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Tomographic particle image velocimetry measurement on three-dimensional swirling flow in dual-stage counter-rotating swirler

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Chinese Journal of Aeronautics 2024年第3期37卷 7-20页

作者： Yuyang ZHOU Ling DONG Mingtao SHANG Jibao LI akira RINOSHIKA Key Laboratory of Fluid Mechanics of Ministry of Education Beihang UniversityBeijing 100191China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China AECC Commercial Aircraft Engine Co. Ltd.Shanghai 200241China Department of Mechanical Systems Engineering Yamagata UniversityYamagata 992-8510Japan

Three-Dimensional(3D)swirling flow structures,generated by a counter-rotating dualstage swirler in a confined chamber with a confinement ratio of 1.53,were experimentally investigated at Re=2.3×10^(5)using Tomographic Particle Image Velocimetry(Tomo-PIV)and planar Particle Image Velocimetry(PIV).Based on the analysis of the 3D time-averaged swirling flow structures and 3D Proper Orthogonal Decomposition(POD)of the Tomo-PIV data,typical coherent flow structures,including the Corner Recirculation Zone(CRZ),Central Recirculation Zone(CTRZ),and Lip Recirculation Zone(LRZ),were *** counter-rotating dual-stage swirler with a Venturi flare generates the independence process of vortex breakdown from the main stage and pilot stage,leading to the formation of an LRZ and a smaller CTRZ near the nozzle *** confinement squeezes the CRZ to the corner and causes a reverse rotation flow to limit the shape of the CTRZ.A large-scale flow structure caused by the main stage features an explosive breakup,flapping,and Precessing Vortex Core(PVC).The explosive breakup mode dominates the swirling flow structures owing to the expansion and construction of the main jet,whereas the flapping mode is related to the wake *** limits the expansion of PVC and causes it to contract after the impacting area.

关键词： Coherent structures Dual-stage counter-rotating swirler cup Precessing vortex core Proper orthogonal decomposition Swirling flow Tomographic particle image velocimetry

Medaka factor in the germline alpha(figα)is indispensable for oogenesis but not for gonadal sex differentiation

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Aquaculture and Fisheries 2024年第3期9卷 347-354页

作者： Katsuyasu Kamimura Masato Kinoshita akira Kanamori Division of Biological Science Graduate School of ScienceNagoya UniversityNagoyaAichi464-8602Japan Division of Applied Biosciences Graduate School of AgricultureKyoto UniversityKyoto606-8502Japan

A basic helix-loop-helix transcription factor,figα,is one of the earliest marker genes of oocyte differentiation in *** the present study,we made figαknockout medaka by CRISPR/Cas9,expecting aborted progress of oogenesis,to see if differentiation of somatic ovarian tissues is ***αknockout male gonads differentiated normally into testes with functional *** females,on the other hand,were sterile;there are oocytes only up to *** growing oocytes in diplotene were *** phenotype was already apparent at 10 days after hatching,when diplotene oocytes start to develop in the ***,several putative target genes of figαwere not expressed in the mutant female *** studies showed that medaka lacking germ cells have morphologically abnormal gonads and female to male sex reversal ***αknockout female gonads differentiated morphologically into ovaries,suggesting that in medaka,figαknockout prevents oogenesis progress into diplotene stage,and ovarian differentiation do not need developed oocytes beyond pachytene *** ovarian phenotype reminded us of"pachytene checkpoint",which blocks meiotic progress into diplotene when chromosomal abnormalities are ***,we further analyzed phenotype of oocytes in the mutant *** number of oocytes at each meiotic stage suggested that oogenesis normally proceeded up to pachytene *** number of apoptotic oocytes in the knockout ovaries was ***,we did not detect any abnormal pairings or unrepaired double-strand breaks by *** together,figαknockout likely stop oocyte growth at or around pachytene via unknown mechanisms other than"pachytene checkpoint"and arrested oocytes remained in the *** is in contrast to figαknockout mice where all oocytes underwent apoptosis quickly after birth.

关键词： bHLH transcription factor CRISPR/Cas9 Pachytene checkpoint Oocyte growth Medaka

Moving doubly heavy baryon in a strongly coupled plasma via holography

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Chinese Physics C 2024年第8期48卷 42-55页

作者： Xuan Liu Jia-Jie Jiang Xun Chen Mitsutoshi Fujita akira Watanabe School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Mathematics and Physics University of South ChinaHengyang 421001China

Gauge/gravity duality is used to study the properties of the doubly heavy baryon(QQq)at finite rapidity and temperature in heavy-ion *** investigate the impact of rapidity on string breaking and screening of QQq and compare these effects with the results for QQ¯in *** reveal that the string-breaking distances of QQq and QQ¯are close in the confined state,and the effects of rapidity and temperature on the string breaking are not *** interesting result shows that QQq cannot be determined at sufficiently high temperatures and ***,QQ¯can exist under any conditions as long as the separation distance is sufficiently ***,the screening distances of QQq and QQ¯are compared at finite rapidity and *** on the above analysis,we infer that QQ¯is more stable than QQq at finite rapidity and temperature.

关键词： holographic QCD QGP heavy quark

Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

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Oncology Research 2024年第3期32卷 503-515页

作者： XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE akira MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG Samuel Oschin Comprehensive Cancer Institute Department of MedicineDepartment of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA90048USA Department of Urology The Second Afiliated Hospital of Anhui Medical UniversityHefei230601China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu610041China Department of Pathology Ningbo Diagnostic Pathology Center Ningbo315021China Department of Public Research Platfom Taizhou Hospital of Zhejiang Province Afliated to Wenzhou Medical UniversityLinhai317000China Department of Rehabilitation West Kyushu UniversityKanzaki shi842-8585Japan Department of Urology Kyung Hee UniversitySeoul446701South Korea Department of Rehabilitation The Afliated Hospital of Southwest Medical UniversityLuwzhou646000China

The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic *** study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in *** observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these *** conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention.

关键词： Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

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化学泵浦的碘激光器

中国激光 1983年第Z1期 589-589页

作者： Kazuhiko Serizawa akira otsuka Hiroshi Murata Taro Uchiyama Tomoo Fujioka 日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系

本文给出了使用小尺寸真空泵的在低流速（2米/秒）下运转的横流化学泵浦碘激光器的性能。由化学发生器射出的气流经一个干冰乙醇吸附器,从而除去作为受激体的有效猝灭剂的水蒸气。激光器部分由一个70×2cm的管道组成,1m长的腔安装在离I... 详细信息

本文给出了使用小尺寸真空泵的在低流速（2米/秒）下运转的横流化学泵浦碘激光器的性能。由化学发生器射出的气流经一个干冰乙醇吸附器,从而除去作为受激体的有效猝灭剂的水蒸气。激光器部分由一个70×2cm的管道组成,1m长的腔安装在离I2注入点大约0.8cm的下游处,共振腔由两块反射镜组成:一块曲率半径为5米的全反射镜,另一块部分透过（T=1.5％）的平面镜。喉高为0.6cm的喷嘴放置在腔轴处,以便使分子碘和氧有效地混合。在90％（重量）H2O2,为1.1升和25％（重量）NaOH为0.5升时,采用大于40％的

关键词：碘激光器吸附器气体净化设备碘分子

赴日清人书法与江户时代日本对中国书法的接受

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故宫博物院院刊 2024年第6期 111-123,151页

作者：松浦章许浩日本关西大学郑州大学外国语与国际关系学院

江户时代日本推崇儒学,涌现出一批喜好汉文化的文人。在书法领域,相对于“和样”书法,日本人对具有中国书法特征的“唐样”书风更加青睐。由于江户日本实行闭关锁国政策,每年定期赴日的仅有前往长崎贸易的清代商船船主、乘员等,其中不... 详细信息

江户时代日本推崇儒学,涌现出一批喜好汉文化的文人。在书法领域,相对于“和样”书法,日本人对具有中国书法特征的“唐样”书风更加青睐。由于江户日本实行闭关锁国政策,每年定期赴日的仅有前往长崎贸易的清代商船船主、乘员等,其中不乏精通书法者。部分日本文人为了得到善书者墨迹,专门造访长崎,请教书法知识。这些书法最能展示当时中国书法的真实面貌,称得上是学习“唐样”书风的首选。

关键词：江户时代 “唐样”书风唐船船主接受中日书法交流

Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial

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World Journal of Gastroenterology 2018年第35期24卷 4077-4085页

作者： Hiromitsu Ban Mitsushige Sugimoto Taketo otsuka Masaki Murata Toshiro Nakata Hiroshi Hasegawa Osamu Inatomi Shigeki Bamba akira Andoh Division of Digestive Endoscopy Shiga University of Medical Science Hospital Department of Gastroenterology Shiga University of Medical Science Hospital Division of Clinical Nutrition Shiga University of Medical Science Hospital

AIM To prospectively investigate the efficacy and safety of clipflap assisted endoscopic submucosal dissection(ESD) for gastric *** From May 2015 to October 2016, we enrolled 104 patients with gastric cancer or adenoma scheduled for ESD at Shiga University of Medical Science Hospital. We randomized patients into two subgroups using the minimization method based on location of the tumor(upper, middle or lower third of the stomach), tumor size( 20 mm) and ulcer status: ESD using an endoclip(the clip-flap group) and ESD without an endoclip(the conventional group). Therapeutic efficacy(procedure time) and safety(complication: Gastrointestinal bleeding and perforation) were assessed. RESULTS En bloc resection was performed in all patients. Four patients had delayed bleeding(3.8%) and two had perforation(1.9%). No significant differences in en bloc resection rate(conventional group: 100%, clip flap group: 100%), curative endoscopic resection rate(conventional group: 90.9%, clip flap group: 89.8%, P = 0.85), procedure time(conventional group: 70.8 ± 46.2 min, clip flap group: 74.7 ± 53.3 min, P = 0.69), area of resected specimen(conventional group: 884.6 ± 792.1 mm^2, clip flap group: 1006.4 ± 1004.8 mm^2, P = 0.49), delayed bleeding rate(conventional group: 5.5%, clip flap group: 2.0%, P = 0.49), or perforation rate(conventional group: 1.8%, clip flap group: 2.0%, P = 0.93) were found between the two groups. Lessexperienced endoscopists did not show any differences in procedure time between the two *** For patients with early-stage gastric tumors, the clipflap method has no advantage in efficacy or safety compared with the conventional method.

关键词： Gastric cancer Clip flap method Endoscopic submucosal dissection Procedure time Complication Randomized clinical trial

Screening for viruses in lung adenocarcinoma in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 197-199页

作者： Zhuxing Chen Peng Liang Haoxiang Xu Shengli Yang Jilong Liu Shifu Chen Ran Zhong akira Sugimoto Wenhua Liang Jianxing He Tomoya Kawaguchi Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Pulmonary Nodule Surgical Department the First People’s Hospital of FoshanFoshanGuangdong 528000China Center for Medical Research the First People’s Hospital of YulinThe Sixth Affiliated Hospital of Guangxi Medical UniversityYulinGuangxi 537000China Department of General Medicine the Second Affiliated Hospital(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou University of Chinese MedicineGuangzhouGuangdong 510120China Day Surgery Center the First People’s Hospital of FoshanFoshanGuangdong 528000China BGI Genomics BGI-ShenzhenShenzhenGuangdong 510120China HaploX Biotechnology Co.LtdShenzhenGuangdong 518000China Department of Respiratory Medicine Graduate School of MedicineOsaka Metropolitan UniversityChemotherapy CenterOsaka City University HospitalOsaka 558-8585Japan The First Clinical College Southern Medical UniversityGuangzhouGuangdong 510120China

To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been *** and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still *** staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid ***-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of *** studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian ***,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.

关键词： adenocarcinoma lung respiratory