检索结果-南通市图书馆

The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

Molecular Plant 2024年第7期17卷 1129-1150页

作者： Paula Berman Luis alejandro de haro Ana-Rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel The Maurice and Vivienne Wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA Department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing with comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

引用

Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero Sergio haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超声设备如何实现小型化

引用

科技纵览 2024年第4期 40-45,4页

作者： F.LEVENT DEGERTEKIN EDMON DE haro(图) 不详

在医院和诊室,医疗超声设备正在发生惊人的变化.长期以来,先进的超声设备一直被放在手推车上推来推去,上面挂着各种各样的线和探头,现在它们即将被永久地推放到一边,取而代之的是能够向手机发送影像的手持式探头.

关键词：超声设备手推车手持式探头诊室小型化

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic and ballistic impact behavior of biocomposite armors made of HDPE reinforced with chonta palm wood(Bactris gasipaes) microparticles

引用

Defence Technology（防务技术） 2018年第3期14卷 238-249页

作者： Edison E.haro Jerzy A.Szpunar Akindele G.Odeshi Department of Mechanical Engineering University of Saskatchewan

The mechanical behavior of chonta palm wood(Bactris gasipaes) microparticles reinforced high density polyethylene(HDPE) under high strain-rate compressive and ballistic impact loading were *** palm wood microparticles were introduced into the HDPE via an extrusion process using parallel twin screw extruder to produce biocomposite containing 10, 20, 25, and 30 wt % chonta wood microparticles. In addition to mechanical tests, fractographic analysis was done to understand the failure mechanism in the biocomposites under dynamic and ballistic impact loads. The results indicate that both quasi-static and dynamic mechanical properties of HDPE are enhanced by reinforcement with chonta palm wood particles. The biocomposites containing 25 wt % wood microparticles exhibited the highest strength, stiffness, ballistic impact resistance and impact energy absorption capability. Introduction of microparticles of chonta palm wood as reinforcement into a polymeric matrix such as HDPE is therefore a promising method to develop biocomposites with enhanced capacity to withstand dynamic impact loading and absorb impact energy.

关键词： HDPE 弹道行为盔甲机械测试吸收能力密度聚乙烯挤出过程

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Traditional Healer’s Medicinal Practice Survey and Clinical Evidence Assessment of “YIKI”: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso

引用

Pharmacology & Pharmacy 2024年第7期15卷 248-267页

作者： Zachari Kabre Rakiswende Serge Yerbanga Aminata Fofana Roland Nâg-Tiero Meda Anyirekun Fabrice Some al.ssane haro Natacha A. J. A. Boro Fazhira B. Ye Benjamin Kouliga Koama Sami Eric Kam Eliasse Zongo Hadidjatou Belèm Windmi Kagambèga Florence Fournet Georges A. Ouedraogo Jean-Bosco Ouedraogo Institut de Recherche en Sciences de la Sant Direction Rgionale de lOuest Bobo-Dioulasso Burkina Faso Laboratoire de Recherche et dEnseignement en Sant et Biotechnologies Animales Universit Nazi BONI Bobo-Dioulasso Burkina Faso Institut des Sciences et Techniques Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactriologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso Maladies Infectueuses et Vecteurs: Ecologie Gntique Evolution et Contrle (MIVEGEC) Institut de Recherche pour le Dveloppement Universit de Monpellier Montpellier France

YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to identify the medicinal practices of the healer holder of YIKI and assess the clinical evidence of its phytomedicine in the uncomplicated malaria treatment. Ethnomedical survey based on a semi-structured and open questionnaire was conducted from October to December 2019 with the healer. Malaria knowledge and diagnosis methods, patient treatment and monitoring, and recipe formulation steps were surveyed. Moreover, thick and thin blood smears were taken, haemoglobin levels and temperature of consenting patients were measured before treatment, mid-treatment and at the end of treatment. The survey revealed that the healer has a good knowledge of malaria symptoms and his diagnosis is based on observation and physical examination of patients. The healer’s malaria diagnosis was rudimentary and had accuracy problems, with only 62.79% of malaria cases confirmed by microscopy. The formulation of YIKI and its use to treat malaria follow a standard process for plant harvesting, powder quantities and posology, but do not use any reproducible parameters for dose adjustment. Forty-three patients diagnosed and treated by the healer participated in the study. Laboratory results revealed 27 Plasmodium falciparum infection cases, including 2 with parasitaemia ≥ 200,000 p/µl blood. 25 patients were selected for therapeutic evidence assessment. There was a 48% elimination of parasites, a 28% parasitaemia decrease without complete cure, with gametocytogenesis in some patients, and a 24% parasitaemia increase. Haemoglobin and temperature results suggested that YIKI was not cytotoxic and reduced fever. Encouraging preliminary results have been obtained, but in view of the low number of patients, further YIKI efficacy and toxicity studies will be necessary for patient safety.

关键词： Antimalarial-Phytomedicine Efficacy Traditional Practices Bobo-Dioulasso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Patterns of treatment with PDE5 inhibitors in the clinical practice in Italy： longitudinal data from the Erectile Dysfunction Observational Study

引用

Asian Journal of Andrology 2009年第5期11卷 629-637,I0005页

作者： Ferdinando Fusco[意大利] Riccardo Sicuteri[意大利] Andrea Rossi[意大利] Stathis Kontodimas[意大利] Jose Maria haro[意大利] Ciro Imbimbo[意大利] 无 Clinica Urologica- Universita Federico Ⅱ Napoli 80100 Italy Ely Lilly Italia Firenze 50019 Italy Eli Lilly and Company Windlesham Surrey GU20 6PH UK Fundacio Sant Joan de Deu Esplugues de Llobregat 08950 Spain

The Erectile Dysfunction Observational Study （EDOS） is a 6-months observational prospective multicentric study enrolling men with erectile dysfunction （ED） who asked, to be started on a treatment or to change a previous treatment. Aims of the study were to analyse the pattern of treatment and compare the efficacy of treatments used. Patients were enrolled during a normal hospital visit and were prescribed a treatment for ED. They were asked at baseline and after 3 and 6 months, to answer a set of questions from the International Index of Erectile Function, Erectile Dysfunction Inventory of Treatment Satisfaction （EDITS） and Short Form of the Psychological and Interpersonal Relationships Scale questionnaires （SF-PAIRS）. Clinicians were free to prescribe any therapy for ED available in the market, and to change therapy at any time during the study. Out of 1 338 patients, available for analysis at 6 months, 624 （47%） changed their treatment during the study and 714 （53%） continued with the drug prescribed at baseline. Patients assuming tadalafil had a significantly higher probability of maintaining the same treatment compared to sildenafil or vardenafil. There was no clinically significant difference in terms of efficacy, patient satisfaction, self-confidence and spontaneity between the different inhibitors of PDE5. The ‘time concerns＇ domain score of SF-PAIRS, was statistically better in patients assuming tadalafil. In conclusion sildenafil, vardenafil and tadalafil show similar efficacy in the clinical practice. However, patients receiving tadalafil display a lower risk to discontinue or change the treatment.

关键词： clinical practice Italy phosphodiesterase type 5 inhibitors sildenafil tadalafil vardenafil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of plunge pool configuration on downstream passage survival of juvenile blueback herring

引用

Aquaculture and Fisheries 2021年第2期6卷 135-143页

作者： Theodore Castro-Santos Kevin B.Mulligan Micah Kieffer alexander J.haro u.s.geological survey-leetown science center s.o.conte anadromous fish research centerone migratory wayturners fallsma01376usa

Anadromous alosines are widespread throughout the Northern *** of this clade are notoriously fragile animals that are at high risk of injury and death associated with passage at hydroelectric *** turbine mortality is a common concern,conditions encountered when bypassed around these routes may also be *** bypass structures typically discharge into plunge pools,which are highly turbulent and may cause mechanical *** subjected live,actively migrating juvenile blueback herring to a suite of realistic plunge pool conditions(3 m drop,pool depth of 60-180 cm,and discharge of 0.28-1.70 m^(3)/s)and monitored them for≥96 *** was generally higher than expected(>80%in all cases).However,both plunge pool volume and total discharge affected survival with elevated discharge and shallow conditions associated with increased *** was often delayed:rates remained elevated throughout the monitoring period,indicating that survival studies based on shorter periods underestimate total mortality.

关键词： Fish passage River herring Blueback herring Plunge pool Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of Atypical Individuals of Lannea in Burkina Faso

引用

American Journal of Plant Sciences 2023年第7期14卷 782-792页

作者： Kadidia Semdé Hadou haro Souleymane Ganaba Institute of Environment and Agricultural Research/Environment and Forests Department (INERA/DEF) University of Nazi Boni Ouagadougou Burkina Faso Institute of Environment and Agricultural Research/Environment and Forests Department (INERA/DEF) University Joseph Ki-Zerbo Ouagadougou Burkina Faso

Background and Objectives: The species to the Lannea genus are trees, shrubs with compound leaves. Thus, individuals called atypical Lannea with single leaves and of socio-economic interests have been identified in the central plateau region (Burkina Faso). This study aimed to contribute to the identification of atypical species. Material and Methods: The Polymerase Chain Reaction (PCR) method using specific primers was performed and consisted of extracting DNA from young leaves of Lannea individuals, amplifying and then sequencing portions of discriminating DNA (matK, rbcL and rps16). Results: It was shown that individuals belong to the Lannea genus, but are subdivided into three subgroups: a first subgroup containing Lannea microcarpa and two subgroups with no previously identified Lannea species. Conclusion: These atypical individuals are ecotypes or mutants of Lannea microcarpa.

关键词： Characterization Lannea Atypical Individuals Agrosystems Polymerase Chain Reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling of Multi-Pulse VSC Based SSSC and STATCOM

引用

Journal of Electromagnetic Analysis and Applications 2010年第3期2卷 145-161页

作者： Pavel Zuniga- haro Juan Manuel Ramirez 不详

The aim of this paper is to contribute to the dynamic modeling of multi-pulse voltage sourced converter based static synchronous series compensator and static synchronous compensator. Details about the internal functioning and topology connections are given in order to understand the multi-pulse converter. Using the 24 and 48-pulse topologies switching functions models are presented. The models correctly represent commutations of semiconductor devices in multi-pulse converters, which consequently allows a precise representation of harmonic components. Additionally, time domain models that represent harmonic components are derived based on the switching functions models. Switching functions, as well as time domain models are carried out in the original abc power system coordinates. Effectiveness and precision of the models are validated against simulations performed in Matlab/Simulink?. Additionally, in order to accomplish a more realistic comparison, a laboratory prototype set up is used to assess simulated waveforms.

关键词： Commutations Harmonics Multi-Pulse Modeling SSSC STATCOM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Nd3+doping on structure,microstructure,lattice distortion and electronic properties of TiO_2 nanoparticles

引用

Journal of Rare Earths 2017年第3期35卷 259-270页

作者： Balter Trujillo-Navarrete María del Pilar haro-Vázquez Rosa María Félix-Navarro Francisco Paraguay-Delgado Henry alvarez-Huerta Sergio Pérez-Sicairos Edgar alonso Reynoso-Soto institute technology of tijuana(itt) blvd.alberto limón padillaP.O.B 1166.Tijuana B.C.Mexico university autonomous of baja california(uabc) roadway university14418P.O.B 22390Tijuana B.C.Mexico investigations center of advanced materials(cimav).miguel de cervantes 120.P.O.B31109ChihuahuaMexico

Doped and undoped TiCh nanoparticles were prepared by Stober method and thermally treated at 600 ℃.The effect of Nd^（3＋） ion on the structure and micro structure of anatase-phase TiCh nanocrystals was studied by Rietveld refinement method using X-ray powder diffraction *** lengths,bond angles,and edges distances were *** phase formation was confirmed by high-resolution transmission electron *** adjustment of Ti-0 bond length induced by the addition of Nd^（3＋） ions,reduced the octahedral distortion and altered the octahedral array in the anatase-phase TiCh *** changes of structure and microstructure were mainly observed for TiCh nanoparticles doped with 0.1 at.%of Nd^（3＋） ions and attributed to the cationic substitution of Ti^（4＋） ions which promoted changes in the density of states and gap band of *** dopant insertion resulted in a better structural stability of the nanocrystals that enhanced their charge transference and photocatalytic efficiency.

关键词： neodymium TiO_2 nanoparticles microstructure lattice distortion photocatalytic activity optical properties Rietveld refinement rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：