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Hepatoid carcinoma of the pancreas mimicking neuroendocrine tumor

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 501-502页

作者： Kentaro Fukushima akira Kobayashi First Department of Surgery Shinshu University School of MedicineMatsumotoJapan

A 44-year-old man was admitted to our hospital for further investigation of a tumor in the pancreatic *** had no symptoms or chronic liver *** hormones,CEA,and CA19-9 were *** alpha-fetoprotein and des-gamma-carboxy p... 详细信息

关键词： admitted pancreas assessed

Scattering Characteristics of Liquid Droplets Spun Off from Rotating Disk Edge

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Journal of Thermal Science 2012年第1期21卷 42-48页

作者： Mizue MUNEKATA akira NOGUCHI Jun NISHIYAMA Hiroaki KURISHIMA Hiroyuki YOSHIKAWA Dept. of Mech. System Eng. Kumamoto University 2-39-1 Kurokami Tokyo Electron Kyushu Ltd. Fukuhara

Scattering characteristics of liquid droplets spun off from a rotating disk edge are experimentally investigated. In the present research, aluminum disks are utilized and ethanol is employed for liquid. Scattering phenomena of the droplets are captured by the high-speed digital camera. Frequency distribution of the droplet diameter is evaluated from these images and distributions of horizontal flying velocity and angle of the droplets were measured by PTV. Liquid filaments are stretched outward from the stagnant liquid layer by centrifugal force and skew complicatedly by aerodynamic force. Some peaks appear in the distribution of the scattered droplet diameter and they are origi- nated from large terminal droplets and small droplets generated from filamentwise breakup. Most of the scattered droplets fly slightly inside in the tangential direction of the disk edge. The droplets spun off from the thin disk scatter widely compared with that from the thick one.

关键词： Rotating disk Scattering droplet Visualization Particle tracking velocimetry

Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation

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World Journal of Gastroenterology 2012年第20期18卷 2517-2525页

作者： Masahiro Tajika Yasumasa Niwa Vikram Bhatia Hiroki Kawai Shinya Kondo akira Sawaki Nobumasa mizuno Kazuo Hara Susumu Hijioka Kazuya Matsumoto Yuji Kobayashi akira Saeki Asana Akabane Koji Komori Kenji Yamao Department of Endoscopy Aichi Cancer Center Hospital Nagoya 464-8681Japan Department of Medical Hepatology Institute of Liver and Biliary SciencesNew Delhi 110070India Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan

AIM:To evaluate the efficacy and safety of adjunctive mosapride citrate for bowel preparation before colonoscopy. METHODS:We conducted a randomized,double-blind, placebo-controlled study with mosapride in addition to polyethylene glycol(PEG)-electrolyte *** 250 patients undergoing colonoscopy,124 were randomized to receive 2 L PEG plus 15 mg of mosapride citrate (mosapride group),and 126 received 2 L PEG plus placebo(placebo group).Patients completed a questionnaire reporting the acceptability and tolerability of the bowel preparation *** efficacy of bowel preparation was assessed by colonoscopists using a 5-point scale based on Aronchick's *** primary end point was optimal bowel preparation rates(scores of excellent/good/fair vs poor/inadequate). RESULTS:A total of 249 patients were included in the *** the mosapride group,optimal bowel preparation rates were significantly higher in the left colon compared with the placebo group(78.2%vs 65.6%,P<0.05),but not in the right colon(76.5%vs 66.4%,P=0.08).After excluding patients with severe constipation,there was a significant difference in bowel preparation in both the left and right colon(82.4%vs 66.7%,80.8%vs 67.5%,P<0.05,P<0.01).The incidence of adverse events was similar in both groups. Among the subgroup who had previous colonoscopy experience,a significantly higher number of patients in the mosapride group felt that the current preparation was easier compared with patients in the placebo group(34/72 patients vs 24/74 patients,P<0.05). CONCLUSION:Mosapride citrate may be an effective and safe adjunct to PEG-electrolyte solution that leads to improved quality of bowel preparation,especially in patients without severe constipation.

关键词： Mosapride citrate Bowel preparation Polyethylene glycol-electrolyte solution Colonoscopy Prokinetics

The methodology of lymphatic anatomy studies in a cadaver model: an overview

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Plastic and Aesthetic Research 2019年第12期6卷 50-60页

作者： Hiroo Suami akira Shinaoka Australian Lymphoedema Education Research and Treatment ProgramFaculty of Medicine and Health SciencesMacquarie UniversitySydneyNSW 2109Australia Department of Human Morphology Okayama University Graduate School of MedicineDentistryand Pharmaceutical ScienceOkayama 700-8558Japan

The lymphatic system is the area least investigated in the field of anatomical *** major reason for this is the technical difficulty in identifying the lymphatics in the surrounding tissue in post-mortem *** a result,the medical illustration masterpieces crafted by pioneer anatomists on the basis of cadaver dissections remain a vital component of current anatomical *** innovative techniques were developed in the past to allow anatomists to distinguish the transparent lymphatic structures from their surroundings and enable thorough investigation of the lymphatic system in a cadaver *** paper focuses on these techniques,including the current technique developed by the authors themselves.

关键词： Anatomy lymphatic system cadaver mercury indocyanine green

Medaka factor in the germline alpha(figα)is indispensable for oogenesis but not for gonadal sex differentiation

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Aquaculture and Fisheries 2024年第3期9卷 347-354页

作者： Katsuyasu Kamimura Masato Kinoshita akira Kanamori Division of Biological Science Graduate School of ScienceNagoya UniversityNagoyaAichi464-8602Japan Division of Applied Biosciences Graduate School of AgricultureKyoto UniversityKyoto606-8502Japan

A basic helix-loop-helix transcription factor,figα,is one of the earliest marker genes of oocyte differentiation in *** the present study,we made figαknockout medaka by CRISPR/Cas9,expecting aborted progress of oogenesis,to see if differentiation of somatic ovarian tissues is ***αknockout male gonads differentiated normally into testes with functional *** females,on the other hand,were sterile;there are oocytes only up to *** growing oocytes in diplotene were *** phenotype was already apparent at 10 days after hatching,when diplotene oocytes start to develop in the ***,several putative target genes of figαwere not expressed in the mutant female *** studies showed that medaka lacking germ cells have morphologically abnormal gonads and female to male sex reversal ***αknockout female gonads differentiated morphologically into ovaries,suggesting that in medaka,figαknockout prevents oogenesis progress into diplotene stage,and ovarian differentiation do not need developed oocytes beyond pachytene *** ovarian phenotype reminded us of"pachytene checkpoint",which blocks meiotic progress into diplotene when chromosomal abnormalities are ***,we further analyzed phenotype of oocytes in the mutant *** number of oocytes at each meiotic stage suggested that oogenesis normally proceeded up to pachytene *** number of apoptotic oocytes in the knockout ovaries was ***,we did not detect any abnormal pairings or unrepaired double-strand breaks by *** together,figαknockout likely stop oocyte growth at or around pachytene via unknown mechanisms other than"pachytene checkpoint"and arrested oocytes remained in the *** is in contrast to figαknockout mice where all oocytes underwent apoptosis quickly after birth.

关键词： bHLH transcription factor CRISPR/Cas9 Pachytene checkpoint Oocyte growth Medaka

Role of hepatitis C virus in myocarditis and cardiomyopathies

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Journal of Geriatric Cardiology 2004年第2期1卷 83-89页

作者： akira Matsumori Department of Cardiovascular Medicine Kyoto University Graduate School of MedicineKyotoJapan

Recent nationwide clinico-epidemiological surveys in Japan showed that the occurrence of cardiomyopathies was most frequently seen in the age of sixties, and that cardiomyopathies are important causes of heart failure in the elderly. Viral infection was conventionally considered to cause myocarditis, which resulted in the development of dilated cardiomyopathy. Recent studies suggest that hepatitis C virus (HCV) is involved in the development of dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy in addition to myocarditis. Furthermore, left ventricular aneurysm represents the same morbid state not only after myocardial infarction but also after myocarditis. There were wide variations in the frequency of detection of HCV genomes in cardiomyopathy in different regions and in different populations. Major histocompatibility complex class Ⅱ genes may play a role in the susceptibility to HCV infection, and may influence the development of different phenotypes of cardiomyopathy. If in fact the myocardial damage is caused by HCV, it might be expected that interferon (IFN) administration would be useful for its treatment. Hepatitis patients receiving IFN treatment for hepatitis were screened by thallium myocardial scintigraphy, and an abnormality was discovered in half of the patients. Treatment with IFN resulted in a disappearance of the image abnormality. It has thus been suggested that mild myocarditis and myocardial damage may be cured with IFN. We have recently found that high concentrations of circulating cardiac troponin T are a specific marker of cardiac involvement in HCV infection. By measuring cardiac troponin T in patients with HCV infection, the prevalence of cardiac involvement in HCV infection will be clarified. We are proposing a collaborative work on a global network on myocarditis/cardiomyopathies due to HCV infection. (J Geriatr Cardiol 2004;1(2):83-89. )

关键词： myocarditis cardiomyopathy hepatitis C virus hypertrophy heart failure interferon major histocompatibility complex

Electrochemical reduction of CO_2 and degradation of KHP on boron-doped diamond electrodes in a simultaneous and enhanced process

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Chinese Chemical Letters 2019年第2期30卷 509-512页

作者： Daibing Luo Shanhu Liu Kazuya Nakata akira Fujishima Analytical ξ Testing Center Sichuan University Research Institute for Science and Technology Photocatalysis International Research Center Tokyo University of Science Henan Key Laboratory of Polyxometalate Chemistry Institute of Molecular and Crystal Engineering College of Chemistry and Chemical EngineeringHenan University

In this research a novel electrochemical system using dual boron-doped diamond (BDD) electrodes as the anode and cathode, for the first time, has been developed for CO_2 conversion and wastewater treatment in a synergetic and simultaneous process. On the BDD cathode CO_2 is converted into formaldehyde while in the anodic side organic wastes are decomposed on the BDD anode. Interestingly, when potassium hydrogen phthalate (KHP) was used as the organic model to be degraded in the anodic side, a higher efficiency of formaldehyde generation from CO_2 was observed on the BDD cathode. The enhanced effect of formaldehyde formation in the presence of KHP oxidation suggests that this novel electrochemical system can combine conversion of CO_2 to the form of high-value chemicals and wastewater purification in a simultaneous and harmonious process.

关键词： CO2 Wlectrochemical reduction Boron-doped diamond Wastewater treatment Formaldehyde

An Approximate High Gain Observer for Speed-sensorless Estimation of Induction Motors

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IEEE/CAA Journal of Automatica Sinica 2019年第1期6卷 53-63页

作者： Yebin Wang Lei Zhou Scott A.Bortoff akira Satake Shinichi Furutani IEEE Mitsubishi Electric Research Laboratories the Department of Mechanical Engineering Massachusetts Institute of Technology the Advanced Technology R&D Center Mitsubishi Electric Corporation

Rotor speed estimation for induction motors is a key problem in speed-sensorless motor drives. This paper performs nonlinear high gain observer design based on the full-order model of the induction motor. Such an effort appears nontrivial due to the fact that the full-model at best admits locally a non-triangular observable form(NTOF), and its analytical representation in the NTOF can not be obtained. This paper proposes an approximate high gain estimation algorithm, which enjoys a constructive design, ease of tuning, and improved speed estimation and tracking performance. Experiments demonstrate the effectiveness of the proposed algorithm.

关键词： Induction motor industrial applications nonlinear state estimation speed-sensorless motor drive

Design Study of Top Lid with Clamp Structure in JT-60SA Cryostat

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Plasma Science and Technology 2013年第2期15卷 188-191页

作者： Shigetoshi NAKAMURA Yusuke K. SHIBAMA Kei MASAKI akira SAKASAI Japan Atomic Energy Agency Mukouyama 801-1 Naka Ibaraki 311-0193 Japan

JT-60SA is a fully superconducting coil tokamak upgraded from the JT-60U. This paper focused on the integrity of the top lid of cryostat in JT-60SA. The design requirement for the cryostat in normal operations is to achieve vacuum insulation of 10-1 Pa, and the top flange of the top lid is lightly welded onto its body flange. The weld is tensile-loaded by bending deformation of the top lid due to vacuum pressure of external 0.1 MPa. This weld integrity is evaluated with tensile-load reduction, which results in clamp reinforcement. The structural integrity of the top lid is validated.

关键词： clamp vacuum insulation top lid cryostat JT-60SA