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抗HLA－A2单抗重链可变区基因的克隆及其序列分析

1987年

作者：胡笳选编 20001120d1987 km y0chiy0120 ea

来源：汇雅图书（南通市图书馆... 评论

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中国免疫学杂志 1995年第6期11卷 355-358页

作者：苏娜 Ar.,ea 同济医科大学免疫学教研室

从５株抗ＨＬＡ－Ａ２单抗杂交瘤细胞株中提取ｍＲＮＡ，以特异性引物采用ＰＣＲ技术，扩增和克隆出单抗可变区重链基因，并采用双脱氧链式终止法及计算机基因文库测定和分析了其全部的氨基酸序列，对抗体的生物学特性的研究具有重要意... 详细信息

从５株抗ＨＬＡ－Ａ２单抗杂交瘤细胞株中提取ｍＲＮＡ，以特异性引物采用ＰＣＲ技术，扩增和克隆出单抗可变区重链基因，并采用双脱氧链式终止法及计算机基因文库测定和分析了其全部的氨基酸序列，对抗体的生物学特性的研究具有重要意义，为构建基因工程抗体奠定了基础。

关键词：单克隆抗体基因克隆序列分析脱氧核糖核酸

Socio-cultural factors influencing insecticide treated bed net utilization in a malaria endemic city in north-central Nigeria

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 402-406页

作者： Jombo GTA Mbaawuaga EM Gyuse AN Enenebeaku MNO Okwori EE Peters EJ Akpan S Odey F Etukumana ea Akosu JT Department of Medical Microbiology and Parasitology College of Health SciencesBenue State UniversityPMB 102119 MakurdiNigeria Department of Biological Sciences Faculty of ScienceBenue State UniversityPMB 102119 MakurdiNigeria Department of Family Medicine College of Medical SciencesUniversity of CalabarPMB 1115 CalabarNigeria Department of Medical Microbiology College of Medical SciencesUniversity of Jos Department of Internal Medicine College of Medical SciencesUniversity of Calabar PMB 1115 CalabarNigeria Department of Medical Microbiology and Parasitology College of Medical SciencesUniversity of CalabarPMB 1115 CalabarNigeria Department of Paediatrics College of Medical SciencesUniversity of CalabarPMB 1115 CalabarNigeria Department of Family Medicine University of Uyo Teaching Hospital Department of Community Medicine College of Medical SciencesUniversity of Jos

Objective:To ascertain the socio-cultural factors influencing the rate of utilization of insecticide treated bed nets(ITNs) in a malaria endemic city of Makurdi,north central Nigeria. Methods:The study was cross-sectional in nature using systematic sampling method to identify *** quantitative and qualitative data was generated from adult women using structured and semi structured questionnaires,and focused group discussions(FGDs) to obtain information on rate and patterns of utilization of *** such as age,educational level, marital status,awareness or otherwise of the existence of malaria,and factors influencing rate of ownership and utilization of ITNs were *** were used to obtain qualitative information on rate of utilization of ITNs not captured in the *** obtained was analysed using Epi Info 6 statistical ***:Among the respondents interviewed,97.0% (2 013/2 075) were aware of existence of malaria and 87.0% of these(1 751/2 013) would associate it with *** rate of ownership of any bed net,ITNs and untreated bed nets(UTNs) was 25.1% ,17.0% and 8.3% ,*** of ITNs among children was 30.0% (112/373) and UTNs 12.9% (48/373).Positive contributors to ITNs utilization were literacy,enhanced economy, experience of marriage,and being gainfully employed(Pal beliefs and ***:A more synchronized advocacy should be carried out on the potential benefits of ITNs utilization and *** ITNs should be made available to the people of the community at minimal or no cost.

关键词： Insecticide treated bed nets Utilization Households Malaria endemic city

Respiratory Tract, Ventilation, and Pulmonary Functions Tests

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Journal of Clinical and Nursing Research 2022年第3期6卷 209-215页

作者： Sara M Tony Mohamed ea Abdelrahim Beni-Suef Specialized Hospital Beni-Sueft Egypt Clinical Pharmacy Department Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

Breathing is considered the common factor that links studying,sleeping,and *** is one of the primary indicators that is frequently considered when determining whether or not an unconscious individual is still *** evolution and development process of the respiratory system that occurs in a foetus is primarily from head to tail(cephalocaudal).Many changes occur throughout this period until the 28th week of pregnancy at which the foetus^respiratory system will attain adequate development for the rest of his or her *** respiratory system comprises of the lungs and the encompassing thoracic wall,which includes the thoracic cages,midriff(diaphragm),and the abdominal *** is a procedure used for estimating air volumes that enter and exit the pulmonary system with the aid of a *** various pulmonary parameters that reflect pulmonary ventilation are of great significance in diagnosing respiratory *** respiratory system will be discussed in more detail in this article.

关键词： Respiratory tract Ventilation Pulmonary functions tests

Inhalation Devices and Pulmonary Drug Delivery

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Journal of Clinical and Nursing Research 2022年第3期6卷 54-72页

作者： Sara M Tony Mohamed ea Abdelrahim Beni-Suef Specialized Hospital Beni-Suef Egypt Clinical Pharmacy Department Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

Inhaled drug delivery is mainly used to treat pulmonary airway disorders by transporting the drug directly to its targeted location for *** decreases the dose required to exert a therapeutic effect and minimizes any potential adverse *** drug delivery to air passages facilitates a faster onset of action;it also minimizes irritation to the stomach,which frequently occurs with oral medications,and prevents the exposure of drugs to pre-systemic metabolism that takes place in the intestine and *** addition to that,the lung is regarded as a route for transporting medications throughout the entire body's blood *** type of medication and the device used to deliver it are both important elements in carrying the drug to its target in the *** types of inhalation methods are used in inhaled *** differ in the dose delivered,inhalation technique,and other *** paper will discuss these factors in more detail.

关键词： Pulmonary drug delivery pMDI,DPI Nebulizer

Methods in Determining the Bioequivalence of Inhaled Products

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Journal of Clinical and Nursing Research 2022年第3期6卷 73-88页

作者： Sara M Tony Mohamed ea Abdelrahim Beni-Suef Specialized Hospital Beni-Sueft Egypt Clinical Pharmacy Department Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

Aerosol delivery to the lungs can be achieved with several devices that differ in their operating mechanisms and efficacies of aerosol *** are several methods to measure aerosol delivery and deposition in a subject's lung,in order to assess the efficacy of aerosol generators and the impact of certain *** such as cascade impactors,imaging techniques,and laser diffraction are available for measuring the particle size of aerosols,which is the main factor in the deposition and distribution of the produced *** impactors to laser difEractors,they have different operating mechanisms,analysis times,and characteristics,in which each has its own advantages and *** models are available to investigate aerosol delivery and deposition,such as in vitro,in vivo,and ex vivo models.

关键词： In vitro In vivo Ex vivo Clinical study

关于淋巴丝虫病的感染与致病——一种免疫学的观点

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国外医学（寄生虫病分册） 1993年第2期20卷 71-73页

作者： Ottesen ea 蒋作君

淋巴丝虫病免疫学观点的基本内容是宿主不同的免疫应答导致不同的临床表现。不同免疫应答的机制反映了不同T淋巴细胞因子的应答特点。淋巴病变的发生有两种不同的机制,一种取决于宿主免疫应答诱导的炎症反应,另一种则完全独立于宿主免... 详细信息

淋巴丝虫病免疫学观点的基本内容是宿主不同的免疫应答导致不同的临床表现。不同免疫应答的机制反映了不同T淋巴细胞因子的应答特点。淋巴病变的发生有两种不同的机制,一种取决于宿主免疫应答诱导的炎症反应,另一种则完全独立于宿主免疫系统,反映了丝虫及其产物对淋巴系统的直接作用。因此,不但对丝虫感染有较强免疫应答的个体,而且无症状微丝蚴血症者均有发展成淋巴系统病变的危险。本文简要描述了淋巴丝虫病的临床类型,较为详细地阐述了淋巴丝虫感染的致病机制,并提出了解释病理学发生的三种假说。

关键词：丝虫病感染致病免疫学

Diseases of the Respiratory Tract: Asthma and Chronic Obstructive Pulmonary Disease

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Journal of Clinical and Nursing Research 2022年第3期6卷 236-250页

作者： Sara M Tony Mohamed ea Abdelrahim Beni-Suef Specialized Hospital Beni-Sueft Egypt Clinical Pharmacy Department Faculty of PharmacyBeni-Suef University Beni-SuefEgypt

Short acting β2-agonists(SABAs)such as salbutamol and terbutaline are commonly used in the treatment of asthma and chronic obstructive pulmonary disease(COPD).According to the guideline produced by the British Thoracic Society(BTS)and the Scottish Intercollegiate Guidelines Network(SIGN),SABAs are considered to be the first line of treatment in asthma *** National Institute for Health and Clinical Excellence(NICE)guidelines also recommend the use of SABA as the first line of treatment for managing patients with *** recommendations in NICE guidelines state that in COPD patients,breathlessness and exercise limitation should be first medicated with short-acting bronchodilators(including β2-agonists or anticholinergics)when it is *** salbutamol and terbutaline have been widely used for asthma and COPD,and they have been found to be extremely beneficial in the two pathologic conditions.

关键词： Respiratory tract Asthma COPD