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Journal of Health Science 2017年第1期5卷 9-17页

作者： Seisuke Mimori Toru Hosoi Masayuki Kaneko Koichiro Ozawa Tetsuto Kanzaki akinori nishi Yasuyuki Nomura Department of Clinical Medicine Chiba Institute of Science Choshi 288-0025 Japan Department of Pharmacotherapy Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima734-8553 Japan Department of Biochemistry Institute of Biomedical & Health Sciences Hiroshima University Hiroshima 734-8553 Japan Department of Drug Informatics Graduate School and Faculty of Pharmaceutical Sciences Chiba University Chiba 260-8675Japan Department of Pharmacology Kurume University School of Medicine Kurume 830-0011 Japan

Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Yamato Ninomiya Miho Yamamoto Akihito Kazuno Kazuhito Nabeshima Takayuki nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past *** antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative ***,anti-cytotoxic T-lymphocyte–associated protein 4(CTLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 *** understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic T-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

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铁路三维电子沙盘搭建及其应用研究

铁道标准设计 2024年第8期68卷 50-57页

作者：赵亮亮董凤翔黄旎诗中铁二院工程集团有限责任公司成都610031

为解决目前铁路行业电子沙盘存在的表达方式不一、应用内容单一、数据泄露风险大、数据加载效率低等问题,研究海量地理地质及BIM模型的数据处理、管理和应用方法,建立以BIM+GIS为技术核心的标准化电子沙盘,从而更好地服务于铁路设计和... 详细信息

为解决目前铁路行业电子沙盘存在的表达方式不一、应用内容单一、数据泄露风险大、数据加载效率低等问题,研究海量地理地质及BIM模型的数据处理、管理和应用方法,建立以BIM+GIS为技术核心的标准化电子沙盘,从而更好地服务于铁路设计和建造。根据鲁南高铁、拉林铁路、成渝中线高铁等项目实践总结,在中国铁路BIM联盟和国铁集团相关标准基础上提出了面向电子沙盘应用的地形、影像、BIM模型、专题图的数据制作标准,从坐标转换、数据转换、数据切片、知识图谱建立、模型发布、前端数据汇集的方法完成了电子沙盘的搭建。最后,在电子沙盘中实现了百公里级、多专业数据的在线高效组织和管理,提出的方法和标准适用于铁路设计、建设过程的管理和分析应用。

关键词：铁路 BIM GIS 智能化电子沙盘专题图高效组织

Treatment of portosystemic shunt-borne hepatic encephalopathy in a 97-year-old woman using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2023年第4期11卷 945-951页

作者： Akihiro nishi Tsuneaki Kenzaka Misa Sogi Shuichiro Nakaminato Takahiro Suzuki General Medicine Awa Regional Medical CenterTateyama 2940014ChibaJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 6500017HyogoJapan Department of Radiology Kameda Medical CenterKamogawa 2968602ChibaJapan

BACKGROUND Hyperammonemia and hepatic encephalopathy are common in patients with portosystemic *** shunt occlusion has been standard treatment,although recently the less invasive balloon-occluded retrograde transvenous obliteration(B-RTO)has gained increasing *** far,there have been no reports on the treatment of portosystemic shunts with B-RTO in patients aged over 90 *** this study,we present a case of hepatic encephalopathy caused by shunting of the left common iliac and inferior mesenteric veins,successfully treated with *** SUMMARY A 97-year-old woman with no history of liver disease was admitted to our hospital because of disturbance of *** had no jaundice,spider angioma,palmar erythema,hepatosplenomegaly,or *** blood tests showed hyperammonemia,and abdominal contrast-enhanced computed tomography revealed a portosystemic shunt running between the left common iliac vein and the inferior mesenteric *** was diagnosed with hepatic encephalopathy secondary to a portosystemic *** patient did not improve with conservative treatment:Lactulose,rifaximin,and a low-protein diet.B-RTO was performed,which resulted in shunt closure and improvement in hyperammonemia and disturbance of ***,there was no abdominal pain or elevated levels of liver enzymes due to *** patient was discharged without further consciousness *** Portosystemic shunt-borne hepatic encephalopathy must be considered in the differential diagnosis for consciousness disturbance,including abnormal behavior and speech.

关键词： Hepatic encephalopathy Hyperammonemia Portosystemic shunt Balloon-occluded retrograde transvenous obliteration Elderly Case report

Is machine learning redefining the perovskite solar cells?

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Journal of Energy Chemistry 2022年第3期31卷 74-90,I0004页

作者： nishi Parikh Meera Karamta Neha Yadav Mohammad Mahdi Tavakoli Daniel Prochowicz Seckin Akin Abul Kalam Soumitra Satapathi Pankaj Yadav Department of Science School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Electrical Engineering School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Telecommunication Ministry of CommunicationMumbai LSAMumbai 400072MaharashtraIndia Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA Institute of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of Metallurgical and Materials Engineering Karamanoglu Mehmetbey University70200 KaramanTurkey Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413P.O.Box 9004Saudi Arabia Department of Physics Indian Institute of Technology RoorkeeRoorkeeHaridwarUttarakhand 247667India Department of Solar Energy School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

Development of novel materials with desirable properties remains at the forefront of modern scientific *** learning(ML),a branch of artificial intelligence,has recently emerged as a powerful technology in optoelectronic devices for the prediction of various properties and rational design of *** halide perovskites(MHPs)have been at the centre of attraction owing to their outstanding photophysical properties and rapid development in solar cell ***,the application of ML in the field of MHPs is also getting much attention to optimize the fabrication process and reduce the cost of ***,we comprehensively reviewed different applications of ML in the designing of both MHP absorber layers as well as complete perovskite solar cells(PSCs).At the end,the challenges of ML along with the possible future direction of research are *** believe that this review becomes an indispensable roadmap for optimizing materials composition and predicting design strategies in the field of perovskite technology in the future.

关键词： Machine learning Metal halide perovskites Perovskite solar cell Lead free perovskites

A novel shaft-less double suction mini pump

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Science China(Technological Sciences) 2010年第1期53卷 105-110页

作者： nishi Michihiro Kyushu Institute of Technology Sensui-cho 1TobataKitakyushu 804-8550Japan

A novel double suction shaft-less mini pump was developed for heat control of small energy systems in this *** mini pump impeller with an exit diameter of 40 mm was combined with the motor rotor supported by the hybrid dynamic *** specific speed of the pump was 125 min-1 m3 min-1 *** hydraulic performance of the pump was investigated experimen-tally under four rotational *** the test results,it was recognized that the pump could provide a flow discharge of 5 L/min and head of 1.5 m,which are applicable for the heat control system of a 3 kW fuel cell.A three-dimensional turbulent flow simulation in the pump was also conducted near the design *** numerical results showed that the average hydraulic performance of the mini pump was predicted *** the internal flow simulation,it was revealed that the favorable inflow condition upstream of impeller inlet could be attained by applying the double suction shaft-less design for the mini pump.

关键词： double suction seal-less shaft-less uniform inflow mini pump

ELASTOMERIC SEISMIC-PROTECTION ISOLATORS FOR BUILDINGS AND BRIDGES

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Chinese Journal of Polymer Science 2013年第1期31卷 50-57页

作者： Toshio nishi Nobuo Murota International Division Tokyo Institute of Technology Department of Seismic Isolation &Vibration Control Development

A giant earthquake of magnitude 9.0 occurred in Pacific Ocean off of Tohoku District Japan on March 11,2011. The highest seismic intensity of 7 in JMA scale was recorded in Miyagi. In the Tohoku district, around 230 buildings are seismically isolated （hereafter, SI） mainly by elastomeric isolators （seismic rubber bearings）. According to the official survey reports by several organizations （for example）, the records of those buildings have verified the effectiveness of the seismic isolation. The response acceleration of the SI buildings was reduced by 30% to 50% of the input ground acceleration. Additionally, the difference of the conditions inside the room between SI and the fixed-base buildings was obvious as well as the damage in main structures of the buildings. The displacements of the isolators by the earthquake were around 200 mm according to the records of the instruments. As a result, the performance of SI buildings and the elastomeric isolators in the Tohoku District -- Off the Pacific Ocean Earthquake 2011 were excellent, and the efficiency of the seismic isolation was verified by the records of many buildings in wide area.

关键词： Elastomeric isolator Seismic isolation Rubber bearing.

Optimization of laser illumination configuration for directly driven inertial confinement fusion

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Matter and Radiation at Extremes 2017年第2期2卷 55-68页

作者： Masakatsu Murakami Daiki nishi Institute of Laser Engineering Osaka UniversityOsaka 565-0871Japan

Optimum laser configurations are presented to achieve high illumination uniformity with directly driven inertial confinement fusion *** axisymmetric absorption pattern of individual laser beams,theoretical models are reviewed in terms of the number of laser beams,system imperfection,and laser beam *** a self-organizing system of charged particles on a sphere,a simple numerical model is provided to give an optimal configuration for an arbitrary number of laser *** a result,such new configurations as“M48”and“M60”are found to show substantially higher illumination uniformity than any other existing direct drive systems.A new polar direct-drive scheme is proposed with the laser axes keeping off the target center,which can be applied to laser configurations designed for indirectly driven inertial fusion.

关键词： Analytical model Laser illumination design Polar direct drive Inertial confinement fusion

Performance Test and Flow Measurement of Contra-Rotating Axial Flow Pump

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Journal of Thermal Science 2007年第1期16卷 7-13页

作者： akinori Furukawa Toru Shigemitsu Satoshi Watanabe Division of Mechanical Engineering Science Kyushu University744 MotookaNishi-kuFukuoka 819-0395JAPAN

contra-rotating 转子的一个应用程序对对开发更高特定的速度的一个要求被建议了轴的流动泵。在现在的纸，使用 contra-rotating 转子的优点和劣势与转子定子的常规类型比较被描述，基于理论、试验性的调查。优点如下：(1 ) 泵内在地作... 详细信息

contra-rotating 转子的一个应用程序对对开发更高特定的速度的一个要求被建议了轴的流动泵。在现在的纸，使用 contra-rotating 转子的优点和劣势与转子定子的常规类型比较被描述，基于理论、试验性的调查。优点如下：(1 ) 泵内在地作为更小被设计缩放并且以更低的旋转速度。(2 ) 为有否定斜坡的流动率的一条稳定的头特征曲线出现。(3 ) 作为后面的转子，旋转速度作为前面转子的独立控制被改变，高效操作的更宽的范围被后面的转子速度控制除了前面转子速度控制获得。劣势如下：(1 ) 两倍柄系统的结构变得复杂。(2 ) 泵表演是劣等的在在是的流动率上，装载的后面的转子被削弱。(3 ) 片更强烈从后面的转子划相互作用到前面转子出现。当时，后面的转子设计是一把钥匙完成更高的泵性能。克服这些劣势的一些方法将向 contra-rotating 的更宽的用法更详细地被讨论各种各样的工业地里的轴的流动泵。

关键词：转子对转轴流泵性能试验流量计量多相流

Study on Performance and Flow Field of an Undershot Cross-Flow Water Turbine Comprising Different Number of Blades

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Journal of Thermal Science 2017年第5期26卷 413-430页

作者： Yasuyuki nishi Kentaro Hatano Terumi Inagaki Department of Mechanical Engineering Ibaraki University 4-12-1 Nakanarusawa-cho Hitachi-shi Ibaraki 316-8511JAPAN Graduate School of Science and Engineering Ibaraki University 4-12-1 Nakanarusawa-cho Hitachi-shi Ibaraki316-8511 JAPAN

Recently, small hydroelectric generators have gained attention as a further development in water turbine technology for ultra low head drops in open channels. The authors have evaluated the application of cross-flow water turbines in open channels as an undershot type after removing the casings and guide vanes to substantially simplify these water turbines. However, because undershot cross-flow water turbines are designed on the basis of cross-flow water turbine runners used in typical pipelines, it remains unclear whether the number of blades has an effect on the performance or flow fields. Thus, in this research, experiments and numerical analyses are employed to study the performance and flow fields of undershot cross-flow water turbines with varying number of blades. The findings show that the turbine output and torque are lower, the fluctuation is significantly higher, and the turbine efficiency is higher for runners with 8 blades as opposed to those with 24 blades.

关键词：水轮机技术导流叶片性能流场小型水轮发电机水轮机转轮同数贯流式水轮机