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Methanol extracts of Basella alba leaves alleviate stress in rats

Chinese Herbal Medicines 2020年第2期12卷 163-170页

作者： Olubayode Bamidele Nkiruka Chisom Okeke Temitope Gabriel Adedeji Lawrence Dayo Adedayo akinjide moses akinnuga Department of Physiology Faculty of Basic Medical and Health SciencesCollege of Health SciencesBowen UniversityIwo 232101 Nigeria Department of Physiology Federal University of TechnologyAkure 340252Nigeria Department of Human Physiology Cross River University of Technology Okuku CampusYala 550107Nigeria

Objective:Stress is becoming an unavoidable threat in recent times,there has been increasing interest by researchers in the use of naturally occurring biologically active compounds with medicinal value to cure body *** present work was carried out to investigate the effect of methanol extract of Basella alba leaves on stress in Wistar rats(Rattus norvegicus).Methods:A total of 35 male rats were used in this *** were grouped into seven groups of five rats *** 1(normal control)was received 10 m L/kg normal *** 2 contained restraint stress rats *** 3 contained forced swim stress rats *** 4 and 5 were treated with 60 mg/kg of *** extract(BAE)thereafter subjected to restraint and forced swim stresses *** 6 and 7 were treated with 120 mg/kg of BAE thereafter subjected to restraint and forced swim stresses *** procedures were carried out at the end of first and third ***:In the stressed rats,there were significant increases(P<0.05)in fasting blood glucose and white blood cell count while there were significant decreases in superoxide dismutase activity and glutathione concentration when compared to group *** were significant decreases(P<0.05)in blood glucose and white blood cell count and significant increases in superoxide dismutase and glutathione concentrations in BAE treated rats when compared to group 2 and *** of the significant differences were either dose or duration ***:In conclusion,results from this research suggest that BAE alleviates hyperglycaemia,chronic activation of immune system and generation of free radicals due to stress in Wistar rats.

关键词： antioxidant enzymes Basella alba L fasting blood glucose haematological parameters stress

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