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World Journal of Gastroenterology 2018年第28期24卷 3155-3162页

作者： Masanori Ochi Toshiro Kamoshida Atsushi Ohkawara Haruka Ohkawara Nobushige Kakinoki Shinji Hirai akinori yanaka Department of Gastroenterology Hitachi General Hospital Hitachi Medical Education and Research Center University of Tsukuba

AIM To investigate the relationship between the onsets of multikinase inhibitor(MKI)-associated hand-foot skin reaction(HFSR) and prognosis under intervention by pharmacists after the introduction of *** We conducted a retrospective study involving 40 patients treated with sorafenib. Intervention by pharmacists began at the time of treatment introduction and continued until the appearance of symptomatic exacerbation or non-permissible adverse reactions. We examined the relationship between MKI-associated HFSR and overall survival(OS) after the initiation of *** The median OS was 10.9 mo in the MKI-associated HFSR group and 3.4 mo in the no HFSR group, showing a significant difference in multivariate analysis. A multivariate analysis of the time to treatment failure indicated that the intervention by pharmacists and MKI-associated HFSR were significant factors. The median cumulative dose and the mean medication possession ratio were significantly higher in the intervention group than in the non-intervention group. A borderline significant difference was observed in terms of OS in this *** Intervention by pharmacists increased drug adherence. Under increased adherence, MKI-associated HFSR was an advantageous surrogate marker. Intervention by healthcare providers needs to be performed for adequate sorafenib treatment.

关键词： Hepatocellular carcinoma Surrogate marker Multikinase inhibitor-associated hand-foot skin reaction Sorafenib Intervention by pharmacists

Early colonoscopy and urgent contrast enhanced computed tomography for colonic diverticular bleeding reduces risk of rebleeding

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World Journal of Clinical Cases 2021年第11期9卷 2446-2457页

作者： Masanori Ochi Toshiro Kamoshida Yukako Hamano Atsushi Ohkawara Haruka Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai akinori yanaka Department of Gastroenterology Hitachi General HospitalIbaraki 317-0077Japan Hitachi Medical Education and Research Center University of TsukubaIbaraki 317-0077Japan

BACKGROUND Colonoscopy within 24 h of hospital admission for colonic diverticular bleeding(CDB)is ***,little is known about rates of rebleeding within 30 *** posited that a group of patients who underwent contrast-enhanced computed tomography(CT)within 4 h of the last hematochezia and colonoscopy within 24 h would experience fewer incidences of *** To evaluate the outcomes of early colonoscopy for CDB among different groups of *** Data from 182 patients with CDB who underwent contrast-enhanced CT and colonoscopy between January 2011 and December 2018 at the study site were retrospectively *** were divided into groups based on the timing of the CT imaging,within or at 4 h were defined as urgent CTs(n=100)and those performed after 4 h were defined as elective CTs(n=82).Main outcomes included rebleeding within 30 d and the identification of stigmata of recent hemorrhage(SRH)(i.e.,active bleeding,non-bleeding visible vessels,or adherent clots).RESULTS In total,182 patients(126 men and 56 women)with median ages of 68.6(range,37-92)and 73.7(range,48-93)years,respectively,underwent CT imaging and colonoscopy within 24 h of the last *** for whom CT was performed within 4 h of the last hematochezia were included in the urgent CT group(n=100)and patients for whom CT was performed after 4 h were included in the elective CT group(n=82).SRH were identified in 35.0%(35/100)of the urgent CT cases and 7.3%(6/82)of the elective CT cases(P<0.01).Among all patients with extravasation-positive images on CT,SRH was identified in 31 out of 47 patients(66.0%)in the urgent CT group and 4 out of 20 patients(20.0%)in the elective CT group(P<0.01).Furthermore,rates of rebleeding within 30 d were significantly improved in the urgent CT and extravasation-positive cases(P<0.05).Results from the evaluation of early colonoscopy did not show a difference in the ability to detect SRH identification or rebleeding *** case

关键词： Colonoscopy Gastrointestinal hemorrhage Colon Diverticular diseases Xray computed tomography

Low-Dose of the Sulforaphane Precursor Glucoraphanin as a Dietary Supplement Induces Chemoprotective Enzymes in Humans

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Food and Nutrition Sciences 2015年第17期6卷 1603-1612页

作者： Yusuke Ushida Hiroyuki Suganuma akinori yanaka Research & Development Division Kagome Co. Ltd. Tochigi Japan Hitachi Medical Education and Research Center Faculty of Medicine University of Tsukuba Hospital Ibaraki Japan

Broccoli sprout (BS) supplements have been marketed for over a decade for the promising health beneficial effects of sulforaphane (SFN), which induces Nrf2 signaling and downstream chemoprotective genes, including phase 2 enzymes. Most commercially available BS supplements encapsulate heat-processed BS containing glucoraphanin (GR), which is hydrolyzed to SFN by the intestinal microbiota. However, the absorption behavior of SFN following the intake of such BS supplements is still unclear. Additionally, the GR dose (around 30 mg) recommended by many manufacturers of BS supplements is relatively lower than the effective dose determined in previous intervention studies. The aims of this study were to assess the effects of a single administration of a typical BS supplement containing lower doses of GR (30 or 60 mg from 3 or 6 capsules, respectively) on SFN absorption, and also to assess the serum activities of phase 2 enzymes as possible surrogate markers of the beneficial effects of SFN. Urinary excreted isothiocyanates and dithiocarbamates showed that the SFN absorption following administration of BS supplement was prolonged and varied among individuals, which conforms to the well-known characteristics of intestinal microbiota-mediated SFN absorption. The amount of SFN absorbed increased dose-dependently but not linear fashion (9.27 μmol and 13.5 μmol for 3 and 6 capsules, respectively). There was no significant difference in SFN bioavailability and the number of capsules consumed. Serum activities of phase 2 enzymes glutathione S-transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1), which have been reported to display “chemoprotected states” in organs such as the liver, were dose-dependently and synchronously elevated (p < 0.05) following BS supplement intake. This suggests that a low dose of GR (30 mg) exerts chemoprotective effects in humans. In conclusion, our findings will be useful in future clinical studies investigating the chemoprotective effects of

关键词： Sulforaphane Glucoraphanin Chemoprotection Broccoli Sprout Phase 2 Enzymes

High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection

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World Journal of Gastroenterology 2021年第38期27卷 6442-6452页

作者： Masanori Ochi Ryosuke Kawagoe Toshiro Kamoshida Yukako Hamano Haruka Ohkawara Atsushi Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai akinori yanaka Kiichiro Tsuchiya Department of Gastroenterology Hitachi General HospitalHitachi City 317-0077IbarakiJapan Department of Gastroenterology Faculty of MedicineUniversity of TsukubaTsukuba 305-8576IbarakiJapan

BACKGROUND We hypothesized that thermal damage accumulation during endoscopic submucosal dissection(ESD)causes the pathogenesis of post-ESD electrocoagulation syndrome(PECS).AIM To determine the association between Joule heat and the onset of *** We performed a retrospective cohort study in patients who underwent colorectal ESD from May 2013 to March 2021 in *** developed a novel device that measures swift coagulation time with a sensor adjacent to the electrosurgical coagulation unit foot switch,which enabled us to calculate total Joule *** was defined as localized abdominal pain(visual analogue scale≥30 mm during hospitalization or increased by≥20 mm from the baseline)and fever(temperature≥37.5 degrees or white blood cell count≥10000μ/L).Patients exposed to more or less than the median Joule heat value were assigned to the high and low Joule heat groups,*** analyses included Mann-Whitney U and chisquare tests and logistic regression and receiver operating characteristic curve(ROC)*** We evaluated 151 *** PECS incidence was 10.6%(16/151 cases),and all patients were followed conservatively and discharged without severe *** multivariate analysis,high Joule heat was an independent PECS risk *** area under the ROC curve showing the correlation between PECS and total Joule heat was high[0.788(95%confidence interval:0.666-0.909)].CONCLUSION Joule heat accumulation in the gastrointestinal wall is involved in the onset of ***-related thermal damage to the peeled mucosal surface is probably a major component of the mechanism underlying PECS.

关键词： Post-endoscopic submucosal dissection electrocoagulation syndrome Joule heat Colorectal endoscopic submucosal dissection Colorectal neoplasms Electrocoagulation Gastrointestinal tract

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

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World Journal of Gastroenterology 2013年第17期19卷 2718-2722页

作者： Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui akinori yanaka Aki Hirayama Ichinosuke Hyodo Department of Gastroenterology Institute of Clinical Medicine University of Tsukuba Graduate School Center of Integrative Medicine Tsukuba University of Technology

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

关键词： Qing Dai Herbal medicine Ulcerative colitis Hydroxyl radical Electron spin resonance

Display Method for Online Bookstore Emulating Real Bookstore by WebGL

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Journal of Electronic Science and Technology 2014年第1期12卷 59-63页

作者： Kazuhisa yanaka Terumichi Iizuka Faculty of Information Technology Kanagawa Institute of Technology Faculty of Information Technology Kanagawa Institute of Technology until March 2013

Thanks to the spread of the Internet, opportunities to use online bookstores have been increasing in recent years. However, it is difficult for the typical customer to intuitively grasp which book sells well or which book is recommended by the shop. We have therefore developed a display system for virtual bookstores in which an image of books arranged in a bookshelf or stacked on a table is reproduced by using WebGL. Since the amount of book stock that is managed by the server side needs to be changed as orders come in from clients, we introduce a server side technology using a hypertext preprocessor （PHP）.

关键词： Net shopping online bookstore,WebGL.

Myosin Heavy Chain Expression and Oxidative Modifications in Diabetic Rat Hearts

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Open Journal of Applied Sciences 2012年第4期2卷 248-256页

作者： Mai Kuratani Keita Kanzaki Noriyuki yanaka Satoshi Matsunaga Masanobu Wada Faculty of Education and Culture Miyazaki University Miyazaki Japan Faculty of Food Culture Kurashiki-Sakuyo University Okayama Japan Graduate School of Biosphere Science Hiroshima University Hiroshima Japan Graduate School of Integrated Arts and Sciences Hiroshima University Hiroshima Japan

In this study, we tested the hypotheses that 1) diabetes-induced disturbances in cardiac my-ATPase activity would be attributed to not only myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC protein;and 2) if diabetes results in declines in the MHC protein content, this change would relate to oxidative damage to MHC. Diabetes was induced by a single intraperitoneal injection of streptozotocin. After 6 weeks of injection, the left ventricles were excised for mechanical and biochemical analyses. Peak twitch tension and the rate of force development in papillary muscles were decreased by 23.4% and 34.1%, respectively. A 33.5% reduction in myofibrillar ATPase activity occurred in conjunction with a 9.5% decrease in MHC protein as well as MHC isoform transitions towards a slower phenotype. The decreased MHC content was not accompanied by elevations in carbonyl groups present in MHC. Whole muscle analyses indicated that the contents of malondialdehyde and reduced glutathione were elevated. These results suggest that decreases in the MHC content may be associated, at least in part, with a diabetes-related inactivation of cardiac my-ATPase and may not be due to accumulation of oxidative damage to protein.

关键词： Myofibrillar ATPase Reactive Oxygen Species Protein Degradation Isomyosin

Change in Aggregate Shape of Heat Treated Carbon Nanoparticles

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Journal of Chemistry and Chemical Engineering 2013年第4期7卷 326-333页

作者： Kiminori Ono Mlkl yanaka Aki Watanabe Yoshiya Matsukawa Yasuhiro Saito Hideyuki Aoki OkiteruFukuda Takayuki Aoki Togo Yamaguchi Department of Chemical Engineering Graduate School of Engineering Tohoku University Sendai 980-8579 Japan ASAHI CARBON Co. Ltd. Niigata 950-0883 Japan

To better understand the fusion mechanism of heated carbon black, heat treatment is conducted for carbon black produced by benzene pyrolysis. The effects of （a） heating time, （b） heating temperature and （c） heating rate on the aggregate shape and mean primary particle diameter of the carbon black are investigated using TEM （transmission electron microscopy）. The mean primary particle diameter does not change significantly when carbon black is heat treated. For short heating times and low heating temperatures, the aggregate shapes become simple when compared with those of non-heated carbon black, and shapes become complex with an increase in the heating time. Also, for low heating rates, the aggregate shapes become significantly simple when compared with those of non-heated carbon black. The results of this study suggest that sintering between primary particles is promoted under relatively low heating temperatures, and Ostwald ripening among aggregates is promoted under relatively high heating temperatures.

关键词： Carbon black soot heat treatment.

新疆冬小麦地方品种高分子量麦谷蛋白亚基的地理分布及其新发现亚基的特性(英文)

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新疆农业科学 2011年第9期48卷 1576-1584页

作者：丛花池田达哉高田兼则谷中美贵子藤卷宏长峰司新疆农业科学院农作物品种资源研究所乌鲁木齐830091 近畿中国四国农业研究中心东京农业大学大学院农学研究科

【目的和方法】为了揭示新疆小麦地方品种高分子量谷蛋白亚基（HMW—GS）的遗传多样性，对新疆北部地区（北疆）、东部地区（东疆）和南部地区（南疆）小麦地方品种HMW—GS的分布进行了研究。【结果】研究表明：新疆小麦地方品种HMW—G... 详细信息

【目的和方法】为了揭示新疆小麦地方品种高分子量谷蛋白亚基（HMW—GS）的遗传多样性，对新疆北部地区（北疆）、东部地区（东疆）和南部地区（南疆）小麦地方品种HMW—GS的分布进行了研究。【结果】研究表明：新疆小麦地方品种HMW—GS等位变异的分布与其地理来源具有密切关系，除Glu-B1位点外，G2u—A1和Glu—D1位点等位变异在北部地区、东部地区和南部地区的分布频率存在显著差异。在Glu—A1位点，Glu—A1c编码的Null亚基出现的频率最高，其次是Glu—A1b编码的2^＊亚基；但在北部地区，几乎所有品种都含有Glu—A1c编码的Null亚基，仅有1个品种含有Glu—A1b编码的2^＊亚基。在Glu-81位点，新疆大多数小麦地方品种含有Glu—B1b编码的7＋8亚基。在Glu—D1位点，新发现的等位基因Glu—D16p（t）编码的2．6亚基在东疆和南疆出现的频率较高，但在北疆出现的频率最低，分别为91％（东疆），61％（南疆），19％（北疆）；等位基因Glu—D1bp（t）在南疆冬小麦地方品种中普遍存在。然而，北疆是以等位基因Glu—D1a编码的2＋12亚基为主，其频率为83％。关于Glu—D1bp（t）的起源，推测可能是在南疆地区自然突变产生，然而由于南疆和东疆荒漠化造成的地理阻碍使其向北疆传播的概率较低，同时抑制了该基因向东亚地区的迁移。【结论】基于DNA序列的氨基酸序列比对，发现Glu—D1bp（t）编码的2．6亚基与Glu—D1al编码的2．2^＊亚基非常相似。

关键词：遗传差异 Glu-D1 Glu-B1 Glu-A1 等位基因频率地区差异制约因素 2.6亚基氨基酸序列