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Who needs further evaluations to diagnose upper urinary tract urothelial cancers among patients with abnormal findings by enhanced CT?

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Asian Journal of Urology 2016年第1期3卷 44-48页

作者： akio Takayanagi Atsushi takahashi Fumimasa Fukuta Manabu Okada Masahiro Matsuki Shunsuke Sato Teruhisa Uehara Shuichi Kato Yoshio Takagi Department of Urology Hakodate Goryoukaku HospitalHakodateHokkaidoJapan Department of Urology Sapporo Medical University School of MedicineSapporoHokkaidoJapan

Objective:We evaluated who would need further evaluations such as retrograde pyelography(RP)and/or ureteroscopy to diagnose upper urinary tract urothelial cancers(UUTUCs)when abnormal findings for the upper urinary tract(UUT)were detected by enhanced computed tomography(CT).Methods:We retrospectively analyzed 125 patients who underwent enhanced CT for various reasons and had abnormal findings for the UUT.Patients whose tumors were suspected to be of extraureteral origin were excluded.All patients received RP and/or ureteroscopy to evaluate the UUTUCs.Results:The median age of the 125 patients was 70 years and gross hematuria(26.4%)was the most frequently observed symptoms.RP,ureteroscopy and both were performed for 121,59 and 55 patients,respectively.CT revealed tumor-like lesions in 58 patients and the other patients had non-tumor-like lesions.UUTUCs were found in 43(34.4%)of the 125 patients.All of them had tumor-like lesions on CT.In 58 patients who had tumor-like lesions on CT,univariate and multivariate analyses revealed that tumor diameter and tumor enhancement were significant predictive factors for UUTUCs.ROC curve analysis of enhanced CT to diagnose UUTUCs revealed that a tumor diameter of 18 mm was the best cutoff point.The sensitivity,specificity and accuracy were 90.0%,98.8% and 92.7% for RP and 95.5%,100% and 97.1%for ureteroscopy,respectively.Both of them had high sensitivity,specificity and accuracy.Conclusion:We should decide to evaluate the UUT according to the tumor diameter on enhanced CT.When we evaluate the UUT in patients with tumor diameters of less than 20 mm,ureteroscopy is recommended.

关键词： Upper urinary tract urothelial cancers Enhanced CT Ureteroscopy Retrograde pyelography

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Remain Aggressive Behavior in Children with Temporal Lobe Epilepsy after Surgery

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Journal of Behavioral and Brain Science 2015年第3期5卷 81-87页

作者： Sayuri Sukigara Eiji Nakagawa Masanori Ishikawa Kenji Sugai Masayuki Sasaki Takanobu Kaido Akio takahashi Taisuke Otsuki Department of Child Neurology National Center Hospital National Center of Neurology and Psychiatry (NCNP) Tokyo Japan Department of Psychiatry NCNP Tokyo Japan Department of Neurosurgery NCNP Tokyo Japan

Behavioral problems have a high rate in patients with temporal lobe epilepsy but there have been few detailed reports about pediatric patients. We report two children with temporal lobe epilepsy who manifest behavior abnormality remaining after surgery. One child developed complex partial seizures at 10 years and 3 months of age caused by a left temporal ganglioglioma and manifested behavioral problems of lability, aggression, impulsivity and disinhibition. Seizures were relieved after temporal lobe resection at 10 years and 8 months of age but behavioral symptoms had been remained. The second child developed epilepsy at 3 years of age. He manifested similar behavioral problems at 7 years old. Seizures were relieved after temporal lobe resection at 13 years old but behavioral symptoms had been remained. Their courses suggested that aggressive behavior might be associated with not only temporal lesion but also other lesions such as frontal lobe or neural circuitry between both lobes. It is important to inform families of patients that behavioral disorders may not improve after epileptic surgery.

关键词： Temporal Lobe Epilepsy Behavioral Disorder Aggression Epileptic Surgery

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Resected tumor seeding in stomach wall due to endoscopic ultrasonography-guided fine needle aspiration of pancreatic adenocarcinoma

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World Journal of Gastroenterology 2015年第27期21卷 8458-8461页

作者： Akiko Tomonari akio Katanuma Tomoaki Matsumori Hajime Yamazaki Itsuki Sano Ryuki Minami Manabu Sen-yo Satoshi Ikarashi Toshifumi Kin Kei Yane Kuniyuki takahashi Toshiya Shinohara Hiroyuki Maguchi Center for Gastroenterology Teine-Keijinkai Hospital Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Department of Pathology Teine-Keijinkai Hospital

Endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) is a useful and relatively safe tool for the diagnosis and staging of pancreatic cancer. However, there have recently been several reports of tumor seeding after EUS-FNA of adenocarcinomas. A 78-year-old man was admitted to our hospital due to upper gastric pain. Examinations revealed a 20 mm mass in the pancreatic body, for which EUS-FNA was performed. The cytology of the lesion was adenocarcinoma, and the stage of the cancer was T3N0M0. The patient underwent surgery with curative intent, followed by adjuvant chemotherapy with S-1. An enlarging gastric submucosal tumor was found on gastroscopy at 28 mo after surgery accompanied by a rising level of CA19-9. Biopsy result was adenocarcinoma, consistent with a pancreatic primary tumor. Tumor seeding after EUS-FNA was strongly suspected. The patient underwent surgical resection of the gastric tumor with curative intent. The pathological result of the resected gastric specimen was adenocarcinoma with a perfectly matched mucin special stain result with the previously resected pancreatic cancer. This is the first case report of tumor seeding after EUS-FNA which was surgically resected and inspected pathologically.

关键词： Endoscopic ultrasonography-guided fine needle aspiration Tumor seeding Pancreatic cancer

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Recovery Method of Pyrolytic Carbon Surface after Exposure to Chlorine Trifluoride Gas

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Advances in Chemical Engineering and Science 2021年第1期11卷 65-76页

作者： Masaya Hayashi Keisuke Kurashima Hitoshi Habuka akio Ishiguro Shigeaki Ishii Yoshiaki Daigo Hideki Ito Ichiro Mizushima Yoshinao takahashi Yokohama National University Hodogaya Yokohama Japan NuFlare Technology Inc. Yokohama Japan KANTO DENKA KOGYO CO. LTD. Marunouchi Chiyoda Tokyo Japan

An annealing process was developed for the practical recover of a purified py-rolytic carbon (PPyC) surface from damage, such as color change and peeling, due to fluorination during exposure to chlorine trifluoride gas at high tempera-tures for the cleaning of a silicon carbide chemical vapor deposition reactor. The PPyC surface was annealed at 900°C for 10 min in ambient nitrogen con-taining oxygen at the concentrations of 0.01% - 20%. The rainbow-like colored surface returned to the dark gray color of the original PPyC. Simultaneously, the thin peeled films disappeared. The Raman spectra showed that the PPyC surface chemical bonding returned to that of the original one. The oxygen concentration as low as 0.01% could recover the PPyC surface along with re-ducing the surface pit formation, when the combination of the exposure to chlorine trifluoride gas and the recovery was repeated.

关键词： Pyrolytic Carbon Recovery Chlorine Trifluoride Fluorine Out-Diffusion Annealing

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Three-Dimensional Analysis of Melanosomes Isolated from B16 Melanoma Cells by Using Ultra High Voltage Electron Microscopy

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Microscopy Research 2014年第1期2卷 1-8页

作者： Shuuichi Akazaki Toshie takahashi Yujiro Nakano Tomoki Nishida Hirotarou Mori akio Takaoka Hitomi Aoki Huayua Chen Takahiro Kunisada Kenzo Koike Beauty Research Center Kao Corporation Tokyo Japan Department of Anatomy Gifu University Gifu Japan. Department of Tissue and Organ Development Regeneration Gifu University Gifu Japan Research Center for Ultra-High Voltage Electron Microscopy Osaka University Suita Japan

Melanosomes, isolated by centrifugal separation from culture broth of B16 melanoma cells derived from mouse, were observed by scanning electron microscopy (SEM), and by transmission electron microscopy (TEM). Some interesting structural features were found inside and outside of the melanosomes. By SEM observation, the melanosomes were ellipsoid shape, their surface was not smooth and was covered with rough substructure, 10 to 20 nm particles. By TEM, uneven structure and micro particles were observed in the melanosomes. Furthermore, three-dimensional analysis was tried by using the ultra-high voltage electron microscopy(UHVEM). Micrographs of the melanosomes were taken at various tilted angles by UHVEM, after preparing 500 nm thickness specimens stained with lead citrate. From the micrographs collected, the three-dimensional structures were reconstructed by using i-mode software. Melanin stained by lead and non stained parts was clearly observed in the reconstructed structure. Non stained parts were round, regular size, and distributed widely in the melanosomes.

关键词： B16 Melanoma Melanosome Scanning Electron Microscopy Transmission Electron Microscopy Ultra High Voltage Electron Microscopy Three-Dimensional Structure

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