lack sufficient electrical performance,thus prompting the search for new materials with high hole mobility and long-term *** tellurium(Te),featuring a one-dimensional chiral atomic structure,has emerged as a promising candidate due to its narrow bandgap,high hole mobility,and versatility in industrial applications,particularly in electronics and renewable *** review highlights recent progress in Te nanostructures and related devices,focusing on synthesis methods,including vapor deposition and hydrothermal synthesis,which produce Te nanowires,nanorods,and other *** applications in photodetectors,gas sensors,and energy harvesting devices are discussed,with a special emphasis on their role within the internet of things(IoT)framework,a rapidly growing field that is reshaping our technological *** prospects and potential applications of Te-based technologies are also highlighted.

关键词： elemental tellurium photodetector field-effect transistor gas sensor energy harvesting device

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Study of the semilepottonic decays Υ(1S)→B_((c))lν_(l)

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chinese Physics c 2025年第1期49卷 177-185页

作者： c.T.Tran M.A.Ivanov P.Santorelli H.c.Tran Department of Physics HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisica“E.Pancini” Universitàdi Napoli Federico IIComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126NapoliItaly Istituto Nazionale di Fisica Nucleare Sezione di Napoli80126 NapoliItaly

We study the exclusive semileptonic decaysΥ(1S)→B_((c))lν_(l),where t=e,μ,*** relevant hadronic form factors are calculated using the covariant confined quark model developed previously by our *** predict the branching fractions B(Υ(1S)→B_((c))lν_(l))(vl)to be of the order of 10^(-13)and 10^(-10)for the case of B and B_(c),*** predictions agree well with other theoretical *** also consider the effects of possible new physics in the case of Υ(1S)→B_((c))τν_(τ)and show that the branching fraction of this decay can be enhanced by an order of magnitude using constraints from the B-→D^((*))lν_(l)and B_(c)→J/Ψlν_(l)experimental data.

关键词： heavy quarkonia covariant confined quark model semileptonic decay