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Review of tribological properties of nanoparticle-based lubricants and their hybrids and composites

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Friction 2024年第4期12卷 569-590页

作者： ye Zar Ni HTWE Aws.S.al-JANABI Yasmin WADZER Hussin MAMAT Ku NOORYASMIN School of Materials&Mineral Resources Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Malaysia School of Aerospace Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Malaysia Universiti Sains Malaysia

Due to their encouraging results,nanolubricants have been revolutionary in the field of *** degree,to which the new material may improve the tribology,energy savings,and durability,is a crucial consideration for any new additive to a conventional *** results of the earlier research on carbon,metal,metal oxide,and their composites and hybrid nanolubricants as well as their effects on tribology,are summarized in this review *** most popular measuring methodologies,the tribology results for lubricants with an oil base,biodegradable base,and a water base,as well as the reasons that explain these tribological advancements,are all included in this ***,prospects for more study in this area are emphasized.

关键词： nanolubricants tribology carbon metal metal oxide hybrid

SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1205-1216页

作者： Hui Cui di Sun Sheng Meng Tian-Ju Ma Zi ye Zhao-Hui Li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1(SIRT1)on modulating apoptosis of human lens epithelial cells(HLECs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(ER)***:HLECs(SRA01/04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1 and C/EBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01/04 cell apoptosis model,which underwent siRNA transfection for SIRT1 knockdown and SRT1720 treatment for its activation,the expression levels of SIRT1,CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1 knockdown effects by 4-phenyl butyric acid(4-PBA;an ER stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1,activated by SRT1720 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&E)staining,Western blotting,and ***:SIRT1 expression was downregulated in TMinduced SRA01/04 ***,in SRA01/04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01/04 cell apoptosis *** of SIRT1 by siRNA knockdown increased ER stress activation,whereas SRT1720 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1 knockdown on *** vivo,SRT1720 attenuated the lens opacification and weakened the ER stress activation in ARC rat ***:SIRT1 plays a protective role against TM-induced apoptosis in HLECs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

Insights into in-situ imbibition behavior of fracturing fluid in propped shale fractures based on nuclear magnetic resonance:A case study from Longmaxi Formation shale,Sichuan Basin,China

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Petroleum Science 2024年第1期21卷 410-429页

作者： Jing-Jing Guo Kai-Xiang di Lie-Hui Zhang Yu-Long Zhao Hui-Ying Tang Rui-Han Zhang ye Tian National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina

Shale gas is an important component of unconventional oil and gas *** the imbibition behavior is helpful to optimize flowback parameters and enhance gas *** imbibition studies have focused on shale matrix,and the pressure conditions discussed were mostly *** initial imbibition behavior begins from propped fractures to matrix,but there are few studies working on explaining the imbibition behavior in propped fractures or the phenomenon of many shale wells exhibit higher productivity after a“soaking”***,propped fracture samples were designed for imbibition and migration *** order to accurately study the mechanism and main influencing factors of fracturing fluid imbibition and migration in propped and unpropped shale fractures under high temperature and high pressure,a series of experiments based on nuclear magnetic resonance(NMR)were carried *** showed that NMR T_(2) spectra of all samples exhibited a bimodal *** final imbibition volume of fracturing fluid was positively related to pressure and fracture *** imbibition effect of fracturing fluid was more evident in matrix pores under high *** the migration during soaking stage,the fracturing fluid gradually migrated from large pores to small pores and gradually displaced the shale gas from the matrix,thus allowing the water blocking in propped fractures to self-unlock to some *** permeability decreased in the imbibition stage,while it recovered in the migration stage to some extent.

关键词： Forced imbibition Migration Soaking NMR T_(2)spectra Propped fracture Permeability recovery

Simplified liver imaging reporting and data system for the diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2439-2448页

作者： Rong Lyu Wei-Juan Hu di Wang Jiao Wang Yu-Bing ye Ke-Feng Jia Department of Radiology Tianjin Third Central HospitalTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin 300170China

BACKGROUND The liver imaging reporting and data system(LI-RADS)diagnostic table has 15 cells and is too *** diagnostic performance of LI-RADS for hepatocellular carcinoma(HCC)is not satisfactory on gadoxetic acid-enhanced magnetic resonance imaging(EOB-MRI).AIM To evaluate the ability of the simplified LI-RADS(sLI-RADS)to diagnose HCC on *** A total of 331 patients with 356 hepatic observations were retrospectively *** diagnostic performance of sLI-RADS A-D using a single threshold was evaluated and compared with LI-RADS v2018 to determine the optimal *** algorithms of sLI-RADS A-D are as follows:The single threshold for sLI-RADS A and B was 10 mm,that is,classified observations≥10mm using an algorithm of 10-19 mm observations(sLI-RADS A)and≥20 mm observations(sLI-RADS B)in the diagnosis table of LI-RADS v2018,respectively,while the classification algorithm remained unchanged for observationsalgorithms foralgorithm remained unchanged for observations≥20 *** hepatobiliary phase(HBP)hypointensity as a major feature(MF),the final sLI-RADS(F-sLI-RADS)was formed according to the optimal sLI-RADS,and its diagnostic performance was *** times needed to classify the observations according to F-sLIRADS and LI-RADS v2018 were *** The optimal sLI-RADS was sLI-RADS D(with a single threshold of 20 mm),because its sensitivity was greater than that of LI-RADS v2018(89.8%vs 87.0%,P=0.031),and its specificity was not lower(89.4%vs 90.1%,P>0.999).With HBP hypointensity as an MF,the sensitivity of F-sLI-RADS was greater than that of LI-RADS v2018(93.0%vs 87.0%,P<0.001)and sLI-RADS D(93.0%vs 89.8%,P=0.016),without a lower specificity(86.5%vs 90.1%,P=0.062;86.5%vs 89.4%,P=0.125).Compared with that of LI-RADS v2018,the time to classif

关键词： Hepatocellular carcinoma Magnetic resonance imaging Liver diagnosis Contrast agent

Prognostic factors for lacrimal gland adenoid cystic carcinoma:a retrospective study in Chinese patients

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1423-1430页

作者： Lu-di Yang Shi-Chong Jia Jie Yang Xin Song ye-Fei Wang Xian-Qun Fan Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital diseases and Ocular Oncology Shanghai 200011China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceNankai University Affiliated Eye HospitalTianjin Eye InstituteTianjin 300074China

AIM:To explore the prognostic factors for lacrimal gland adenoid cystic carcinoma(LGACC)in Chinese ***:Clinical and histopathological data were reviewed in patients with pathologically confirmed *** recurrence,metastasis,and disease-specific death were the main outcome *** and multivariate analyses were performed by the Kaplan-Meier method and a Cox proportional hazard ***:This retrospective cohort study included 45 patients with pathologically confirmed LGACC between January 2008 and June ***(T)classification(P=0.005),nodal metastasis(N)classification(P=0.018)and positive margin(P=0.008)were independent risk factors of recurrence;T(P=0.013)and N(P=0.003)classification and the basaloid tumor type(P=0.032)were independent risk factors for metastasis;T classification(Palysis,the durations from first surgery to radiotherapy is correlated with metastatic risk in LGACC patients with basaloid component(P=0.022).CONCLUSION:Histological subtype should be emphasized when evaluating prognosis and guiding *** radiotherapy may reduce the risk of metastasis in patients with basaloid component.

关键词： lacrimal gland adenoid cystic carcinoma risk factors prognostic analysis histological subtypes

GUE via Frobenius *** Matrix Gravity to Topological Gravity and Back

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Acta Mathematica Sinica,English Series 2024年第1期40卷 383-405页

作者： di YANG School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026P.R.China

Dubrovin establishes a certain relationship between the GUE partition function and the partition function of Gromov-Witten invariants of the complex projective *** this paper,we give a direct proof of Dubrovin’s *** ... 详细信息

关键词： Frobenius manifold Dubrovin-Zhang hierarchy GUE Toda lattice hierarchy jet space topological gravity matrix gravity

Investigations of Water Flow Behaviors Induced by Local Temperature Variations through a Single Rough Fracture for the Enhanced Geothermal Systems

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Journal of Thermal Science 2024年第3期33卷 1055-1064页

作者： LI Jiawei ye Lin Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China

In recent years,Enhanced Geothermal System(EGS)technologies have been applied to the geothermal resources production in the Hot Dry Rock(HDR).The core of EGS technologies is to adopt hydraulic fracturing in the reservoir to create a connected network of discrete fractures with the consideration of water as a working fluid for hydraulic fracturing and heat *** paper investigates the characteristics of water flow behaviors through a single rough fracture under different temperature and pressure conditions.A single fracture model with rough fracture surfaces is constructed and then characterized,and influences of the anisotropic factor on the average tortuosity and frictional resistance coefficient of water flow through a single fracture with rough surfaces have been compared and *** consideration of other impacting factors(temperature,pressure,fracture roughness),the impact of mass flow rate has also been *** simulation results present that changes of average tortuosity for water flow through a single rough facture are mainly affected by *** can be observed that higher temperature leads to larger average tortuosity but the frictional resistance coefficient shows an opposite *** for pressure conditions,it is found that effects of pressure on average tortuosity and frictional resistance coefficient is very small,which can be neglected under high pressure ***,the average tortuosity shows a progressively linear relationship with the mass flow *** the contrary,the frictional resistance coefficient has a negative relationship with the mass flow *** is revealed that when the mass flow rate reaches a critical point,the influences of temperature on the frictional resistance coefficient will be *** of single rough fractures with different anisotropic factors show that values of average tortuosity and frictional resistance coefficient have positive relationships with the increase

关键词： single rough fracture tortuosity frictional resistance enhanced geothermal system

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： di Wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 239-246页

作者： Yue di Zhong-Bao Qiao Hai-Yun ye Xin-Yue Li Wen-Ting Luo Wang-Yi Fang Tong Qiao Department of Ophthalmology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China

AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python ***:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes *** corresponding photo pixels-actual length ratio was acquired by a proportional *** edge coordinates were identified artificially by ginput *** and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal *** curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric ***,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in *** results were compared between in vivo and in ***:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the *** horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°*** the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical ***:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in *** are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of *** study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.

关键词： ocular morphological parameters guinea pig digital measurement Python