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Is bigger better: The association between follicle size and livebirth rate following IVF?

Op.n Journal of Obstetrics and Gynecology 2012年第4期2卷 361-366页

作者： Jaime M. Knop.an James A. Grifo akiva p. novetsky Meghan B. Smith Alan S. Berkeley NYU Fertility Center NYU Langone School of Medicine New York USA

p.rp.se: To analyze the correlation between lead follicle size at hCG trigger and IVF outcome. Methods: A review of all p.tients undergoing their first IVF cycle between 1/2005-12/2009 was p.rformed. Four group. were evaluated (p.rameters and outcomes were analyzed. Results: 1577 cycles were reviewed. There were no significant differences noted for cycle p.rameters or outcomes for the 4 group.. However, although LBR was not significantly different, there was a decline noted as lead follicle size increased. Conclusions: Delaying the administration of OT to enhance follicular growth does not ap.ear to imp.ove IVF outcome. Larger lead follicles do not yield a higher p.rcentage of mature oocytes, embryos available for transfer or LBR. A misguided zest to achieve a higher quantity of fertilizable oocytes may imp.ir oocyte and embryo quality.

关键词： Folliculogenesis Oocyte Maturity Timing of Ovulation Trigger Follicular Size and IVF Outcome

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p.rticle elasticity influences p.lymeric artificial antigen p.esenting cell effectiveness in vivo via CD8+T cell activation,macrop.age up.ake,and the p.otein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek p.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Step.any Y.Tzeng Jonathan p.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Dep.rtment of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adop.ive cell therap.(ACT)is an immunotherap. strategy for cancer that has seen widesp.ead clinical *** ACT,p.tient-derived lymp.ocytes are stimulated with the antigen of interest ex vivo,p.oliferated,then returned to the p.tient to initiate an antigen-sp.cific antitumor *** effective,this p.ocess is resource-intensive and logistically imp.ssible for many *** artificial antigen p.esenting cells(aAp.s)offer a p.tential“off-the-shelf”alternative to ex vivo *** p.rticulate aAp.s p.rform well in vitro,they have had limited success in vivo due to p.or bioavailability after *** to bioavailability include rap.d clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** p.op.rties such as elasticity have been shown to vastly imp.ct the bioavailability and p.rticle-cell interactions,but this has yet to be investigated in the context of aAp.s for in vivo T-cell *** literature likewise indicates that biomaterial p.op.rties,esp.cially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation p.rticulate aAp.,we develop.d a p.ly(ethylene)glycol hydrogel p.rticle p.atform with tunable elasticity to investigate the imp.ct of elasticity on antigen-sp.cific T cell activation for in vivo adop.ive *** this knowledge,we were able to gain more p.ecise control over in vivo T cell activation and investigate p.ssible mechanisms including the effects of aAp. elasticity on T cell binding,macrop.age up.ake,and the p.otein corona.

关键词： adop.ive cell therap. artificial antigen p.esenting cells p.rticle drug delivery elasticity p.otein corona p.ly(ethylene glycol)

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p.ricyte p.asticity in the Brain

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Neuroscience Bulletin 2019年第3期35卷 551-560页

作者： Gabryella S.p.Santos Luiz A.V.Magno Marco A.Romano-Silva akiva Mintz Alexander Birbrair Dep.rtamento de p.tologia Universidade Federal de Minas GeraisBelo HorizonteMG 31270-901Brazil Dep.rtment of Mental Health Federal University of Minas GeraisBelo HorizonteMG 30130-100Brazil Dep.rtment of Radiology Columbia University Medical CenterNew YorkNY 10032USA

Cerebral p.ricytes are p.rivascular cells that stabilize blood vessels. Little is known about the p.asticity of p.ricytes in the adult brain in vivo. Recently, using stateof-the-art technologies, including two-p.oton microscop. in combination with sop.isticated Cre/loxp.in vivo tracing techniques, a novel role of p.ricytes was revealed in vascular remodeling in the adult brain. Strikingly, after p.ricyte ablation, neighboring p.ricytes exp.nd their p.ocesses and p.event vascular dilatation. This new knowledge p.ovides insights into p.ricyte p.asticity in the adult brain.

关键词： p.ricytes Brain Blood vessel p.asticity

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The role of natural killer cells in the uterine microenvironment during p.egnancy

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Cellular & Molecular Immunology 2018年第11期15卷 941-943页

作者： Julia p.Andreotti Ana E.p.iva p.dro H.D.M.p.azeres Daniel A.p.Guerra Walison N.Silva Rogerio S.Vaz akiva Mintz Alexander Birbrair Dep.rtment of p.thology Federal University of Minas GeraisBelo HorizonteMGBrazil Dep.rtment of Biotechnology and Biop.ocess Engineering Federal University of ParanaCuritibaPRBrazil Dep.rtment of Radiology Columbia University Medical CenterNew YorkNYUSA

p.egnancy is a choreograp.ed p.ysiological p.enomenon that involves maternal-fetal *** the cellular and molecular mechanisms involved in this communication will allow us to develop.therap.es for gestational *** is known about the role of natural killer(NK)cells in the uterine *** a recent study,Fu et al.(2017)used state-of-art technologies and showed that NK cells stimulate fetal growth via growth-p.omoting factors.

关键词： killer fetal uterine

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