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Pseudo-Dynamic Testing for Seismic Performance Assessment of Buildings with Seismic Isolation System Using Scrap Tire Rubber Pad Isolators

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Journal of Civil Engineering and Architecture 2014年第1期8卷 73-88页

作者： Huma Kanta Mishra akira igarashi Dang Ji Hiroshi Matsushima Department of Urban Management Kyoto University Kyoto 615-8540 Japan Department of Civil and Earth Resource Engineering Kyoto University Kyoto 615-8540 Japan

Investigation of seismic performance of buildings with STRP (scrap tire rubber pad) seismic isolators by means of pseudo-dynamic tests and numerical simulation is presented. The isolated building is numerically modeled, while the base isolation layer is considered as the experimental substructure in the pseudo-dynamic tests. The test result verifies that the STRP isolator shows acceptable shear deformation performance predicted by the design methods, and demonstrated that seismic isolation using STRP works as a protective measure to provide enhanced seismic performance of the building indicated by the reduction of top floor absolute acceleration, drift and base shear as designated.

关键词：抗震性能评估动态测试废旧轮胎隔震系统建筑物橡胶垫科学技术拟动力试验

Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1173-1179页

作者： Takeshi Arima Tsutomu igarashi Masaaki Uchiyama Maika Kobayashi Ikuroh Ohsawa akira Shimizu Hiroshi Takahashi Department of Ophthalmology Nippon Medical SchoolTokyo1138602Japan Department of Analytic Human Pathology Nippon Medical SchoolTokyo1138602Japan Biological Process of Aging Tokyo Metropolitan Institute of GerontologyTokyo173-0015Japan

AIM: To investigate the effects of hydrogen(H2) on Cu, Zn superoxide dismutase(SOD1) activation in a rat model of corneal alkali burn. METHODS: In each rat, one cornea was subjected to alkali exposure. Physiological saline(saline group) or H2-dissolved saline(H2 group) was instilled continuously on the cornea for 5 min before and after alkali exposure. Inflammatory cells, neovascularization, and cytoplasmic SOD1 levels were evaluated immunohistochemically in enucleated eyes from both groups. Three-dimensional ultrastructural tissue changes in the eyes were analyzed using low-vacuum scanning electron ***: The numbers of both inflammatory and vascular endothelial cells were significantly reduced in the corneas of the H2 group(P<0.01). Furthermore, H2 treatment increased both cytoplasmic SOD1 levels(P<0.01) and activity in corneal epithelial cells(P<0.01). Notably, the SOD1 activity level in the H2 group was approximately 2.5-fold greater than that in the saline ***: H2 treatment suppresses inflammation and neovascularization in the injured cornea and indirectly suppresses oxidative insult to the cornea by upregulating the SOD1 enzyme protein level and activity.

关键词： hydrogen alkali burn Cu,Zn superoxide dismutase low-vacuum scanning electron microscopy rats

Investigation of the Association of TLR2 and TLR4 Polymorphisms with Susceptibility to <i>Helicobacter pylori</i>-Related Gastrointestinal Diseases

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Open Journal of Internal Medicine 2014年第4期4卷 130-136页

作者： Takayoshi Suzuki akira Meguro Masashi Matsushima Aya Masui Shingo Tsuda Jun Nakamura Ryoko Nishina Tetsufumi Uchida Hiroki Yuhara Muneki igarashi Jun Koike Tetsuya Mine Hidetoshi Inoko Atsushi Takagi Division of Gastroenterology & Hepatology Department of Internal Medicine Tokai University School of Medicine Isehara Japan Division of Molecular Life Science Department of Genetic Information Tokai University School of Medicine Isehara Japan Division of General Internal Medicine Department of Internal Medicine Tokai University School of Medicine Isehara Japan

Background and Aim: Toll-like receptor (TLR) 2 and TLR4 are cell surface signaling receptors that are involved in the recognition of and host response to Helicobacter pylori. Our aim was to investigate the association between TLR gene polymorphisms and susceptibility of Japanese subjects to 4 H. pylori-related gastrointestinal diseases. Methodology: A total of 100 patients with histologically diagnosed gastric cancer, 105 patients with gastric ulcer, 102 with atrophic gastritis, 72 with duodenal ulcer and 428 healthy controls were recruited. A TaqMan assay was used to genotype 7 single nucleotide polymorphisms (SNPs) in TLR2 and 6 SNPs in TLR4. Results: There was a tendency for TLR4 rs10759932 TC/CC genotypes to be associated with a decreased risk of gastric cancer (p = 0.059);however, this did not reach statistical significance. No significant associations were found between polymorphisms in TLR2 or TLR4 and the risks for gastric cancer, gastric ulcer, duodenal ulcer, or atrophic gastritis. Conclusion: The 13 SNPs inTLR2 and TLR4 examined in this study may not be linked with the development of H. pylori-related gastrointestinal diseases. Further studies with larger numbers of subjects are necessary to verify the present findings.

关键词： TLR2 TLR4 Polymorphisms Helicobacter pylori

Prevalence of Non-Responders to Both Oral Bisphosphonate Monotherapy and Intravenous Ibandronate in Patients with Postmenopausal Osteoporosis

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Open Journal of Orthopedics 2020年第3期10卷 43-53页

作者： Naohisa Miyakoshi Yuji Kasukawa Michio Hongo akira Horikawa Yoichi Shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Hondo Akita Japan igarashi Memorial Hospital Tsuchizakiminato-Chuo Akita Japan

Objectives: Although bisphosphonates (BPs) are effective for the majority of patients with osteoporosis, some individuals do not adequately respond to these drugs. The objective of this study was to estimate the prevalence of true BP non-responders who showed insufficient response after both oral BPs and intravenous ibandronate. Methods: Among 146 consecutive patients with postmenopausal osteoporosis who received oral BP monotherapy for more than 12 months, insufficient responders to oral BP monotherapy were switched to intravenous ibandronate injection and followed for more than 12 months. Serum N-terminal telopeptide of type I collagen (NTX) and bone alkaline phosphatase (BAP) concentrations were measured. Patients who also showed insufficient response to intravenous ibandronate were defined as true BP non-responders. Insufficient response to BP therapy was evaluated based on the serum NTX reduction cut-off for minimum significant change. Results: Sixty-one patients (41.8%) were diagnosed as oral BP non-responders. Fourteen patients who switched to intravenous ibandronate and had complete data available were used for final analysis. After switching to intravenous ibandronate, both NTX and BAP decreased significantly (p Conclusion: These results estimated that as few as 9% - 15% (i.e., 21.4% - 35.7% of 41.8%) or as many as 24% - 27% (i.e., 57.1% - 64.3% of 41.8%) of patents might be true BP non-responders.

关键词： Bone Resorption Biphosphonates Ibandronic Acid Osteoporosis Prevalence

Admission and Traffic Control Schemes Suitable for QoS Applications in WLAN Systems

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American Journal of Operations Research 2012年第3期2卷 382-390页

作者： Takefumi Hiraguri Takayuki Kimura Toshiyuki Ogawa Hiroshi Takase akira Kishida Kentaro Nishimori Doctoral Program in Graduate School of Electrical Engineering Nippon Institute of Technology 4-1 Gakuendai Miyashiro Minami-Saitama Saitama Japan Graduate School of Science & Technology Niigata University 8010 Igarashi 2-nocho Nishi-ku Niigata Japan Nippon Institute of Technology 4-1 Gakuendai Miyashiro Minami-Saitama Saitama Japan NTT Access Network Service Systems Laboratories 1-1 Hikarinooka Yokosuka Kanagawa Japan

This paper proposes the use of admission and traffic control schemes for real-time applications. The admission control scheme determines the admission of high-priority real-time applications such as voice and video streams in terms of their bandwidth utilization time (medium time), whereas the traffic control scheme maintains the communication quality of applications permitted admission by restricting other traffic. Owing to the use of contention-based access, a conventional scheme without admission control will degrade the communication quality when the number of terminals using high-priority applications increases. Moreover, only the capabilities (i.e., frame and sequence procedures) of admission control are defined in the IEEE 802.11e standard;the detailed usage in terms of the application characteristics is not specified, and it may be difficult to achieve a sufficient level of quality of service (QoS). The proposed schemes achieve the optimum QoS for actual services. The software used in the proposed schemes was implemented into hardware at the access point, and was evaluated experimentally. Based on the evaluation results, excellent performances with high QoS applications were obtained.

关键词： QoS IEEE 802.11 Admission Control Traffic Control EDCA

Endoscopic approach through the minor papilla for the management of pancreatic diseases

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World Journal of Gastrointestinal Endoscopy 2013年第3期5卷 81-88页

作者： Nao Fujimori Hisato igarashi akira Asou Ken Kawabe Lingaku Lee Takamasa Oono Taichi Nakamura Yusuke Niina Masayuki Hijioka Masahiko Uchida Kazuhiro Kotoh Kazuhiko Nakamura Tetsuhide Ito Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityHigashi-kuFukuoka 812-8582Japan Department of Gastroenterology National Hospital OrganizationKyushu Medical CenterChuou-kuFukuoka 810-8563Japan

AIM:To clarify the efficacy and safety of an endoscopic approach through the minor papilla for the management of pancreatic ***:This study included 44 endoscopic retrograde cholangiopancreatography(ERCP) procedures performed in 34 patients using a minor papilla approach between April 2007 and March *** retrospectively evaluated the clinical profiles of the patients,the endoscopic interventions,short-term outcomes,and ***:Of 44 ERCPs,26 were diagnostic ERCP,and 18 were therapeutic *** most common cause of difficult access to the main pancreatic duct through the major papilla was pancreas divisum followed by distortion of Wirsung's *** overall success rate of minor papilla cannulation was 80%(35/44),which was significantly improved by wire-guided cannulation(P = 0.04).Endoscopic minor papillotomy(EMP) was performed in 17 of 34 patients(50%) using a needle-knife(13/17) or a pull-type papillotome(4/17).EMP with pancreatic stent placement,which was the main therapeutic option for patients with chronic pancreatitis,recurrent acute pancreatitis,and pancreatic pseudocyst,resulted in short-term clinical improvement in 83% of *** post-ERCP pancreatitis occurred as an early complication in 2 cases(4.5%).CONCLUSION:The endoscopic minor papilla approach is technically feasible,safe,and effective when the procedure is performed in a high-volume referral center by experienced endoscopists.

关键词： Endoscopic papillotomy Endoscopic retrograde cholangiopancreatography Minor papilla Pancreas divisum Pancreatitis