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Current status of sperm banking for young cancer patients in Japanese nationwide survey

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Asian Journal of Andrology 2018年第4期20卷 336-341页

作者： Yasushi Yumura akira tsujimura Hiroshi Okada Kuniaki Ota Masahumi Kitazawa Tatsuya Suzuki Tosiyuki Kakinuma Seido Takae Nao Suzuki Teruaki Iwamoto Reproduction Center Yokohama City University Medical Center Yokohama 232-0024 Japan Department of Urology Juntendo University Urayasu Hospital Chiba 279-0021 Japan Department of Urology Dokkyo Medical University Koshigaya Hospital Saitama 343-8555 Japan Department of Obstetrics and Gynecology Nasu Red Cross Hospital Tochigi 324-8686 Japan Department of Obstetrics and Gynecology Dokkyo Medical University Tochigi 321-0293 Japan Department of Obstetrics and Gynecology Jichi Medical University Tochigi 329-0498 Japan Department of Obstetrics and Gynecology International University of Health and Welfare Tochigi 329-2763 Japan Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki 216-8511 Japan Division Male Infertility Center for Human Reproduction International University of Health and Welfare Sanno Hospital Tokyo 107-0052 Japan

This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. In all, 820 cancer patients （237 testicular, 383 hematological, 46 bone and soft tissue, 20 brain, and 134 other malignancy） consulted the responding institutes for sperm cryopreservation. Except for testicular tumor, the number of patients whose sperm was preserved before cancer treatment was low compared to that of young cancer patients. Approximately 20% of patients with malignancies other than testicular tumor underwent chemotherapy before cryopreservation. The success rate of cryopreservation in hematological malignancy was 82.5%, significantly lower than that of both the testicular cancer （93.6%） and other malignancy groups （95.6%）（P 〈 0.05）. The primary reasons for preservation failure were azoospermia and poor semen quality. Patients with hematological malignancies had a higher rate of unsuccessful cryopreservation compared to those in other groups, possibly due to the large number of patients requesting sperm cryopreservation after chemotherapy induction. In Japan, information regarding sperm banking prior to cancer treatment appears to be lacking. Information regarding sperm preservation before chemotherapy should be provided to all Japanese oncologists.

关键词： cancer chemotherapy fertility preservation sperm preservation survey

A single nucleotide polymorphism in SPA TA17 may be a genetic risk factor for Japanese patients with meiotic arrest

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Asian Journal of Andrology 2009年第5期11卷 623-628,I0004,I0005页

作者： Toshinobu Miyamoto[日本] akira tsujimura[日本] Yasushi Miyagawa[日本] Eitetsu Koh[日本] Naoko Sakugawa[日本] Hiroe Miyakawa[日本] Hisashi Sato[日本] Mikio Namiki[日本] Akihiko Okuyama[日本] Kazuo Sengoku[日本] Department of Obstetrics and Gynecology Asahikawa Medical College Asahikawa Hokkaido 078-851 O Japan＂ Department of Urology Graduate School of Medicine Osaka University Suita 565-0871 Japan＂ Department of Integrated Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa920-8641 Japan

Genetic mechanisms have been implicated as a cause of some cases of male infertility. Recently, 10 novel genes involved in human spermatogenesis were identified by microarray analysis of human testicular tissue. One of these is spermatogenesis-associated 17 （SPATA17）. To investigate whether defects in the SPATA17 gene are associated with azoospermia due to meiotic arrest, a mutational analysis was conducted, in which the SPATA17 coding regions of 18 Japanese patients with this condition were sequenced. A statistical analysis was carried out that included 18 patients with meiotic arrest, 20 patients with Sertoli-cell-only syndrome （SCOS） and 96 healthy control men. No mutations were found in SPA TA17. However, three coding single nucleotide polymorphisms （cSNPs： SNP 1-SNP3） were detected in the patients with meiotic arrest. No significant differences in the genotype or allele frequencies of SNP1 and SNP2 were found between patients with meiotic arrest and the others. However, the frequency of the SNP3 allele was significantly elevated in the meiotic arrest group （P 〈 0.05）. This study suggests that SPATA17 may play a critical role in human spermatogenesis, especially in meiosis.

关键词： azoospermia meiosis polymorphism SNP SPATA17

Genetic Variation in the Testis-Specific HASPIN Gene Encoding a Serine/Threonine Protein Kinase in Infertile Japanese Males

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Advances in Sexual Medicine 2016年第3期6卷 19-25页

作者： Hiromitsu Tanaka akira tsujimura Yasushi Miyagawa Dakyo Oh Damin Choi Morimasa Wada Hiromi Nishimura Yoshitake Nishimune Lab of Molecular Biology Faculty of Pharmaceutical Sciences Nagasaki International University Sasebo Japan Department of Urology Graduate School of Medicine Juntendo University Tokyo Japan Department of Urology Graduate School of Medicine Osaka University Suita Japan Department of Science for Laboratory Animal Experimentation Research Institute for Microbial Diseases Osaka University Suita Japan

HASPIN is a serine/threonine protein kinase predominantly expressed during spermatogenesis and localized in the nucleus. The HASPIN gene is conserved from yeast to mammals and plants. To investigate any possible associations between HASPIN polymorphisms and impaired spermatogenesis in Japanese males, we screened for mutations in the HASPIN coding sequence (CDS) using DNA from 282 sterile male patients and 262 fertile male volunteers. Polymorphisms were found at 10 positions within the HASPIN CDS. Among these 10 polymorphisms, 5 were found only in the infertile group, 3 of which were nonsynonymous. These polymorphisms found only in the infertile patients may be a cause of male infertility and thus valuable candidates for further study of this condition.

关键词： Single-Nucleotide Polymorphism Spermatogenesis Meiosis Sperm Nucleus HASPIN Gene

Weyl points and Dirac lines protected by multiple screw rotations

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Science Bulletin 2017年第11期62卷 788-794页

作者： akira Furusaki Condensed Matter Theory Laboratory RIKEN Wako Saitama 351-0198 Japan

In three-dimensional noncentrosymmetric materials two-fold screw rotation symmetry forces electron＇s energy bands to have Weyl points at which two bands touch. This is illustrated for space groups No. 19 （P212121 ） and No. 198 （P213）, which have three orthogonal screw rotation axes. In the case of space groups No. 61 （Pbca） and No. 205 （Pa-3） that have extra inversion symmetry, Weyl points are promoted to four-fold degenerate line nodes in glide-invariant planes. The three-fold rotation symmetry present in the space groups No. 198 and No. 205 allows Weyl and Dirac points, respectively, to appear along its rotation axes in the Brillouin zone and generates four-fold and six-fold degeneracy at the F point and R point, respectively.

关键词： Weyl points Dirac points Nodal lines Nonsymmorphic symmetry

Estimations of the Maximum Tangential Velocity V_(θm) in the Vortex Core Region and also the Mean Rotational Velocity V_(oi) near the Concave Wall Surface in the Returned Flow Type Cyclone Dust Collector

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Journal of Thermal Science 2010年第6期19卷 553-560页

作者： akira Ogawa T 110-0011. Minowa 2-14-7 Taitou-Ku Tokyo Japan

There are many types of cyclone dust collectors for separating the fine solid and dust particles from gases in the various industries and also in the home used purposes. For estimating the power loss and the collection efficiency, one of the most important factors is the maximum tangential velocity V0m in the vortex core region in the cyclone body. In order to determine V0~ by the simple method, it is useful to apply the mechanical balance of the angular momentum fluxes under the assumption of Ogawa combined vortex model which is composed of the quasi-forced vortex in the vortex core region and also the quasi-free vortex surrounded the vortex core region and also under the assumption of the introduction of equivalent length Heq corresponding to the cone spaces of the cyclone body and the dust bunker. On the other hand, the mean rotational velocity Voi near the concave wall surface is also estimated by the mechanical balance of angular momentum fluxes with the moment of viscous friction force. For confirming the general applications of the obtained equations, the returned flow types cyclones changed the throat diameter D3 are designed. The material of the cyclone is the transparent acrylic resin. Therefore the inner surface of the cyclone body can be regarded as smooth surface. The comparisons of the measured velocities V~ and Voi by a cylindrical Pitot tube are shown in good agreement with those of the proposed equations. The above stated results are described in detail.

关键词： Cyclone Dust Collector Maximum Tangential Velocity Mean Rotational Velocity Angular Momentum Flux Equivalent Length Surface Frictional Force Ogawa Combined Vortex Model Reynolds Number.

Comparison of generalized engine control and MPC based on maximum principle

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Control Theory and Technology 2017年第2期15卷 150-157页

作者： akira OHATA TECHNOVA Inc. The Imperial Hotel Tower 1-1 Uchisaiwai-cho 1 Chiyoda-ku Tokyo 100-0011 Japan

Automotive engine control has been continuously improved due to the strong demands from the society and the market since introducing electronic controls but not always following control theories. Therefore, it is not easy for researchers from academia and even engineers from the automotive industry to grasp the whole aspect of engine control. To encounter the issue, important features of engine control are extracted and generalized from the standpoint of control engineering. Comparisons of the control and model predictive control （MPC） showed an outstanding performance of the control generalized from engine controls and how to apply MPC in the framework.

关键词： Automotive engine history of engine control control design input constraints time delay model predictive control

Control of Collection Efficiency for Axial Flow Cyclone Dust Collectors with Fixed Guide Vanes and with Funnel Shaped Exit Pipes

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Journal of Thermal Science 2006年第3期15卷 240-250页

作者： akira Ogawa Masaru Arakawa T-110-0011 Minowa 2-14-7Taitou-KuTokyoJapan SHINWA RULES Co. Ltd.Sanjo-ShiNiigataJapan

The experimental result of the collection efficiency of the axial flow cyclone with the fixed guide vanes is lower than that with the tangential inlet pipe to the cyclone body due to the weak angular momentum transfer given by flowing through the guide vanes. However, one of the interesting points is the control of the collection efficiency depended on the funnel shaped exit pipes. The collection efficiencies for these funnel shaped exit pipes are depended on the Froude number. Then, in this paper, the experimental results of the pressure drop and also the collection efficiency using the fly-ash particles and also the comparison of the calculated results of the collection efficiency with the experimental results are described i~ detail.

关键词： Axial flow cyclone funnel shaped exit pipe fixed guide vanes pressure drop collection efficiency,Froude number cut-Size

Spin-up and Spin-Down Times of Rotational Air Flow Depended on Mean Air Velocity and Surface Roughness on Inner Surface in Cylindrical Vortex Chamber

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Journal of Thermal Science 2004年第1期13卷 46-55页

作者： akira Ogawa Hiroyuki Murakami Department of Mechanical Eng.College of Eng. Nihon UniversityT-963.TokusadaTamura-machiKooriyama-CityJapanThe Marine Self Defense Forcethe Defense AgencyJapan

The spin-up time TA in the spin-up process and spin-down time TD in the spin-down process of rotational air flow in the cylindrical vortex chamber with three kinds of the artificial surface roughness were investigated. One of the most different characteristics between the smooth and rough surface conditions was the spin-down time TD. Also the transient response of the tangential velocity on the spin-up process was analyzed numerically and this result was compared with the experimental results. The above stated results are reported here in detail.

关键词： vortex chamber spin-up time spin-down time transient response surface roughness.

Petrological study of the western Iratsu mass from the Sambagawa metamorphic belt, central Shikoku, Japan

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第7期6卷 649-655页

作者：厉子龙 TAKASU akira Department of Earth Science Zhejiang University Department of Earth Science Shimane University

The western Iratsu mass, the largest tectonic body in the Sambagawa metamorphic belt, central Shikoku, is mainly composed of epidote amphibolite with minor amounts of eclogite. Systematically, a majority of garnets show bell-shaped chemical zoning of pyrope contents and Mg/(Mg+Fe2+) monotonously increasing outward. The grossular component in zonal garnet increases outwards, maximizes at an intermediate part, and then decreases towards the outermost rim, reflecting a process from increasing to decreasing pressure conditions during the prograde metamorphism. Jadeite contents of omphacite range from 25～20mole% within the cores to 15～10 mole% at the rims, implying a pressure-decreasing process (from 11 × 105 Pa to 8 × 105 Pa). The peak pressure-temperature (P-T) condition of 630～680 ℃ and ca. 15× 105 Pa in the western Iratsu mass is much higher than that of (610±25) ℃ and (10± 1)× 105 Pa of the Sambagawa oligoclase-biotite zone schists. The authors suggest a clockwise P-T-t path for the western Iratsu mass.

关键词： Petrology P-T-t path Western Iratsu mass Sambagawa belt