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Journal of Cancer Therapy 2015年第11期6卷 993-999页

作者： Kiyoshi Ohara Katsuhiko Oyama akiyoshi suzuki Keizo Kawano Shinji Morimoto Ayako Okawa Department of Radiation Oncology Tsuchiura Kyodo General Hospital Tsuchiura City Japan Department of Urology Tsuchiura Kyodo General Hospital Tsuchiura City Japan

Purpose: The impact of radiotherapy on bladder cancers heightened by increase of fraction size using three-dimensional conformal radiotherapy (3DCRT) was verified with biologically effective dose (BED, Gy10). Method: Twenty-five patients who were considered unsuitable for total cystectomy underwent 3DCRT between 2009 and 2014. When a gross tumor volume (GTV) did not neighbor guts and the patient was cooperative to radiotherapy (radical), the GTV was treated with a fraction size of ≥3.0 Gy, while a clinical target volume (CTV) of a whole bladder and lymph nodes at small pelvis were treated with a conventional fraction size of 2.0 Gy. When a GTV neighbored guts (palliative), only a CTV was treated with an increased fraction size of 2.5 Gy. Results: Compared to conventional two-dimensional radiotherapy, BED increased to 62.3 - 77.0 Gy10 (radical) or to 56.1 - 68.0 Gy10 (palliative) but the treatment period shortened to 4 - 5 weeks. Acute adverse events (≤3 months), determined by common terminology criteria for adverse events, were Grade 2 at most, but late adverse events were not observed. Only one patient (6%) lost the bladder. Conclusions: Patients who receive bladder preservation therapy appear good candidates to intensify impact of radiotherapy with 3DCRT.

关键词： Intensive Radiotherapy Hypofractionation Parallel Organ

The binding site for acute corticosterone effects on <i>N</i>-methyl-D-aspartate receptor-mediated Ca<sup>2+</sup>signals in mouse hippocampal slices

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Journal of Biophysical Chemistry 2011年第4期2卷 430-433页

作者： Hiromi Osanai akiyoshi suzuki Yoshimasa Komatsuzaki Hideo Mukai Suguru Kawato Minoru Saito 不详

We have examined acute effects of corticosterone (CORT) on N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ signals in adult mouse hippocampal slices. We found so far that the 30 min preincubation of CORT induced a signifcant decrease of the peak amplitude of NMDA-induced Ca2+ elevation in the CA1 region. The membrane non-permeable bovine serum albumin-conjugated CORT also induced a similar effect in the CA1 region. Therefore the acute CORT effects should be induced via putative surface CORT receptors. A possible candidate is a classical intracellular glucocorticoid receptor (GR). To confirm this speculation, we here examined the effects of dexamethasone (DEX: an agonist of GR) and CORT with RU38486 (an antagonist of GR) on NMDA-induced Ca2+ signals. As a result, DEX induced a similar effect to the suppressive CORT effect in the CA1 region, and RU38486 inhibited the suppressive CORT effect. These results indicate that the surface CORT receptor should be GR bound to plasma mem- brane.

关键词： Corticosterone Ca2+ Signal NMDA Receptor Glucocorticoid Receptor Hippocampus

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氧浓度对近临界水中纤维素分解的影响

太阳能学报 2002年第4期23卷 467-471页

作者：吕秀阳 Sakoda akiyoshi suzuki Motoyuki 浙江大学二次资源化国家专业实验室杭州310027 东京大学生产技术研究所

研究了不同初始氧浓度对纤维素在近临界水中分解的影响 ,实验结果表明 ,氧浓度显著地影响产物总碳收支平衡、液相不同组分的收率、气体的产量以及气相产物的组成。微量氧对产物总碳收支平衡影响不大 ,而对液相不同组分的收率有一定的影... 详细信息

研究了不同初始氧浓度对纤维素在近临界水中分解的影响 ,实验结果表明 ,氧浓度显著地影响产物总碳收支平衡、液相不同组分的收率、气体的产量以及气相产物的组成。微量氧对产物总碳收支平衡影响不大 ,而对液相不同组分的收率有一定的影响。从实验结果可以看出 ,离子型反应机理在纤维素水解的第一步中起主导作用。

关键词：氧浓度近临界水纤维素分解生物质

Polyvinyl alcohol–potassium iodide gel probe to monitor the distribution of reactive species generation around atmospheric-pressure plasma jet

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Plasma Science and Technology 2023年第3期25卷 78-86页

作者： Trung Nguyen TRAN Min HU Tomohiro OGASAWARA Yuki IWATA Haruka suzuki Jin SAKAMOTO Masafumi akiyoshi Hirotaka TOYODA Hiroto MATSUURA Department of Quantum and Radiation Engineering Osaka Prefecture University Department of Electronics Nagoya University Faculty of Chemistry Materials and BioengineeringKansai University Department of Quantum and Radiation Engineering Osaka Metropolitan University

This study proposes polyvinyl alcohol–potassium iodide(PVA–KI)as a novel gel chemical *** probe uses the reactions among PVA,KI,water,borax,and oxidative species to visualize the distribution of reactive *** method provides information regarding the distribution of reactive species by coloration on the gel *** effects of the surrounding gas phase on the distribution and diffusion of the reactive species are also investigated using the PVA–KI gel ***,the relationship between the irradiation distance and reactive species diffusion is determined on the surface of the PVA–KI probe with and without plastic *** the irradiation distance appropriately leads to an increase in the modified area as detected by the PVA–KI gel probe *** relative concentration distributions of the reactive species are also obtained from visualized color distributions measured using a ***,reactive species generation by long-scale line plasma is confirmed by the color reaction on the PVA–KI gel surface,with a greater area being covered by an atmospheric-pressure pulsed microwave line plasma source.

关键词： atmospheric-pressure plasma jet(APPJ) PVA–KI gel chemical probe argon plasma jets

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生物质资源高压连续输送的研究

农业机械学报 2001年第3期32卷 27-30页

作者：吕秀阳夏文莉刘田春 SAKODA akiyoshi suzuki Motoyuki 浙江大学二次资源化工国家专业实验室杭州市310027 浙江大学科技部东京大学生产技术研究所日本东京1068558

建立了近中试规模的生物质资源高压连续输送装置 ,通过将生物质资源与水混成浆料的方法实现了生物质资源的高压连续输送 ,浆料的固含量可达 10 % (wt)以上 ,压力可达 40 MPa,最大浆料供应量为 2 .4L / h。

关键词：生物质资源输送装置高压连续输送浆料

Ultrasound-guided vs endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer diagnosis

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World Journal of Gastroenterology 2013年第15期19卷 2368-2373页

作者： Masato Matsuyama Hiroshi Ishii Kensuke Kuraoka Seigo Yukisawa akiyoshi Kasuga Masato Ozaka Sho suzuki Kouichi Takano Yuko Sugiyama Takao Itoi Department of Gastroenterology Cancer Institute HospitalTokyo 135-8550Japan Department of Gynecology Cancer Institute HospitalTokyo 135-8550Japan Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

AIM: To clarify the effectiveness and safety of endo- scopic ultrasound-guided fine-needle aspiration (EUS-FNA) for the diagnosis of pancreatic cancer (PC). METHODS: Patients who were diagnosed with unresectable, locally advanced or metastatic PC between February 2006 and September 2011 were selected for this retrospective study. FNA biopsy for pancreatic tumors had been performed percutaneously under extracorporeal ultrasound guidance until October 2009; then, beginning in November 2009, EUS-FNA has been performed. We reviewed the complete medical records of all patients who met the selection criteria for the following data: sex, age, location and size of the targeted tumor, histological and/or cytological findings, details of puncture procedures, time from day of puncture until day of definitive diagnosis, and details of severe adverse events. RESULTS: Of the 121 patients who met the selection criteria, 46 had a percutaneous biopsy (Group A) and 75 had an EUS-FNA biopsy (Group B). Adequate cytological specimens were obtained in 42 Group A patients (91.3%) and all 75 Group B patients (P=0.0192), and histological specimens were obtained in 41 Group A patients (89.1%) and 65 Group B patients (86.7%). Diagnosis of malignancy by cytology was positive in 33 Group A patients (78.6%) and 72 Group B patients (94.6%) (P=0.0079). Malignancy by both cytology and pathology was found in 43 Group A (93.5%) and 73 Group B (97.3%) patients. The mean period from the puncture until the cytological diagnosis in Group B was 1.7 d, which was significantly shorter than that in Group A (4.1 d) (P < 0.0001). Severe adverse events were experienced in two Group A patients (4.3%) and in one Group B patient (1.3%). CONCLUSION: EUS-FNA, as well as percutaneous needle aspiration, is an effective modality to obtain cytopathological confirmation in patients with advanced PC.

关键词： Endoscopic ultrasound-guided fine needle aspiration Percutaneous needle aspiration Pancreatic cancer

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固体物料向高温高压反应器连续供给的研究

浙江大学学报（工学版） 2001年第5期35卷 577-579页

作者：吕秀阳詹晓力 SAKODA akiyoshi suzuki Motoyuki 浙江大学材料与化工学院浙江杭州310027 东京大学生产技术研究所

A pilot-scale continuous high-pressure slurry supplying system was developed to feed the solid materials-water slurries to a high-pressure reactor. It can be used to pressure up to 40 MPa, maximum solid content of slurry up to 10% and maximum amount of slurry supply \{2.4 L/h.\} The system was described in detail and experiences on adjusting and running the system were given. Actual continuous runs of cellulose microcrystalline, cellulose powder, rice hull, TOFU wastes, rice bran have been made. The possibility of continuous feed of solid materials to a high pressure reactor up to 40 MPa was confirmed.

关键词：反应器近临界高温高压固体物料甲醇供给装置中试连续可分解介质

豆腐渣资源在近临界水中的分解动力学实验研究

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农业工程学报 2003年第3期19卷 209-211页

作者：吕秀阳詹晓力夏文莉 Sakoda akiyoshi suzuki Motoyuki 浙江大学材料与化工学院杭州310027 东京大学生产技术研究所

根据豆腐渣中的主要组分蛋白质、脂肪、纤维素、糖分等在近临界水中分解速度的不同 ,提出了一条豆腐渣资源化新工艺。该工艺包括豆腐渣在近临界水中分解、过滤和分离等工序。对近临界水中豆腐渣的分解动力学进行了研究。在该实验条件下 ... 详细信息

根据豆腐渣中的主要组分蛋白质、脂肪、纤维素、糖分等在近临界水中分解速度的不同 ,提出了一条豆腐渣资源化新工艺。该工艺包括豆腐渣在近临界水中分解、过滤和分离等工序。对近临界水中豆腐渣的分解动力学进行了研究。在该实验条件下 ,豆腐渣分解的表观活化能为 10 .2 k J/m ol。通过对分解产物的分析 ,初步确认了新工艺的可行性。

关键词：豆腐渣资源化新工艺近临界水分解动力学

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稻壳资源化新工艺的研究

农业工程学报 2001年第2期17卷 132-135页

作者：吕秀阳夏文莉刘田春 Sakoda A kiyoshi suzuki M otoyuki 浙江大学杭州310027 东京大学

根据纤维素、半纤维素、木质素在高温高压水中分解速度相差很大的特点 ,提出了一条稻壳资源化的新工艺 ,以便减少废弃物、最大限度地得到糖类化合物。新工艺主要包括连续水蒸汽蒸煮爆碎处理、连续近临界水处理和燃烧三步。研究了连续近... 详细信息

根据纤维素、半纤维素、木质素在高温高压水中分解速度相差很大的特点 ,提出了一条稻壳资源化的新工艺 ,以便减少废弃物、最大限度地得到糖类化合物。新工艺主要包括连续水蒸汽蒸煮爆碎处理、连续近临界水处理和燃烧三步。研究了连续近临界水处理过程中温度和停留时间对液相分解产物的收率和残渣组成的影响 ,并得到了较优的操作条件。通过对新工艺中固形物组成变化的研究得知 :水蒸汽蒸煮爆碎处理过程主要分解半纤维素 ,而连续近临界水处理同时水解纤维素和含硅化合物。新工艺可将约 80 %的碳源转化为水溶性物质 ,其中多聚糖和单糖的收率可达 40 % (wt)以上。新工艺为稻壳的全面综合利用提供了一条新途径。

关键词：稻壳资源化新工艺近临界水水蒸汽蒸煮爆碎

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投影装置中的激光扫描自动对准

电子工业专用设备 1985年第3期 18-24页

作者： akiyoshi suzuki 杨天凤

众所周知,采用激光扫描方法进行自动对准,对于接触式和接近式都是一种有利的技术,并且该方法现已用于实际中了。该方法采用激光光点作为探针同时探测来自掩模和硅片的信息。激光光束在物体上形成一很小的光点,并且通过旋转的多梭反射镜... 详细信息

众所周知,采用激光扫描方法进行自动对准,对于接触式和接近式都是一种有利的技术,并且该方法现已用于实际中了。该方法采用激光光点作为探针同时探测来自掩模和硅片的信息。激光光束在物体上形成一很小的光点,并且通过旋转的多梭反射镜和F—θ光学系统对物体进行恒速扫描。物体上的对准标记沿着扫描线设置。为了增大物体信息信号—噪声的比率系数,可用光学滤波方法对标记的部份散射光进行有选择的探测,采用此方法可获得硅片信息的高效率探测,以及高精度的自动探测。该激光光点扫描方法也可同样方便的用于投影复印技术中,如透镜或反射镜系统中。在充分利于投影装置的特性方面,该方法又具其独特的优点。例如,通过混合使用一个四分之一波片或相移反射镜以及利用激光器的偏振特性,便可消除掩模与硅片之间盼干涉现象,因而可获得稳定的输出信号,并可使对准精度达到0.3微米(2σ)。

关键词：投影装置反射式透镜反射镜反射点反光镜自动对准掩模图激光扫描