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澳门建筑遗产之移植特征

合肥工业大学学报（自然科学版） 2009年第6期32卷 911-915页

作者：吴尧 Francisco Vizeu pinheiro 江南大学设计学院江苏无锡214122 澳门民政总署中国澳门999078

澳门历史城区被新增为世界历史文化遗产,澳门历史建筑的价值也正逐步被发掘,它是我国最古老的西式建筑遗产,也是东西方建筑艺术的综合体现,是中国历史城市中极具特色的组合。其中,"移植性"是澳门建筑遗产一个重要的文化特征,并体现在其... 详细信息

澳门历史城区被新增为世界历史文化遗产,澳门历史建筑的价值也正逐步被发掘,它是我国最古老的西式建筑遗产,也是东西方建筑艺术的综合体现,是中国历史城市中极具特色的组合。其中,"移植性"是澳门建筑遗产一个重要的文化特征,并体现在其城市格局、建筑风格、建筑构造与细部装饰中,反映出澳门建筑对来自世界各地不同文化的移植与包容。

关键词：澳门遗产移植

MicroRNA expression in inflammatory bowel disease-associated colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 995-1016页

作者： Thais Gagno Grillo Ana Elisa Valencise Quaglio Rodrigo Fedatto Beraldo Talles Bazeia Lima Julio pinheiro Baima Luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology São Paulo State University(Unesp)Institute of BiosciencesBotucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs)are non-coding RNA molecules composed of 19–25 nucleotides that regulate gene expression and play a central role in the regulation of several immune-mediated disorders,including inflammatory bowel diseases(IBD).IBD,represented by ulcerative colitis and Crohn’s disease,is characterized by chronic intestinal inflammation associated with an increased risk of colorectal cancer(CRC).CRC is one of the most prevalent tumors in the world,and its main risk factors are obesity,physical inactivity,smoking,alcoholism,advanced age,and some eating habits,in addition to chronic intestinal inflammatory processes and the use of immunosuppressants administered to IBD *** studies have identified miRNAs associated with an increased risk of developing CRC in this *** identification of miRNAs involved in this tumorigenic process could be useful to stratify cancer risk development for patients with IBD and to monitor and assess ***,the present review aimed to summarize the role of miRNAs as biomarkers for the diagnosis and prognosis of IBD-associated *** the future,therapies based on miRNA modulation could be used both in clinical practice to achieve remission of the disease and restore the quality of life for patients with IBD,and to identify the patients with IBD at high risk for tumor development.

关键词： MicroRNA Colorectal cancer Inflammatory bowel disease Crohn's disease Ulcerative colitis Cancer Diagnosis Prognosis Targets

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基于低成本立体视觉测距系统研究

基于低成本立体视觉测距系统研究

作者： Cheman Julio pinheiro 大连理工大学

学位级别：硕士

随着机器人领域的迅速发展,许多计算机视觉系统也得到了发展。立体视觉作为一种计算机视觉技术,它能够实现通过使用两个对齐的相机从场景中提取深度信息。而深度图像可以通过比较来自两个相机的对应像素的偏移来估计。但是,在实时立体... 详细信息

随着机器人领域的迅速发展,许多计算机视觉系统也得到了发展。立体视觉作为一种计算机视觉技术,它能够实现通过使用两个对齐的相机从场景中提取深度信息。而深度图像可以通过比较来自两个相机的对应像素的偏移来估计。但是,在实时立体视觉中,图像必须以合理的帧速率进行计算。实时立体视觉的移动机器人平台允许自主导航和提供深度的场景与环境互动。目前解决立体声对应问题成为研究热点,但现有的开发用于实时移动机器人平台的解决方案,其计算能力和硬件非常有限。在本论文中,我们提出了一种低成本的立体视觉系统,能够以30Hz的帧率从运动物体中提取深度图像。本文所提出的方法是基于局部密集立体对应算法,其使用先前的前景提取来简化视差。此外,本文提出了一种基于权重均值的方法来提高视差图像的稳定性。本实验结果表明了所提出的方法的鲁棒性和良好的时间性能。

关键词：立体视觉距离测量前景分割

Influence of Protease Inhibitors on Bond Degradation of Self-Etch Adhesive Systems to Caries-Affected Dentin: An <i>in Vitro</i>Study

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Advances in Biological Chemistry 2018年第1期8卷 15-28页

作者： Diana Roberta Pereira Grandizoli Sérgio Luiz pinheiro Health Sciences Pontifícia Universidade Católica de Campinas (PUC-Campinas) S&atilde o Paulo SP Brazil Master’s Program in Health Sciences PUC-Campinas School of Dentistry. Campinas S&atilde o Paulo SP Brazil

Background: A decline in pH and dissolution of the inorganic content of the dental tissues are followed by exposure of the organic portion of the tooth, which, in dentin, is largely composed of collagen fibres. These unprotected fibres are then degraded by metalloproteinases and cysteine cathepsins, proteolytic enzymes present in dentin. We evaluated the influence of protease inhibitors on the bond strength of a self-etch adhesive system to caries-affected dentin. Eighty permanent third molars were selected for the study. Dentinal caries were induced artificially by the microbial method and the teeth were divided in four groups: G1—application of Clearfil SE Bond adhesive system (CL);G2—2% chlorhexidine (CLX) + CL;G3—sodium bicarbonate (BIC) + CL;G4—BI + CLX + CL. Bond strength was assessed immediately and at six months. During the six months, the specimens were stored in distilled water. Microtensile bond strength testing was performed. On immediate testing, there was no significant difference in bond strength across the control, BIC, and CLX groups. The combination of BIC + CLX, however, led to an immediate, significant reduction in bond strength. After six months, bond strength was reduced in all groups. The highest bond strength was obtained in the control group (P 0.05). Most fractures were adhesive, both immediately and at six months. We concluded that the cavity pretreatment with 2% CLX or 2% BIC did not have an immediate negative impact on bond strength of the Clearfil SE Bond system. After specimens were stored for six months in water, their bond strength of specimens was reduced in all groups. This reduction was the greatest in the groups exposed to the inhibitors.

关键词： Protease Inhibitors Chlorhexidine Sodium Bicarbonate Mi-crotensile Bond Pretreatment

Reaction Time of Children with and without Autistic Spectrum Disorders

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Open Journal of Medical Psychology 2017年第2期6卷 166-178页

作者： Brett Baisch Sean Cai Zongming Li Victor pinheiro Constellation Schools Cleveland OH USA School of Sport Science & Wellness Education University of Akron Akron OH USA Departments of Biomedical Engineering Physical Medicine and Rehabilitation and Orthopaedic Surgery Cleveland Clinic Foundation Cleveland OH USA

This study was conducted to evaluate and compare simple and choice reaction times for the comparison of perceptual-motor development levels found in children with and without autism. The participants of the study consisted of 24 children with autism and 10 typically developing (TD) children. Within the group of children with autism, only 10 were able to offer a full set data and four offered partial data. Data were collected through a computer-based procedure of reaction time test software, where the participant reacted by pressing a key on a laptop upon the appearance of one of the boxes turning yellow. Simple and choice reaction times appeared on the screen and were then recorded. The means and standard deviations were calculated for comparison and the data were evaluated from the results of a t-test. Significant differences were found among all reaction time tasks, whereas the group consisting of children with autism demonstrated slower reaction times and greater standard deviations compared with the typically developing/control group.

关键词： Autism Reaction Time Perceptual-Motor Development Motor Impairments Physical Education

Second Note on the Definition of S<sub>1</sub>-Convexity

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Advances in Pure Mathematics 2015年第3期5卷 127-130页

作者： I. M. R. pinheiro RGMIA AMS PROz. Melbourne Australia

In this note, we discuss the definition of the S1-convexity Phenomenon. We first make use of some results we have attained for?? in the past, such as those contained in [1], to refine the definition of the phenomenon. We then observe that easy counter-examples to the claim extends K0 are found. Finally, we make use of one theorem from [2] and a new theorem that appears to be a supplement to that one to infer that? does not properly extend K0 in both its original and its revised version.

关键词： Analysis Convexity Definition s-Convexity Geometry Shape S-Convexity s-Convex Function S-Convex Function

Minima Domain Intervals and the S-Convexity, as well as the Convexity, Phenomenon

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Advances in Pure Mathematics 2012年第6期2卷 457-458页

作者： I. M. R. pinheiro P.O. Box 12396 A’Beckett St Melbourne VIC AU 8006

In this paper, we propose a refinement in the analytical definition of the s2-convex classes of functions aiming to progress further in the direction of including s2-convexity properly in the body of Real Analysis.

关键词： Analysis Convexity Definition S-Convexity

Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3219-3226页

作者： Ana Lorena Sousa de Vasconcelos Garate Thiara Barcelos Rocha Luciana Rocha almeida Rodrigo Quera Jaqueline Ribeiro Barros Julio pinheiro Baima Rogerio Saad-Hossne Ligia Yukie Sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Inflammatory Bowel Disease Program GastroenterologyMedicine DepartmentClínica Universidad de los AndesSantiago 7550000Chile

BACKGROUND Acute severe ulcerative colitis (ASUC) is a complication of ulcerative colitisassociated with high levels of circulating tumor necrosis factor alpha, due to theintense inflammation and faster stool clearance of anti-tumor necrosis factordrugs. Dose-intensified infliximab treatment can be beneficial and is associatedwith lower rates of colectomy. The aim of the study was to present a case of apatient with ASUC and megacolon, treated with hydrocortisone and acceleratedscheme of infliximab that was monitored by drug trough *** SUMMARYA 22-year-old female patient diagnosed with ulcerative colitis, presented withdiarrhea, rectal bleeding, abdominal pain, vomiting, and distended *** investigation, a positive toxin for Clostridium difficile and colonic dilatationof 7 cm consistent with megacolon were observed. She was treated with oralvancomycin for pseudomembranous colitis and intravenous hydrocortisone forsevere colitis, which led to the resolution of megacolon. Due to the persistentsevere colitis symptoms, infliximab 5 mg/kg was prescribed, monitored by drugtrough level (8.8 μg/mL) and fecal calprotectin of 921 μg/g (sion at week 1, consistent with the acceleratedregimen (infusions at weeks 0, 1, 2 and 6). We achieved a positive clinical andendoscopic response after 6 mo of therapy, without the need for a *** accelerated infusions can be beneficial in ASUC unresponsive to thetreatment with intravenous corticosteroids. Longitudinal studies are necessary todefine the best therapeutic drug monitoring and treatment regimen for thesepatients.

关键词： Infliximab Acute severe ulcerative colitis Toxic megacolon Ulcerative colitis Inflammatory bowel disease Case report

Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 405-413页

作者： Patrícia Gonçalves pinheiro Gilvandete Maria pinheiro Santiago Francisco Erivaldo Freitas da Silva Ana Carolina Justino de Araújo Cícera Rejane Tavares de Oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose alencar de Menezes Henrique Douglas Melo Coutinho JoséGalberto Martins da Costa Departamento de Química Biológica Programa de Pos-Graduação em Química BiológicaUniversidade Regional do Cariri–URCACrato–CEBrazil Programa de Pós-Graduação em Química Centro de CiênciasUniversidade Federal do Ceará–UFCFortaleza–CEBrazil

Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus ***:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance *** minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium *** docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using *** best scoring model was used as a receptor for ligand-receptor ***:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial ***,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified *** docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all *** PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA *** pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug ***:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump.

关键词： Ferulic acid Esterified derivatives Efflux pump Staphylococcus aureus Resistance mechanisms