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Flexible visualization framework for head-mounted display with gesture interaction interface

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 22-41页

作者： Pierre J.Jarsaillon Naohisa Sakamoto akira kageyama Computer Science Department INSA Lyon 20 avenue Albert EinsteinVilleurbanne Cedex 69621France Graduate School of System Informatic Kobe University 1-1 Rokko-daiNada-ku Kobe 657-8501Japan Department of Computational Science Kobe University 1-1 Rokko-dai Nada-kuKobe 657-8501Japan

As the development of new visualization systems,within the field of simulation,offers their users more insights from their simulations,immersive systems are becoming a part of the visualization *** the recent advancements of the Head-Mounted Displays(HMDs)and popularity of motion sensors,human beings and computer become more *** study aims to evaluate the potential of such systems as a visualization tool through the development of a new flexible framework for visualization within virtual reality(VR)environment,using an Oculus Rift and a Leap *** approaches are then compared:high-3D object rendering within the virtual scene approach and a user experience-oriented system with an intuitive *** assess the quality of the interface and its relevance for the user,different types of gestures are implemented and *** an experiment on users to evaluate the developed system as a proper visualization tool,the HMDs,paired with a motion sensor to make a gesture-controlled interface seem to be promising mediums despite various constraints on development regarding the technology limitations.

关键词： Virtual reality motion sensor interactive tool user experience immersive visualization.

IMMERSIVE VR VISUALIZATIONS BY VFIVE: PART 2: APPLICATIONS

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 54-69页

作者： akira kageyama NOBUAKI OHNO SHINTARO KAWAHARA KAZUO KASHIYAMA HIROAKI OHTANI Graduate School of System Informatics Kobe University Kobe 657-8501Japan Graduate School of Simulation Studies University of Hyogo Kobe 650-0047Japan Earth Simulator Center Japan Agency for Marine-Earth Science and Technology Yokohama 236-0001 Japan Department of Civil and Environmental Engineering Chuo University Bunkyo-ku 112-8551Japan National Institute for Fusion Science Toki 509-5292 Japan The Graduate University for Advanced Studies(SOKENDAI)Toki 509-5292Japan

VFIVE is a scientific visualization application for CAVE-type immersive virtual reality(VR)*** source codes are freely *** is used as a research tool in various VR *** also lays the groundwork for developments of new visualization software for *** this paper,we pick up five CAVE systems in four different institutions in *** of VFIVE in each CAVE system are *** emphases will be placed on scientific and technical achievements made possible by VFIVE.

关键词： Virtual reality CAVE system immersive display system.

Visualization framework for CAVE virtual reality systems

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International Journal of Modeling, Simulation, and Scientific Computing 2016年第4期7卷 2-15页

作者： akira kageyama Asako Tomiyama Department of Computational Science Kobe University Kobe 657-8501Japan

We have developed a software framework for scientific visualization in immersive-type,room-sized virtual reality(VR)systems,or Cave automatic virtual environment(CAVEs).This program,called Multiverse,allows users to select and invoke visualization programs without leaving CAVE’s VR *** is a kind of immersive“desktop environment”for users,with a three-dimensional graphical user *** application developers,Multiverse is a software framework with useful class libraries and practical visualization programs as samples.

关键词： Data visualization scientific visualization computational fluid dynamics vir-tual reality

Necessity of neutrophil-to-lymphocyte ratio monitoring for hypothyroidism using nivolumab in patients with cancer

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World Journal of Clinical Oncology 2022年第7期13卷 641-651页

作者： Ako Gannichida Yusuke Nakazawa akira kageyama Hirofumi Utsumi Kazuyoshi Kuwano Takashi Kawakubo Department of Pharmacy The Jikei University HospitalTokyo 105-8471Japan Division of Respiratory Diseases Department of Internal MedicineThe Jikei University School of MedicineTokyo 105-8461Japan

BACKGROUND Low neutrophil-to-lymphocyte ratio(NLR)has been shown to be associated with a favorable therapeutic response to *** activation of immunocompetent cells such as lymphocytes exhibits an antitumor effect;however,the development of excessive immune responses in autologous organs along with the breakdown of self-tolerance causes immune-related adverse events,including ***,the possibility that NLR is associated with immune response shows that NLR can be not only a predictive factor for good response to nivolumab but also a predictive factor for the development of *** To evaluate whether continuous NLR monitoring during nivolumab treatment is useful for predicting the incidence and onset period of *** This retrospective study comprised patients who received nivolumab for treating all types of cancer at our hospital between January 2015 and December *** NLRs of patients were measured before each administration,and the patients were followed up till the administration of 12 *** at treatment initiation was compared between patients with and without *** who developed hypothyroidism were categorized into three groups:those with NLR<3.5,3.5 to<5,and≥5 according to their maximum NLR from treatment initiation to hypothyroidism ***,the onset periods of hypothyroidism were compared between the *** Overall,104 patients were included in the ***-one patients developed hypothyroidism throughout the observation *** at treatment initiation was significantly lower(2.54±1.21 vs 4.58±4.03;P=0.017)in patients with hypothyroidism than in those without hypothyroidism,and patients with NLR<5 had a significantly higher incidence of hypothyroidism than those with NLR≥5(26%:20 of 78 patients vs 4%:1 of 26 patients;P=0.022).Additionally,treatment continuity in patients with hypothyroidism was significantly longer than in those without hypothyroidism

关键词： Nivolumab Hypothyroidism Immune checkpoint inhibitors Immune-related adverse event Neutrophil-to-lymphocyte ratio

Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells

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Cellular & Molecular Immunology 2021年第7期18卷 1729-1738页

作者： Ken-Ichi Suehiro akira Suto Kensuke Suga Hiroki Furuya Arifumi Iwata Taro Iwamoto Shigeru Tanaka Takahiro kageyama Kotaro Suzuki Koichi Hirose Véronique Lefebvre Hiroshi Nakajima Department of Allergy and Clinical Immunology Graduate School of MedicineChibaJapan Institute for Global Prominent Research Chiba UniversityChibaJapan Department of Surgery/Division of Orthopedic Surgery Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA

Allergic asthma that is caused by inhalation of house dust mites(HDMs)is mainly mediated by Th2 ***,the roles of Sox(SRY-related high-mobility-group(HMG)-box)family members in various immune responses have been ***,the roles of Sox12,a member of the SoxC group,in Th2 cell differentiation and allergic airway inflammation,remain *** showed that Sox12 mRNA was significantly increased during Th2 cell *** vivo,HDM-induced eosinophil infiltration into the lung and Th2 cell differentiation were exacerbated in Sox12−/−mice compared with those in control Sox12+/−*** vitro,Sox12−/−CD4^(+)T cells that were cultured under Th2 conditions had increased production of Th2 cytokines and GATA3 protein compared with those of control Sox12+/−CD4^(+)T ***,forced expression of Sox12 decreased the protein levels of GATA3 in CD4^(+)T cells under Th2 conditions without affecting mRNA ***,Sox12 induced degradation of GATA3 through the proteasome pathway in CD4^(+)T ***,Sox12 enhanced ubiquitination of GATA3,which was mediated by the E3 ligase ***,we found that Fbw7 knockdown partly abrogated Sox12-mediated GATA3 suppression in CD4^(+)T *** together,these results suggest that Sox12 suppresses Th2 cell differentiation by accelerating Fbw7-mediated GATA3 degradation,and attenuates HDM-induced allergic inflammation.

关键词： Sox12 Asthma GATA3 Th2 ubiquitination