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TEMPO纤维素纳米纤维功能复合膜材料

TEMPO纤维素纳米纤维功能复合膜材料

Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding

2016年全国高分子材料科学与工程研讨会

作者：杨全岭石竹群熊传溪 Tsuguyuki saito akira Isogai 武汉理工大学材料科学与工程学院武汉理工大学化学化工与生命科学学院东京大学生物材料科学系

日益增长的环境污染以及能源、资源危机已经严重影响了人类社会的发展,因此开发和利用资源丰富、来源广泛、环境友好、可再生、可降解的天然高分子环境友好材料对构建和谐可持续发展的社会具有重要意义。纤维素是地球上含量最为丰富的... 详细信息

日益增长的环境污染以及能源、资源危机已经严重影响了人类社会的发展,因此开发和利用资源丰富、来源广泛、环境友好、可再生、可降解的天然高分子环境友好材料对构建和谐可持续发展的社会具有重要意义。纤维素是地球上含量最为丰富的天然高分子,其特殊的晶体结构赋予其良好的力学性能。植物中纤维素分子自组装形成一个宽度约为3 nm的高结晶的纤维素微纤,纤维素微纤作为骨架与半纤维素和木质素一起形成保护植物抵抗其他生物攻击和外部压力的天然纳米复合材料,即细胞壁。纤维素微纤具有高的力学强度、硬度和热尺寸稳定性,是优良的天然生物基一维纳米材料。然而,它们之间强烈的氢键使其很难被分离。因此,通过经济有效的工艺将纤维素微纤维抽离出来制备纤维素纳米纤维,并开发高附加值的功能材料具有重要意义。TEMPO表面催化氧化水体系可以高效完全分离天然纤维素微纤,并制备水相分散、尺寸均一(nm)、高长度(1-2μm)、高比表面积(00 m/g)、高表面羧基含量(.7个/nm)的纤维素纳米纤维。基于这种TEMPO纤维素纳米纤维,我们成功的制备出了一系列性能优异的纳米纤维素功能膜材料。首先,结合天然纤维素纳米纤维优异的增强作用(高强度、高模量、高长径比),以及再生纤维素容易大量制备成型并且韧性好的特点,通过共混复合以天然纤维素纳米纤维为增强相,再生纤维素为基底,成功制备出具有高力学强度、高韧度、高阻氧性、优异热尺寸稳定性的完全可生物降解的全纤维素纳米复合材料。并且,即便纤维素纳米纤维在复合材料中的含量只有1%,但纤维素材料的性能得到显著的提高。另外,利用纤维素纳米纤维直径小、长度大、高比表面积以及高表面羧基含量的特点,以其为模板制备了含有线性排列或均相分散的量子点的纤维素纳米纤维/量子点复合材料,此材料自然光下透明,紫外光下发光,具有很高的光活性,将在太阳能电池、人造光源、防伪识别等领域具有潜在的应用价值。

关键词： TEMPO 纤维素纳米纤维全纤维素材料增强材料线性模板

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World Journal of Gastroenterology 2014年第36期20卷 13133-13138页

作者： Junichi Iwamoto Yuji Mizokami Yoshifumi saito Koichi Shimokobe akira Honda Tadashi Ikegami Yasushi Matsuzaki Department of Gastroenterology Tokyo Medical University Ibaraki Medical Center Ibaraki 300-0395 Japan Department of Gastroenterology University of Tsukuba Ibaraki 305-8576 Japan

AIM: To investigate the clinical differences between small intestinal injuries in low-dose aspirin(LDA) users and in non-steroidal anti-inflammatory drug(NSAID) users who were examined by capsule endoscopy(CE) for obscure gastrointestinal bleeding(OGIB). METHODS: A total of 181 patients who underwent CE for OGIB were included in this study. Based on clinical records, laboratory data such as hemoglobin levels, major symptoms, underlying diseases, the types and duration of LDA and NSAID use, and endoscopic characteristics of CE were reviewed.RESULTS: Out of a total of 45 cases of erosive lesions, 27 cases were taking LDA or NSAIDs(7 were on NSAIDs, 9 were on LDA alone, 9 were on LDA and thienopyridine, and 2 were on LDA and warfarin).The prevalence of ulcers or erosion during chronic use of LDA, LDA and the anti-platelet drug thienopyridine (clopidogrel or ticlopidine), and NSAIDs were 64.3%, 80.0%, and 75.0%, respectively. Erosive lesions were observed predominantly in chronic LDA users, while ulcerative lesions were detected mainly in NSAID users. However, concomitant use of thienopyridine such as clopidogrel with LDA increased the proportion of ulcers. The erosive lesions were located in the whole of the small intestine(jejunum and ileum), whereas ulcerative lesions were mainly observed in the ileum(P < 0.05). CONCLUSION: Our CE findings indicate that chronic LDA users and NSAID users show different types and locations of small-bowel mucosal injuries. The concomitant use of anti-platelet drugs with LDA tends to exacerbate the injuries from LDA-type to NSAID-type injuries.

关键词： Non-steroidal anti-inflammatory drugs Lowdose aspi

Effects of soil nutrient availability and ozone on container-grown Japanese larch seedlings and role of soil microbes

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Journal of Forestry Research 2020年第6期31卷 2295-2311页

作者： Evgenios Agathokleous Mitsutoshi Kitao Masabumi Komatsu Yutaka Tamai Hideyuki saito Hisanori Harayama akira Uemura Hiroyuki Tobita Takayoshi Koike Institute of Ecology Key Laboratory of Agrometeorology of Jiangsu ProvinceSchool of Applied MeteorologyNanjing University of Information Science and Technology(NUIST)Nanjing 210044JiangsuPeople’s Republic of China Hokkaido Research Center Forestry and Forest Products Research Institute(FFPRI)Forest Research and Management Organization7 HitsujigaokaSapporoHokkaido 062-8516Japan Department of Mushroom Science and Forest Microbiology Forestry and Forest Products Research Institute(FFPRI)Matsunosato 1Tsukuba 305-8687Japan Research Faculty of Agriculture Hokkaido UniversityKita 9 Nishi 9SapporoHokkaido 060-8589Japan Department of Plant Ecology Forestry and Forest Products Research Institute(FFPRI)Matsunosato 1Tsukuba 305-8687Japan

The interactive eff ects of ozone,soil nutrient availability and root microorganisms on physiological,growth,and productivity traits were studied for the fi rst time for Japanese larch(Larix kaempferi)seedlings grown in containers over a growing season,using a free air ozoneconcentration enrichment exposure system.High nutrient availability altered leaf and root nutrient dynamics and enhanced plant growth;however,it also enhanced seedling susceptibility to damping-off disease compared to low nutrient availability.Negative eff ects of elevated ozone,as compared with ambient ozone,on leaf gas exchange and plant stem form were neither off set nor exacerbated by soil nutrient availability and root colonizers.Such negative eff ects suggest that elevated ozone may have implications for ecological health even when plant vigor is limited by factors other than ozone.Inoculation of roots with ectomycorrhizae had negligible infl uence on the eff ects of either soil nutrient availability or ozone.However,this lack of eff ect may be upon impeded formation of complete mycorrhizal root tips due to factors other than the manipulated variables.B and Na appeared to have an important role in stress responses,so further studies to examine their link with physiological mechanisms as a function of time.This study provides an important perspective for designing forestry practices to enhance seedling health.

关键词： Ectomycorrhizae Fertilizer Oxidative stress Plant-fungi interaction

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清辩对数论派映像理论的批判

宗教研究 2011年第1期 221-231页

作者：斋藤明何欢欢东京大学中国社会科学院哲学研究所

'映像'(pratibimba,gzugs brnyan)理论是数论派用来解释'人我'(purusa,skyes bu),即'纯粹意识',如何能够认识'觉'(buddhi,blo/shes pa)的对象的著名理论。~②这一解释是必要的,因为数论派宣称被感觉器官感知的对象最终由来于觉认识,而... 详细信息

'映像'(pratibimba,gzugs brnyan)理论是数论派用来解释'人我'(purusa,skyes bu),即'纯粹意识',如何能够认识'觉'(buddhi,blo/shes pa)的对象的著名理论。~②这一解释是必要的,因为数论派宣称被感觉器官感知的对象最终由来于觉认识,而觉是无知的(acentana,sems/rtogs[pa]med[pa]);同时,具有知(cetana,sems/rtogs[pa]can)的人我被数论派看做是见者(drastr,SK.19)和享受者(bhoktr,SK.17)),并且能够认知[事物](jfia,SK.2)。虽然自在黑(Isvarakrsna,约5世纪)在《数论颂》(Samkhyakārikā)

关键词：数论派映像理论

空与语言——以《中论》第24品第7颂的解释为中心

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宗教研究 2011年第1期 232-247页

作者：斋藤明叶少勇东京大学

引言关于龙树的语言观,至今已经积累了很多研究。从聚焦于'戏论'(prapanca)、'假托[某者]的施设'(upādāya prajnaptih,假名)这两个概念开始,~①近年来又将维特根斯坦的语言观,特别是'语言游戏'(sprachspiel)和'家族相似性'(Familien(a... 详细信息

引言关于龙树的语言观,至今已经积累了很多研究。从聚焦于'戏论'(prapanca)、'假托[某者]的施设'(upādāya prajnaptih,假名)这两个概念开始,~①近年来又将维特根斯坦的语言观,特别是'语言游戏'(sprachspiel)和'家族相似性'(Familien(a|¨)hnlichkeit)等支撑其后期哲学思想的基本概念所体现的语言观,与龙树的语言观进行对比考察,此类研究引人注目。~②然而,从迄今为止有关龙树语言观的研究之中,可以看出一个显著特色,即大都以《中论》第24品第8至10颂所展开的'二谛说'为着眼点。

关键词：《中论》胜义谛

Role of T-box transcription factor 3 in gastric cancers

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World Journal of Gastrointestinal Pathophysiology 2023年第2期14卷 12-20页

作者： Naoki Asano akira Imatani Akio Takeuchi Masashi saito Xiao-Yi Jin Waku Hatta Kaname Uno Tomoyuki Koike Atsushi Masamune Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

The expression of T-box transcription factor 3(TBX3)has been identified in various cancers,including gastric cancers.Its role in breast cancers and melanomas has been intensively studied,and its contribution to the progression of cancers through suppressing senescence and promoting epithelial-mesenchymal transition has been reported.Recent reports on the role of TBX3 in gastric cancers have implied its involvement in gastric carcinogenesis.Considering its pivotal role in the initiation and progression of cancers,TBX3 could be a promising therapeutic target for gastric cancers.

关键词： Aging Wnt β-catenin Transforming growth factor-β Stomach Carcinogenesis

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World Journal of Clinical Cases 2019年第21期7卷 3553-3561页

作者： Takeshi Mizusawa Kenya Kamimura Hiroki Sato Takeshi Suda Hiroyuki Fukunari Go Hasegawa Osamu Shibata Shinichi Morita akira Sakamaki Junji Yokoyama Yu saito Yoshihisa Hori Yuduru Maruyama Fumitoshi Yoshimine Takahiro Hoshi Shinichi Morita Tsutomu Kanefuji Masaaki Kobayashi Shuji Terai Department of Internal Medicine Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8122Japan Department of Gastroenterology and Hepatology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Surgery Niigata Prefectural Tokamachi HospitalTokamachiNiigata 948-0065Japan Department of Pathology Uonuma Institute of Community Medicine Niigata University HospitalMinami UonumaNiigata 949-7302Japan Department of Internal Medicine Tokamachi Central ClinicTokamachiNiigata 948-0065Japan

BACKGROUND Immunosuppression is effective in treating a number of diseases,but adverse effects such as bone marrow suppression,infection,and oncogenesis are of concern.Methotrexate is a key immunosuppressant used to treat rheumatoid arthritis.Although it is effective for many patients,various side effects have been reported,one of the most serious being methotrexate-related lymphoproliferative disorder.While this may occur in various organs,liver involvement is rare.Information on these liver lesions,including clinical characteristics,course,and imaging studies,has not been summarized to date.CASE SUMMARY We present a case of 70-year-old woman presented with a 2-wk history of fever and abdominal pain.She had had rheumatoid arthritis for 5 years and was being treated with medication including methotrexate.Contrast-enhanced computed tomography revealed multiple low density tumors in the liver and the histological analyses showed significant proliferation of lymphocytes in masses that were positive on immunohistochemical staining for CD3,CD4,CD8,and CD79a but negative for CD20 and CD56.Staining for Epstein-Barr virus-encoded RNA was negative.And based on these findings,the liver tumors were diagnosed as Methotrexate-related lymphoproliferative disorders.A timedependent disappearance of the liver tumors after stopping methotrexate supported the diagnoses.CONCLUSION The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.

关键词： Arthritis Rheumatoid Methotrexate Malignant lymphoma Case report

Hepatocellular carcinoma occurring in a Crohn’s disease patient

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World Journal of Gastroenterology 2010年第25期16卷 3215-3218页

作者： Mitsuaki Ishida Shigeyuki Naka Hisanori Shiomi Tomoyuki Tsujikawa akira Andoh Tamio Nakahara Yasuharu saito Yoshi-hide Fujiyama Mikiko Takikita-Suzuki Fumiyoshi Kojima Machiko Hotta Tohru Tani Yoshimasa Kurumi Hidetoshi Okabe Department of Clinical Lab-oratory Medicine and Division of Diagnostic Pathology Shiga University of Medical Science Otsu Shiga 520-2192 Japan Department of Surgery Shiga University of Medical Sci-ence Otsu Shiga 520-2192 Japan Department of Gastroenterology Shiga Uni-versity of Medical Science Otsu Shiga 520-2192 Japan Division of Endoscopy Shiga University of Medical Science Otsu Shiga 520-2192 Japan

We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn’s disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients. A 37-year-old Japanese man with an 8-year history of CD and a medication history of azathioprine underwent resection of a liver tumor. The histopathology of the liver tumor was pseudoglandular type HCC. In the nonneoplastic liver, focal hepatocyte glycogenosis (FHG) was observed, however, there was no evidence of liver cirrhosis or primary sclerosing cholangitis. Only nine cases of HCC in CD patients have been reported previously in the English-language literature. Eight of 10cases (including the present case) had received azathioprine treatment, and four of these cases also showed FHG, which is considered a preneoplastic liver lesion, within the non-neoplastic liver. Although the precise mechanism of the development of HCC in CD patients is controversial, these results suggest that azathioprine therapy and FHG in the non-neoplastic liver contribute to the development of HCC. These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors.

关键词： Crohn’s disease Hepatocellular carcinoma Azathioprine Focal hepatocyte glycogenosis Hepato-carcinogenesis

Cost-Effectiveness Analysis of Neoadjuvant Chemotherapy with Zoledronic Acid for HER2-Negative Breast Cancer in Japan: The JONIE1 Study

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Health 2019年第8期11卷 1017-1027页

作者： Kyoko Nakazawa Shota saito Masayuki Nagahashi Akimitsu Yamada akira Toyama Kouhei Akazawa Department of Medical Informatics and Statistics Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Pharmacy Niigata University Medical and Dental Hospital Niigata Japan Department of Health Informatics Niigata University of Health and Welfare Niigata Japan Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Gastroenterological Surgery Yokohama City University School of Medicine Kanagawa Japan Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan

Objective: Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate that induces osteoclast apoptosis and inhibits bone resorption. Adding ZOL to neoadjuvant chemotherapy has been shown to have potential anticancer benefits in women with HER2-negative breast cancer. The objective of the present study was to investigate ZOL’s cost-effectiveness from the perspective of health care payers in Japan. Methods: A Markov model was developed to evaluate the costs and effectiveness associated with ZOL + chemotherapy (CTZ) and chemotherapy (CT) alone over a 10-year time horizon. Monthly transition probabilities were estimated according to JONIE1 (Japan Organization of Neoadjuvant Innovative Expert) Study data and an extrapolated Weibull model. Health outcomes were measured in quality-adjusted life years (QALYs). Costs were calculated using year-2018 Japanese yen (JPY) (1.00 US dollars (USD) = 110.4 JPY). Model robustness was addressed through one-way and probabilistic sensitivity analysis. The costs and QALYs were discounted at a rate of 2% per year. Results: In the base case, the use of CTZ was associated with a gain of 3.94 QALYs. The incremental cost per QALY of the CTZ gain was 681,056.1 JPY (6168.99 USD) per QALY. Conclusion: It is convincing that neoadjuvant CTZ for patients with breast cancer would be expected to have statistically significant clinical efficacy. Addition of ZOL to CT might be a cost-effective option compared with CT alone.

关键词： Cost-Effectiveness Incremental Cost-Effectiveness Ratio (ICER) Quality-Adjusted Life Year (QALY) Chemotherapy HER2-Negative Breast Cancer