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The boys are back in town: Rethinking the function of ribosomal DNA repeats in the genomic era

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Molecular Plant 2023年第3期16卷 514-516页

作者： Francesca B.Lopez Peter C.mckeown Antoine Fort Galina Brychkova Charles Spillane Genetics and Biotechnology Laboratory Plant&AgriBiosciences Research Centre(PABC)Ryan InstituteUniversity of GalwayH91 REW4 GalwayIreland Present address:Department of Plant Biology and Genome Center University of CaliforniaDavisUC Davis Genome CenterDavisCA 95616USA

Next-generation sequencing technological advances,affording high-throughput,scalable,and fast assemblies,have enabled genome editing techniques that allow us to remove,insert,and modify genes for rapid and precise fun... 详细信息

关键词： remove precise function

Molecular basis of inherited calcium channelopathies:role of mutations in pore-forming subunits

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Acta Pharmacologica Sinica 2006年第7期27卷 799-812页

作者： Lynn mckeown Philip ROBIN Owen T JONES Faculty of Life Sciences the University of ManchesterManchesterUK

The pore-forming alpha subunits of voltage-gated calcium channels contain theessential biophysical machinery that underlies calcium influx in response to *** combination with requisite auxiliary subunits,these pore sub-units form calcium channel complexes that are pivotal to the physiology andpharmacology of diverse cells ranging from sperm to *** surprisingly,mutations in the pore subunits generate diverse pathologies,termedchannelopathies,that range from failures in excitation-contraction coupling tonight *** the last decade,major insights into the mechanisms ofpathogenesis have been derived from animals showing spontaneous or *** parallel,there has been considerable growth in our understandingof the workings of voltage-gated ion channels from a structure-function,regula-tion and cell biology *** we document our current understandingof the mutations underlying channelopathies involving the voltage-gated calciumchannel alpha subunits in humans and other species.

关键词： calcium channels channelopathies mutation

Computational discovery of ultra-strong, stable, and lightweight refractory multi-principal element alloys. Part II: comprehensive ternary design and validation

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npj Computational Materials 2023年第1期9卷 1469-1481页

作者： Kate L.M.Elder Joel Berry Aurélien Perron Brandon Bocklund Jibril Shittu Connor J.Rietema Hunter B.Henderson Scott K.McCall Joseph T.mckeown Materials Science Division Lawrence Livermore National LaboratoryLivermoreCA 94550USA.✉

Here the discovery of refractory multi-principal element alloys(MPEAs)with high-temperature strength and stability is pursued within a constrained and application-relevant design space.A comprehensive approach is developed and applied to explore all 165 ternary systems in the al-Ce-Fe-Hf-Mo-Nb-Ta-Ti-V-W-Zr family.A subset of ternary systems that contain large areas in composition–temperature space with high strength and robust BCC phase stability is *** sets of high-performing alloys are identified,each set optimized for one combination of phase constraint,optimization target,and temperature *** mechanical tests support the viability of the *** work highlights the importance of considering phase stability,exploring non-equiatomic regions of composition space,and applying application-relevant *** I and II provide three down-selection techniques for identifying high-performing BCC refractory MPEAs,design guidelines,and many candidates predicted to have BCC phase stability and strengths 2–3 times higher than any reported to date.

关键词： alloys element ternary

Meeting SEN in the Curriculum : Modern Foreign Languages 1

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Long-term chorioretinal changes following strabismus surgery——possible occult needle penetration

2004年

作者： mckeown Sally.

Includes bibliographical references.

ISBN: (纸本)1843121654;141758209X

Includes bibliographical references.

关键词： Special education Languages Modern

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 518-519页

作者： Victor M.Villegas Stephen G.Schwartz Craig A.mckeown Harry W.Flynn Jr Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFlorida 33136United States

Dear Editor,cleral penetration during strabismus surgery was k3 first reported over 50 years ago[1].Early manuscripts reported the incidence of this complication around 10%[1].However,more recent studies suggest that ... 详细信息

关键词： IRB possible occult needle penetration Long-term chorioretinal changes following strabismus surgery

死刑案件上诉复核：“死刑非比寻常”--促进死刑制度的合法与公正

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法学杂志 2008年第2期29卷 113-116页

作者： M.Margaret mckeown 邱凌(翻译) 美国联邦第九上诉法院美国纽约北京师范大学刑事法律科学研究院

各国的死刑实践,实际上也就是各国司法在死刑制度中的作用,取决于该国历史以及政治格局。这个问题之所以备受关注,是人们充分认识到死刑无可挽回并且其刑不可测的自然结果;也就是说死刑非比寻常。中国最高人民法院院长在对人民代表大会... 详细信息

各国的死刑实践,实际上也就是各国司法在死刑制度中的作用,取决于该国历史以及政治格局。这个问题之所以备受关注,是人们充分认识到死刑无可挽回并且其刑不可测的自然结果;也就是说死刑非比寻常。中国最高人民法院院长在对人民代表大会所做的一份报告中也表达了类似情感:"人命关天。死刑核准权的行使绝对不能草率。"由于"死刑非比寻常",因此,死刑也突显出法律伦理的重要性。约束法官行为的众多伦理原则在死刑问题上显得龙为重要。

关键词：死刑死刑核准权法律伦理

Non-responsive celiac disease in children on a gluten free diet

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World Journal of Gastroenterology 2021年第13期27卷 1311-1320页

作者： Gopal Veeraraghavan Amelie Therrien Maya Degroote allison mckeown Paul D Mitchell Jocelyn A Silvester Daniel A Leffler alan M Leichtner Ciaran P Kelly Dascha C Weir Division of Gastroenterology Hepatology and NutritionBoston Children's HospitalBostonMA 02115United States The Celiac Center Department of Medicine and Division of GastroenterologyBeth Israel Deaconess Medical CenterBostonMA 02215United States Celiac Research Program Harvard Medical SchoolBostonMA 02115United States Institutional Centers for Clinical and Translational Research Boston Children's HospitalBostonMA 02115United States Gastrointestinal Therapeutics Takeda Pharmaceutical International CoCambridgeMA 02139United States

BACKGROUND Non-responsive celiac disease(NRCD) is defined as the persistence of symptoms in individuals with celiac disease(CeD) despite being on a gluten-free diet(GFD). There is scant literature about NRCD in the pediatric *** To determine the incidence, clinical characteristics and underlying causes of NRCD in *** Retrospective cohort study performed at Boston Children’s Hospital(BCH). Children al biopsies compatible with Marsh Ⅲ histology between 2008 and 2012 were identified in the BCH’s Celiac Disease Program database. Medical records were longitudinally reviewed from the time of diagnosis through September 2015. NRCD was defined as persistent symptoms at 6 mo after the initiation of a GFD and causes of NRCD as well as symptom evolution were detailed. The children without symptoms at 6 mo(responders) were compared with the NRCD group. Additionally, presenting signs and symptoms at the time of diagnosis of CeD among the responders and NRCD patients were collected and compared to identify any potential predictors for NRCD at 6 mo of GFD *** Six hundred and sixteen children were included. Ninety-one(15%) met criteria for NRCD. Most were female(77%). Abdominal pain [odds ratio(OR) 1.8 95% confidence interval(CI) 1.1-2.9], constipation(OR 3.1 95%CI 1.9-4.9) and absence of abdominal distension(OR for abdominal distension 0.4 95%CI 0.1-0.98) at diagnosis were associated with NRCD. NRCD was attributed to a wide variety of diagnoses with gluten exposure(30%) and constipation(20%) being the most common causes. Other causes for NRCD included lactose intolerance(9%), gastroesophageal reflux(8%), functional abdominal pain(7%), irritable bowel syndrome(3%), depression/anxiety(3%), eosinophilic esophagitis(2%), food allergy(1%), eating disorder(1%), gastric ulcer with Helicobacter pylori(1%), lymphocytic colitis(1%), aerophagia(1%) and undetermined(13%). 64% of children with NRCD

关键词： Celiac disease Non-responsive celiac disease Children Gluten-free diet Constipation Abdominal pain

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Realization of palladium-based optomechanical cantilever hydrogen sensor

2005年

作者： Mike North and Sally mckeown.

Includes bibliographical references.

ISBN: (纸本)1843121603;9781843121602

Includes bibliographical references.

关键词： Information technology Special education

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Microsystems & Nanoengineering 2017年第1期3卷 367-372页

作者： Steven J.mckeown xiaozhen Wang xin Yu Lynford L.Goddard Photonic Systems Laboratory Department of Electrical and Computer EngineeringMicro and Nanotechnology LabUniversity of Illinois at Urbana-Champaign208 North Wright StreetMNTL 2254UrbanaIL 61801USA

Hydrogen has attracted attention as an alternative fuel source and as an energy storage ***,the flammability of hydrogen at low concentrations makes it a safety ***,gas concentration measurements are a vital safety *** we present the experimental realization of a palladium thin film cantilever optomechanical hydrogen gas *** measured the instantaneous shape of the cantilever to nanometer-level accuracy using diffraction phase ***,we were able to quantify changes in the curvature of the cantilever as a function of hydrogen concentration and observed that the sensor’s minimum detection limit was well below the 250 *** of our test *** the change in curvature versus the hydrogen curve for calibration,we accurately determined the hydrogen concentrations for a random sequence of *** addition,we calculated the change in film stress as a function of hydrogen concentration and observed a greater sensitivity at lower concentrations.

关键词： hydrogen detection imaging and sensing interference microscopy optomechanics optical sensors surface dynamics