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Tecia solanivora infestation increases tuber starch accumulation in Pastusa Suprema potatoes

Journal of Integrative Plant Biology 2018年第11期60卷 1083-1096页

作者： Pavan kumar Etzel Garrido Kun Zhao Yi Zheng Saleh Alseekh Erandi Vargas-Ortiz Alisdair R.Fernie Zhangjun Fei Katja Poveda Georg Jander Boyce Thompson Institute for Plant Research 533 Tower RoadIthacaNY 14853USA Department of Entomology Cornell UniversityIthacaNY 14853USA Max Planck Institute of Molecular Plant Physiology Wissenschaftspark GolmAm Muhlenberg 114476 PotsdamGermany department of entomology and nematology university of floridaGainesvilleFL 32611USA unidad de microbiologia basica y aplicada facultad de ciencias naturalesuniversidad autonoma de queretaroAv.de las Ciencias SINJuriquillaquerdtaroMdxico department of molecular biology institute for scientific and technological research of san luis potosiMexico

In response to infestation with larvae of the Guatemalan tuber moth （Tecia solanivora）, some Solanum tuberosum （potato） varieties exhibit an overcompensa- tion response, whereby the total dry mass of uninfested tubers is increased. Here, we describe early responses, within the first few days, of T. solanivora feeding, in the Colombian potato variety Pastusa Suprema. Non- targeted metabolite profiling showed significant second- ary metabolism changes in T. solanivora-infested tubers, but not in uninfested systemic tubers. In contrast, changes in primary metabolism were greater in unin- fested systemic tubers than in the infested tubers, with a notable 80% decline in systemic tuber sucrose levels within 1 d of T. solanivora infestation. This suggested either decreased sucrose transport from the leaves or increased sink strength, i.e., more rapid sucrose to starch conversion in the tubers. Increased sucrose synthesis was indicated by higher rubisco activase and lower starch synthase gene expression in the leaves of infested plants. Elevated sink strength was demonstrated by 45% more total starch deposition in systemic tubers of T. solanivord- infested plants compared to uninfested control plants. Thus, rather than investing in increased defense of uninfested tubers, Pastusa Suprema promotes deposition of photoassimilates in the form of starch as a response to T. solanivora infestation.

关键词： Tecia solanivora infestation increases tuber starch accumulation in Pastusa Suprema potatoes Figure

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Needs monitoring with quetiapine

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Chinese Medical Journal 2019年第1期132卷 113-114页

作者： Pugazhenthan Thangaraju Sajitha Venkatesan Vineet kumar Chadha Department of Pharmacology All India Institute of Medical SciencesRaipurChhattisgarh 492099India Clinical Division Central Leprosy Teaching and Research InstituteChengalpattuTamilnadu 603001India

To the Editor:We read with great interest regarding the article on "Acute Pancreatitis Associated with Valproate Treatment."By Quan et al^[1] published in your esteemed journal.

关键词： Acute Pancreatitis Associated Valproate Treatment quetiapine

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Sensitivity analysis of borehole thermal energy storage: examining key factors for system optimization

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Energy Storage and Saving 2024年第3期3卷 218-230页

作者： Piyush kumar Kumawat Haiyan Zhou Kevin Kitz John McLennan Kody Powell Milind Deo Palash Panja Department of Chemical Engineering University of UtahSalt Lake CityUT 84112USA Energy&Geoscience Institute University of UtahSalt Lake CityUT 84108USA RESPEC Company LLC Rapid CitySD 57703USA Kitzworks LLC BoiseID 83717USA

Borehole thermal energy storage(BTES)systems have garnered significant attention owing to their efficacy in storing thermal energy for heating and cooling *** modeling is paramount for ensuring the precise design and operation of BTES *** study conducts a sensitivity analysis of BTES modeling by employing a comparative investigation of five distinct parameters on a wedge-shaped model,with implications extendable to a cylindrical *** parameters examined included two design factors(well spacing and grout thermal conductivity),two operational variables(charging and discharging rates),and one geological attribute(soil thermal conductivity).Finite element simulations were carried out for the sensitivity analysis to evaluate the round-trip efficiency,both on a per-cycle basis and cumulatively over three years of operation,serving as performance *** results showed varying degrees of sensitivity across different models to changes in these *** particular,the round-trip efficiency exhibited a greater sensitivity to changes in spacing and volumetric flow ***,this study underscores the importance of considering the impact of the soil and grout-material thermal conductivities on the BTES-system performance over *** optimized scenario is modelled and compared with the base case,over a comparative assessment based on a 10-year *** analysis revealed that,at the end of the 10-year period,the optimized BTES model achieved a cycle efficiency of 83.4%.This sensitivity analysis provides valuable insights into the merits and constraints of diverse BTES modeling methodologies,aiding in the selection of appropriate modeling tools for BTES system design and operation.

关键词： Borehole thermal energy storage(BTES) Outlet temperature Round-trip efficiency Heating and cooling modes Well spacing Grout thermal conductivity Charging and discharging rates Soil thermal conductivity

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Chemotherapy advances in locally advanced head and neck cancer

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World Journal of Clinical Oncology 2014年第5期5卷 966-972页

作者： Peter Georges kumar Rajagopalan Chady Leon Priya Singh Nadir Ahmad Kamyar Nader Gregory J Kubicek Department of Medical Oncology Cooper University Hospital Camden NJ 08103 United States Department of Otolaryngology Cooper University Hospital Camden NJ 08103 United States Department of Radiation Oncology Cooper University Hospital Camden NJ 08103 United States

The management of locally advanced unresectable head and neck squamous cell cancer(HNSCC) continues to improve. One of the major advances in the treatment of HNSCC was the addition of chemotherapy to radiation in the treatment of non-surgical patients. The majority of the data regarding chemotherapy in HNSCC involve cisplatin chemotherapy with concurrent radiation. However, several new approaches have included targeted therapy against epidermal growth factor receptor and several recent studies have explored the role of induction chemotherapy in the treatment of HNSCC. The purpose of this article is to provide an overview of the role of chemotherapy in the treatment of locally advanced HNSCC.

关键词： Head and neck cancer Chemotherapy Induction

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Bioengineered humanized livers as better three-dimensional drug testing model system

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World Journal of Hepatology 2018年第1期10卷 22-33页

作者： Sandeep kumar Vishwakarma Avinash Bardia Chandrakala Lakkireddy Raju Nagarapu Md Aejaz Habeeb Aleem Ahmed Khan Central Laboratory for Stem Cell Research and Translational Medicine Centre for Liver Research and Diagnostics Deccan College of Medical Sciences

AIM To develop appropriate humanized three-dimensional ex-vivo model system for drug testing. METHODS Bioengineered humanized livers were developed in this study using human hepatic stem cells repopulation within the acellularized liver scaffolds which mimics with the natural organ anatomy and physiology. Six cytochrome P-450 probes were used to enable efficient identification of drug metabolism in bioengineered humanized livers. The drug metabolism study in bioengineered livers was evaluated to identify the absorption, distribution, metabolism, excretion and toxicity *** The bioengineered humanized livers showed cellular and molecular characteristics of human livers. The bioengineered liver showed three-dimensional natural architecture with intact vasculature and extra-cellular matrix. Human hepatic cells were engrafted similar to the human liver. Drug metabolism studies provided a suitable platform alternative to available ex-vivo and in vivo models for identifying cellular and molecular dynamics of pharmacological *** The present study paves a way towards the development of suitable humanized preclinical model systems for pharmacological testing. This approach may reduce the cost and time duration of preclinical drug testing and further overcomes on the anatomical and physiological variations in xenogeneic systems.

关键词： Acellularization Repopulation Drug testing Humanized liver Bioengineering

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Revealing Genetic Relationship and Prospecting of Novel Donors Among Upland Rice Genotypes Using qDTY-Linked SSR Markers

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Rice science 2018年第6期25卷 308-319页

作者： Mitadru MUKHERJEE Barada PADHY Bharathkumar SRINIVASAN Pradosh MAHADANI Sk Yasin BAKSH Ravindra DONDE Onkar Nath SINGH Lambodar BEHERA Padmini SWAIN Sushanta kumar DASH Crop Improvement Division ICAR-National Rice Research Institute Departement of Botany Kandaswamy Kandar’s College Crop Physiology and Biochemistry Division National Rice Research Institute

A total of 17 simple sequence repeat(SSR) markers linked to QTLs(qDTYs) governing grain yield under reproductive stage(RS) drought stress were used to assess the genetic relationship and prospecting new donors for q DTYs among 32 popular upland rice genotypes. These SSR markers generated a total of 36 alleles with an average allele count of 2.1 per locus. Polymorphic information content value of the markers ranged from 0.376 to 0.662 with an average value of 0.484. The expected heterozyogosity ranged from 0.381 to 0.632. STRUCTURE analysis divided the 32 genotypes into three sub-populations. Subsequent phenotyping revealed that all the tolerant genotypes were grouped into one sub-population, whereas the moderately tolerant and susceptible genotypes were grouped into separate sub-populations. Phylogenetic tree constructed by the unweighted neighbour-joining method also divided the genotypes into three clusters. The grouping pattern of genotypes into the clusters was similar to that into the STRUCTURE analysis, on the basis of drought tolerance level. The average value of genetic dissimilarity coefficient among the genotypes was observed to be 0.486. Furthermore, by combining genotyping data with phenotyping data, 16 new donors for 6 qDTYs were identified.

关键词： drought screening genetic relationship population structure qDTY donor upland rice grain yield

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Immune function biomarker QuantiFERON-monitor is associated with infection risk in cirrhotic patients

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World Journal of Hepatology 2016年第35期8卷 1569-1575页

作者： Siddharth Sood Lijia Yu kumar Visvanathan Peter William Angus Paul John Gow Adam Gareth Testro Department of Gastroenterology and Hepatology University of Melbourne Royal Melbourne Hospital Liver Transplant Unit Victoria University of Melbourne Innate Immune Laboratory University of Melbourne St Vincent’s Hospital

AIMTo investigate whether a novel immune function biomarker QuantiFERON-Monitor (QFM) can identify cirrhotic patients at greatest risk of infection. METHODSAdult cirrhotic patients on the liver transplant waiting list were recruited for this observational cohort study from a tertiary liver transplant referral unit. The immune function biomarker, QFM was performed using the same method as the widely available Quantiferon-gold assay, and measures output in interferon gamma in IU/mL after dual stimulation of the innate and adaptive immune systems. Ninety-one cirrhotic patients were recruited, with 47 (52%) transplanted on the day of their QFM. The remaining 44 (48%) were monitored for infections until transplant, death, or census date of 1st February 2014. RESULTSCirrhotic patients express a median QFM significantly lower than healthy controls (94.5 IU/mL vs 423 IU/mL), demonstrating that they are severely immunosuppressed. Several factors including model for end stage liver disease, presence of hepatocellular carcinoma, bilirubin, international normalized ratio and haemoglobin were associated with QFM on univariate analysis. Disease aetiology did not appear to impact QFM. On multivariate analysis, only Child-Pugh score and urea were significantly associated with a patient’s immune function as objectively measured by QFM. In the 44 patients who were not transplanted immediately after their blood test and could be monitored for subsequent infection risk, 13 (29.5%) experienced a pre-transplant infection a median 20 d (range 2-182) post-test. QFM P = 0.01) for infection. A very low QFM P = 0.003) with death in three patients who died while awaiting transplantation (HR = 56.6). CONCLUSIONQFM is lower in cirrhotics, allowing objective determinations of an individual’s unique level of immune dysfunction. Low QFM was associated with increased susceptibility to infection.

关键词： Infection Biomarker Immune dysfunction Immune function Immunosuppression Liver Immune system Cirrhosis Mortality

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An Optimized Fuzzy Based Ant Colony Algorithm for 5G-MANET

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Computers, Materials & Continua 2022年第1期70卷 1069-1087页

作者： R.Nithya K.Amudha A.Syed Musthafa Dilip kumar Sharma Edwin Hernan Ramirez-Asis Priya Velayutham V.Subramaniyaswamy Sudhakar Sengan Department of Computer Science and Engineering Vivekananda College of Engineering for WomenTiruchengode637205Tamil NaduIndia Department of Electronics and Communication Engineering Kongunadu College of Engineering and TechnologyThottiam621215Tamil NaduIndia Department of Information Technology M.Kumarasamy College of EngineeringKarur639113Tamil NaduIndia Department of Mathematics Jaypee University of Engineering and TechnologyGuna473226M.P.India Business and Tourism Faculty Universidad Nacional Santiago Antunez De MayoloHuarazPeru Department of Computer Science and Engineering Paavai Engineering CollegeNamakkal637018Tamil NaduIndia School of Computing SASTRA Deemed UniversityThanjavur613401Tamil NaduIndia Department of Computer Science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia

The 5G demonstrations in a business has a significant role in today’s fast-moving *** in 5G,drives a wireless system intended at an enormously high data rate,lower energy,low latency,and *** this reason,routing protocols of MANET have the possibility of being fundamentally flexible,high performance,and *** 5G communication aims to afford higher data rates and significantly low Over-The-Air *** through supplementary ACO routing processes,a security-aware,fuzzy improved ant colony routing optimization protocol is proposed in *** goal is to develop aMANET routing protocol that could provide a stable packet transmission ratio,less overhead connectivity,and low end-to-end latency in shared standard scenarios and attack *** demonstrates effective results with hybrid architecture and proved to be effective than other state-of-the-art routing protocols of MANETs,like AODV,its routing organization implemented through Optimized Fuzzy based ACO Algorithm for ***-wavelengths are required to perform a significant role in *** research proposed to test the efficiency of MANET consisting of only mmWave User *** reduced packet transmission loss of UEs withmmWave,meaning well-transmitted SNR leads directly to a better packet delivery *** verify results,simulation using the NS-3 simulator mmWave module is used.

关键词： 5G attacks D2D communications MANET mmWave security

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Impedance spectroscopy study on Mn_(1+x)Fe_(2-2x)Ti_xO_4(0≤x≤0.5) ferrites

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Journal of Central South University 2010年第6期17卷 1133-1138页

作者： kumar S BATOO K M PRAKASH R CHOI H K KOO B H SONG J I CHUNG H JEONG H LEE C G School of Nano and Advanced Materials Engineering Changwon National UniversityChangwon 641773Korea King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia Department of Mechanical Engineering Changwon National UniversityChangwon 641773Korea Department of Precision & Mechanical Engineering and BK21 Eco-Friendly Heat & Cold Energy Mechanical Research Team Gyeongsang National U niversityTongyeong 650160Korea

The complex impedance spectroscopy and surface morphology of Mn1+xFe2-2xTixO4(0≤x≤0.5) system,prepared using a conventional solid state reaction technique,were *** impedance spectroscopy measurements were carried out at room temperature in the frequency range of 42-5 *** electrical processes in the samples were modeled in the form of an equivalent circuit made up of a combination of two parallel RC circuits attributed to grain and grain *** DC conductivity obtained by extrapolation of AC data using impedance spectroscopy and four-probe method increases at 10% doping of Ti *** energy-dispersive X-ray(EDX) pattern confirmed the homogeneous mixing of the Mn,Fe,Ti and O atoms in pure and doped ferrite samples.

关键词： spinel ferrite magnetic properties impedance spectroscopy Ti4+ ions doping

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太阳能辅助燃煤电厂的动态特性研究

太阳能辅助燃煤电厂的动态特性研究

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作者： Vinod kumar 华北电力大学(北京)

学位级别：硕士

煤炭利用及由此导致的二氧化碳排放问题是21世纪的主要关注点。大部分电力是由化石燃料的燃烧产生的,另一方面,可再生能源的贡献很小。由于分别比原始的燃煤电厂和CSP技术更低的燃煤消耗率和较低的初始成本,太阳能辅助燃煤发电(SAPG)系... 详细信息

煤炭利用及由此导致的二氧化碳排放问题是21世纪的主要关注点。大部分电力是由化石燃料的燃烧产生的,另一方面,可再生能源的贡献很小。由于分别比原始的燃煤电厂和CSP技术更低的燃煤消耗率和较低的初始成本,太阳能辅助燃煤发电(SAPG)系统在全球受到越来越多的关注。本文提出了整合槽式太阳能的330MW燃煤互补发电系统并开展动态特性研究。太阳能用来预热锅炉给水以降低煤炭消耗率。在EBSILON Professional软件和工程方程求解器(EES)软件上开发了系统仿真模型,并在巴基斯坦塔尔的典型天气数据下,通过燃料节约模式分析了 1天和1年系统动态特性性能。仿真结果表明,典型日下所有参数均在安全范围内工作,功率输出恒定。对于本文提出的案例,计算出的太阳场面积为304084 m2,每年将节省110200吨煤。因此,在典型的日照高峰期间的一天中,添加到给水中的太阳能有效热量为171MW。电厂热效率达到48%,煤流量从245 t/h降至190 t/h。

关键词： SAPG系统动态特性参数变化太阳能

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