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Involvement of A5/A7 noradrenergic neurons and B2 serotonergic neurons in nociceptive processing:a fiber photometry study

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Neural Regeneration Research 2022年第4期17卷 881-886页

作者： Shunpei Moriya akira Yamashita Daiki Masukawa Junichi Sakaguchi Yoko Ikoma Yoshimune Sameshima Yuki Kambe Akihiro Yamanaka Tomoyuki Kuwaki Department of Physiology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan Department of Molecular Pharmacologyand Neurobiology Yokohama City University Graduate School of MedicineYokohamaJapan Department of Pharmacology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan Research Institute of Environmental Medicine Nagoya UniversityNagoyaJapan

In the central nervous system,the A6 noradrenaline(NA)and the B3 serotonin(5-HT)cell groups are well-recognized players in the descending antinociceptive system,while other NA/5-HT cell groups are not well characterized.A5/A7 NA and B25-HT cells project to the spinal horn and form descending *** recorded G-Ca MP6 green fluorescence signal intensities in the A5/A7 NA and the B25-HT cell groups of awake mice in response to acute tail pinch stimuli,acute heat stimuli,and in the context of a non-noxious control test,using fiber photometry with a calcium imaging *** first introduced G-Ca MP6 in the A5/A7 NA or B25-HT neuronal soma,using transgenic mice carrying the tetracycline-controlled transactivator transgene under the control of either a dopamineβ-hydroxylase or a tryptophan hydroxylase-2 promoters and by the site-specific injection of adeno-associated virus(AAV-Tet O(3 G)-G-Ca MP6).After confirming the specific expression patterns of G-Ca MP6,we recorded G-Ca MP6 green fluorescence signals in these sites in awake mice in response to acute nociceptive stimuli.G-Ca MP6 fluorescence intensity in the A5,A7,and B2 cell groups was rapidly increased in response to acute nociceptive stimuli and soon after,it returned to baseline fluorescence *** was not observed in the non-noxious control *** results indicate that acute nociceptive stimuli rapidly increase the activities of A5/A7 NA or B25-HT neurons but the non-noxious stimuli do *** present study suggests that A5/A7 NA or B25-HT neurons play important roles in nociceptive processing in the central nervous *** suggest that A5/A7/B2 neurons may be new therapeutic *** performed procedures were approved by the Institutional Animal Use Committee of Kagoshima University(MD17105)on February 22,2018.

关键词： A5 NA neurons A7 NA neurons B25-HT neurons DBH-tTA mice fiber photometry G-CaMP6 mCherry monoaminergic signaling nociception TPH-t TA mice

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Petrological study of the western Iratsu mass from the Sambagawa metamorphic belt, central Shikoku, Japan

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第7期6卷 649-655页

作者：厉子龙 TAKASU akira Department of Earth Science Zhejiang University Department of Earth Science Shimane University

The western Iratsu mass, the largest tectonic body in the Sambagawa metamorphic belt, central Shikoku, is mainly composed of epidote amphibolite with minor amounts of eclogite. Systematically, a majority of garnets show bell-shaped chemical zoning of pyrope contents and Mg/(Mg+Fe2+) monotonously increasing outward. The grossular component in zonal garnet increases outwards, maximizes at an intermediate part, and then decreases towards the outermost rim, reflecting a process from increasing to decreasing pressure conditions during the prograde metamorphism. Jadeite contents of omphacite range from 25～20mole% within the cores to 15～10 mole% at the rims, implying a pressure-decreasing process (from 11 × 105 Pa to 8 × 105 Pa). The peak pressure-temperature (P-T) condition of 630～680 ℃ and ca. 15× 105 Pa in the western Iratsu mass is much higher than that of (610±25) ℃ and (10± 1)× 105 Pa of the Sambagawa oligoclase-biotite zone schists. The authors suggest a clockwise P-T-t path for the western Iratsu mass.

关键词：岩石学变质结构硬玉绿辉石片岩

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Airway ultrasound for patients anticipated to have a difficult airway:Perspective for personalized medicine

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World Journal of Clinical Cases 2023年第9期11卷 1951-1962页

作者： Harumasa Nakazawa Kohji Uzawa Joho Tokumine Alan Kawarai Lefor akira Motoyasu Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

Airway ultrasound allows for precise airway evaluation,particularly for assessing the difficult airway and the potential for front of neck *** studies have shown that identification of the cricothyroid membrane by airway ultrasound is more accurate than digital ***,no reports to date have provided clinical evidence that ultrasound identification of the cricothyroid membrane increases the success rate of *** is a narrative review which describes patients with difficult airways for whom airway ultrasound may have been useful for clinical decision *** role of airway ultrasound for the evaluation of difficult airways is summarized and an approach to the use of ultrasound for airway management is *** goal of this review is to present practical applications of airway ultrasound for patients predicted to have a difficult airway and who undergo cricothyroidotomy.

关键词： Airway ultrasound Difficult airway Point-of-care ultrasound Cricothyroidotomy Intubation Mask ventilation

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Slow and fast light in quantum-well and quantum-dot semiconductor optical amplifiers Invited Paper

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Chinese Optics Letters 2008年第10期6卷 736-742页

作者： Piotr Konrad Kondratko akira Matsudaira Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbana IL61801USA

Slow and fast light in quantum-well （QW） and quantum-dot （QD） semiconductor optical amplifiers （SOAs） using nonlinear quantum optical effects are presented. We demonstrate electrical and optical controls of fast light using the coherent population oscillation （CPO） and four wave mixing （FWM） in the gain regime of QW SOAs. We then consider the dependence on the wavelength and modal gain of the pump in QW SOAs. To enhance the tunable photonic delay of a single QW SOA, we explore a serial cascade of multiple amplifiers. A model for the number of QW SOAs in series with variable optical attenuation is developed and matched to the experimental data. We demonstrate the scaling law and the bandwidth control by using the serial cascade of multiple QW SOAs. Experimentally, we achieve a phase change of 160^o and a scaling factor of four at 1 GHz using the cascade of four QW SOAs. Finally, we investigate CPO and FWM slow and fast light of QD SOAs. The experiment shows that the bandwidth of the time delay as a function of the modulation frequency changes in the absorption and gain regimes due to the carrier-lifetime variation. The tunable phase shift in QD SOA is compared between the ground- and first excited-state transitions with different modal gains.

关键词： SOA CPO Slow and fast light in quantum-well and quantum-dot semiconductor optical amplifiers Invited Paper FWM well

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Robust Stability of Nonlinear Plants with a Non-symmetric Prandtl-Ishlinskii Hysteresis Model

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International Journal of Automation and computing 2010年第2期7卷 213-218页

作者： akira Inoue Graduate School of Natural Science and Technology Okayama University

In this paper, robust stability of nonlinear plants represented by non-symmetric Prandtl-Ishlinskii （PI） hysteresis model is studied. In general, PI hysteresis model is the weighted superposition of play or stop hysteresis operators, and the slopes of the operators are considered to be the same. In order to make a hysteresis model, a modified form of non-symmetric play hysteresis operator with unknown slopes is given. The hysteresis model is described by a generalized Lipschitz operator term and a bounded parasitic term. Since the generalized Lipschitz operator is unknown, a new condition using robust right coprime factorization is proposed to guarantee robust stability of the controlled plant with the hysteresis nonlinearity. As a result, based on the proposed robust condition, a stabilized plant is obtained. A numerical example is presented to validate the effectiveness of the proposed method.

关键词： Prandtl-Ishlinskii (PI) hysteresis model robust stability right coprime factorization non-symmetric play hysteresis operator nonlinear plants.

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Study on the Possibility of Raw Seawater into Beverage—Using Ethanol as a Renewable Resource

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Journal of Water Resource and Protection 2022年第4期14卷 349-384页

作者： akira Hiratsuka Tsutomu Demizu Jomo Kenyatta College of Agriculture and Technology (Formerly) Kyoto Japan The University of Tokyo (Formerly) Osaka Japan

In COVID-19 pandemic in the world, alcohol (ethanol) can be listed as a sterilizing disinfectant. It absolutely played a Messianic function on the sterilization effect. And it is said that it has one more function called “salinity reduction” but that function is not widely known. The two functions (Sterilization & Salinity Reduction) mentioned above are extremely important regarding the theme of “raw seawater into beverage” in this study. It is thought that if the two functions are achieved other water quality items such as NO-2 and other items can be cleared with comparative ease. To put briefly the feature of modern waterworks in a word, it can be said that “source of water is river water and its sterilization is chlorine”. In this study, we set up it with a completely new sanitization method (great reset), that is, “source of water is mixtures (seawater and rainwater) and its sterilization is ethanol”. And it can be also expected that the capture and storage of ethanol as a renewable resource is basically possible by utilizing sunlight as a natural power. Therefore, we think that this resolves itself into a question of the choice (sense of value/culture) of the users. It means that how users finally balance out with three factors, i.e., cost, risk (safety) and benefit. Based on the viewpoint mentioned above, we examined the possibility of raw seawater into beverage using ethanol as a renewable resource to create humankind’s wisdom to the settlement (breakthrough) of the water scarcity in the world including Asia and Africa. As a result, we have obtained the new findings that suggest the possibility of raw seawater into beverage using ethanol as a renewable resource.

关键词： Raw Seawater Beverage Ethanol Renewable Resource Great Reset

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Surface Texturing of TiO_2 Film by Mist Deposition of TiO_2 Nanoparticles

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Nano-Micro Letters 2013年第2期5卷 129-134页

作者： Gang Qin akira Watanabe Institute of Multidisciplinary Research for Advanced Materials Tohoku University School of Materials Science and Engineering Henan Polytechnic University

Unique and various microstructures of titanium oxide(TiO_2 ) film including macroporous structure, chromatic veins and rings, have been easily fabricated by mist deposition method on silicon substrate with mild preparation conditions. Rutile phase TiO_2 nanoparticles were directly used as starting material to prepare film and led to a simple preparation process. It was found that several different microstructures existed in the sample and changed with the varied positions from the center to the edge of the film when the concentration of the TiO_2 suspension is 0.06 mol/l, the deposition time is 30 min, the flow rate is 1 l/min and the temperature is150. The surface texturing shows apparent distinction as the concentration of the TiO_2 suspension decreased to 0.03 mol/l and 0.01 mol/l.

关键词： Mist deposition TiO2 film TiO2 nanoparticle Surface texturing Microstructure

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Growth phase dependent changes in the structure and protein composition of nucleoid in Escherichia coli

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Science China(Life Sciences) 2015年第9期58卷 902-911页

作者： TALUKDER AliAzam ISHIHAMA akira Department of Microbiology Jahangirnagar University Micro-Nano Technology Research Center Hosei University Department of Molecular Genetics National Institute of Genetics

The genomic DNA of bacteria is highly compacted in a single or a few bodies known as nucleoids. Here, we have isolated Escherichia coli nucleoid by sucrose density gradient centrifugation. The sedimentation rates, structures as well as protein/DNA composition of isolated nucleoids were then compared under various growth phases. The nucleoid structures were found to undergo changes during the cell growth; i. e., the nucleoid structure in the stationary phase was more tightly compacted than that in the exponential phase. In addition to factor for inversion stimulation(Fis), histone-like nucleoid structuring protein(H-NS), heat-unstable nucleoid protein(HU) and integration host factor(IHF) here we have identified, three new candidates of E. coli nucleoid, namely DNA-binding protein from starved cells(Dps), host factor for phage Qβ(Hfq) and suppressor of td- phenotype A(Stp A). Our results reveal that the major components of exponential phase nucleoid are Fis, HU, H-NS, Stp A and Hfq, while Dps occupies more than half of the stationary phase nucleoid. It has been known for a while that Dps is the main nucleoid-associated protein at stationary phase. From these results and the prevailing information, we propose a model for growth phase dependent changes in the structure and protein composition of nucleoid in E. coli.

关键词：蛋白组成生长阶段核结构菌类大肠依赖性蔗糖密度梯度离心法基因组DNA

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Dynamic distribution of TTK in HeLa cells: insights from an ultrastructural study

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Cell Research 2003年第6期13卷 443-449页

作者： akira SAWAGECHI,LAWRENCE BRAKO Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA Electron Microscopy Facility Morhouse School of Medicine Atlanta GA 30310 USA

Entry into mitosis is driven by signaling cascades of mitotic kinases. Our recent studies show that TTK, a kinetochore-associated protein kinase, interacts with CENP-E, a mitotic kinesin located to corona fiber of kinetochore. Using immunoelectron microscopy, here we show that TTK is present at the nuclear pore adjacent complex of interphase HeLa cells. Upon nuclear envelope fragmentation, TTK targets to the outermost region of the developing kinetochores of monoorient chromosome as well as to spindle poles. After stable attachment, throughout chromosome congression, TTK is a constituent of the corona fibers, extending up to 90 nm away from the kinetochore outer plate. Upon metaphase alignment, TTK departs from the kinetochore and migrates toward the centrosomes. Taken together, this evidence strongly supports a model in which TTK functions in spindle checkpoint signaling cascades at both kinetochore and centrosome.

关键词： mitosis kinetochore TTK.

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Functionally Graded Dual-nanoparticulate-reinforced Aluminium Matrix Bulk Materials Fabricated by Spark Plasma Sintering

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Journal of Materials Science & Technology 2014年第8期30卷 736-742页

作者： Hansang Kwon Marc Leparoux akira Kawasaki Department of Materials System Engineering Pukyong National University365 Sinsenro608-759 BusanKorea Empa Swiss Federal Laboratories for Materials Science and TechnologyAdvanced Materials ProcessingFeuerwerkerstrasse 39CH-3602 ThunSwitzerland Department of Materials Processing Engineering Graduate School of EngineeringTohoku University980-8579 SendaiJapan

Functionally graded（FG） carbon nanotubes（CNT） and nano-silicon carbide（nSiC） reinforced aluminium（Al）matrix composites have been successfully fabricated using high-energy ball milling followed by solid-state spark plasma sintering *** CNTs were well-dispersed in the Al particles using the nSiC as a solid mixing *** different types of multi-walled CNTs were used to add different amounts of CNTs in the same *** ball milled Al—CNT—nSiC and Al—CNT powder mixtures were fully densified and demonstrated good adhesion with no serious microcracks and pores within an FG multilayer *** layer contained different amounts of the CNTs,and the nSiC additions showed different microstructures and *** is possible to control the characteristics of the FG multilayer composite through the efficient design of an Al—CNT—nSiC gradient *** concept offers a feasible approach for fabricating the dualnanoparticulate-reinforced Al matrix nanocomposites and can be applied to other scenarios such as polymer and ceramic systems.

关键词： Carbon nanotubes(CNT) Silicon carbide High-energy ball milling Spark plasma sintering(SPS) Functionally graded materials(FGM)

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