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Macrolide-Clarithromycin Task-Force for the Treatment and Prophylaxis of Covid-19 as a Single Agent

Pharmacology & Pharmacy 2020年第6期11卷 85-104页

作者： Eduardo Mansilla Ricardo Rangel Martínez Gustavo Horacio Marín Idiberto Zotarelli Filho Elsa Rivas Jaime Rivas Katherine Athayde Teixeira de Carvalho Mohammad Reza Dayer alí samadikuchaksaraei Internal Medicine School of Medical Sciences UNLP La Plata Argentina ExomePharma Ciudad de México DF México Pharmacology School of Medical Sciences UNLP La Plata Argentina Faceres Medical School Sao José do Rio Preto Sao Paulo Brazil Intensive Care Units-Hospital de la Amistad Perú Corea II Santa Rosa and Salvador University Hospital Piura Perú Intensive Care Unit Hospital de la Amistad Perú Corea II Santa Rosa Piura Perú Pequeno Príncipe Faculty & Pelé Pequeno Príncipe Institute Curitiba Paraná Brazil Department of Biology Faculty of Science Shahid Chamran University of Ahvaz Ahvaz Iran Department of Tissue Engineering & Regenerative Medicine Iran University of Medical Sciences Tehran Iran

SARS-CoV-2 is a novel RNA coronavirus responsible of a deadly pandemic: the clinical illness COVID-19. With only one authorized drug for emergency use in critically ill patients: Remdesivir, there is not any other approved drug or vaccine yet with proven potential to overcome this infection. We exposed here many scientific evidences to support our novel idea that a macrolide, basically Clarithromycin, could be effective as a single agent for treatment and prophylaxis of COVID-19. Clarithromycin could change the history of this pandemic. It could reduce the costs of treatment and the potential adverse effects when combining more than one drug such as with Hydroxychloroquine. Clarithromycin treatment and prophylaxis as a single agent could be much more simple, safe and cheaper as giving Chloroquine or Hydroxychloroquine alone or in combination with Azithromycin as well as other therapeutic options.

关键词： COVID-19 Macrolides Clarithromycin Single Agent Therapy Prophylaxis

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